GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer

Oncotarget

Volumn 5, Issue 19, 2014, Pages 9460-9471

  Marszalowicz, Glen P ^a   Snook, Adam E ^b   Magee, Michael S ^b   Merlino, Dante ^b   Berman Booty, Lisa D ^b   Waldman, Scott A ^b  

^a DREXEL UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

GUCY2C; Immunotoxin; Metastatic colorectal cancer; Therapeutic targeting

Indexed keywords

CAVEOLIN; CLATHRIN; GUANYLATE CYCLASE; GUANYLATE CYCLASE C; IMMUNOTOXIN; RICIN A; UNCLASSIFIED DRUG; ATRIAL NATRIURETIC FACTOR RECEPTOR; DRUG CARRIER; ENTEROTOXIN RECEPTOR; MONOCLONAL ANTIBODY; RECEPTOR; RICIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CANCER SIZE; CELL SURFACE; COLORECTAL CANCER; CONTROLLED STUDY; DISULFIDE BOND; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; ENDOCYTOSIS; ESOPHAGUS CANCER; HISTOPATHOLOGY; INTERNALIZATION; INTESTINE CANCER; LIGAND BINDING; LUNG METASTASIS; LYSOSOME; LYSOSOMOTROPIC ENDOCYTOSIS; METASTATIC COLORECTAL CANCER; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STOMACH CANCER; SURVIVAL RATE; ANIMAL; GASTROINTESTINAL NEOPLASMS; GENETICS; IMMUNOLOGY; IMMUNOTHERAPY; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PROTEIN TRANSPORT; RNA INTERFERENCE; TUMOR CELL LINE;

ANIMALS; ANTIBODIES, MONOCLONAL; CAVEOLINS; CELL LINE, TUMOR; CLATHRIN; DRUG CARRIERS; ENDOCYTOSIS; GASTROINTESTINAL NEOPLASMS; IMMUNOTHERAPY; IMMUNOTOXINS; LYSOSOMES; MICE; MOLECULAR TARGETED THERAPY; PROTEIN TRANSPORT; RECEPTORS, GUANYLATE CYCLASE-COUPLED; RECEPTORS, PEPTIDE; RICIN; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84910092222     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.2455     Document Type: Article

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