A wireless-implantable microsystem for continuous blood glucose monitoring

IEEE Transactions on Biomedical Circuits and Systems

Volumn 3, Issue 3, 2009, Pages 169-180

  Ahmadi, Mohammad Mahdi ^a,b   Jullien, Graham A ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b Sound Design Technologies Ltd   (Canada)

Author keywords

Amperometric sensor; Glucose; Implantable; Implantable microsystem; Microsystem; Potentiostat; Telemetry; Transponder chip; Wireless

Indexed keywords

IMPLANTABLE; IMPLANTABLE MICROSYSTEMS; POTENTIOSTAT; POTENTIOSTATS; TRANSPONDER CHIPS;

AMPEROMETRIC SENSORS; BIOSENSORS; BLOOD; CMOS INTEGRATED CIRCUITS; GLUCOSE; GLUCOSE SENSORS; MICROFABRICATION; MONITORING; TELEMETERING; TELEMETERING EQUIPMENT; TRANSPONDERS; VOLTAGE REGULATORS;

MICROSYSTEMS;

EID: 77955091787     PISSN: 19324545     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBCAS.2009.2016844     Document Type: Article

References (42)

1. Diabetes Control and Complications Trial Research Group, "The effect of intensive treatment of diabetes on the development and pro-gressionof long-term complications ininsulin-dependent diabetes mel-litus," New Engl. J. Med., vol.329, no.14, pp. 977-986, 1993.
2. UK Prospective Diabetes Study (UKPDS) Group, "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)," The Lancet, vol.352, no.9131, pp. 837-853, Sep. 1998.
3. Y. Ohkubo et al., "Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin dependent diabetes mellitus: A randomized prospective six year study," Diabetes Res. Clin. Pract., vol.28, no.2, pp. 103-117, 1995.
4. S. K. Garg, H. K. Hoff, and H. P. Chase, "The role of continuous glucose sensors in diabetes care," Endocrinol. Metab. Clin. N. Am., vol.33, pp. 163-173, 2004.
5. D. C. Klonoff, "Continuous glucose monitoring: Roadmap for 21st century diabetes therapy," Diabetes Care, vol.28, no.5, pp. 1231-1239, 2005.
6. E. Kulcu, J. A. Tamada, G. Reach, R. O. Potts, and M. J. Lesho, "Physiological differences between interstitial glucose and blood glucose measured in human subjects," Diabetes Care, vol.26, no.8, pp. 2405-2409, 2003.
7. B. D. McKean and D. A. Gough, "A telemetry instrumentation system for chronically implanted glucose and oxygen sensors," IEEE Trans. Biomed. Eng., vol.35, no.7, pp. 526-532, Jul. 1988.
8. M. C. Shults, R. K. Rhodes, S. J. Updike, B. J. Gilligan, and W. N. Reining, "A telemetry instrumentation system for monitoring multiple subcutaneously implanted glucose sensors," IEEE Trans. Biomed. Eng., vol.41, no.10, pp. 937-942, Oct. 1994.
9. B. J. Gilligan, M. C. Shults, R. K. Rhodes, and S. J. Updike, "Evaluation of a subcutaneous glucose sensor out to 3 months in a dog model," Diabetes Care, vol.17, pp. 882-887, 1994.
10. E. Wilkins, P. Atanosov, and B. A. Muggenburg, "Integrated im-plantable device for long-term glucose monitoring," Biosensors Bioelectron., vol.10, pp. 485-494, 1995.
11. E. Wilkins and P. Atanosov, "Glucose monitoring: State of the art and future possibilities," Med. Eng. Phys., vol.18, no.4, pp. 273-288, 1996.
12. P. Atanasov, S. Yang, C. Salehi, A. L. Ghindilis, E. Wilkins, and D. Schade, "Implantation of a refillable glucose monitoring-telemetry device," Biosensors Bioelectron., vol.12, pp. 669-680, 1997.
13. S. J. Updike, B. J. Gilligan, M. C. Shults, and R. K. Rhodes, "A subcutaneous glucose sensor with improved longevity, dynamic range, and stability of calibration," Diabetes Care, vol.23, no.2, pp. 208-214, 2000.
14. B. J. Gilligan, M. C. Shults, R. K. Rhodes, P. G. Jacobs, J. H. Brauker, T. J. Pintar, and S. J. Updike, "Feasibility of continuous long-term glucose monitoring from a subcutaneous glucose sensor in humans," Diabetes Technol Ther., vol.6, no.3, pp. 378-386, 2004.
15. R. D. Beach, F. V. Kuster, and F. Moussy, "Towards a miniature implantable in-vivo telemetry monitoring system dynamically configurable as a potentiostat or galvanostat for two-and three-electrode biosensors," IEEE Trans. Instrum. Meas., vol.54, no.1, pp. 61-72, Feb. 2005.
16. A.P. F. Turner, I. Karube, and G. S. Wilson, Biosensors: Fundamentals and Applications. Oxford, U.K.: Oxford University Press, 1987.
17. E. M. Abu Irhayem, "Fabrication and characterization of nanoparticu-late and related iridium oxide-based glucose biosensors," Ph.D. dissertation, Univ. Calgary, Calgary, AB, Canada, 2004.
18. A. S. Jhas, "Development of an electrode mediated glucose sensor using iridium oxide nanoparticles," M.Sc. dissertation, Univ. Calgary, Calgary, AB, Canada, 2007.
