메뉴 건너뛰기




Volumn 9, Issue 11, 2014, Pages

20(S)-protopanaxadiol inhibition of progression and growth of castration-resistant prostate cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; ENZALUTAMIDE; PROTOPANAXADIOL; ANTINEOPLASTIC AGENT; SAPOGENIN;

EID: 84910135031     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111201     Document Type: Article
Times cited : (32)

References (61)
  • 1
    • 79957640371 scopus 로고    scopus 로고
    • Minireview: Alternative activation pathways for the androgen receptor in prostate cancer
    • Lamont KR, Tindall DJ (2011) Minireview: Alternative Activation Pathways for the Androgen Receptor in Prostate Cancer. Mol Endocrinol 25: 897-907.
    • (2011) Mol Endocrinol , vol.25 , pp. 897-907
    • Lamont, K.R.1    Tindall, D.J.2
  • 2
    • 84892878803 scopus 로고    scopus 로고
    • Castration-resistant prostate cancer: Adaptive responses in the androgen axis
    • Egan A, Dong Y, Zhang H, Qi Y, Balk SP, et al. (2014) Castration-resistant prostate cancer: Adaptive responses in the androgen axis. Cancer Treat Rev 40: 426-433.
    • (2014) Cancer Treat Rev , vol.40 , pp. 426-433
    • Egan, A.1    Dong, Y.2    Zhang, H.3    Qi, Y.4    Balk, S.P.5
  • 3
    • 68049140791 scopus 로고    scopus 로고
    • Starving the addiction: New opportunities for durable suppression of AR signaling in prostate cancer
    • Knudsen KE, Scher HI (2009) Starving the addiction: new opportunities for durable suppression of AR signaling in prostate cancer. Clin Cancer Res 15: 4792-4798.
    • (2009) Clin Cancer Res , vol.15 , pp. 4792-4798
    • Knudsen, K.E.1    Scher, H.I.2
  • 4
    • 0034125195 scopus 로고    scopus 로고
    • Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor
    • Zhao XY, Malloy PJ, Krishnan AV, Swami S, Navone NM, et al. (2000) Glucocorticoids can promote androgen-independent growth of prostate cancer cells through a mutated androgen receptor. Nat Med 6: 703-706.
    • (2000) Nat Med , vol.6 , pp. 703-706
    • Zhao, X.Y.1    Malloy, P.J.2    Krishnan, A.V.3    Swami, S.4    Navone, N.M.5
  • 5
    • 0031946389 scopus 로고    scopus 로고
    • Expression, structure, and function of androgen receptor in advanced prostatic carcinoma
    • Culig Z, Hobisch A, Hittmair A, Peterziel H, Cato AC, et al. (1998) Expression, structure, and function of androgen receptor in advanced prostatic carcinoma. Prostate 35: 63-70.
    • (1998) Prostate , vol.35 , pp. 63-70
    • Culig, Z.1    Hobisch, A.2    Hittmair, A.3    Peterziel, H.4    Cato, A.C.5
  • 6
    • 15644368237 scopus 로고    scopus 로고
    • Androgen receptor gene amplification: A possible molecular mechanism for androgen deprivation therapy failure in prostate cancer
    • Koivisto P, Kononen J, Palmberg C, Tammela T, Hyytinen E, et al. (1997) Androgen receptor gene amplification: a possible molecular mechanism for androgen deprivation therapy failure in prostate cancer. Cancer Res 57: 314-319.
    • (1997) Cancer Res , vol.57 , pp. 314-319
    • Koivisto, P.1    Kononen, J.2    Palmberg, C.3    Tammela, T.4    Hyytinen, E.5
  • 7
    • 0028944138 scopus 로고
    • In vivo amplification of the androgen receptor gene and progression of human prostate cancer
    • Visakorpi T, Hyytinen E, Koivisto P, Tanner M, Keinanen R, et al. (1995) In vivo amplification of the androgen receptor gene and progression of human prostate cancer. Nat Genet 9: 401-406.
