A subcutaneous biochip for remote monitoring of human metabolism: Packaging and biocompatibility assessment

IEEE Sensors Journal

Volumn 15, Issue 1, 2015, Pages 417-424

  Cavallini, Andrea ^a   Jost, Tanja Rezzonico ^b   Ghoreishizadeh, Seyedeh Sara ^a   Olivo, Jacopo ^a   De Beeck, Maaike Op ^c   Gorissen, Benjamin ^d   Grassi, Fabio ^b   De Micheli, Giovanni ^a   Carrara, Sandro ^a  

^a EPFL   (Switzerland)

^b Fondazione per l'istituto di ricerca in biomedicina   (Switzerland)

^c IMEC   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOCHIPS; METABOLISM; MICROARRAYS; PHYSIOLOGY; REMOTE CONTROL; SILICONES;

CONFERENCE PAPERS; CONFORMAL COATINGS; ELECTRONIC COMPONENT; EXTENDED VERSIONS; HAZARDOUS SUBSTANCES; IMPLANTABLE BIOSENSORS; INFLAMMATORY RESPONSE; REMOTE MONITORING;

BIOCOMPATIBILITY;

EID: 84910610872     PISSN: 1530437X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSEN.2014.2339638     Document Type: Article

References (39)

1. F. Valgimigli, F. Lucarelli, C. Scuffi, S. Morandi, and I. Sposato, "Evaluating the clinical accuracy of GlucoMen day: A novel microdialysisbased continuous glucose monitor," J. Diabetes Sci. Technol., vol. 4, no. 5, pp. 1182-1192, 2010.
2. A. Poscia, D. Messeri, D. Moscone, F. Ricci, and F. Valgimigli, "A novel continuous subcutaneous lactate monitoring system," Biosensors Bioelectron., vol. 20, no. 11, pp. 2244-2250, 2005.
3. B. Yu, N. Long, Y. Moussy, and F. Moussy, "A long-term flexible minimally-invasive implantable glucose biosensor based on an epoxyenhanced polyurethane membrane," Biosensors Bioelectron., vol. 21, no. 12, pp. 2275-2282, 2006.
4. D. A. Gough, L. S. Kumosa, T. L. Routh, J. T. Lin, and J. Y. Lucisano, "Function of an implanted tissue glucose sensor for more than 1 year in animals," Sci. Translational Med., vol. 2, no. 42, pp. 42ra53-42ra53, 2010.
5. S. Carrara et al., "Single-metabolite bio-nano-sensors and system for remote monitoring in animal models," in Proc. IEEE Sensors, Oct. 2011, pp. 716-719.
6. A. Cavallini, G. De Micheli, and S. Carrara, "Comparison of three methods of biocompatible multi-walled carbon nanotubes confinement for the development of implantable amperometric adenosine-5-triphosphate biosensors," Sensor Lett., vol. 9, no. 5, pp. 1838-1844, 2011.
7. S. Carrara, A. Cavallini, V. Erokhin, G. Albini, and G. De Micheli, "Multi-panel drugs detection in human serum for personalized therapy," Biosensors Bioelectron., vol. 26, no. 9, pp. 3914-3919, 2011.
8. A. Cavallini, S. Carrara, G. De Micheli, and V. Erokhin, "P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy," in Proc. Conf. Ph.D. Res. Microelectron. Electron. (PRIME), Jul. 2010, pp. 1-4.
9. S. K. Smart, A. I. Cassady, G. Q. Lu, and D. J. Martin, "The biocompatibility of carbon nanotubes," Carbon, vol. 44, no. 6, pp. 1034-1047, 2006.
10. D. L. Johnson, B. C. Lewis, D. J. Elliot, J. O. Miners, and L. L. Martin, "Electrochemical characterisation of the human cytochrome p450 cyp2c9," Biochem. Pharmacol., vol. 69, no. 10, pp. 1533-1541, 2005.
11. S. Carrara, A. Cavallini, A. Garg, and G. De Micheli, "Dynamical spot queries to improve specificity in p450s based multi-drugs monitoring," in Proc. Int. Conf. Complex Med. Eng. (ICME), Apr. 2009, pp. 1-6.
12. S. Carrara, M. D. Torre, A. Cavallini, D. De Venuto, and G. De Micheli, "Multiplexing pH and temperature in a molecular biosensor," in Proc. IEEE Biomed. Circuits Syst. Conf. (BioCAS), Nov. 2010, pp. 146-149.
13. J. Olivo, S. Carrara, and G. De Micheli, "A study of multi-layer spiral inductors for remote powering of implantable sensors," IEEE Trans. Biomed. Circuits Syst., vol. 7, no. 4, pp. 536-547, Aug. 2013.
14. S. S. Ghoreishizadeh, S. Carrara, and G. De Micheli, "Circuit design for human metabolites biochip," in Proc. IEEE Biomed. Circuits Syst. Conf. (BioCAS), Nov. 2011, pp. 460-463.
15. B. Krajewska, "Application of chitin-And chitosan-based materials for enzyme immobilizations: A review," Enzyme Microbial Technol., vol. 35, no. 2, pp. 126-139, 2004.
16. S. Carrara, A. Cavallini, S. Ghoreishizadeh, J. Olivo, and G. De Micheli, "Developing highly-integrated subcutaneous biochips for remote monitoring of human metabolism," in Proc. IEEE Sensors, Oct. 2012, pp. 1-4.
17. P. R. N. Childs, J. R. Greenwood, and C. A. Long, "Review of temperature measurement," Rev. Sci. Instrum., vol. 71, no. 8, pp. 2959-2978, Aug. 2000.
18. T. V. Thamaraiselvi and S. Rajeswari, "Biological evaluation of bioceramic materials-A review," Carbon, vol. 24, no. 31, p. 172, 2004.
