Effects of sex and gender on adaptation to space: Cardiovascular alterations

Journal of Women's Health

Volumn 23, Issue 11, 2014, Pages 950-955

  Platts, Steven H ^a   Bairey Merz, C Noel ^b   Barr, Yael ^c   Fu, Qi ^d   Gulati, Martha ^e   Hughson, Richard ^f   Levine, Benjamin D ^d   Mehran, Roxana ^g   Stachenfeld, Nina ^h   Wenger, Nanette K ⁱ  

^a NASA JOHNSON SPACE CENTER   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f UNIVERSITY OF WATERLOO   (Canada)

^g MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^h YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTATION; ARTICLE; BED REST; BLOOD VESSEL COMPLIANCE; BLOOD VOLUME; CARDIOVASCULAR DISEASE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RESPONSE; CARDIOVASCULAR RISK; CARDIOVASCULAR SYSTEM; CLINICAL TRIAL (TOPIC); COSMONAUT; HORMONE DETERMINATION; HUMAN; INTRACRANIAL PRESSURE; LOWER BODY NEGATIVE PRESSURE; MENSTRUAL CYCLE; MICROGRAVITY; NONHUMAN; PLASMA VOLUME; RESEARCH PRIORITY; SEX DIFFERENCE; SPACE FLIGHT; VASCULAR ENDOTHELIUM; VASOMOTOR REFLEX; VISUAL IMPAIRMENT; VISUAL IMPAIRMENT INTRACRANIAL PRESSURE SYNDROME; ADAPTIVE BEHAVIOR; AEROSPACE MEDICINE; CARDIOVASCULAR DISEASES; CARDIOVASCULAR EFFECT; FEMALE; HEALTH STATUS; MALE; STATISTICS AND NUMERICAL DATA; WEIGHTLESSNESS;

ADAPTATION, PHYSIOLOGICAL; ADAPTATION, PSYCHOLOGICAL; AEROSPACE MEDICINE; ASTRONAUTS; CARDIOVASCULAR DECONDITIONING; CARDIOVASCULAR DISEASES; FEMALE; HEALTH STATUS; HUMANS; MALE; SEX FACTORS; SPACE FLIGHT; WEIGHTLESSNESS; WEIGHTLESSNESS COUNTERMEASURES;

EID: 84911077691     PISSN: 15409996     EISSN: 1931843X     Source Type: Journal    
DOI: 10.1089/jwh.2014.4912     Document Type: Article

References (53)