    • (1995) Nat Genet , vol.9 , pp. 401-406
    • Visakorpi, T.1    Hyytinen, E.2    Koivisto, P.3    Tanner, M.4    Keinanen, R.5
  • 8
    • 51049098138 scopus 로고    scopus 로고
    • Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer
    • Locke JA, Guns ES, Lubik AA, Adomat HH, Hendy SC, et al. (2008) Androgen levels increase by intratumoral de novo steroidogenesis during progression of castration-resistant prostate cancer. Cancer Res 68: 6407-6415.
    • (2008) Cancer Res , vol.68 , pp. 6407-6415
    • Locke, J.A.1    Guns, E.S.2    Lubik, A.A.3    Adomat, H.H.4    Hendy, S.C.5
  • 9
    • 49249119358 scopus 로고    scopus 로고
    • Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    • Montgomery RB, Mostaghel EA, Vessella R, Hess DL, Kalhorn TF, et al. (2008) Maintenance of intratumoral androgens in metastatic prostate cancer: a mechanism for castration-resistant tumor growth. Cancer Res 68: 4447-4454.
    • (2008) Cancer Res , vol.68 , pp. 4447-4454
    • Montgomery, R.B.1    Mostaghel, E.A.2    Vessella, R.3    Hess, D.L.4    Kalhorn, T.F.5
  • 10
    • 1842612441 scopus 로고    scopus 로고
    • Molecular determinants of resistance to antiandrogen therapy
    • Chen CD, Welsbie DS, Tran C, Baek SH, Chen R, et al. (2004) Molecular determinants of resistance to antiandrogen therapy. Nat Med 10: 33-39.
    • (2004) Nat Med , vol.10 , pp. 33-39
    • Chen, C.D.1    Welsbie, D.S.2    Tran, C.3    Baek, S.H.4    Chen, R.5
  • 11
    • 0037226103 scopus 로고    scopus 로고
    • Novel mutations of androgen receptor: A possible mechanism of bicalutamide withdrawal syndrome
    • Hara T, Miyazaki J, Araki H, Yamaoka M, Kanzaki N, et al. (2003) Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome. Cancer Res 63: 149-153.
    • (2003) Cancer Res , vol.63 , pp. 149-153
    • Hara, T.1    Miyazaki, J.2    Araki, H.3    Yamaoka, M.4    Kanzaki, N.5
  • 12
    • 0026562430 scopus 로고
    • The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens
    • Veldscholte J, Berrevoets CA, Ris-Stalpers C, Kuiper GG, Jenster G, et al. (1992) The androgen receptor in LNCaP cells contains a mutation in the ligand binding domain which affects steroid binding characteristics and response to antiandrogens. J Steroid Biochem Mol Biol 41: 665-669.
    • (1992) J Steroid Biochem Mol Biol , vol.41 , pp. 665-669
    • Veldscholte, J.1    Berrevoets, C.A.2    Ris-Stalpers, C.3    Kuiper, G.G.4    Jenster, G.5
  • 13
    • 27544485276 scopus 로고    scopus 로고
    • Antiandrogen bicalutamide promotes tumor growth in a novel androgen-dependent prostate cancer xenograft model derived from a bicalutamide-treated patient
    • Yoshida T, Kinoshita H, Segawa T, Nakamura E, Inoue T, et al. (2005) Antiandrogen Bicalutamide Promotes Tumor Growth in a Novel Androgen-Dependent Prostate Cancer Xenograft Model Derived from a Bicalutamide-Treated Patient. Cancer Research 65: 9611-9616.
    • (2005) Cancer Research , vol.65 , pp. 9611-9616
    • Yoshida, T.1    Kinoshita, H.2    Segawa, T.3    Nakamura, E.4    Inoue, T.5
  • 14
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm SM, Schmidt LJ, Heemers HV, Vessella RL, Tindall DJ (2008) Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res 68: 5469-5477.
