메뉴 건너뛰기




Volumn 18, Issue 11, 2012, Pages 1061-1069

Safety and tolerability of panax ginseng root extract: A randomized, placebo-controlled, clinical trial in healthy Korean volunteers

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CHOLESTEROL; CREATININE; GINSENG EXTRACT; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; KETONE; PLACEBO; TRIACYLGLYCEROL; UROBILINOGEN;

EID: 84869404161     PISSN: 10755535     EISSN: 15577708     Source Type: Journal    
DOI: 10.1089/acm.2011.0591     Document Type: Article
Times cited : (49)

References (42)
  • 1
    • 33645058893 scopus 로고    scopus 로고
    • Use of ginseng in medicine with emphasis on neurodegenerative disorders
    • Radad K, Gille G, Liu L, Rausch WD. Use of ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 2006;100:175-186.
    • (2006) J Pharmacol Sci , vol.100 , pp. 175-186
    • Radad, K.1    Gille, G.2    Liu, L.3    Rausch, W.D.4
  • 4
    • 54549084799 scopus 로고    scopus 로고
    • Herbal supplement sales in United States show growth in all channels
    • Blumenthal M, Cavaliere C, Rea P. Herbal supplement sales in United States show growth in all channels. HerbalGram 2008;78:60-63.
    • (2008) HerbalGram , vol.78 , pp. 60-63
    • Blumenthal, M.1    Cavaliere, C.2    Rea, P.3
  • 5
    • 70350099283 scopus 로고    scopus 로고
    • Association between ginseng intake and mortality: Kangwha cohort study
    • Yi SW, Sull JW, Hong JS, et al. Association between ginseng intake and mortality: Kangwha cohort study. J Altern Complement Med 2009;15:921-928.
    • (2009) J Altern Complement Med , vol.15 , pp. 921-928
    • Yi, S.W.1    Sull, J.W.2    Hong, J.S.3
  • 6
    • 24044443225 scopus 로고    scopus 로고
    • Radioprotective potential of ginseng
    • Lee TK, Johnke RM, Allison RR, et al. Radioprotective potential of ginseng. Mutagenesis. 2005;20:237-243.
    • (2005) Mutagenesis , vol.20 , pp. 237-243
    • Lee, T.K.1    Johnke, R.M.2    Allison, R.R.3
  • 7
    • 0036283370 scopus 로고    scopus 로고
    • Panax ginseng: A systematic review of adverse effects and drug interactions
    • Coon JT, Ernst E. Panax ginseng: A systematic review of adverse effects and drug interactions. Drug Saf 2002;25:323-344.
    • (2002) Drug Saf , vol.25 , pp. 323-344
    • Coon, J.T.1    Ernst, E.2
  • 8
    • 69249216621 scopus 로고    scopus 로고
    • Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction
    • Kim TH, Jeon SH, Hahn EJ, et al. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl 2009;11: 356-361.
    • (2009) Asian J Androl , vol.11 , pp. 356-361
    • Kim, T.H.1    Jeon, S.H.2    Hahn, E.J.3
  • 9
    • 77954951295 scopus 로고    scopus 로고
    • Anti-fatigue activity of the watersoluble polysaccharides isolated from Panax ginseng C. A. Meyer
    • Wang J, Li S, Fan Y, et al. Anti-fatigue activity of the watersoluble polysaccharides isolated from Panax ginseng C. A. Meyer. J Ethnopharmacol 2010;130:421-423.
    • (2010) J Ethnopharmacol , vol.130 , pp. 421-423
    • Wang, J.1    Li, S.2    Fan, Y.3
  • 10
    • 52649150959 scopus 로고    scopus 로고
    • Panax ginseng enhances cognitive performance in Alzheimer disease
    • Lee ST, Chu K, Sim JY, et al. Panax ginseng enhances cognitive performance in Alzheimer disease. Alzheimer Dis Assoc Disord 2008;22:222-226.
    • (2008) Alzheimer Dis Assoc Disord , vol.22 , pp. 222-226
    • Lee, S.T.1    Chu, K.2    Sim, J.Y.3
  • 11
    • 55949136010 scopus 로고    scopus 로고
    • Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3- kinase signal transduction
    • Wang Z, Li M, Wu WK, et al. Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3-kinase signal transduction. Cardiovasc Drugs Ther 2008;22:443-452.
    • (2008) Cardiovasc Drugs Ther , vol.22 , pp. 443-452
    • Wang, Z.1    Li, M.2    Wu, W.K.3
  • 12
    • 45249091464 scopus 로고    scopus 로고
    • Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: Nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin
