Predictors of recurrence of Crohn's disease after ileocolectomy: A review

World Journal of Gastroenterology

Volumn 20, Issue 39, 2014, Pages 14393-14406

  Connelly, Tara M ^a   Messaris, Evangelos ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Crohn's disease; Ileocolectomy; Inflammatory bowel disease; Recurrence; Surgical genetics

Indexed keywords

AZATHIOPRINE; BIOLOGICAL MARKER; BUDESONIDE; INFLIXIMAB; MERCAPTOPURINE; MESALAZINE; METRONIDAZOLE; ANTIINFLAMMATORY AGENT; GASTROINTESTINAL AGENT;

ANASTOMOSIS; ANTIBIOTIC THERAPY; COLON RESECTION; CORTICOSTEROID THERAPY; CROHN DISEASE; DEMOGRAPHY; DISEASE ASSOCIATION; DISEASE BEHAVIOR; ELECTIVE SURGERY; GRANULOMATOSIS; HEALTH BEHAVIOR; HUMAN; ILEOCOLECTOMY; IMMUNOSUPPRESSIVE TREATMENT; IMMUNOTHERAPY; INTERMETHOD COMPARISON; LAPAROSCOPIC SURGERY; META ANALYSIS (TOPIC); MOLECULAR GENETICS; MULTICENTER STUDY (TOPIC); NUTRITIONAL STATUS; POSTOPERATIVE COMPLICATION; RANDOMIZED CONTROLLED TRIAL (TOPIC); RECURRENT DISEASE; REVIEW; SCORING SYSTEM; SEPSIS; SEROLOGY; SYSTEMATIC REVIEW (TOPIC); ADVERSE EFFECTS; BLOOD; ILEUM; PATHOLOGY; PROCEDURES; REMISSION; RISK FACTOR; SECONDARY PREVENTION; TIME FACTOR; TREATMENT OUTCOME;

ANTI-INFLAMMATORY AGENTS; BIOMARKERS; COLECTOMY; CROHN DISEASE; GASTROINTESTINAL AGENTS; HUMANS; ILEUM; RECURRENCE; REMISSION INDUCTION; RISK FACTORS; SECONDARY PREVENTION; TIME FACTORS; TREATMENT OUTCOME;

EID: 84910150702     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i39.14393     Document Type: Review

References (90)

1. Crohn BB, Ginzburg L, Oppenheimer GD. Landmark article Oct 15, 1932. Regional ileitis. A pathological and clinical entity. By Burril B. Crohn, Leon Ginzburg, and Gordon D. Oppenheimer. JAMA 1984; 251: 73-79 [PMID: 6361290]
2. Baumgart DC, Sandborn WJ. Crohn's disease. Lancet 2012; 380: 1590-1605 [PMID: 22914295 DOI: 10.1016/S0140-6736(12)60026-9]
3. Cullen G, O'toole A, Keegan D, Sheahan K, Hyland JM, O'donoghue DP. Long-term clinical results of ileocecal resection for Crohn's disease. Inflamm Bowel Dis 2007; 13: 1369-1373 [PMID: 17600379]
4. Whelan G, Farmer RG, Fazio VW, Goormastic M. Recurrence after surgery in Crohn's disease. Relationship to location of disease (clinical pattern) and surgical indication. Gastroenterology 1985; 88: 1826-1833 [PMID: 3996839]
5. Thompson JS, Iyer KR, DiBaise JK, Young RL, Brown CR, Langnas AN. Short bowel syndrome and Crohn's disease. J Gastrointest Surg 2003; 7: 1069-1072 [PMID: 14675717]
6. Cunningham MF, Docherty NG, Coffey JC, Burke JP, O'Connell PR. Postsurgical recurrence of ileal Crohn's disease: an update on risk factors and intervention points to a central role for impaired host-microflora homeostasis. World J Surg 2010; 34: 1615-1626 [PMID: 20195604 DOI: 10.1007/s00268-010-0504-6]
7. Irvine EJ. Quality of life of patients with ulcerative colitis: past, present, and future. Inflamm Bowel Dis 2008; 14: 554-565 [PMID: 17973299]
8. Harvey RF, Bradshaw JM. A simple index of Crohn's-disease activity. Lancet 1980; 1: 514 [PMID: 6102236]
9. Best WR, Becktel JM, Singleton JW, Kern F. Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study. Gastroenterology 1976; 70: 439-444 [PMID: 1248701]
10. Walters TD, Steinhart AH, Bernstein CN, Tremaine W, MkKenzie M, Wolff BG, McLeod RS. Validating Crohn's disease activity indices for use in assessing postoperative recurrence. Inflamm Bowel Dis 2011; 17: 1547-1556 [PMID: 21674711 DOI: 10.1002/ibd.21524]