    • (2008) Cancer Res , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 15
    • 65549168746 scopus 로고    scopus 로고
    • A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth
    • Guo Z, Yang X, Sun F, Jiang R, Linn DE, et al. (2009) A novel androgen receptor splice variant is up-regulated during prostate cancer progression and promotes androgen depletion-resistant growth. Cancer Res 69: 2305-2313.
    • (2009) Cancer Res , vol.69 , pp. 2305-2313
    • Guo, Z.1    Yang, X.2    Sun, F.3    Jiang, R.4    Linn, D.E.5
  • 16
    • 58249110391 scopus 로고    scopus 로고
    • Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer
    • Hu R, Dunn TA, Wei S, Isharwal S, Veltri RW, et al. (2009) Ligand-independent androgen receptor variants derived from splicing of cryptic exons signify hormone-refractory prostate cancer. Cancer Res 69: 16-22.
    • (2009) Cancer Res , vol.69 , pp. 16-22
    • Hu, R.1    Dunn, T.A.2    Wei, S.3    Isharwal, S.4    Veltri, R.W.5
  • 17
    • 0037112372 scopus 로고    scopus 로고
    • Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line
    • Tepper CG, Boucher DL, Ryan PE, Ma AH, Xia L, et al. (2002) Characterization of a novel androgen receptor mutation in a relapsed CWR22 prostate cancer xenograft and cell line. Cancer Res 62: 6606-6614.
    • (2002) Cancer Res , vol.62 , pp. 6606-6614
    • Tepper, C.G.1    Boucher, D.L.2    Ryan, P.E.3    Ma, A.H.4    Xia, L.5
  • 18
    • 84866948935 scopus 로고    scopus 로고
    • Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: Final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study
    • Fizazi K, Scher HI, Molina A, Logothetis CJ, Chi KN, et al. (2012) Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled phase 3 study. Lancet Oncol 13: 983-992.
    • (2012) Lancet Oncol , vol.13 , pp. 983-992
    • Fizazi, K.1    Scher, H.I.2    Molina, A.3    Logothetis, C.J.4    Chi, K.N.5
  • 19
    • 84866770294 scopus 로고    scopus 로고
    • Increased survival with enzalutamide in prostate cancer after chemotherapy
    • Scher HI, Fizazi K, Saad F, Taplin ME, Sternberg CN, et al. (2012) Increased survival with enzalutamide in prostate cancer after chemotherapy. N Engl J Med 367: 1187-1197.
    • (2012) N Engl J Med , vol.367 , pp. 1187-1197
    • Scher, H.I.1    Fizazi, K.2    Saad, F.3    Taplin, M.E.4    Sternberg, C.N.5
  • 20
    • 84863979005 scopus 로고    scopus 로고
    • Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer
    • Hu R, Lu C, Mostaghel EA, Yegnasubramanian S, Gurel M, et al. (2012) Distinct transcriptional programs mediated by the ligand-dependent full-length androgen receptor and its splice variants in castration-resistant prostate cancer. Cancer Res 72: 3457-3462.
    • (2012) Cancer Res , vol.72 , pp. 3457-3462
    • Hu, R.1    Lu, C.2    Mostaghel, E.A.3    Yegnasubramanian, S.4    Gurel, M.5
  • 21
    • 84872534568 scopus 로고    scopus 로고
    • Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines
    • Li Y, Chan SC, Brand LJ, Hwang TH, Silverstein KA, et al. (2012) Androgen receptor splice variants mediate enzalutamide resistance in castration-resistant prostate cancer cell lines. Cancer Res 73: 483-489.
    • (2012) Cancer Res , vol.73 , pp. 483-489
    • Li, Y.1    Chan, S.C.2    Brand, L.J.3    Hwang, T.H.4    Silverstein, K.A.5
  • 22
    • 84902471998 scopus 로고    scopus 로고
    • Mechanisms of the androgen receptor splicing in prostate cancer cells
    • Liu LL, Xie N, Sun S, Plymate S, Mostaghel E, et al. (2013) Mechanisms of the androgen receptor splicing in prostate cancer cells. Oncogene 33: 3140-50.
