4β-hydroxywithanolide E isolated from Physalis pruinosa calyx decreases inflammatory responses by inhibiting the NF-κB signaling in diabetic mouse adipose tissue

International Journal of Obesity

Volumn 38, Issue 11, 2014, Pages 1432-1439

  Takimoto, T ^a   Kanbayashi, Y ^a   Toyoda, T ^a   Adachi, Y ^a   Furuta, C ^a   Suzuki, K ^a   Miwa, T ^a   Bannai, M ^a  

^a AJINOMOTO CO INC   (Japan)

Author keywords

Adipose tissue; Anti inflammation; Glucose metabolism; Inflammatory cytokines; Withanolide

Indexed keywords

4BETA WITHANOLIDE E; ADIPONECTIN; FATTY ACID; GLUCOSE; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PLANT EXTRACT; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WITHANOLIDE; 4-HYDROXYWITHANOLIDE E; CCL2 PROTEIN, MOUSE;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BINDING SITE; CELL VIABILITY; COCULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DIABETES MELLITUS; DRUG STRUCTURE; ENZYME PHOSPHORYLATION; EPIDIDYMIS FAT; FATTY ACID BLOOD LEVEL; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRACELLULAR SIGNALING; LIQUID CHROMATOGRAPHY; MACROPHAGE; MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSALIS; PHYSALIS PRUINOSA; PROTEIN BLOOD LEVEL; UPREGULATION; 3T3 CELL LINE; ADIPOSE TISSUE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; IMMUNOBLOTTING; INFLAMMATION; INSULIN RESISTANCE; ISOLATION AND PURIFICATION; MALE; METABOLISM; NONOBESE DIABETIC MOUSE; NUCLEAR MAGNETIC RESONANCE; PATHOLOGY; PHYTOTHERAPY; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CHEMOKINE CCL2; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCULTURE TECHNIQUES; GLUCOSE; IMMUNOBLOTTING; INFLAMMATION; INSULIN RESISTANCE; MACROPHAGES; MALE; MASS SPECTROMETRY; MICE; MICE, INBRED NOD; NF-KAPPA B; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHYSALIS; PHYTOTHERAPY; PLANT EXTRACTS; SIGNAL TRANSDUCTION; WITHANOLIDES;

EID: 84910118554     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2014.33     Document Type: Article

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