11. Rutgeerts P, Geboes K, Vantrappen G, Kerremans R, Coenegrachts JL, Coremans G. Natural history of recurrent Crohn' s disease at the ileocolonic anastomosis after curative surgery. Gut 1984; 25: 665-672 [PMID: 6735250]
12. Marshall JK. Reporting ileocolonoscopy in inflammatory bowel disease. Can J Gastroenterol 2006; 20: 399-400 [PMID: 16779456]
13. Sailer J, Peloschek P, Reinisch W, Vogelsang H, Turetschek K, Schima W. Anastomotic recurrence of Crohn's disease after ileocolic resection: comparison of MR enteroclysis with endoscopy. Eur Radiol 2008; 18: 2512-2521 [PMID: 18504592 DOI: 10.1007/s00330-008-1034-6]
14. Bordeianou L, Stein SL, Ho VP, Dursun A, Sands BE, Korzenik JR, Hodin RA. Immediate versus tailored prophylaxis to prevent symptomatic recurrences after surgery for ileocecal Crohn's disease? Surgery 2011; 149: 72-78 [PMID: 20434748 DOI: 10.1016/j.surg.2010.03.009]
15. McLeod RS, Wolff BG, Steinhart AH, Carryer PW, O'Rourke K, Andrews DF, Blair JE, Cangemi JR, Cohen Z, Cullen JB, Chaytor RG, Greenberg GR, Jaffer NM, Jeejeebhoy KN, Mac- Carty RL, Ready RL, Weiland LH. Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease. Gastroenterology 1997; 113: 1823-1827 [PMID: 9394721]
16. Regueiro M, Kip KE, Schraut W, Baidoo L, Sepulveda AR, Pesci M, El-Hachem S, Harrison J, Binion D. Crohn's disease activity index does not correlate with endoscopic recurrence one year after ileocolonic resection. Inflamm Bowel Dis 2011; 17: 118-126 [PMID: 20848538 DOI: 10.1002/ibd.21355]
17. Malireddy K, Larson DW, Sandborn WJ, Loftus EV, Faubion WA, Pardi DS, Qin R, Gullerud RE, Cima RR, Wolff B, Dozois EJ. Recurrence and impact of postoperative prophylaxis in laparoscopically treated primary ileocolic Crohn disease. Arch Surg 2010; 145: 42-47 [PMID: 20083753 DOI: 10.1001/archsurg.2009.248]
18. Stocchi L, Milsom JW, Fazio VW. Long-term outcomes of laparoscopic versus open ileocolic resection for Crohn's disease: follow-up of a prospective randomized trial. Surgery 2008; 144: 622-627; discussion 627-628 [PMID: 18847647 DOI: 10.1016/j.surg.2008.06.016]
19. Ellis L, Calhoun P, Kaiser DL, Rudolf LE, Hanks JB. Postoperative recurrence in Crohn's disease. The effect of the initial length of bowel resection and operative procedure. Ann Surg 1984; 199: 340-347 [PMID: 6703794]
20. Anseline PF, Wlodarczyk J, Murugasu R. Presence of granulomas is associated with recurrence after surgery for Crohn's disease: experience of a surgical unit. Br J Surg 1997; 84: 78-82 [PMID: 9043461]
21. Unkart JT, Anderson L, Li E, Miller C, Yan Y, Gu CC, Chen J, Stone CD, Hunt S, Dietz DW. Risk factors for surgical recurrence after ileocolic resection of Crohn's disease. Dis Colon Rectum 2008; 51: 1211-1216 [PMID: 18536967 DOI: 10.1007/s10350-008-9348-7]
22. Kane SV, Flicker M, Katz-Nelson F. Tobacco use is associated with accelerated clinical recurrence of Crohn's disease after surgically induced remission. J Clin Gastroenterol 2005; 39: 32-35 [PMID: 15599207]
23. Cottone M, Rosselli M, Orlando A, Oliva L, Puleo A, Cappello M, Traina M, Tonelli F, Pagliaro L. Smoking habits and recurrence in Crohn's disease. Gastroenterology 1994; 106: 643-648 [PMID: 8119535]
24. Reese GE, Nanidis T, Borysiewicz C, Yamamoto T, Orchard T, Tekkis PP. The effect of smoking after surgery for Crohn' s disease: a meta-analysis of observational studies. Int J Colorectal Dis 2008; 23: 1213-1221 [PMID: 18762954 DOI: 10.1007/s00384-008-0542-9]
