Screening of promising chemotherapeutic candidates against human adult T-cell leukemia/lymphoma from plants: Active principles from Physalis pruinosa and structure-activity relationships with withanolides

Journal of Natural Medicines

Volumn 65, Issue 3-4, 2011, Pages 559-567

  Nakano, Daisuke ^a   Ishitsuka, Kenji ^a   Hatsuse, Takahiro ^a   Tsuchihashi, Ryota ^a   Okawa, Masafumi ^a   Okabe, Hikaru ^a   Tamura, Kazuo ^a   Kinjo, Junei ^a  

^a FUKUOKA UNIVERSITY   (Japan)

Author keywords

Adult T cell leukemia lymphoma; Physalis pruinosa; Structure activity relationships; Withanolides

Indexed keywords

(3BETA,4BETA,5BETA,6BETA,17ALPHA,22) 5,6 EPOXY 4,14,17,20,22 PENTAHYDROXY 3 METHOXY 1 OXO ERGOST 24 EN 26 OIC ACID DELTA LACTONE; 4BETA HYDROXYWITHANOLIDE E; 5ALPHA METHOXYWITHANOLIDE S; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; CARICA PAPAYA EXTRACT; CENTELLA ASIATICA EXTRACT; CHENOPODIUM AMBROSIOIDES EXTRACT; CIMICIFUGA RACEMOSA EXTRACT; COPTIS JAPONICA EXTRACT; CROTON EXTRACT; DOXORUBICIN; EUGENIA UNIFLORA EXTRACT; GUAVA EXTRACT; LANTANA CAMARA EXTRACT; LONICERA JAPONICA EXTRACT; MANGIFERA INDICA EXTRACT; MELIA AZEDARACH EXTRACT; PHYSALIS PRUINOSA EXTRACT; PLANT EXTRACT; PORTULACA OLERACEA EXTRACT; ROSMARINUS OFFICINALIS EXTRACT; SALVIA MILTIORRHIZA EXTRACT; SCUTELLARIA BAICALENSIS EXTRACT; SOLANUM NIGRUM EXTRACT; STEPHANIA TETRANDRA EXTRACT; TERMINALIA CHEBULA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; WITHANOLIDE; WITHANOLIDE S;

ADULT; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG STRUCTURE; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 1; PHYSALIS; PHYSALIS PRUINOSA; STRUCTURE ACTIVITY RELATION; T CELL LEUKEMIA; T LYMPHOCYTE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; HUMANS; LEUKEMIA-LYMPHOMA, ADULT T-CELL; PHYSALIS; PLANT EXTRACTS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; WITHANOLIDES;

EID: 79960465787     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-011-0543-9     Document Type: Article

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