Application of principal component analysis enables to effectively find important physical variables for optimization of fluid bed granulator conditions

International Journal of Pharmaceutics

Volumn 409, Issue 1-2, 2011, Pages 81-88

  Otsuka, Tomoko ^a   Iwao, Yasunori ^a   Miyagishima, Atsuo ^a   Itai, Shigeru ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Compactability; Fluid bed granulation; Multiple regression analysis; Powder property; Principal component analysis; Tablet property

Indexed keywords

HYDROXYPROPYLCELLULOSE; PARACETAMOL;

ARTICLE; CONTROLLED STUDY; DRUG GRANULATION; DRUG GRANULE; FLOW RATE; FLUID BED GRANULATOR; MULTIPLE REGRESSION; PARTICLE SIZE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; TABLET COMPRESSION; TABLET DISINTEGRATION TIME; TABLET FORMULATION; TABLET FRIABILITY; TENSILE STRENGTH; THICKNESS; WEIGHT;

ACETAMINOPHEN; EXCIPIENTS; PARTICLE SIZE; POWDERS; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; TABLETS; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH;

EID: 79955037320     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.02.044     Document Type: Article

References (22)

1. R.L. Carr Evaluating flow properties of solids Chem. Eng. 72 1965 163 168
2. T. Charinpanitkul, W. Tanthapanichakoon, P. Kulvanich, and K. Kim Granulation and tabletization of pharmaceutical lactose granules prepared by a top-sprayed fluidized bed granulator J. Ind. Eng. Chem. 14 2008 661 666
3. G.C. Dacanal, and F.C. Menegalli Selection of operational parameters for the production of instant soy protein isolate by pulsed fluid bed agglomeration Powder Technol. 203 2010 565 573
4. J.A.H. De Jong Tablet properties as a function of the properties of granules made in a fluidized bed process Powder Technol. 65 1991 293 303
5. E. Doelker, and D. Massurelle Benefits of die-wall instrumentation for research and development in tabletting Eur. J. Pharm. Biopharm. 58 2004 427 444 (Pubitemid 39037245)
6. A. Donev, I. Cisse, D. Sachs, E.A. Variano, F.H. Stillinger, R. Connelly, S. Torquato, and P.M. Chaikin Improving the density of jammed disordered packings using ellipsoids Science 303 2004 990 993 (Pubitemid 38209698)
7. H. Ehlers, A. Liu, H. Raikkonen, J. Hatara, O. Antikainen, S. Airaksinen, J. Heinamaki, H. Lou, and J. Yliruusi Granule size control and targeting in pulsed spray fluid bed granulation Int. J. Pharm. 377 2009 9 15
8. J.T. Fell, and J.M. Newton Determination of tablet strength by the diametral-compression test J. Pharm. Sci. 59 1970 688 691
9. F. Fichtner, A. Rasmuson, and G. Alderborn Particle size distribution and evolution in tablet structure during and after compaction Int. J. Pharm. 292 2005 211 225 (Pubitemid 40255803)
10. C.C. Furnas Grading aggregates. I. Mathematical relations for beds of broken solids of maximum density Ind. Eng. Chem. 18 1931 1052 1058
11. R.V. Haware, I. Tho, and A. Bauer-Brandl Application of multivariate methods to compression behavior evaluation of directly compressible materials Eur. J. Pharm. Biopharm. 72 2009 148 155
12. B. Johansson, M. Wikberg, R. Ek, and G. Alderborn Compression behaviour and compactability of microcrystalline cellulose pellets in relationship to their pore structure and mechanical properties Int. J. Pharm. 117 1995 57 73
13. I.T. Jolliffe Principal Component Analysis 2002 Springer Us New York
14. H. Kokubo, S. Nakamura, and H. Sunada Effect of several cellulosic binders on particle size distribution in fluidized bed granulation Chem. Pharm. Bull. 43 1995 1402 1406
15. K. Lin, and G.E. Peck Development of agglomerated talc. I. Evaluation of fluidized bed granulation parameters on the physical properties of agglomerated talc Drug Dev. Ind. Pharm. 21 1995 447 460
16. P. Merkku, A.S. Lindqvist, K. Leiviska, and J. Yliruusi Influence of granulation and compression process variables on flow rate of granules and on tablet properties, with special reference to weight variation Int. J. Pharm. 102 1994 117 125 (Pubitemid 24042985)
17. B. Rambali, L. Baert, and D.L. Massart Using experimental design to optimize the process parameters in fluid bed granulation on a semi-full scale Int. J. Pharm. 220 2001 149 160 (Pubitemid 32476851)
18. S.H. Schaafsma, P. Vonk, and N.W.F. Kossen Fluid bed agglomeration with a narrow droplet size distribution Int. J. Pharm. 193 2000 175 187 (Pubitemid 30001860)
19. K. Shiino, Y. Iwao, A. Miyagishima, and S. Itai Optimization of a novel wax matrix system using aminoalkyl methacrylate copolymer E and ethylcellulose to suppress the bitter taste of acetaminophen Int. J. Pharm. 395 2010 71 77
20. K. Takayama, H. Okabe, Y. Obata, and T. Nagai Formulation design of indomethacin gel ointment containing d-limonene using computer optimization methodology Int. J. Pharm. 61 1990 225 234 (Pubitemid 20209078)
21. H. Takeuchi, S. Nagira, H. Yamamoto, and Y. Kawashima Die wall pressure measurement for evaluation of compaction property of pharmaceutical materials Int. J. Pharm. 274 2004 131 138 (Pubitemid 38457012)
22. M. Wikberg, and G. Alderborn Compression characteristics of granulated materials. IV. The effect of granule porosity on the fragmentation propensity and the compatibility of some granulations Int. J. Pharm. 69 1991 239 253