25. Ryan WR, Allan RN, Yamamoto T, Keighley MR. Crohn's disease patients who quit smoking have a reduced risk of reoperation for recurrence. Am J Surg 2004; 187: 219-225 [PMID: 14769308]
26. Yamamoto T, Keighley MR. The association of cigarette smoking with a high risk of recurrence after ileocolonic resection for ileocecal Crohn's disease. Surg Today 1999; 29: 579-580 [PMID: 10385380]
27. Aratari A, Papi C, Leandro G, Viscido A, Capurso L, Caprilli R. Early versus late surgery for ileo-caecal Crohn's disease. Aliment Pharmacol Ther 2007; 26: 1303-1312 [PMID: 17848181]
28. Sorrentino D, Terrosu G, Paviotti A, Geraci M, Avellini C, Zoli G, Fries W, Danese S, Occhipinti P, Croatto T, Zarifi D. Early diagnosis and treatment of postoperative endoscopic recurrence of Crohn's disease: partial benefit by infliximab - a pilot study. Dig Dis Sci 2012; 57: 1341-1348 [PMID: 22252267 DOI: 10.1007/s10620-011-2025-z]
29. Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Büning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC, Cho JH. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012; 491: 119-124 [PMID: 23128233 DOI: 10.1038/nature11582]
30. Koltun WA. The future of surgical management of inflammatory bowel disease. Dis Colon Rectum 2008; 51: 813-817 [PMID: 18461398 DOI: 10.1007/s10350-008-9266-8]
31. Cleynen I, González JR, Figueroa C, Franke A, McGovern D, Bortlík M, Crusius BJ, Vecchi M, Artieda M, Szczypiorska M, Bethge J, Arteta D, Ayala E, Danese S, van Hogezand RA, Panés J, Peña SA, Lukas M, Jewell DP, Schreiber S, Vermeire S, Sans M. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project. Gut 2013; 62: 1556-1565 [PMID: 23263249 DOI: 10.1136/gutjnl-2011-300777]
32. Hugot JP, Chamaillard M, Zouali H, Lesage S, Cézard JP, Belaiche J, Almer S, Tysk C, O'Morain CA, Gassull M, Binder V, Finkel Y, Cortot A, Modigliani R, Laurent-Puig P, Gower- Rousseau C, Macry J, Colombel JF, Sahbatou M, Thomas G. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603 [PMID: 11385576]
33. McCauley JL, Abreu MT. Genetics in diagnosing and managing inflammatory bowel disease. Gastroenterol Clin North Am 2012; 41: 513-522 [PMID: 22500532 DOI: 10.1016/j.gtc.2012.01.002]
34. Roberts RL, Hollis-Moffatt JE, Gearry RB, Kennedy MA, Barclay ML, Merriman TR. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a populationbased cohort. Genes Immun 2008; 9: 561-565 [PMID: 18580884 DOI: 10.1038/gene.2008.49]
35. Ahmad T, Armuzzi A, Bunce M, Mulcahy-Hawes K, Marshall SE, Orchard TR, Crawshaw J, Large O, de Silva A, Cook JT, Barnardo M, Cullen S, Welsh KI, Jewell DP. The molecular classification of the clinical manifestations of Crohn's disease. Gastroenterology 2002; 122: 854-866 [PMID: 11910336]
36. Büning C, Genschel J, Bühner S, Krüger S, Kling K, Dignass A, Baier P, Bochow B, Ockenga J, Schmidt HH, Lochs H. Mutations in the NOD2/CARD15 gene in Crohn's disease are associated with ileocecal resection and are a risk factor for reoperation. Aliment Pharmacol Ther 2004; 19: 1073-1078 [PMID: 15142196]
37. Maconi G, Colombo E, Sampietro GM, Lamboglia F, D'Incà R, Daperno M, Cassinotti A, Sturniolo GC, Ardizzone S, Duca P, Porro GB, Annese V. CARD15 gene variants and risk of reoperation in Crohn's disease patients. Am J Gastroenterol 2009; 104: 2483-2491 [PMID: 19638967 DOI: 10.1038/ajg.2009.413]