    • Li QF, Shi SL, Liu QR, et al. Anticancer effects of ginsenoside Rg1, cinnamic acid, and tanshinone IIA in osteosarcoma MG-63 cells: Nuclear matrix downregulation and cytoplasmic trafficking of nucleophosmin. Int J Biochem Cell Biol 2008;40:1918-1929.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1918-1929
    • Li, Q.F.1    Shi, S.L.2    Liu, Q.R.3
  • 13
    • 77956432021 scopus 로고    scopus 로고
    • Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages
    • Jang HI, Shin HM. Wild Panax ginseng (Panax ginseng C.A. Meyer) protects against methotrexate-induced cell regression by enhancing the immune response in RAW 264.7 macrophages. Am J Chin Med 2010;38:949-960.
    • (2010) Am J Chin Med , vol.38 , pp. 949-960
    • Jang, H.I.1    Shin, H.M.2
  • 14
    • 76449095468 scopus 로고    scopus 로고
    • Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide
    • Li XT, Chen R, Jin LM, Chen HY. Regulation on energy metabolism and protection on mitochondria of Panax ginseng polysaccharide. Am J Chin Med. 2009;37:1139-1152.
    • (2009) Am J Chin Med , vol.37 , pp. 1139-1152
    • Li, X.T.1    Chen, R.2    Jin, L.M.3    Chen, H.Y.4
  • 15
    • 0019991680 scopus 로고
    • Reproduction study in rats or ginseng extract G115
    • Hess FG Jr, Parent RA, Cox GE, et al. Reproduction study in rats or ginseng extract G115. Food Chem Toxicol 1982;20: 189-192.
    • (1982) Food Chem Toxicol , vol.20 , pp. 189-192
    • Hess Jr., F.G.1    Parent, R.A.2    Cox, G.E.3
  • 16
    • 0020538509 scopus 로고
    • Effects of subchronic feeding of ginseng extract G115 in beagle dogs
    • Hess FG Jr, Parent RA, Stevens KR, et al. Effects of subchronic feeding of ginseng extract G115 in beagle dogs. Food Chem Toxicol 1983;21:95-97.
    • (1983) Food Chem Toxicol , vol.21 , pp. 95-97
    • Hess Jr., F.G.1    Parent, R.A.2    Stevens, K.R.3
  • 17
    • 0015720945 scopus 로고
    • A review of the properties and clinical effects of ginseng
    • Popov IM, Goldwag WJ. A review of the properties and clinical effects of ginseng. Am J Chin Med (Gard City N Y) 1973;1:263-270.
    • (1973) Am J Chin Med (Gard City N Y) , vol.1 , pp. 263-270
    • Popov, I.M.1    Goldwag, W.J.2
  • 18
  • 19
    • 84870815988 scopus 로고    scopus 로고
    • NIH. Common Terminology Criteria for Adverse Events Accessed November 2010
    • NIH. Common Terminology Criteria for Adverse Events. General Characteristics of the CTCAE Grading (Severity) Scale. 2010. https://webapps.ctep.nci.nih.gov/webobjs/ctc/webhelp/Grading-General- Characteristics.htm Accessed November 2010.
    • (2010) General Characteristics of the CTCAE Grading (Severity) Scale
  • 21
    • 3142596226 scopus 로고    scopus 로고
    • Proof of the mysterious efficacy of ginseng: Basic and clinical trials: Clinical effects of medical ginseng, korean red ginseng: Specifically, its anti-stress action for prevention of disease
    • Kaneko H, Nakanishi K. Proof of the mysterious efficacy of ginseng: Basic and clinical trials: Clinical effects of medical ginseng, korean red ginseng: specifically, its anti-stress action for prevention of disease. J Pharmacol Sci 2004;95:158-162.
    • (2004) J Pharmacol Sci , vol.95 , pp. 158-162
    • Kaneko, H.1    Nakanishi, K.2
  • 22
    • 0036268271 scopus 로고    scopus 로고
    • Ginseng, sex behavior, and nitric oxide
    • Murphy LL, Lee TJ. Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci 2002;962:372-377.
    • (2002) Ann N y Acad Sci , vol.962 , pp. 372-377
    • Murphy, L.L.1    Lee, T.J.2
  • 23
    • 0030757369 scopus 로고    scopus 로고
    • Panax ginseng pharmacology: A nitric oxide link?
    • Gillis CN. Panax ginseng pharmacology: A nitric oxide link? Biochem Pharmacol 1997;54:1-8.
    • (1997) Biochem Pharmacol , vol.54 , pp. 1-8
    • Gillis, C.N.1
  • 24
    • 0027992709 scopus 로고
    • Evaluation of the ergogenic properties of ginseng
    • Bahrke MS, Morgan WP. Evaluation of the ergogenic properties of ginseng. Sports Med 1994;18:229-248.
    • (1994) Sports Med , vol.18 , pp. 229-248
    • Bahrke, M.S.1    Morgan, W.P.2
  • 25
    • 0000035742 scopus 로고
