Origin of profound changes in powder properties during wetting and nucleation stages of high-shear wet granulation of microcrystalline cellulose

Powder Technology

Volumn 208, Issue 3, 2011, Pages 663-668

  Shi, Limin ^a   Feng, Yushi ^b   Sun, Changquan Calvin ^b  

^a UNIVERSITY OF MINNESOTA   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Flow property; High shear wet granulation; Shape rounding; Surface smoothing; Tabletability; Wetting and nucleation

Indexed keywords

FLOW PROPERTIES; HIGH-SHEAR WET GRANULATION; SHAPE ROUNDING; SURFACE SMOOTHING; TABLETABILITY;

CELLULOSE; COMPRESSIVE STRENGTH; GRANULATION; NUCLEATION; SHEAR FLOW; WETTING;

SURFACE MORPHOLOGY;

MICROCRYSTALLINE CELLULOSE;

ARTICLE; CHEMICAL ANALYSIS; PARTICLE SIZE; POROSITY; POWDER; SHEAR FLOW; SHEAR STRESS; STRUCTURE ANALYSIS; SURFACE PROPERTY; TENSILE STRENGTH; WATER ABSORPTION;

EID: 79952737822     PISSN: 00325910     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.powtec.2011.01.006     Document Type: Article

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