38. Solon JG, Burke JP, Walsh SR, Coffey JC. The effect of NOD2 polymorphism on postsurgical recurrence in Crohn's disease: a systematic review and meta-analysis of available literature. Inflamm Bowel Dis 2013; 19: 1099-1105 [PMID: 23493074 DOI: 10.1097/MIB.0b013e3182813391]
39. Sehgal R, Berg A, Polinski JI, Hegarty JP, Lin Z, McKenna KJ, Stewart DB, Poritz LS, Koltun WA. Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease. Dis Colon Rectum 2012; 55: 115-121 [PMID: 22228152 DOI: 10.1097/DCR.0b013e31823ccea8]
40. Meresse B, Rutgeerts P, Malchow H, Dubucquoi S, Dessaint JP, Cohard M, Colombel JF, Desreumaux P. Low ileal interleukin 10 concentrations are predictive of endoscopic recurrence in patients with Crohn's disease. Gut 2002; 50: 25-28 [PMID: 11772962]
41. Wagner IJ, Rombeau JL. Nutritional support of surgical patients with inflammatory bowel disease. Surg Clin North Am 2011; 91: 787-803, viii [PMID: 21787968 DOI: 10.1016/j.suc.2011.04.013]
42. Yamamoto T, Shiraki M, Nakahigashi M, Umegae S, Matsumoto K. Enteral nutrition to suppress postoperative Crohn's disease recurrence: a five-year prospective cohort study. Int J Colorectal Dis 2013; 28: 335-340 [PMID: 23014978 DOI: 10.1007/s00384-012-1587-3]
43. Manichanh C, Borruel N, Casellas F, Guarner F. The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol 2012; 9: 599-608 [PMID: 22907164 DOI: 10.1038/nrgastro.2012.152]
44. Rahimi R, Nikfar S, Rahimi F, Elahi B, Derakhshani S, Vafaie M, Abdollahi M. A meta-analysis on the efficacy of probiotics for maintenance of remission and prevention of clinical and endoscopic relapse in Crohn's disease. Dig Dis Sci 2008; 53: 2524-2531 [PMID: 18270836 DOI: 10.1007/s10620-007-0171-0]
45. Pimentel-Nunes P, Dinis-Ribeiro M, Magro F. Systematic review on drug and diet-induced endoscopic remission in Crohn's disease. Eur J Gastroenterol Hepatol 2009; 21: 491-503 [PMID: 19293722 DOI: 10.1097/MEG.0b013e3283196b03]
46. Van Gossum A, Dewit O, Louis E, de Hertogh G, Baert F, Fontaine F, DeVos M, Enslen M, Paintin M, Franchimont D. Multicenter randomized-controlled clinical trial of probiotics (Lactobacillus johnsonii, LA1) on early endoscopic recurrence of Crohn's disease after lleo-caecal resection. Inflamm Bowel Dis 2007; 13: 135-142 [PMID: 17206696]
47. Satsangi J, Silverberg MS, Vermeire S, Colombel JF. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut 2006; 55: 749-753 [PMID: 16698746]
48. Pariente B, Cosnes J, Danese S, Sandborn WJ, Lewin M, Fletcher JG, Chowers Y, D'Haens G, Feagan BG, Hibi T, Hommes DW, Irvine EJ, Kamm MA, Loftus EV, Louis E, Michetti P, Munkholm P, Oresland T, Panés J, Peyrin-Biroulet L, Reinisch W, Sands BE, Schoelmerich J, Schreiber S, Tilg H, Travis S, van Assche G, Vecchi M, Mary JY, Colombel JF, Lémann M. Development of the Crohn's disease digestive damage score, the Lémann score. Inflamm Bowel Dis 2011; 17: 1415-1422 [PMID: 21560202 DOI: 10.1002/ibd.21506]
49. Cosnes J, Cattan S, Blain A, Beaugerie L, Carbonnel F, Parc R, Gendre JP. Long-term evolution of disease behavior of Crohn's disease. Inflamm Bowel Dis 2002; 8: 244-250 [PMID: 12131607]
50. Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J. Behaviour of Crohn's disease according to the Vienna classification: changing pattern over the course of the disease. Gut 2001; 49: 777-782 [PMID: 11709511]
