Age and lesion-induced increases of GDNF transgene expression in brain following intracerebral injections of DNA nanoparticles

Neuroscience

Volumn 284, Issue , 2015, Pages 500-512

  Yurek, D M ^a   Hasselrot, U ^a   Cass, W A ^a   Sesenoglu Laird, O ^b   Padegimas, L ^b   Cooper, M J ^b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Department of Anatomy and Neurobiology University of Kentucky College of Medicine ^*  (United States)

Author keywords

Aging; Astrocytes; Gene therapy; Glial fibrillary acidic protein (GFAP); Parkinson's disease

Indexed keywords

DNA; DNA NANOPARTICLE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; NANOPARTICLE; UBIQUITIN C; UNCLASSIFIED DRUG; GDNF PROTEIN, HUMAN; OXIDOPAMINE; POLYUBIQUITIN;

ADULT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CORPUS STRIATUM; DISEASE COURSE; GDNF GENE; GENE EXPRESSION; GENE THERAPY; GFAP GENE; MALE; MIDDLE AGED; NERVE DEGENERATION; NONHUMAN; PROMOTER REGION; RAT; STEREOMETRY; TRANSGENE; UBC GENE; YOUNG ADULT; ANIMAL; CELL CULTURE; DEGENERATIVE DISEASE; DISEASE MODEL; GENE VECTOR; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES; SEVERITY OF ILLNESS INDEX; SPRAGUE DAWLEY RAT;

AGING; ANIMALS; ASTROCYTES; CELLS, CULTURED; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; GENETIC VECTORS; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; HUMANS; MALE; NANOPARTICLES; NEURODEGENERATIVE DISEASES; OXIDOPAMINE; POLYUBIQUITIN; PROMOTER REGIONS, GENETIC; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; TRANSFECTION; TRANSGENES;

EID: 84910068062     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2014.10.026     Document Type: Article

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