Epigenetic control of Ccr7 expression in Distinct lineages of lung dendritic cells

Journal of Immunology

Volumn 193, Issue 10, 2014, Pages 4904-4913

  Moran, Timothy P ^a,b   Nakano, Hideki ^c   Kondilis Mangum, Hrisavgi D ^c   Wade, Paul A ^c   Cook, Donald N ^c  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD103 ANTIGEN; CD11B ANTIGEN; CHEMOKINE RECEPTOR CCR7; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENTARY DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE H3; INTERLEUKIN 4; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; MESSENGER RNA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 3; CCR7 PROTEIN, MOUSE; HISTONE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BONE MARROW CULTURE; CCR7 GENE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MIGRATION; CHEMOTAXIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DENDRITIC CELL; EPIGENETIC REPRESSION; EPIGENETICS; FLOW CYTOMETRY; GENE AMPLIFICATION; GENE EXPRESSION; GENE EXPRESSION REGULATION; HISTONE MODIFICATION; LUNG; LYMPHOCYTE SUBPOPULATION; MONOCYTE; MOUSE; NONHUMAN; POSTTRANSCRIPTIONAL GENE SILENCING; PROMOTER REGION; PROTEIN MODIFICATION; STEM CELL; ANIMAL; BONE MARROW CELL; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; IMMUNOLOGY; LYMPH NODE; METHYLATION; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CELL MOVEMENT; CELL PROLIFERATION; DENDRITIC CELLS; EPIGENESIS, GENETIC; HISTONES; LUNG; LYMPH NODES; METHYLATION; MICE; MICE, TRANSGENIC; MONOCYTES; PRIMARY CELL CULTURE; PROMOTER REGIONS, GENETIC; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 84910110809     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1401104     Document Type: Article

References (56)