    • (2013) Oncogene , vol.33 , pp. 3140-3150
    • Liu, L.L.1    Xie, N.2    Sun, S.3    Plymate, S.4    Mostaghel, E.5
  • 23
    • 80052827038 scopus 로고    scopus 로고
    • Resistance to CYP17A1 inhibition with abiraterone in castration-resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants
    • Mostaghel EA, Marck BT, Plymate SR, Vessella RL, Balk S, et al. (2011) Resistance to CYP17A1 Inhibition with Abiraterone in Castration-Resistant Prostate Cancer: Induction of Steroidogenesis and Androgen Receptor Splice Variants. Clinical Cancer Research 17: 5913-5925.
    • (2011) Clinical Cancer Research , vol.17 , pp. 5913-5925
    • Mostaghel, E.A.1    Marck, B.T.2    Plymate, S.R.3    Vessella, R.L.4    Balk, S.5
  • 24
    • 84882274167 scopus 로고    scopus 로고
    • NF-kappaB2/p52 induces resistance to enzalutamide in prostate cancer: Role of androgen receptor and its variants
    • Nadiminty N, Tummala R, Liu C, Yang J, Lou W, et al. (2013) NF-kappaB2/p52 Induces Resistance to Enzalutamide in Prostate Cancer: Role of Androgen Receptor and Its Variants. Mol Cancer Ther 12: 1629-1637.
    • (2013) Mol Cancer Ther , vol.12 , pp. 1629-1637
    • Nadiminty, N.1    Tummala, R.2    Liu, C.3    Yang, J.4    Lou, W.5
  • 25
    • 70350244512 scopus 로고    scopus 로고
    • Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens
    • Waltering KK, Helenius MA, Sahu B, Manni V, Linja MJ, et al. (2009) Increased expression of androgen receptor sensitizes prostate cancer cells to low levels of androgens. Cancer Res 69: 8141-8149.
    • (2009) Cancer Res , vol.69 , pp. 8141-8149
    • Waltering, K.K.1    Helenius, M.A.2    Sahu, B.3    Manni, V.4    Linja, M.J.5
  • 26
    • 84863056052 scopus 로고    scopus 로고
    • ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors
    • Yamashita S, Lai KP, Chuang KL, Xu D, Miyamoto H, et al. (2012) ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia 14: 74-83.
    • (2012) Neoplasia , vol.14 , pp. 74-83
    • Yamashita, S.1    Lai, K.P.2    Chuang, K.L.3    Xu, D.4    Miyamoto, H.5
  • 27
    • 78049280194 scopus 로고    scopus 로고
    • Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor
    • Watson PA, Chen YF, Balbas MD, Wongvipat J, Socci ND, et al. (2010) Constitutively active androgen receptor splice variants expressed in castration-resistant prostate cancer require full-length androgen receptor. Proc Natl Acad Sci U S A 107: 16759-16765.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 16759-16765
    • Watson, P.A.1    Chen, Y.F.2    Balbas, M.D.3    Wongvipat, J.4    Socci, N.D.5
  • 28
    • 77955296562 scopus 로고    scopus 로고
    • Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant
    • Sun S, Sprenger CC, Vessella RL, Haugk K, Soriano K, et al. (2010) Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant. J Clin Invest 120: 2715-2730.
    • (2010) J Clin Invest , vol.120 , pp. 2715-2730
    • Sun, S.1    Sprenger, C.C.2    Vessella, R.L.3    Haugk, K.4    Soriano, K.5
  • 29
    • 79955719838 scopus 로고    scopus 로고
    • Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival
    • Hornberg E, Ylitalo EB, Crnalic S, Antti H, Stattin P, et al. (2011) Expression of androgen receptor splice variants in prostate cancer bone metastases is associated with castration-resistance and short survival. PLoS One 6: e19059.
