Improvement of the stability of doxycycline hydrochloride pellet-containing tablets through a novel granulation technique and proper excipients

Powder Technology

Volumn 270, Issue Part A, 2015, Pages 221-229

  Peng, Tingting ^a   Zhu, Chune ^a   Huang, Ying ^a   Quan, Guilan ^a   Huang, Linchong ^a   Wu, Linna ^a   Pan, Xin ^a   Li, Ge ^b   Wu, Chuanbin ^a,c  

^a SUN YAT SEN UNIVERSITY   (China)

^b Guangzhou Neworld Pharm Co Ltd   (China)

^c Guangdong Research Center for Drug Delivery Systems   (China)

Author keywords

Centrifugal granulation; Excipients; Granulated pellet containing tablets; Stability

Indexed keywords

BINARY MIXTURES; CELLULOSE; COMPRESSIBILITY; CONVERGENCE OF NUMERICAL METHODS; DEGRADATION; DRUG DELIVERY; GRANULATION; STABILITY;

CENTRIFUGAL GRANULATION; DEGRADATION RATE; DOXYCYCLINE HYDROCHLORIDE; EXCIPIENTS; GRANULATED PELLET-CONTAINING TABLETS; GRANULATION TECHNIQUES; HUMIDITY SENSITIVE; MICROCRYSTALLINE CELLULOSE;

PELLETIZING;

CARBOXYMETHYLCELLULOSE; CROSPOVIDONE; DIHYDROGEN PHOSPHATE CALCIUM; DOXYCYCLINE; EXCIPIENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG COATING; DRUG DEGRADATION; DRUG FORMULATION; DRUG GRANULATION; DRUG PELLET; DRUG RELEASE; DRUG STABILITY; GRANULATED PELLET; GRANULATED PELLET CONTAINING TABLET; HIGH TEMPERATURE; HUMIDITY; WETTABILITY;

EID: 84910069459     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2014.10.023     Document Type: Article

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