19. T. Akin, K. Najafi, and R. M. Bradley, "A wireless implantable multichannel digital neural recording system for a micromachined sieve electrode," IEEE J. Solid-State Circuits, vol.33, no.1, pp. 109-118, Jan. 1998.
20. D. A. Gough, K. Kreutz-Delgado, and T. M. Bremer, "Frequency characterization of blood glucose dynamics," Ann. Biomed. Eng., vol.31, no.1, pp. 91-97, 2003.
21. H. Banba et al., "A CMOS bandgap reference circuit with sub-1-V operation," IEEE J. Solid-State Circuits, vol.34, no.5, pp. 670-674, May 1999.
22. M. Ghovanloo and K. Najafi, "Fully integrated wideband high-current rectifiers for inductively powered devices," IEEE J. Solid-State Circuits, vol.39, no.11, pp. 1976-1984, Nov. 2004.
23. P. Rakers, L. Connell, T. Collins, and D. Russell, "Secure contactless smartcard ASIC with DPA protection," IEEE J. Solid-State Circuits, vol.36, no.3, pp. 559-565, Mar. 2001.
24. R. Reay, S. Kounaves, and G. Kovacs, "An integrated CMOS potentio-stat for miniaturized electroanalytical instrumentation," in Proc. IEEE Int. Solid-State Circuits Conf., 1994, pp. 162-163.
25. R. Kakerow, H. Kappert, E. Spiegel, and Y. Manoli, "Low-power single-chip CMOS potentiostat," in Proc. 8th Int. Conf. Solid-State Sensors Actuators, 1995, pp. 142-145.
26. Frey et al., "Design of an integrated potentiostat circuit for CMOS bio sensor chips," in Proc. IEEE Int. Symp. Circuits and Systems, 2003, vol.5, pp. 9-12.
27. H. S. Narula and J. G. Harris, "VLSI potentiostat for amperometric measurements for electrolytic reactions," in Proc. IEEE Int. Symp. Circuits and Systems, 2004, vol.1, pp. 457-460.
28. S. Martin, F. Gebara, T. Strong, and R. Brown, "A low-voltage, chemical sensor interface for systems-on-chip: The fully differential poten-tiostat," in Proc. IEEE Int. Symp. Circuits and Systems, 2004, vol.4, pp. 892-895.
29. S. Martin, F. Gebara, B. J. Larivee, and R. Brown,"ACMOS-integrated microinstrument for trace detection of heavy metals," IEEE J. Solid-State Circuits, vol.40, no.12, pp. 2777-2786, Dec. 2005.
30. R. Genov, M. Stanacevic, M. Naware, G. Cauwenberghs, and N. V. Thakor, "16-channel integrated potentiostat for distributed neuro-chemical sensing," IEEE Trans. Circuits Syst. I, vol.53, no.11, pp. 2371-2376, Nov. 2006.
31. A. Gore, S. Chakrabartty, S. Pal, and E. C. Alocilja, "A multichannel femtoampere-sensitivity potentiostat array for biosensing applications," IEEE Trans. Circuits Syst. I, vol.53, no.11, pp. 2357-2363, Nov. 2006. (Pubitemid 44829049)
32. M. Stanacevic, K. Murari, A. Rege, G. Cauwenberghs, and N. V. Thakor, "VLSI potentiostat array with oversampling gain modulation for wide-range neurotransmitter sensing," IEEE Trans. Biomed. Circuits Syst., vol.1, no.1, pp. 63-72, Mar. 2007.
33. M. M. Ahmadi and G. A. Jullien, "Current-mirror based potentiostats for three-electrode amperometric electrochemical sensors," IEEE Trans. Circuits Syst. I, 2009, to be published.
34. M. M. Ahmadi and G. Jullien, "A low power CMOS potentiostat for bioimplantable applications," in Proc. 5th Int. Workshop on System-on-Chip, 2005, pp. 184-189. (Pubitemid 44425071)
35. M. Lambrechts and W. Sansen, Biosensors: Microelectrochemical Devices. Washington, DC: IOP, 1992.
36. A. J. Bard and L. R. Faulkner, Electrochemical Methods: Fundamentals and Applications, 2nd ed. New York: Wiley, 2001.
37. R. Tummalo, Fundamentals of Microsystem Packaging. New York: McGraw-Hill, 2001.
38. S. Zimmermann, D. Fienbork, B. Stoeber, A. W. Flounders, and D. Liepmann, "A microneedle-based glucose monitor: Fabricated on a wafer-level using in device enzyme immobilization," in Proc. 12th Int. Conf. Solid-State Sensors, Actuators and Microsystems, 2003, vol.1, pp. 99-102.
39. S. Bhattacharya, A. Datta, J. M. Berg, and S. Gangopadhyay, "Studies on surface wettability of poly (Dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength," J. Microelectromechan. Syst., vol.14, pp. 590-597, 2005.
40. M. M. Ahmadi, "A wireless implantable microsystem for continuous blood glucose monitoring," Ph.D. dissertation, Univ. Calgary, Calgary, AB, Canada, 2007.
41. P. H. Kvist et al., "Biocompatibility of an enzyme-based, electrochemical glucose sensor for short-term implantation in the subcutis," Diabetes Technol Therapeut., vol.8, no.5, pp. 546-559, 2006.
42. E. A. Irhayem, H. Elzanowska, A. S. Jhas, B. Skrzynecka, and V. Birss, "Glucose detection based on electrochemically formed Ir oxide films," J. Electroanal. Chem., vol.538-539, pp. 153-164, 2002.