    • (2011) PLoS One , vol.6
    • Hornberg, E.1    Ylitalo, E.B.2    Crnalic, S.3    Antti, H.4    Stattin, P.5
  • 30
    • 33751270698 scopus 로고    scopus 로고
    • Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression
    • Cheng H, Snoek R, Ghaidi F, Cox ME, Rennie PS (2006) Short hairpin RNA knockdown of the androgen receptor attenuates ligand-independent activation and delays tumor progression. Cancer Res 66: 10613-10620.
    • (2006) Cancer Res , vol.66 , pp. 10613-10620
    • Cheng, H.1    Snoek, R.2    Ghaidi, F.3    Cox, M.E.4    Rennie, P.S.5
  • 31
    • 58949101975 scopus 로고    scopus 로고
    • In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors
    • Snoek R, Cheng H, Margiotti K, Wafa LA, Wong CA, et al. (2009) In vivo knockdown of the androgen receptor results in growth inhibition and regression of well-established, castration-resistant prostate tumors. Clin Cancer Res 15: 39-47.
    • (2009) Clin Cancer Res , vol.15 , pp. 39-47
    • Snoek, R.1    Cheng, H.2    Margiotti, K.3    Wafa, L.A.4    Wong, C.A.5
  • 33
    • 79951785879 scopus 로고    scopus 로고
    • Chemical and pharmacological studies of saponins with a focus on American ginseng
    • Yuan CS, Wang CZ, Wicks SM, Qi LW (2010) Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res 34: 160-167.
    • (2010) J Ginseng Res , vol.34 , pp. 160-167
    • Yuan, C.S.1    Wang, C.Z.2    Wicks, S.M.3    Qi, L.W.4
  • 34
    • 84872975678 scopus 로고    scopus 로고
    • 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor
    • Cao B, Liu X, Li J, Liu S, Qi Y, et al. (2013) 20(S)-protopanaxadiol-aglycone downregulation of the full-length and splice variants of androgen receptor. Int J Cancer 132: 1277-1287.
    • (2013) Int J Cancer , vol.132 , pp. 1277-1287
    • Cao, B.1    Liu, X.2    Li, J.3    Liu, S.4    Qi, Y.5
  • 35
    • 1342325380 scopus 로고    scopus 로고
    • Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer
    • Gregory CW, Fei X, Ponguta LA, He B, Bill HM, et al. (2004) Epidermal growth factor increases coactivation of the androgen receptor in recurrent prostate cancer. J Biol Chem 279: 7119-7130.
    • (2004) J Biol Chem , vol.279 , pp. 7119-7130
    • Gregory, C.W.1    Fei, X.2    Ponguta, L.A.3    He, B.4    Bill, H.M.5
  • 36
    • 0037224465 scopus 로고    scopus 로고
    • Delineation of the molecular basis for selenium-induced growth arrest in human prostate cancer cells by oligonucleotide array
    • Dong Y, Zhang H, Hawthorn L, Ganther HE, Ip C (2003) Delineation of the Molecular Basis for Selenium-induced Growth Arrest in Human Prostate Cancer Cells by Oligonucleotide Array. Cancer Research 63: 52-59.
    • (2003) Cancer Research , vol.63 , pp. 52-59
    • Dong, Y.1    Zhang, H.2    Hawthorn, L.3    Ganther, H.E.4    Ip, C.5
  • 37
    • 1642576240 scopus 로고    scopus 로고
    • Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling
    • Dong Y, Lee SO, Zhang H, Marshall J, Gao AC, et al. (2004) Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res 64: 19-22.