1. Vermaelen, K. Y., I. Carro-Muino, B. N. Lambrecht, and R. A. Pauwels. 2001. Specific migratory dendritic cells rapidly transport antigen from the airways to the thoracic lymph nodes. J. Exp. Med. 193: 51-60
2. Hintzen, G., L. Ohl, M. L. del Rio, J. I. Rodriguez-Barbosa, O. Pabst, J. R. Kocks, J. Krege, S. Hardtke, and R. Förster. 2006. Induction of tolerance to innocuous inhaled antigen relies on a CCR7-dependent dendritic cell-mediated antigen transport to the bronchial lymph node. J. Immunol. 177: 7346-7354
3. Plantinga, M., M. Guilliams, M. Vanheerswynghels, K. Deswarte, F. Branco- Madeira, W. Toussaint, L. Vanhoutte, K. Neyt, N. Killeen, B. Malissen, et al. 2013. Conventional and monocyte-derived CD11b+ dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. Immunity 38: 322-335
4. GeurtsvanKessel, C. H., M. A. Willart, L. S. van Rijt, F. Muskens, M. Kool, C. Baas, K. Thielemans, C. Bennett, B. E. Clausen, H. C. Hoogsteden, et al. 2008. Clearance of influenza virus from the lung depends on migratory langerin+ CD11b- but not plasmacytoid dendritic cells. J. Exp. Med. 205: 1621-1634
5. Förster, R., A. C. Davalos-Misslitz, and A. Rot. 2008. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 8: 362-371
6. Broggi, A., I. Zanoni, and F. Granucci. 2013. Migratory conventional dendritic cells in the induction of peripheral T cell tolerance. J. Leukoc. Biol. 94: 903-911
7. Lambrecht, B. N., and H. Hammad. 2012. Lung dendritic cells in respiratory viral infection and asthma: from protection to immunopathology. Annu. Rev. Immunol. 30: 243-270
8. + dendritic cells prime Th2 responses to inhaled allergens. Mucosal Immunol. 5: 53-65
9. Satpathy, A. T., X. Wu, J. C. Albring, and K. M. Murphy. 2012. Re(de)fining the dendritic cell lineage. Nat. Immunol. 13: 1145-1154
10. Nakano, H., J. E. Burgents, K. Nakano, G. S. Whitehead, C. Cheong, C. D. Bortner, and D. N. Cook. 2013. Migratory properties of pulmonary dendritic cells are determined by their developmental lineage. Mucosal Immunol. 6: 678-691
11. Liu, K., and M. C. Nussenzweig. 2010. Origin and development of dendritic cells. Immunol. Rev. 234: 45-54
12. Merad, M., P. Sathe, J. Helft, J. Miller, and A. Mortha. 2013. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu. Rev. Immunol. 31: 563-604
13. Bogunovic, M., F. Ginhoux, J. Helft, L. Shang, D. Hashimoto, M. Greter, K. Liu, C. Jakubzick, M. A. Ingersoll, M. Leboeuf, et al. 2009. Origin of the lamina propria dendritic cell network. Immunity 31: 513-525
14. Tamoutounour, S., M. Guilliams, F. Montanana Sanchis, H. Liu, D. Terhorst, C. Malosse, E. Pollet, L. Ardouin, H. Luche, C. Sanchez, et al. 2013. Origins and functional specialization of macrophages and of conventional and monocytederived dendritic cells in mouse skin. Immunity 39: 925-938
15. Murphy, K. M. 2013. Transcriptional control of dendritic cell development. Adv. Immunol. 120: 239-267
16. Kim, H. P., Y. S. Lee, J. H. Park, and Y. J. Kim. 2013. Transcriptional and epigenetic networks in the development and maturation of dendritic cells. Epigenomics 5: 195-204
17. Kondilis-Mangum, H. D., and P. A. Wade. 2013. Epigenetics and the adaptive immune response. Mol. Aspects Med. 34: 813-825
18. Lee, D. U., S. Agarwal, and A. Rao. 2002. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16: 649-660
19. Avni, O., D. Lee, F. Macian, S. J. Szabo, L. H. Glimcher, and A. Rao. 2002. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3: 643-651
20. + T cells. Immunity 30: 155-167
21. Verstraete, K., S. Koch, S. Ertugrul, I. Vandenberghe, M. Aerts, G. Vandriessche, C. Thiede, and S. N. Savvides. 2009. Efficient production of bioactive recombinant human Flt3 ligand in E. coli. Protein J. 28: 57-65
22. Nakano, H., and D. N. Cook. 2013. Pulmonary antigen presenting cells: isolation, purification, and culture. Methods Mol. Biol. 1032: 19-29
23. Carabana, J., A. Watanabe, B. Hao, and M. S. Krangel. 2011. A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRb locus. J. Immunol. 186: 3556-3562
24. Xu, Y., Y. Zhan, A. M. Lew, S. H. Naik, and M. H. Kershaw. 2007. Differential development of murine dendritic cells by GM-CSF versus Flt3 ligand has implications for inflammation and trafficking. J. Immunol. 179: 7577-7584
25. Satpathy, A. T., W. Kc, J. C. Albring, B. T. Edelson, N. M. Kretzer, D. Bhattacharya, T. L. Murphy, and K. M. Murphy. 2012. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J. Exp. Med. 209: 1135-1152
26. Meredith, M. M., K. Liu, G. Darrasse-Jeze, A. O. Kamphorst, H. A. Schreiber, P. Guermonprez, J. Idoyaga, C. Cheong, K. H. Yao, R. E. Niec, and M. C. Nussenzweig. 2012. Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J. Exp. Med. 209: 1153-1165
27. Patenaude, J., M. D'Elia, G. Côté-Maurais, and J. Bernier. 2011. LPS response and endotoxin tolerance in Flt-3L-induced bone marrow-derived dendritic cells. Cell. Immunol. 271: 184-191
28. Tserel, L., R. Kolde, A. Rebane, K. Kisand, T. Org, H. Peterson, J. Vilo, and P. Peterson. 2010. Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics 11: 642
29. Barski, A., S. Cuddapah, K. Cui, T.-Y. Roh, D. E. Schones, Z. Wang, G. Wei, I. Chepelev, and K. Zhao. 2007. High-resolution profiling of histone methylations in the human genome. Cell 129: 823-837
30. Bernstein, B. E., E. Birney, I. Dunham, E. D. Green, C. Gunter, and M. Snyder, ENCODE Project Consortium. 2012. An integrated encyclopedia of DNA elements in the human genome. Nature 489: 57-74