1. Alexander DJ, Gibson CR, Hamilton DR. Human Research Program Human Health Countermeasures Element Evidence Report: Risk of Spaceflight-Induced Intracranial Hypertension and Vision Alterations. Houston, TX: National Aeronautics and Space Administration, 2012. Available at http://humanresearchroadmap.nasa.gov/Evidence/reports/VIIP.pdf Accessed February 11, 2014
2. Mader TH, Gibson CR, Pass AF, et al. Optic disc edema, globe flattening, choroidal folds, and hyperopic shifts observed in astronauts after long-duration space flight. Ophthalmology 2011;118:2058-2069
3. Kramer LA, Sargsyan AE, Hasan KM, Polk JD, Hamilton DR. Orbital and intracranial effects of microgravity: Findings at 3-T MR imaging. Radiology 2012;263:819-827
4. Friedman DI. Idiopathic intracranial hypertension. Curr Pain Headache Rep 2007;11:62-68
5. Kaplan CP, Miner ME, McGregor JM. Pseudotumour cerebri: Risk for cognitive impairment? Brain Inj 1997;11:293-303
6. Sorensen PS, Thomsen AM, Gjerris F. Persistent disturbances of cognitive functions in patients with pseudotumor cerebri. Acta Neurol Scand 1986;73:264-268
7. Bruce BB, Biousse V, Newman NJ. Update on idiopathic intracranial hypertension. Am J Ophthalmol 2011;152:163-169
8. The National Aeronautics and Space Administration (NASA). Life sciences data archive at Johnson Space Center, Houston, Texas. Lifetime surveillance of astronaut health (LSAH), 2013. Available at http://lsda.jsc.nasa.gov/lsah-home1.aspx Accessed February 11, 2014
9. Waters WW, Ziegler MG, Meck JV. Postspaceflight orthostatic hypotension occurs mostly in women and is predicted by low vascular resistance. J Appl Physiol 2002;92: 586-594
10. Morey ER, Sabelman EE, Turner RT, Baylink DJ. A new rat model simulating some aspects of space flight. Physiologist 1979;22:S23-S24
11. Foley CM, Mueller PJ, Hasser EM, Heesch CM. Hindlimb unloading and female gender attenuate baroreflex-mediated sympathoexcitation. Am J Physiol Regul Integr Comp Physiol 2005;289:R1440-R1447
12. Cui Y, Zhang SM, Zhang QY, et al. Modulation of intracellular calcium transient in response to beta-Adrenoceptor stimulation in the hearts of 4-wk-old rats during simulated weightlessness. J Appl Physiol 2010;108:838-844
13. Ogneva IV, Mirzoev TM, Biryukov NS, Veselova OM, Larina IM. Structure and functional characteristics of rat's left ventricle cardiomyocytes under antiorthostatic suspension of various duration and subsequent loading. J Biomed Biotechnol 2012;2012:Article ID 659869
14. Ray CA, Vasques M, Miller TA, Wilkerson MK, Delp MD. Effect of short-Term microgravity and long-Term hindlimb unloading on rat cardiac mass and function. J Appl Physiol 2001;91:1207-1213
15. Delp MD, Brown M, Laughlin MH, Hasser EM. Rat aortic vasoreactivity is altered by old age and hindlimb unloading. J Appl Physiol 1995;78:2079-2086
16. Delp MD, Holder-Binkley T, Laughlin MH, Hasser EM. Vasoconstrictor properties of rat aorta are diminished by hindlimb unweighting. J Appl Physiol 1993;75:2620-2628
17. Behnke BJ, Stabley JN, McCullough DJ, Davis RT, III, Dominguez JM et al. Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice. FASEB J 2013;27:399-409
18. Stabley JN, Dominguez JM, Dominguez CE, et al. Spaceflight reduces vasoconstrictor responsiveness of skeletal muscle resistance arteries in mice. J Appl Physiol 2012; 113:1439-1445
19. Lin LJ, Gao F, Bai YG, et al. Contrasting effects of simulated microgravity with and without daily-Gx gravitation on structure and function of cerebral and mesenteric small arteries in rats. J Appl Physiol 2009;107:1710-1721
20. Zhang LF. Region-specific vascular remodeling and its prevention by artificial gravity in weightless environment. Eur J Appl Physiol 2013;113:2873-2895
21. Geary GG, Krause DN, Purdy RE, Duckles SP. Simulated microgravity increases myogenic tone in rat cerebral arteries. J Appl Physiol 1998;85:1615-1621
22. Jasperse JL, Woodman CR, Price EM, Hasser EM, Laughlin MH. Hindlimb unweighting decreases ecNOS gene expression and endothelium-dependent dilation in rat soleus feed arteries. J Appl Physiol 1999;87:1476-1482
23. Prisby RD, Wilkerson MK, Sokoya EM, et al. Endotheliumdependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms. J Appl Physiol 2006;101:348-353
24. Hwang S, Shelkovnikov SA, Purdy RE. Simulated microgravity effects on the rat carotid and femoral arteries: Role of contractile protein expression and mechanical properties of the vessel wall. J Appl Physiol 2007;102: 1595-1603
25. Tuday EC, Meck JV, Nyhan D, Shoukas AA, Berkowitz DE. Microgravity-induced changes in aortic stiffness and their role in orthostatic intolerance. J Appl Physiol 2007; 102:853-858