    • (2004) Cancer Res , vol.64 , pp. 19-22
    • Dong, Y.1    Lee, S.O.2    Zhang, H.3    Marshall, J.4    Gao, A.C.5
  • 38
    • 0029951486 scopus 로고    scopus 로고
    • Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells
    • Yeh S, Chang C (1996) Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. Proc Natl Acad Sci USA 93: 5517-5521.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5517-5521
    • Yeh, S.1    Chang, C.2
  • 39
    • 23144438782 scopus 로고    scopus 로고
    • Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers
    • Dong Y, Zhang H, Gao AC, Marshall JR, Ip C (2005) Androgen receptor signaling intensity is a key factor in determining the sensitivity of prostate cancer cells to selenium inhibition of growth and cancer-specific biomarkers. Mol Cancer Ther 4: 1047-1055.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1047-1055
    • Dong, Y.1    Zhang, H.2    Gao, A.C.3    Marshall, J.R.4    Ip, C.5
  • 40
    • 0026602518 scopus 로고
    • Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors
    • Gleave ME, Hsieh JT, Wu HC, von Eschenbach AC, Chung LW (1992) Serum prostate specific antigen levels in mice bearing human prostate LNCaP tumors are determined by tumor volume and endocrine and growth factors. Cancer Res 52: 1598-1605.
    • (1992) Cancer Res , vol.52 , pp. 1598-1605
    • Gleave, M.E.1    Hsieh, J.T.2    Wu, H.C.3    Von Eschenbach, A.C.4    Chung, L.W.5
  • 41
    • 79960983495 scopus 로고    scopus 로고
    • Using the mitosis-specific marker anti-phosphohistone H3 to assess mitosis in pulmonary neuroendocrine carcinomas
    • Tsuta K, Liu DC, Kalhor N, Wistuba II, Moran CA (2011) Using the mitosis-specific marker anti-phosphohistone H3 to assess mitosis in pulmonary neuroendocrine carcinomas. Am J Clin Pathol 136: 252-259.
    • (2011) Am J Clin Pathol , vol.136 , pp. 252-259
    • Tsuta, K.1    Liu, D.C.2    Kalhor, N.3    Wistuba, I.I.4    Moran, C.A.5
  • 42
    • 79959312739 scopus 로고    scopus 로고
    • A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities
    • Hu R, Isaacs WB, Luo J (2011) A snapshot of the expression signature of androgen receptor splicing variants and their distinctive transcriptional activities. Prostate 71: 1656-1667.
    • (2011) Prostate , vol.71 , pp. 1656-1667
    • Hu, R.1    Isaacs, W.B.2    Luo, J.3
  • 43
    • 84904256379 scopus 로고    scopus 로고
    • Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy
    • Cao B, Qi Y, Zhang G, Xu D, Zhan Y, et al. (2014) Androgen receptor splice variants activating the full-length receptor in mediating resistance to androgen-directed therapy. Oncotarget 5: 1646-1656.
    • (2014) Oncotarget , vol.5 , pp. 1646-1656
    • Cao, B.1    Qi, Y.2    Zhang, G.3    Xu, D.4    Zhan, Y.5
  • 45
    • 0033887006 scopus 로고    scopus 로고
    • The suppression of human prostate tumor growth in mice by the intratumoral injection of a slow-release polymeric paste formulation of paclitaxel
    • Jackson JK, Gleave ME, Yago V, Beraldi E, Hunter WL, et al. (2000) The suppression of human prostate tumor growth in mice by the intratumoral injection of a slow-release polymeric paste formulation of paclitaxel. Cancer Res 60: 4146-4151.
    • (2000) Cancer Res , vol.60 , pp. 4146-4151
    • Jackson, J.K.1    Gleave, M.E.2    Yago, V.3    Beraldi, E.4    Hunter, W.L.5
  • 46
    • 0034213320 scopus 로고    scopus 로고
    • Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models
    • Miyake H, Pollak M, Gleave ME (2000) Castration-induced up-regulation of insulin-like growth factor binding protein-5 potentiates insulin-like growth factor-I activity and accelerates progression to androgen independence in prostate cancer models. Cancer Res 60: 3058-3064.
