Effect of disintegrants on the properties of multiparticulate tablets comprising starch pellets and excipient granules

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 310-317

  Mehta, Samata ^a   De Beer, Thomas ^a   Remon, Jean Paul ^a   Vervaet, Chris ^a  

^a GHENT UNIVERSITY   (Belgium)

Author keywords

Design of experiment; Disintegrant; Granule; Multiparticulate tablet; Starch pellet

Indexed keywords

CROSPOVIDONE; DISINTEGRATING AGENT; EXCIPIENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; POVIDONE;

ARTICLE; DRUG FORMULATION; DRUG PELLET; FACTORIAL DESIGN; MONTE CARLO METHOD; PRIORITY JOURNAL; SPHERONIZATION; TABLET; TABLET DISINTEGRATION TIME; TABLET FRIABILITY; TABLET HARDNESS; TABLET POROSITY; VALIDATION STUDY;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; COMPRESSIVE STRENGTH; DRUG COMPOUNDING; EXCIPIENTS; HARDNESS; KINETICS; POROSITY; POVIDONE; POWDERS; SOLUBILITY; STARCH; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 84655160868     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.11.017     Document Type: Article

References (19)

1. S. Abdul, A.V. Chandewar, and S.B. Jaiswal A flexible technology for modified-release drugs: multiple-unit pellet system (MUPS) J. Control. Release 147 2010 2 16
2. M.E. Aulton, A.M. Dyer, and K.A. Khan The strength and compaction of millispheres: the design of a controlled-release drug delivery system for ibuprofen in the form of a tablet comprising compacted polymer-coated millispheres Drug Dev. Ind. Pharm. 20 1994 3069 3104
3. S.R. Bechard, and J.C. Leroux Coated pelletized dosage form: effect of compaction on drug release Drug Dev. Ind. Pharm. 18 1992 1927 1944
4. T.E. Beckert, K. Lehmann, and P.C. Schmidt Compression of enteric-coated pellets to disintegrating tablets Int. J. Pharm. 143 1996 13 23 (Pubitemid 26396395)
5. T.E. Beckert, K. Lehmann, and P.C. Schmidt Compression of enteric-coated pellets to disintegrating tablets: uniformity of dosage units Powder Technol. 96 1998 248 254 (Pubitemid 28179460)
6. R. Bodmeier Tableting of coated pellets Eur. J. Pharm. Biopharm. 43 1997 1 8 (Pubitemid 28298804)
7. M. Celik Compaction of Multiparticulate Oral Dosage Forms 1994 Marcel Dekker, Inc. New Jersey
8. A. Dukic-Ott, T. De Beer, J.P. Remon, W. Baeyens, P. Foreman, and C. Vervaet In-vitro and in-vivo evaluation of enteric-coated starch-based pellets prepared via extrusion/spheronisation Eur. J. Pharm. Biopharm. 70 2008 302 312
9. A. Dukic-Ott, M. Thommes, J.P. Remon, P. Kleinebudde, and C. Vervaet Production of pellets via extrusion-spheronisation without the incorporation of microcrystalline cellulose: a critical review Eur. J. Pharm. Biopharm. 71 2009 38 46
10. A. Dukic, R. Mens, P. Adriaensens, P. Foreman, J. Gelan, J.P. Remon, and C. Vervaet Development of starch-based pellets via extrusion/spheronisation Eur. J. Pharm. Biopharm. 66 2007 83 94 (Pubitemid 46412962)
11. European Pharmacopoeia Council of Europe, Strasbourg 6th ed. 2009
12. D. Ghanam, I. Hassan, and P. Kleinebudde Compression behaviour of kappa-carrageenan pellets Int. J. Pharm. 390 2010 117 127
13. E.A. Gorman, C.T. Rhodes, and E.M. Rudnic An evaluation of croscarmellose as a tablet disintegrant in direct compression systems Drug Dev. Ind. Pharm. 8 1982 397 410 (Pubitemid 12088312)
14. Y.S. Habib, L.L. Augsburger, and R.F. Shangraw Production of inert cushioning beads: effect of excipients on the physicomechanical properties of freeze-dried beads containing microcrystalline cellulose produced by extrusion-spheronization Int. J. Pharm. 233 2002 67 83 (Pubitemid 34230420)
15. B. Ivic, S. Ibric, G. Betz, and Z. Djuric Evaluation of diclofenac sodium release from matrix pellets compressed into MUPS tablets Yakugaku Zasshi - J. Pharm. Soc. Jpn. 129 2009 1375 1384
16. . Lundqvist, F. Podczeck, and J.M. Newton Influence of disintegrant type and proportion on the properties of tablets produced from mixtures of pellets Int. J. Pharm. 147 1997 95 107 (Pubitemid 27130069)
17. F. Nicklasson, A. Johansson, and G. Alderborn Tabletting behaviour of pellets of a series of porosities - a comparison between pellets of two different compositions Eur. J. Pharm. 8 1999 11 17 (Pubitemid 29117264)
18. Polyplasdone® Superdisintegrants, Product Overview. http://www.isppharmaceuticals.com/Literature/Polyplasdone-Crospovidone-Sheet. pdf.
19. H.V. Vankamp, G.K. Bolhuis, and C.F. Lerk Improvement by super disintegrants of the properties of tablets containing lactose, prepared by wet granulation Pharm. Weekbl. 5 1983 165 171 Scientific Edition