    • Cardiovascular actions of Panax ginseng in dogs
    • Wood WB, Roh BL, White RP. Cardiovascular actions of Panax ginseng in dogs. Jpn J Pharmacol 1964;14:284-294.
    • (1964) Jpn J Pharmacol , vol.14 , pp. 284-294
    • Wood, W.B.1    Roh, B.L.2    White, R.P.3
  • 26
    • 0034747182 scopus 로고    scopus 로고
    • Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: Role of nitric oxide
    • Scott GI, Colligan PB, Ren BH, Ren J. Ginsenosides Rb1 and Re decrease cardiac contraction in adult rat ventricular myocytes: Role of nitric oxide. Br J Pharmacol 2001;134:1159-1165.
    • (2001) Br J Pharmacol , vol.134 , pp. 1159-1165
    • Scott, G.I.1    Colligan, P.B.2    Ren, B.H.3    Ren, J.4
  • 27
    • 36949031034 scopus 로고    scopus 로고
    • The conduct of drug metabolism studies considered good practice(I): Analytical systems and in vivo studies
    • Liu X, Jia L. The conduct of drug metabolism studies considered good practice (I): Analytical systems and in vivo studies. Curr Drug Metab 2007;8:815-821.
    • (2007) Curr Drug Metab , Issue.8 , pp. 815-821
    • Liu, X.1    Jia, L.2
  • 28
    • 0018743257 scopus 로고
    • Ginseng abuse syndrome: Problems with the panacea
    • Siegel RK. Ginseng abuse syndrome: Problems with the panacea. JAMA 1979;241:1614-1615.
    • (1979) JAMA , vol.241 , pp. 1614-1615
    • Siegel, R.K.1
  • 29
    • 16744367701 scopus 로고
    • Ginseng and mastalgia
    • Dukes MN. Ginseng and mastalgia. Br Med J 1978;1:1621.
    • (1978) Br Med J , vol.1 , pp. 1621
    • Dukes, M.N.1
  • 32
    • 0028931451 scopus 로고
    • Ginseng-associated cerebral arteritis
    • Ryu SJ, Chien YY. Ginseng-associated cerebral arteritis. Neurology 1995;45:829-830.
    • (1995) Neurology , vol.45 , pp. 829-830
    • Ryu, S.J.1    Chien, Y.Y.2
  • 33
    • 0016639032 scopus 로고
    • Agranulocytosis caused by Chinese herbal medicines: Dangers of medications containing aminopyrine and phenylbutazone
    • Ries CA, Sahud MA. Agranulocytosis caused by Chinese herbal medicines: Dangers of medications containing aminopyrine and phenylbutazone. JAMA 1975;231:352-355.
    • (1975) JAMA , vol.231 , pp. 352-355
    • Ries, C.A.1    Sahud, M.A.2
  • 34
    • 0024823282 scopus 로고
    • Eye symptoms due to ginseng poisoning [in Chinese]
    • Lou BY, Li CF, Li PY, Ruan JP. Eye symptoms due to ginseng poisoning [in Chinese]. Yan Ke Xue Bao 1989;5:96-97.
    • (1989) Yan Ke Xue Bao , vol.5 , pp. 96-97
    • Lou, B.Y.1    Li, C.F.2    Li, P.Y.3    Ruan, J.P.4
  • 36
    • 0029586888 scopus 로고
    • Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both [in Japanese
    • Nakagawa A, Yamaguchi T, Takao T, Amano H. [Five cases of drug-induced pneumonitis due to Sho-saiko-to or interferon-alpha or both [in Japanese]. Nihon Kyobu Shikkan Gakkai Zasshi 1995;33:1361-1366.
    • (1995) Nihon Kyobu Shikkan Gakkai Zasshi , vol.33 , pp. 1361-1366
    • Nakagawa, A.1    Yamaguchi, T.2    Takao, T.3    Amano, H.4
  • 37
    • 22344436485 scopus 로고    scopus 로고
    • Single doses of Panax ginseng(G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity
    • Reay JL, Kennedy DO, Scholey AB. Single doses of Panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 2005;19:357-365.
    • (2005) J Psychopharmacol , Issue.19 , pp. 357-365
    • Reay, J.L.1    Kennedy, D.O.2    Scholey, A.B.3
  • 38
    • 0031002860 scopus 로고    scopus 로고
    • Probable interaction between warfarin and ginseng
    • Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm 1997;54:692-693.
    • (1997) Am J Health Syst Pharm , vol.54 , pp. 692-693
    • Janetzky, K.1    Morreale, A.P.2
  • 39
    • 0032997935 scopus 로고    scopus 로고
    • Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats
    • Zhu M, Chan KW, Ng LS, et al. Possible influences of ginseng on the pharmacokinetics and pharmacodynamics of warfarin in rats. J Pharm Pharmacol 1999;51:175-180.
    • (1999) J Pharm Pharmacol , vol.51 , pp. 175-180
    • Zhu, M.1    Chan, K.W.2    Ng, L.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.