    • (2000) Cancer Res , vol.60 , pp. 3058-3064
    • Miyake, H.1    Pollak, M.2    Gleave, M.E.3
  • 47
    • 79954624502 scopus 로고    scopus 로고
    • A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis
    • Lamoureux F, Thomas C, Yin MJ, Kuruma H, Fazli L, et al. (2011) A novel HSP90 inhibitor delays castrate-resistant prostate cancer without altering serum PSA levels and inhibits osteoclastogenesis. Clin Cancer Res 17: 2301-2313.
    • (2011) Clin Cancer Res , vol.17 , pp. 2301-2313
    • Lamoureux, F.1    Thomas, C.2    Yin, M.J.3    Kuruma, H.4    Fazli, L.5
  • 48
    • 80052225259 scopus 로고    scopus 로고
    • Insulin increases de novo steroidogenesis in prostate cancer cells
    • Lubik AA, Gunter JH, Hendy SC, Locke JA, Adomat HH, et al. (2011) Insulin increases de novo steroidogenesis in prostate cancer cells. Cancer Res 71: 5754-5764.
    • (2011) Cancer Res , vol.71 , pp. 5754-5764
    • Lubik, A.A.1    Gunter, J.H.2    Hendy, S.C.3    Locke, J.A.4    Adomat, H.H.5
  • 49
    • 84859633811 scopus 로고    scopus 로고
    • Carbidopa abrogates L-dopa decarboxylase coactivation of the androgen receptor and delays prostate tumor progression
    • Wafa LA, Cheng H, Plaa N, Ghaidi F, Fukumoto T, et al. (2012) Carbidopa abrogates L-dopa decarboxylase coactivation of the androgen receptor and delays prostate tumor progression. Int J Cancer 130: 2835-2844.
    • (2012) Int J Cancer , vol.130 , pp. 2835-2844
    • Wafa, L.A.1    Cheng, H.2    Plaa, N.3    Ghaidi, F.4    Fukumoto, T.5
  • 50
    • 79952395235 scopus 로고    scopus 로고
    • Screening, risk assessment, and the approach to therapy in patients with prostate cancer
    • Freedland SJ (2011) Screening, risk assessment, and the approach to therapy in patients with prostate cancer. Cancer 117: 1123-1135.
    • (2011) Cancer , vol.117 , pp. 1123-1135
    • Freedland, S.J.1
  • 51
    • 84929025574 scopus 로고    scopus 로고
    • Combination AZD5363 with enzalutamide significantly delays enzaluta-mide-resistant prostate cancer in preclinical models
    • Toren P, Kim S, Cordonnier T, Crafter C, Davies BR, et al. (2014) Combination AZD5363 with Enzalutamide Significantly Delays Enzaluta-mide-resistant Prostate Cancer in Preclinical Models. Eur Urol 10.1016/j.eururo.2014.08.006 [doi].
    • (2014) Eur Urol
    • Toren, P.1    Kim, S.2    Cordonnier, T.3    Crafter, C.4    Davies, B.R.5
  • 52
    • 65649090203 scopus 로고    scopus 로고
    • Development of a second-generation antiandrogen for treatment of advanced prostate cancer
    • Tran C, Ouk S, Clegg NJ, Chen Y, Watson PA, et al. (2009) Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 324: 787-790.
    • (2009) Science , vol.324 , pp. 787-790
    • Tran, C.1    Ouk, S.2    Clegg, N.J.3    Chen, Y.4    Watson, P.A.5
  • 53
    • 40449086665 scopus 로고    scopus 로고
    • Dose translation from animal to human studies revisited
    • Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22: 659-661.
    • (2008) FASEB J , vol.22 , pp. 659-661
    • Reagan-Shaw, S.1    Nihal, M.2    Ahmad, N.3
  • 54
    • 79960848384 scopus 로고    scopus 로고
    • Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: A randomized, placebo-controlled clinical trial
    • Kim HG, Yoo SR, Park HJ, Lee NH, Shin JW, et al. (2011) Antioxidant effects of Panax ginseng C.A. Meyer in healthy subjects: a randomized, placebo-controlled clinical trial. Food Chem Toxicol 49: 2229-2235.