19. M. Knez, K. Nielsch, and L. Niinist, "Synthesis and surface engineering of complex nanostructures by atomic layer deposition," Adv. Mater., vol. 19, no. 21, pp. 3425-3438, 2007.
20. A. Cavallini, C. Baj-Rossi, S. Ghoreishizadeh, G. De Micheli, and S. Carrara, "Design, fabrication, and test of a sensor array for perspective biosensing in chronic pathologies," in Proc. IEEE Biomed. Circuits Syst. Conf. (BioCAS), Nov. 2012, pp. 124-127.
21. M. Kimura, H. Fukushima, Y. Sagawa, K. Setsu, H. Hara, and S. Inoue, "An integrated potentiostat with an electrochemical cell using thin-film transistors," IEEE Trans. Electron Devices, vol. 56, no. 9, pp. 2114-2119, Sep. 2009.
22. J. Zhang, Y. Huang, N. Trombly, C. Yang, and A. Mason, "Electrochemical array microsystem with integrated potentiostat," in Proc. IEEE Sensors, Oct./Nov. 2005.
23. L. Li, W. A. Qureshi, X. Liu, and A. J. Mason, "Amperometric instrumentation system with on-chip electrode array for biosensor application," in Proc. IEEE Biomed. Circuits Syst. Conf. (BioCAS), Nov. 2010, pp. 294-297.
24. S. S. Ghoreishizadeh, C. Baj-Rossi, S. Carrara, and G. De Micheli, "Nano-sensor and circuit design for anti-cancer drug detection," in Proc. IEEE/NIH Life Sci. Syst. Appl. Workshop (LiSSA), Apr. 2011, pp. 28-33.
25. M. M. Ahmadi and G. A. Jullien, "A wireless-implantable microsystem for continuous blood glucose monitoring," IEEE Trans. Biomed. Circuits Syst., vol. 3, no. 3, pp. 169-180, Jun. 2009.
26. S. S. Ghoreishizadeh, I. Taurino, S. Carrara, and G. De Micheli, "A current-mode potentiostat for multi-target detection tested with different lactate biosensors," in Proc. IEEE Biomed. Circuits Syst. Conf. (BioCAS), Nov. 2012, pp. 128-131.
27. J.-Y. Xie, W.-Y. Yin, J. Shi, K. Kang, and Z. D. Chen, "Characterization of on-chip miniature multi-layer spiral inductors for RFICs," Microw. Opt. Technol. Lett., vol. 49, no. 12, pp. 2932-2936, 2007.
28. A. Zolfaghari, A. Chan, and B. Razavi, "Stacked inductors and transformers in CMOS technology," IEEE J. Solid-State Circuits, vol. 36, no. 4, pp. 620-628, Apr. 2001.
29. J. Olivo, S. Carrara, and G. De Micheli, "Modeling of printed spiral inductors for remote powering of implantable biosensors," in Proc. 5th Int. Symp. Med. Inform. Commun. Technol. (ISMICT), Mar. 2011, pp. 29-32.
30. M. O. de Beeck, K. Qian, P. Fiorini, K. Malachowski, and C. Van Hoof, "Design and characterization of a biocompatible packaging concept for implantable electronic devices," J. Microelectron. Electron. Packag., vol. 9, no. 1, pp. 43-50, 2012.
31. C. Hassler, R. P. von Metzen, P. Ruther, and T. Stieglitz, "Characterization of parylene C as an encapsulation material for implanted neural prostheses," J. Biomed. Mater. Res. B, Appl. Biomater., vol. 93, no. 1, pp. 266-274, 2010.
32. M. E. Letelier et al., "Possible mechanisms underlying copper-induced damage in biological membranes leading to cellular toxicity," Chem.-Biol. Interactions, vol. 151, no. 2, pp. 71-82, 2005.
33. M. A. Hussain, M. A. Kabir, and A. K. Sood, "On the cytotoxicity of carbon nanotubes," Current Sci., vol. 96, no. 5, pp. 664-673, 2009.
34. T. Takahashi, C. R. Luculescu, K. Uchida, T. Ishii, and H. Yajima, "Dispersion behavior and spectroscopic properties of single-walled carbon nanotubes in chitosan acidic aqueous solutions," Chem. Lett., vol. 34, no. 11, pp. 1516-1517, 2005.
35. S. Arens, U. Schlegel, G. Printzen, W. J. Ziegler, S. M. Perren, and M. Hansis, "Influence of materials for fixation implants on local infection an experimental study of steel versus titanium DCP in rabbits," J. Bone Joint Surgery, Brit. Vol., vol. 78, no. 4, pp. 647-651, 1996.
36. G. B. Ryan and G. Majno, "Acute inflammation. A review," Amer. J. Pathol., vol. 86, no. 1, p. 183, 1977.
37. P. Bodin and G. Burnstock, "Increased release of ATP from endothelial cells during acute inflammation," Inflammation Res., vol. 47, no. 8, pp. 351-354, 1998.
38. G. Melcher, B. Claudi, U. Schlegel, S. M. Perren, G. Printzen, and J. Munzinger, "Influence of type of medullary nail on the development of local infection. An experimental study of solid and slotted nails in rabbits," J. Bone Joint Surgery, Brit. Vol., vol. 76, no. 6, pp. 955-959, 1994.
39. S. S. Ghoreishizadeh, C. Baj-Rossi, A. Cavallini, S. Carrara, and G. De Micheli, "An integrated control and readout circuit for implantable multi-target electrochemical biosensing," IEEE Trans. Biomed. Circuits Syst., to be published, Jun. 2014, doi: 10.1109/TBCAS.2014.2315157.