51. Reinisch W. "How to manage loss of response to anti-TNF in Crohn's disease?". Curr Drug Targets 2010; 11: 152-155 [PMID: 20210764]
52. Caprilli R, Corrao G, Taddei G, Tonelli F, Torchio P, Viscido A. Prognostic factors for postoperative recurrence of Crohn's disease. Gruppo Italiano per lo Studio del Colon e del Retto (GISC) Dis Colon Rectum 1996; 39: 335-341 [PMID: 8603558]
53. Pascua M, Su C, Lewis JD, Brensinger C, Lichtenstein GR. Meta-analysis: factors predicting post-operative recurrence with placebo therapy in patients with Crohn's disease. Aliment Pharmacol Ther 2008; 28: 545-556 [PMID: 18565159 DOI: 10.1111/j.1365-2036.2008.03774.x]
54. Geboes K. What histologic features best differentiate Crohn' s disease from ulcerative colitis? Inflamm Bowel Dis 2008; 14 Suppl 2: S168-S169 [PMID: 18816725 DOI: 10.1002/ibd.20598]
55. Ramzan NN, Leighton JA, Heigh RI, Shapiro MS. Clinical significance of granuloma in Crohn's disease. Inflamm Bowel Dis 2002; 8: 168-173 [PMID: 11979136]
56. Riss S, Schuster I, Papay P, Herbst F, Mittlböck M, Chitsabesan P, Stift A. Surgical recurrence after primary ileocolic resection for Crohn's disease. Tech Coloproctol 2014; 18: 365-371 [PMID: 23982768]
57. Iesalnieks I, Kilger A, Glass H, Müller-Wille R, Klebl F, Ott C, Strauch U, Piso P, Schlitt HJ, Agha A. Intraabdominal septic complications following bowel resection for Crohn' s disease: detrimental influence on long-term outcome. Int J Colorectal Dis 2008; 23: 1167-1174 [PMID: 18690466 DOI: 10.1007/s00384-008-0534-9]
58. Lowney JK, Dietz DW, Birnbaum EH, Kodner IJ, Mutch MG, Fleshman JW. Is there any difference in recurrence rates in laparoscopic ileocolic resection for Crohn's disease compared with conventional surgery? A long-term, follow-up study. Dis Colon Rectum 2006; 49: 58-63 [PMID: 16328612]
59. Patel SV, Patel SV, Ramagopalan SV, Ott MC. Laparoscopic surgery for Crohn's disease: a meta-analysis of perioperative complications and long term outcomes compared with open surgery. BMC Surg 2013; 13: 14 [PMID: 23705825 DOI: 10.1186/1471-2482-13-14]
60. Fazio VW, Marchetti F, Church M, Goldblum JR, Lavery C, Hull TL, Milsom JW, Strong SA, Oakley JR, Secic M. Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial. Ann Surg 1996; 224: 563-571; discussion 571-573 [PMID: 8857860]
61. McLeod RS, Wolff BG, Ross S, Parkes R, McKenzie M. Recurrence of Crohn's disease after ileocolic resection is not affected by anastomotic type: results of a multicenter, randomized, controlled trial. Dis Colon Rectum 2009; 52: 919-927 [PMID: 19502857 DOI: 10.1007/DCR.0b013e3181a4fa58]
62. Simillis C, Purkayastha S, Yamamoto T, Strong SA, Darzi AW, Tekkis PP. A meta-analysis comparing conventional end-to-end anastomosis vs. other anastomotic configurations after resection in Crohn's disease. Dis Colon Rectum 2007; 50: 1674-1687 [PMID: 17682822]
63. Fichera A, Zoccali M, Kono T. Antimesenteric functional end-to- end handsewn (Kono-S) anastomosis. J Gastrointest Surg 2012; 16: 1412-1416 [PMID: 22580840 DOI: 10.1007/s11605-012-1905-7]
64. Hellers G, Cortot A, Jewell D, Leijonmarck CE, Löfberg R, Malchow H, Nilsson LG, Pallone F, Pena S, Persson T, Prantera C, Rutgeerts P. Oral budesonide for prevention of postsurgical recurrence in Crohn's disease. The IOIBD Budesonide Study Group. Gastroenterology 1999; 116: 294-300 [PMID: 9922309]