    • (2011) Food Chem Toxicol , vol.49 , pp. 2229-2235
    • Kim, H.G.1    Yoo, S.R.2    Park, H.J.3    Lee, N.H.4    Shin, J.W.5
  • 55
    • 84869404161 scopus 로고    scopus 로고
    • Safety and tolerability of panax ginseng root extract: A randomized, placebo-controlled, clinical trial in healthy korean volunteers
    • Lee NH, Yoo SR, Kim HG, Cho JH, Son CG (2012) Safety and tolerability of Panax ginseng root extract: a randomized, placebo-controlled, clinical trial in healthy Korean volunteers. J Altern Complement Med 18: 1061-1069.
    • (2012) J Altern Complement Med , vol.18 , pp. 1061-1069
    • Lee, N.H.1    Yoo, S.R.2    Kim, H.G.3    Cho, J.H.4    Son, C.G.5
  • 56
    • 80051591737 scopus 로고    scopus 로고
    • Berberine suppresses androgen receptor signaling in prostate cancer
    • Li J, Cao B, Liu X, Fu X, Xiong Z, et al. (2011) Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer. Molecular Cancer Therapeutics 10: 1346-1356.
    • (2011) Molecular Cancer Therapeutics , vol.10 , pp. 1346-1356
    • Li, J.1    Cao, B.2    Liu, X.3    Fu, X.4    Xiong, Z.5
  • 57
    • 84863023582 scopus 로고    scopus 로고
    • Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice
    • Li X, Liu Z, Xu X, Blair CA, Sun Z, et al. (2012) Kava components down-regulate expression of AR and AR splice variants and reduce growth in patient-derived prostate cancer xenografts in mice. PLoS One 7: e31213.
    • (2012) PLoS One , vol.7
    • Li, X.1    Liu, Z.2    Xu, X.3    Blair, C.A.4    Sun, Z.5
  • 58
    • 77958118514 scopus 로고    scopus 로고
    • Pharmacological targeting of constitutively active truncated androgen receptor by Nigericin and suppression of hormone-refractory prostate cancer cell growth
    • Mashima T, Okabe S, Seimiya H (2010) Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth. Mol Pharmacol 78: 846-854.
    • (2010) Mol Pharmacol , vol.78 , pp. 846-854
    • Mashima, T.1    Okabe, S.2    Seimiya, H.3
  • 59
    • 74849083394 scopus 로고    scopus 로고
    • Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer
    • Narizhneva NV, Tararova ND, Ryabokon P, Shyshynova I, Prokvolit A, et al. (2009) Small molecule screening reveals a transcription-independent pro-survival function of androgen receptor in castration-resistant prostate cancer. Cell Cycle 8: 4155-4167.
    • (2009) Cell Cycle , vol.8 , pp. 4155-4167
    • Narizhneva, N.V.1    Tararova, N.D.2    Ryabokon, P.3    Shyshynova, I.4    Prokvolit, A.5
  • 60
    • 84866889249 scopus 로고    scopus 로고
    • Effects of sorafenib on C-terminally truncated androgen receptor variants in human prostate cancer cells
    • Zengerling F, Streicher W, Schrader AJ, Schrader M, Nitzsche B, et al. (2012) Effects of sorafenib on C-terminally truncated androgen receptor variants in human prostate cancer cells. Int J Mol Sci 13: 11530-11542.
    • (2012) Int J Mol Sci , vol.13 , pp. 11530-11542
    • Zengerling, F.1    Streicher, W.2    Schrader, A.J.3    Schrader, M.4    Nitzsche, B.5
  • 61
    • 84882668677 scopus 로고    scopus 로고
    • Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer
    • Zhan Y, Cao B, Qi Y, Liu S, Zhang Q, et al. (2013) Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer. Int J Cancer 133: 2225-2233.
    • (2013) Int J Cancer , vol.133 , pp. 2225-2233
    • Zhan, Y.1    Cao, B.2    Qi, Y.3    Liu, S.4    Zhang, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.