Inflammatory monocytes promote progression of Duchenne muscular dystrophy and can be therapeutically targeted via CCR2

EMBO Molecular Medicine

Volumn 6, Issue 11, 2014, Pages 1476-1492

  Mojumdar, Kamalika ^a   Liang, Feng ^a   Giordano, Christian ^a   Lemaire, Christian ^a   Danialou, Gawiyou ^a   Okazaki, Tatsuma ^a   Bourdon, Johanne ^a   Rafei, Moutih ^b   Galipeau, Jacques ^c   Divangahi, Maziar ^a   Petrof, Basil J ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF MONTREAL   (Canada)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CCR2; Chemokines; Inflammatory monocytes; Macrophage polarization; Muscular dystrophy

Indexed keywords

CCL2 GM CSF FUSION PROTEIN; CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR2; HYBRID PROTEIN; HYDROXYPROLINE; LIGAND; MESSENGER RNA; RETROVIRUS VECTOR; SOMATOMEDIN C; UNCLASSIFIED DRUG; CCL2 PROTEIN, MOUSE; CCR2 PROTEIN, MOUSE; LY ANTIGEN; LY-6C ANTIGEN, MOUSE; MONOCYTE CHEMOTACTIC PROTEIN 1; MUTANT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL BASED GENE THERAPY; CELL INFILTRATION; CONTROLLED STUDY; DIAPHRAGM MUSCLE; DISEASE COURSE; DISEASE SEVERITY; DUCHENNE MUSCULAR DYSTROPHY; ELECTROSTIMULATION; EMBRYO; FIBER; FLOW CYTOMETRY; GENE TARGETING; GENETIC TRANSDUCTION; HISTOPATHOLOGY; LOSS OF FUNCTION MUTATION; MACROPHAGE; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STROMA CELL; MONOCYTE; MOUSE; MUSCLE REGENERATION; MUSCLE STRENGTH; NONHUMAN; PHENOTYPE; POLARIZATION; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; YOLK SAC; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; DIAPHRAGM; FEMALE; IMMUNOLOGY; IMMUNOTHERAPY; MESENCHYMAL STEM CELL TRANSPLANTATION; METABOLISM; MUSCULAR DYSTROPHY, DUCHENNE; PATHOLOGY; PATHOPHYSIOLOGY; PROCEDURES; TREATMENT OUTCOME; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; ANTIGENS, CD11B; ANTIGENS, LY; CHEMOKINE CCL2; DIAPHRAGM; FEMALE; IMMUNOTHERAPY; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE, INBRED C57BL; MICE, INBRED MDX; MONOCYTES; MUSCULAR DYSTROPHY, DUCHENNE; MUTANT PROTEINS; RECEPTORS, CCR2; TREATMENT OUTCOME;

EID: 84910645572     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201403967     Document Type: Article

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