65. Rutgeerts P, Hiele M, Geboes K, Peeters M, Penninckx F, Aerts R, Kerremans R. Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology 1995; 108: 1617-1621 [PMID: 7768364]
66. Messori A, Brignola C, Trallori G, Rampazzo R, Bardazzi G, Belloli C, d'Albasio G, De Simone G, Martini N. Effectiveness of 5-aminosalicylic acid for maintaining remission in patients with Crohn's disease: a meta-analysis. Am J Gastroenterol 1994; 89: 692-698 [PMID: 8172139]
67. Sutherland LR, Martin F, Bailey RJ, Fedorak RN, Poleski M, Dallaire C, Rossman R, Saibil F, Lariviere L. A randomized, placebo-controlled, double-blind trial of mesalamine in the maintenance of remission of Crohn's disease. The Canadian Mesalamine for Remission of Crohn's Disease Study Group. Gastroenterology 1997; 112: 1069-1077 [PMID: 9097988]
68. Brignola C, Cottone M, Pera A, Ardizzone S, Scribano ML, De Franchis R, D'Arienzo A, D'Albasio G, Pennestri D. Mesalamine in the prevention of endoscopic recurrence after intestinal resection for Crohn's disease. Italian Cooperative Study Group. Gastroenterology 1995; 108: 345-349 [PMID: 7835575]
69. McLeod RS, Wolff BG, Steinhart AH, Carryer PW, O'Rourke K, Andrews DF, Blair JE, Cangemi JR, Cohen Z, Cullen JB. Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease. Gastroenterology 1995; 109: 404-413 [PMID: 7615189]
70. Colombel JF, Sandborn WJ, Reinisch W, Mantzaris GJ, Kornbluth A, Rachmilewitz D, Lichtiger S, D'Haens G, Diamond RH, Broussard DL, Tang KL, van der Woude CJ, Rutgeerts P. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med 2010; 362: 1383-1395 [PMID: 20393175 DOI: 10.1056/NEJMoa0904492]
71. Baert F, Moortgat L, Van Assche G, Caenepeel P, Vergauwe P, De Vos M, Stokkers P, Hommes D, Rutgeerts P, Vermeire S, D'Haens G. Mucosal healing predicts sustained clinical remission in patients with early-stage Crohn's disease. Gastroenterology 2010; 138: 463-468; quiz e10-e11 [PMID: 19818785 DOI: 10.1053/j.gastro.2009.09.056]
72. Cammà C, Giunta M, Rosselli M, Cottone M. Mesalamine in the maintenance treatment of Crohn's disease: a metaanalysis adjusted for confounding variables. Gastroenterology 1997; 113: 1465-1473 [PMID: 9352848]
73. Pearson DC, May GR, Fick GH, Sutherland LR. Azathioprine and 6-mercaptopurine in Crohn disease. A meta-analysis. Ann Intern Med 1995; 123: 132-142 [PMID: 7778826]
74. Ewe K, Press AG, Singe CC, Stufler M, Ueberschaer B, Hommel G, Meyer zum Büschenfelde KH. Azathioprine combined with prednisolone or monotherapy with prednisolone in active Crohn's disease. Gastroenterology 1993; 105: 367-372 [PMID: 8335191]
75. Candy S, Wright J, Gerber M, Adams G, Gerig M, Goodman R. A controlled double blind study of azathioprine in the management of Crohn's disease. Gut 1995; 37: 674-678 [PMID: 8549944]
76. Hanauer SB, Korelitz BI, Rutgeerts P, Peppercorn MA, Thisted RA, Cohen RD, Present DH. Postoperative maintenance of Crohn's disease remission with 6-mercaptopurine, mesalamine, or placebo: a 2-year trial. Gastroenterology 2004; 127: 723-729 [PMID: 15362027]
77. D'Haens GR, Vermeire S, Van Assche G, Noman M, Aerden I, Van Olmen G, Rutgeerts P. Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial. Gastroenterology 2008; 135: 1123-1129 [PMID: 18727929 DOI: 10.1053/j.gastro.2008.07.010]
78. Mañosa M, Cabré E, Bernal I, Esteve M, Garcia-Planella E, Ricart E, Peñalva M, Cortes X, Boix J, Piñol M, Gassull MA, Domènech E. Addition of metronidazole to azathioprine for the prevention of postoperative recurrence of Crohn's disease: a randomized, double-blind, placebo-controlled trial. Inflamm Bowel Dis 2013; 19: 1889-1895 [PMID: 23689809 DOI: 10.1097/MIB.0b013e31828ef13f]
