P450-mediated electrochemical sensing of drugs in human plasma for personalized therapy

6th Conference on Ph.D. Research in Microelectronics and Electronics, PRIME 2010

Volumn , Issue , 2010, Pages

  Cavallini, A ^a   Carrara, S ^a   De Micheli, G ^a   Erokhin, V ^b  

^a EPFL   (Switzerland)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

Electrochemistry; Human serum; P450; Personalized therapy

Indexed keywords

BIOLOGICAL FLUIDS; DRUG MONITORING; ELECTROCHEMICAL BIOSENSOR; ELECTROCHEMICAL SENSING; GENETIC APPROACH; GENETIC FACTORS; HUMAN METABOLISMS; HUMAN PLASMAS; HUMAN SERUM; P450; PERSONALIZED THERAPY; PHARMACOGENOMICS; POINT OF CARE; PROBE MOLECULES;

BIOSENSORS; BODY FLUIDS; ELECTROCHEMISTRY; MICROELECTRONICS; MULTIWALLED CARBON NANOTUBES (MWCN); PATIENT MONITORING;

DRUG THERAPY;

EID: 78049504721     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: None     Document Type: Conference Paper

References (18)

1. M. Aspinall and R. Hamermesh, "Realizing the promise of personalized medicine," Harvard Business Review, vol. 85, p. 108, 2007.
2. J. Lazarou, B. Pomeranz, and P. Corey, "Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies," Jama, vol. 279, p. 1200, 1998.
3. F. Guengerich, "Cytochrome p450 and chemical toxicology," PerspectiVe, vol. 21, p. 71, 2008.
4. S. Joseph, J. Rusling, Y. Lvov, T. Friedberg, and U. Fuhr, "An amperometric biosensor with human CYP3A4 as a novel drug screening tool," Biochemical Pharmacology, vol. 65, pp. 1817-1826, 2003.
5. S. Carrara, V. Shumyantseva, A. Archakov, and B. Samorì, "Screenprinted electrodes based on carbon nanotubes and cytochrome P450scc for highly sensitive cholesterol biosensors," Biosensors and Bioelectronics, vol. 24, pp. 148-150, 2008.
6. D. Johnson, B. Lewis, D. Elliot, J. Miners, and L. Martin, "Electrochemical characterisation of the human cytochrome P450 CYP2C9," Biochemical Pharmacology, vol. 69, pp. 1533-1541, 2005.
7. V. Shumyantseva, S. Carrara, V. Bavastrello, D. Jason Riley, T. Bulko, K. Skryabin, A. Archakov, and C. Nicolini, "Direct electron transfer between cytochrome P450scc and gold nanoparticles on screen-printed rhodium-graphite electrodes," Biosensors and Bioelectronics, vol. 21, pp. 217-222, 2005.
8. S. Carrara, A. Cavallini, A. Garg, and G. De Micheli, "Dynamical Spot Queries to Improve Specificity in P450s based Multi-Drugs Monitoring." International Conference on Complex Medical Engineering, April 9-11, 2009, Tampe, Arizona, U.S.A.
9. S. Carrara, A. Cavallini, G. De Micheli, J. Olivo, L. Benini, V. Shumyantseva, and A. Archakov, "Circuits Design and Nano-Structured Electrodes for Drugs Monitoring in Personalized Therapy," 2008, pp. 325-328.
10. J. Miners and D. Birkett, "Cytochrome P4502C9: an enzyme of major importance in human drug metabolism," British journal of clinical pharmacology, vol. 45, p. 525, 1998.
11. C. Journet, W. Maser, P. Bernier, A. Loiseau, M. Lamy de la Chapelle, S. Lefrant, P. Deniard, R. Lee, and J. Fischer, "Large-scale production of single-walled carbon nanotubes by the electric-arc technique," Nature, vol. 388, pp. 756-757, 1997.
12. A. Bianco, K. Kostarelos, and M. Prato, "Applications of carbon nanotubes in drug delivery," Current Opinion in Chemical Biology, vol. 9, pp. 674-679, 2005.
13. http://www.dropsens.com/en/productos.html#cell DRP-110CNT technical datasheet
14. J. Wang and M. Musameh, "Carbon nanotube screen-printed electrochemical sensors," The Analyst, vol. 129, pp. 1-2, 2004.
15. F. Juma, H. Rogers, and J. Trounce, "Pharmacokinetics of cyclophosphamide and alkylating activity in man after intravenous and oral administration," British journal of clinical pharmacology, vol. 8, p. 209, 1979.
16. A. Frostell-Karlsson, A. Remaeus, H. Roos, K. Andersson, P. Borg, M. Hamalainen, and R. Karlsson, "Biosensor analysis of the interaction between immobilized human serum albumin and drug compounds for prediction of human serum albumin binding levels," J. Med. Chem, vol. 43, pp. 1986-1992, 2000.
17. J. Miners, S. Coulter, R. Tukey, M. Veronese, and D. Birkett, "Cytochromes P450, 1A2, and 2C9 are responsible for the human hepatic O-demethylation of R-and S-naproxen," Biochemical Pharmacology, vol. 51, pp. 1003-1008, 1996.
18. J. Ducharme, S. Abdullah, and I. Wainer, "Dextromethorphan as an in vivo probe for the simultaneous determination of CYP2D6 and CYP3A activity," Journal of Chromatography B: Biomedical Sciences and Applications, vol. 678, pp. 113-128, 1996.