26. Tuday EC, Nyhan D, Shoukas AA, Berkowitz DE. Simulated microgravity-induced aortic remodeling. J Appl Physiol 2009;106:2002-2008
27. Edgell H, Robertson AD, Hughson RL. Hemodynamics and brain blood flow during posture change in younger women and postmenopausal women compared with age-matched men. J Appl Physiol 2012;112:1482-1493
28. Dorfman TA, Levine BD, Tillery T, et al. Cardiac atrophy in women following bed rest. J Appl Physiol 2007;103: 8-16
29. Custaud MA, de Souza Neto EP, Abry P, et al. Orthostatic tolerance and spontaneous baroreflex sensitivity in men versus women after 7 days of head-down bed rest. Auton Neurosci 2002;100:66-76
30. Millet C, Custaud MA, Maillet A, et al. Endocrine responses to 7 days of head-down bed rest and orthostatic tests in men and women. Clin Physiol 2001;21:172-183
31. Fortney SM, Turner C, Steinmann L, Driscoll T, Alfrey C. Blood volume responses of men and women to bed rest. J Clin Pharmacol 1994;34:434-439
32. Vernikos J, Dallman MF, Keil LC, O'Hara D, Convertino VA. Gender differences in endocrine responses to posture and 7 days of-6 degrees head-down bed rest. Am J Physiol 1993;265:E153-E161
33. Grenon SM, Xiao X, Hurwitz S, et al. Why is orthostatic tolerance lower in women than in men? Renal and cardiovascular responses to simulated microgravity and the role of midodrine. J Investig Med 2006;54:180-190
34. Zuj KA, Edgell H, Shoemaker JK, et al. WISE 2005: Responses of women to sublingual nitroglycerin before and after 56 days of 6 degrees head-down bed rest. J Appl Physiol 2012;113:434-441
35. Coupe M, Fortrat JO, Larina I, et al. Cardiovascular deconditioning: From autonomic nervous system to microvascular dysfunctions. Respir Physiol Neurobiol 2009;169: S10-S12
36. Arbeille P, Kerbeci P, Greaves D, Schneider S, Hargens A, Hughson R. Arterial and venous response to Tilt with LBNP test after a 60 day HDT bedrest (WISE study). J Gravit Physiol 2007;14:P47-P48
37. O'Leary DD, Hughson RL, Shoemaker JK, et al. Heterogeneity of responses to orthostatic stress in homozygous twins. J Appl Physiol 2007;102:249-254
38. Watenpaugh DE, O'Leary DD, Schneider SM, et al. Lower body negative pressure exercise plus brief postexercise lower body negative pressure improve post-bed rest orthostatic tolerance. J Appl Physiol 2007;103:1964-1972
39. Cooper G, Kent RL, Mann DL. Load induction of cardiac hypertrophy. J Mol Cell Cardiol 1989;21:11-30
40. Levine BD, Zuckerman JH, Pawelczyk JA. Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance. Circulation 1997;96:517-525
41. Perhonen MA, Franco F, Lane LD, et al. Cardiac atrophy after bed rest and spaceflight. J Appl Physiol 2001;91:645-653
42. Stein TP, Schluter MD. Human skeletal muscle protein breakdown during spaceflight. Am J Physiol 1997;272: E688-E695
43. Zile MR, Tomita M, Ishihara K, et al. Changes in diastolic function during development and correction of chronic LV volume overload produced by mitral regurgitation. Circulation 1993;87:1378-1388
44. Blaber AP, Bondar RL, Kassam MS. Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance. BMC Physiol 2004;4:6
45. Blaber AP, Goswami N, Bondar RL, Kassam MS. Impairment of cerebral blood flow regulation in astronauts with orthostatic intolerance after flight. Stroke 2011;42: 1844-1850
46. Harm DL, Jennings RT, Meck JV, Powell MR, Putcha L et al. Invited review: Gender issues related to spaceflight: A NASA perspective. J Appl Physiol 2001;91:2374-2383
47. Fu Q, Arbab-Zadeh A, Perhonen MA, Zhang R, Zuckerman JH. Hemodynamics of orthostatic intolerance: Implications for gender differences. Am J Physiol Heart Circ Physiol 2004;286:H449-H457
48. Fu Q, Witkowski S, Okazaki K, Levine BD. Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress. Am J Physiol Regul Integr Comp Physiol 2005;289:R109-R116
49. Summers RL, Coleman TG. Computer systems analysis of the cardiovascular mechanisms of reentry orthostasis in astronauts. Comput Cardiol 2002;29:521-524
50. Levine BD, Lane LD, Watenpaugh DE, Gaffney FA, Buckey JC. Maximal exercise performance after adaptation to microgravity. J Appl Physiol 1996;81:686-694
51. Convertino VA, Stremel RW, Bernauer EM, Greenleaf JE. Cardiorespiratory responses to exercise after bedrest in men and women. Acta Astronaut 1977;4:895-905
52. Shirway NA, and Zou MH. Arterial stiffness: A brief review. Acta Pharmacologica Sinca 2010;31:1267-1276
53. Vernikos J, Schneider VS. Space, gravity and the physiology of aging: Parallel or convergent disciplines? A minireview. Gerontology 2010;56:157-166