31. Schlitzer, A., N. McGovern, P. Teo, T. Zelante, K. Atarashi, D. Low, A. W. Ho, P. See, A. Shin, P. S. Wasan, et al. 2013. IRF4 transcription factor-dependent CD11b+ dendritic cells in human and mouse control mucosal IL-17 cytokine responses. Immunity 38: 970-983
32. Fogg, D. K., C. Sibon, C. Miled, S. Jung, P. Aucouturier, D. R. Littman, A. Cumano, and F. Geissmann. 2006. A clonogenic bone marrow progenitor specific for macrophages and dendritic cells. Science 311: 83-87
33. Shi, C., and E. G. Pamer. 2011. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11: 762-774
34. + dendritic cells for immune T cell areas. Cell 143: 416-429
35. Miller, J. C., B. D. Brown, T. Shay, E. L. Gautier, V. Jojic, A. Cohain, G. Pandey, M. Leboeuf, K. G. Elpek, J. Helft, et al. 2012. Deciphering the transcriptional network of the dendritic cell lineage. Nat. Immunol. 13: 888-899
36. Kanno, Y., G. Vahedi, K. Hirahara, K. Singleton, and J. J. O'Shea. 2012. Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. Annu. Rev. Immunol. 30: 707-731
37. Bode, K. A., K. Schroder, D. A. Hume, T. Ravasi, K. Heeg, M. J. Sweet, and A. H. Dalpke. 2007. Histone deacetylase inhibitors decrease Toll-like receptormediated activation of proinflammatory gene expression by impairing transcription factor recruitment. Immunology 122: 596-606
38. Mikhaylova, L., Y. Zhang, L. Kobzik, and A. V. Fedulov. 2013. Link between epigenomic alterations and genome-wide aberrant transcriptional response to allergen in dendritic cells conveying maternal asthma risk. PLoS One 8: e70387
39. Zigmond, E., C. Varol, J. Farache, E. Elmaliah, A. T. Satpathy, G. Friedlander, M. Mack, N. Shpigel, I. G. Boneca, K. M. Murphy, et al. 2012. Ly6Chi monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity 37: 1076-1090
40. Merad, M., M. G. Manz, H. Karsunky, A. Wagers, W. Peters, I. Charo, I. L. Weissman, J. G. Cyster, and E. G. Engleman. 2002. Langerhans cells renew in the skin throughout life under steady-state conditions. Nat. Immunol. 3: 1135-1141
41. Ohl, L., M. Mohaupt, N. Czeloth, G. Hintzen, Z. Kiafard, J. Zwirner, T. Blankenstein, G. Henning, and R. Förster. 2004. CCR7 governs skin dendritic cell migration under inflammatory and steady-state conditions. Immunity 21: 279-288
42. Kitajima, M., and S. F. Ziegler. 2013. Cutting edge: identification of the thymic stromal lymphopoietin-responsive dendritic cell subset critical for initiation of type 2 contact hypersensitivity. J. Immunol. 191: 4903-4907
43. Besnard, A. G., D. Togbe, N. Guillou, F. Erard, V. Quesniaux, and B. Ryffel. 2011. IL-33-activated dendritic cells are critical for allergic airway inflammation. Eur. J. Immunol. 41: 1675-1686
44. Parlato, S., S. M. Santini, C. Lapenta, T. Di Pucchio, M. Logozzi, M. Spada, A. M. Giammarioli, W. Malorni, S. Fais, and F. Belardelli. 2001. Expression of CCR-7, MIP-3b, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities. Blood 98: 3022-3029
45. MartIn-Fontecha, A., S. Sebastiani, U. E. Höpken, M. Uguccioni, M. Lipp, A. Lanzavecchia, and F. Sallusto. 2003. Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming. J. Exp. Med. 198: 615-621
46. O'Meara, M. M., and J. A. Simon. 2012. Inner workings and regulatory inputs that control Polycomb repressive complex 2. Chromosoma 121: 221-234
47. Ezhkova, E., H. A. Pasolli, J. S. Parker, N. Stokes, I. H. Su, G. Hannon, A. Tarakhovsky, and E. Fuchs. 2009. Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells. Cell 136: 1122-1135
48. Kim, J., and H. Kim. 2012. Recruitment and biological consequences of histone modification of H3K27me3 and H3K9me3. ILAR J. 53: 232-239
49. Tan, J., X. Yang, L. Zhuang, X. Jiang, W. Chen, P. L. Lee, R. K. Karuturi, P. B. Tan, E. T. Liu, and Q. Yu. 2007. Pharmacologic disruption of Polycombrepressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev. 21: 1050-1063
50. Höpken, U. E., H. D. Foss, D. Meyer, M. Hinz, K. Leder, H. Stein, and M. Lipp. 2002. Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs. Blood 99: 1109-1116
51. Angeli, V., H. Hammad, B. Staels, M. Capron, B. N. Lambrecht, and F. Trottein. 2003. Peroxisome proliferator-activated receptor g inhibits the migration of dendritic cells: consequences for the immune response. J. Immunol. 170: 5295-5301
52. Fainaru, O., D. Shseyov, S. Hantisteanu, and Y. Groner. 2005. Accelerated chemokine receptor 7-mediated dendritic cell migration in Runx3 knockout mice and the spontaneous development of asthma-like disease. Proc. Natl. Acad. Sci. USA 102: 10598-10603
53. Villablanca, E. J., L. Raccosta, D. Zhou, R. Fontana, D. Maggioni, A. Negro, F. Sanvito, M. Ponzoni, B. Valentinis, M. Bregni, et al. 2010. Tumormediated liver X receptor-a activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses. Nat. Med. 16: 98-105
54. Bajaña, S., K. Roach, S. Turner, J. Paul, and S. Kovats. 2012. IRF4 promotes cutaneous dendritic cell migration to lymph nodes during homeostasis and inflammation. J. Immunol. 189: 3368-3377
55. Kim, S. J., J. Y. Shin, K. D. Lee, Y. K. Bae, K.W. Sung, S. J. Nam, and K. H. Chun. 2012. MicroRNA let-7a suppresses breast cancer cell migration and invasion through downregulation of C-C chemokine receptor type 7. Breast Cancer Res. 14: R14
56. + T-cells: Activationinduced miR-21 supports survival of memory T-cells and regulates CCR7 expression in naive T-cells. PLoS One 8: e76217