Cardiovascular deconditioning: From autonomic nervous system to microvascular dysfunctions

Respiratory Physiology and Neurobiology

Volumn 169, Issue SUPPL., 2009, Pages

  Coupe M ^a   Fortrat, J O ^a   Larina, I ^b   Gauquelin Koch, G ^c   Gharib, C ^d   Custaud, M A ^a  

^a Universite d'Angers   (France)

^b INSTITUTE OF BIOMEDICAL PROBLEMS   (Russian Federation)

^c CNES   (France)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

Baroreflex; Countermeasures; Endothelium; Microcirculation; Orthostatic intolerance

Indexed keywords

ACETYLCHOLINE; VASODILATOR AGENT;

ARTICLE; AUTONOMIC NERVOUS SYSTEM; BED REST; CARDIOVASCULAR EFFECT; CASE CONTROL STUDY; DRUG EFFECT; EXERCISE; FEMALE; HEMODYNAMICS; HUMAN; MICROCIRCULATION; ORTHOSTATIC INTOLERANCE; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESSORECEPTOR REFLEX; VASCULAR ENDOTHELIUM; WEIGHTLESSNESS;

ACETYLCHOLINE; AUTONOMIC NERVOUS SYSTEM; BAROREFLEX; BED REST; CARDIOVASCULAR DECONDITIONING; CASE-CONTROL STUDIES; ENDOTHELIUM, VASCULAR; EXERCISE; FEMALE; HEMODYNAMICS; HUMANS; MICROCIRCULATION; ORTHOSTATIC INTOLERANCE; VASODILATOR AGENTS; WEIGHTLESSNESS; WEIGHTLESSNESS COUNTERMEASURES;

EID: 75549090748     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2009.04.009     Document Type: Article

References (15)

1. Belin de Chantemèle, E., Pascaud, L., Custaud, M.A., Capri, A., Louisy, F., Ferretti, G., Gharib, C., Arbeille, P., 2004. Calf venous volume during stand-test after a 90-day bed-rest study with or without exercise countermeasure. J. Physiol. 561 (Pt. 2), 611-622.
2. Bonnin, P., Ben Driss, A., Benessiano, J., Maillet, A., Pavy le Traon, A., Levy, B.I., 2001. Enhanced flow-dependent vasodilatation after bed rest, a possible mechanism for orthostatic intolerance in humans. Eur. J. Appl. Physiol. 85 (5), 420-426.
3. Convertino, V.A., Doerr, D.F., Eckberg, D.L., Fritsch, J.M., Vernikos-Danellis, J., 1990. Head-down bed rest impairs vagal baroreflex responses and provokes orthostatic hypotension. J. Appl. Physiol. 68 (4), 1458-1464.
4. Cooke, W.H., Ames IV, J.E., Crossman, A.A., Cox, J.F., Kuusela, T.A., Tahvanainen, K.U., Moon, L.B., Drescher, J., Baisch, F.J., Mano, T., Levine, B.D., Blomqvist, C.G., Eckberg, D.L., 2000. Nine months in space: effects on human autonomic cardiovascular regulation. J. Appl. Physiol. 89 (3), 1039-1045.
5. Custaud, M.A., de Souza Neto, E.P., Abry, P., Flandrin, P., Millet, C., Duvareille, M., Fortrat, J.O., Gharib, C., 2002. Orthostatic tolerance and spontaneous baroreflex sensitivity in men versus women after 7 days of head-down bed rest. Auton. Neurosci. 100 (1-2), 66-76.
6. Demiot, C., Dignat-George, F., Fortrat, J.O., Sabatier, F., Gharib, C., Larina, I., Gauquelin-Koch, G., Hughson, R., Custaud, M.A., 2007. WISE 2005: chronic bed rest impairs microcirculatory endothelium inwomen. Am. J. Physiol. Heart. Circ. Physiol. 293 (5), H3159-H3164.
7. Dimmeler, S., Hermann, C., Galle, J., Zeiher, A.M., 1999. Upregulation of superoxide dismutase and nitric oxide synthase mediates the apoptosis-suppressive effects of shear stress on endothelial cells. Arterioscler. Thromb. Vasc. Biol. 19 (3), 656-664.
8. Hamburg, N.M., McMackin, C.J., Huang, A.L., Shenouda, S.M., Widlansky, M.E., Schulz, E., Gokce, N., Ruderman, N.B., Keaney Jr., J.F., Vita, J.A., 2007. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler. Thromb. Vasc. Biol. 27 (12), 2650-2656.
9. Hesse, C., Siedler, H., Luntz, S.P., Arendt, B.M., Goerlich, R., Fricker, R., Heer, M., Haefeli, W.E., 2005. Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition. J. Appl. Physiol. 99 (6), 2196-2203.
10. Hirayanagi, K., Iwase, S., Kamiya, A., Sasaki, T., Mano, T., Yajima, K., 2004. Functional changes in autonomic nervous system and baroreceptor reflex induced by 14 days of 6 degrees head-down bed rest. Eur. J. Appl. Physiol. 92 (1-2), 160-167.
11. Hughson, R.L., Maillet, A., Gharib, C., Fortrat, J.O., Yamamoto, Y., Pavy-Le traon, A., Rivière, D., Güell, A., 1994. Reduced spontaneous baroreflex response slope during lower body negative pressure after 28 days of head-down bed rest. J. Appl. Physiol. 77 (1), 69-77.
12. Koïtka, A., Abraham, P., Bouhanick, B., Sigaudo-Roussel, D., Demiot, C., Saumet, J.L., 2004. Impaired pressure-induced vasodilation at the foot in young adults with type 1 diabetes. Diabetes 53 (3), 721-725.
13. Prisby, R.D., Wilkerson, M.K., Sokoya, E.M., Bryan Jr., R.M., Wilson, E., Delp, M.D., 2006. Endothelium-dependent vasodilation of cerebral arteries is altered with simulated microgravity through nitric oxide synthase and EDHF mechanisms. J. Appl. Physiol. 101, 348-353.
14. Sigaudo-Roussel, D., Custaud, M.A., Maillet, A., Güell, A., Kaspranski, R., Hughson, R.L., Gharib, C., Fortrat, J.O., 2002. Heart rate variability after prolonged spaceflights. Eur. J. Appl. Physiol. 86 (3), 258-265.
15. Traon, A.P., Sigaudo, D., Vasseur, P., Maillet, A., Fortrat, J.O., Hughson, R.L., Gauquelin-Koch, G., Gharib, C., 1998. Cardiovascular responses to orthostatic tests after a 42-day head-downbed-rest. Eur. J. Appl. Physiol. Occup. Physiol. 77 (1-2), 50-59.