79. Alves A, Panis Y, Joly F, Pocard M, Lavergne-Slove A, Bouhnik Y, Valleur P. Could immunosuppressive drugs reduce recurrence rate after second resection for Crohn disease? Inflamm Bowel Dis 2004; 10: 491-495 [PMID: 15472507]
80. Domènech E, Mañosa M, Bernal I, Garcia-Planella E, Cabré E, Piñol M, Lorenzo-Zúñiga V, Boix J, Gassull MA. Impact of azathioprine on the prevention of postoperative Crohn' s disease recurrence: results of a prospective, observational, long-term follow-up study. Inflamm Bowel Dis 2008; 14: 508-513 [PMID: 18183602 DOI: 10.1002/ibd.20359]
81. Lichtenstein GR, Abreu MT, Cohen R, Tremaine W. American Gastroenterological Association Institute medical position statement on corticosteroids, immunomodulators, and infliximab in inflammatory bowel disease. Gastroenterology 2006; 130: 935-939 [PMID: 16530531]
82. Regueiro M, Schraut W, Baidoo L, Kip KE, Sepulveda AR, Pesci M, Harrison J, Plevy SE. Infliximab prevents Crohn's disease recurrence after ileal resection. Gastroenterology 2009; 136: 441-450.e1; quiz 716 [PMID: 19109962 DOI: 10.1053/j.gastro.2008.10.051]
83. Savarino E, Bodini G, Dulbecco P, Assandri L, Bruzzone L, Mazza F, Frigo AC, Fazio V, Marabotto E, Savarino V. Adalimumab is more effective than azathioprine and mesalamine at preventing postoperative recurrence of Crohn's disease: a randomized controlled trial. Am J Gastroenterol 2013; 108: 1731-1742 [PMID: 24019080 DOI: 10.1038/ajg.2013.287]
84. Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987; 40: 373-383 [PMID: 3558716]
85. Yamamoto T, Umegae S, Kitagawa T, Matsumoto K. Mucosal cytokine production during remission after resection for Crohn's disease and its relationship to future relapse. Aliment Pharmacol Ther 2004; 19: 671-678 [PMID: 15023169]
86. Louis E, Belaiche J, van Kemseke C, Franchimont D, de Groote D, Gueenen V, Mary JY. A high serum concentration of inter-leukin- 6 is predictive of relapse in quiescent Crohn's disease. Eur J Gastroenterol Hepatol 1997; 9: 939-944 [PMID: 9391781]
87. Lamb CA, Mohiuddin MK, Gicquel J, Neely D, Bergin FG, Hanson JM, Mansfield JC. Faecal calprotectin or lactoferrin can identify postoperative recurrence in Crohn's disease. Br J Surg 2009; 96: 663-674 [PMID: 19384912 DOI: 10.1002/bjs.6593]
88. Lobatón T, López-García A, Rodríguez-Moranta F, Ruiz A, Rodríguez L, Guardiola J. A new rapid test for fecal calprotectin predicts endoscopic remission and postoperative recurrence in Crohn's disease. J Crohns Colitis 2013; 7: e641-e651 [PMID: 23810085 DOI: 10.1016/j.crohns.2013.05.005]
89. Lasson A, Strid H, Ohman L, Isaksson S, Olsson M, Rydström B, Ung KA, Stotzer PO. Fecal calprotectin one year after ileocaecal resection for Crohn's disease - a comparison with findings at ileocolonoscopy. J Crohns Colitis 2014; 8: 789-795 [PMID: 24418661 DOI: 10.1016/j.crohns.2013.12.015]
90. Domènech E, Zabana Y, Garcia-Planella E, López San Román A, Nos P, Ginard D, Gordillo J, Martínez-Silva F, Beltrán B, Mañosa M, Cabré E, Gassull MA. Clinical outcome of newly diagnosed Crohn's disease: a comparative, retrospective study before and after infliximab availability. Aliment Pharmacol Ther 2010; 31: 233-239 [PMID: 19832727 DOI: 10.1111/j.1365-2036.2009.04170.x]