Interactive actions of Bdnf methylation and cell metabolism for building neural resilience under the influence of diet

Neurobiology of Disease

Volumn 73, Issue , 2015, Pages 307-318

  Tyagi, Ethika ^a   Zhuang, Yumei ^a   Agrawal, Rahul ^a   Ying, Zhe ^a   Gomez Pinilla, Fernando ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anxiety; BDNF; Epigenetics; Metabolism; Omega 3 fatty acid

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BRAIN DERIVED NEUROTROPHIC FACTOR; METHYL CPG BINDING PROTEIN 2; NICOTINAMIDE ADENINE DINUCLEOTIDE; OMEGA 3 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SIRTUIN 1; TRANSCRIPTION FACTOR CTCF; AZACITIDINE; DECITABINE; ENZYME INHIBITOR; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANXIETY; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; DIET; DNA METHYLATION; DOWN REGULATION; EXON; FEMALE; IN VITRO STUDY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PROMOTER REGION; RAT; SPRAGUE DAWLEY RAT; TRANSCRIPTION REGULATION; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMICALLY INDUCED; DIET THERAPY; DISEASE MODEL; DRUG EFFECTS; DRUG THERAPY; GENETICS; LOW FAT DIET; MALE; MAZE TEST; METABOLISM; METHYLATION; NEUROBLASTOMA; PATHOLOGY; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; TUMOR CELL LINE;

ANIMALS; ANXIETY; AZACITIDINE; BRAIN; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL LINE, TUMOR; DIET, FAT-RESTRICTED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FATTY ACIDS, OMEGA-3; FEMALE; MALE; MAZE LEARNING; METHYLATION; MICE; NEUROBLASTOMA; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTORS;

EID: 84910029574     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.09.014     Document Type: Article

References (47)

1. Agrawal R., et al. Coupling energy homeostasis with a mechanism to support plasticity in brain trauma. Biochim Biophys Acta. 2014, 1842:535-546.
2. Awad T.A., et al. Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J Biol Chem. 1999, 274:27092-27098.
3. Boulle F., et al. Epigenetic regulation of the BDNF gene: implications for psychiatric disorders. Mol Psychiatry 2012, 17:584-596.
4. Burcin M., et al. Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol Cell Biol. 1997, 17:1281-1288.
5. Cantó C., Auwerx J. Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?. Pharmacol Rev. 2012, 64:166-187.
6. Chang J., et al. Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus. Proc Natl Acad Sci U S A 2010, 107:21836-21841.
7. Chen W.G., et al. Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. Science 2003, 302:885-889.
8. Cheng A., et al. Involvement of PGC-1α in the formation and maintenance of neuronal dendritic spines. Nat Commun. 2012, 3:1250.
9. Choi S.W., Friso S. Epigenetics: a new bridge between nutrition and health. Adv Nutr. 2010, 1:8-16.
10. Dauncey M.J. Recent advances in nutrition, genes and brain health. Proc Nutr Soc. 2012, 71:581-591.
11. Farooqui A.A., et al. Metabolic syndrome as a risk factor for neurological disorders. Cell Mol Life Sci. 2011, 10.1007/s00018-011-0840-1.
12. Fedoriw A.M., et al. Transgenic RNAi reveals essential function for CTCF in H19 gene imprinting. Science. 2004, 303:238-240.
13. Filippova G.N., et al. An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996, 16:2802-2813.
14. Finkel T. Cell biology: a clean energy programme. Nature. 2006, 444:151-152.
15. Godfrey K.M., et al. Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res. 2007, 61:5R-10R.
16. Gomez-Pinilla F. Brain foods: the effects of nutrients on brain function. Nat Rev Neurosci. 2008, 9:568-578.
17. Gomez-Pinilla F., et al. Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition. Eur J Neurosci. 2008, 28:2278-2287.
18. Greenberg M.E., et al. New insights in the biology of BDNF synthesis and release: implications in CNS function. J Neurosci. 2009, 29:12764-12767.
19. Greiner R.S., et al. Docosapentaenoic acid does not completely replace DHA in n-3 FA-deficient rats during early development. Lipids. 2003, 38:431-435.
20. Hirayama T., et al. CTCF is required for neural development and stochastic expression of clustered Pcdh genes in neurons. Cell Rep. 2012, 2:345-357.
21. Ikegame T., et al. DNA methylation of the BDNF gene and its relevance to psychiatric disorders. J Hum Genet. 2013, 58:434-438.
22. Khaitovich P., et al. Metabolic changes in schizophrenia and human brain evolution. Genome Biol. 2008, 9:R124.
23. Kolb B., et al. Experience and the developing prefrontal cortex. Proc Natl Acad Sci U S A. 2012, 109(Suppl. 2):17186-17193.
24. Li H., et al. Loss of activity-induced phosphorylation of MeCP2 enhances synaptogenesis, LTP and spatial memory. Nat Neurosci. 2011, 14:1001-1008.
25. Lubin F.D., et al. Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory. J Neurosci. 2008, 28:10576-10586.
26. Ma D.K., et al. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science. 2009, 323:1074-1077.
27. Martinowich K., et al. DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. 2003, 302:890-893.
28. Moore L.D., et al. DNA methylation and its basic function. Neuropsychopharmacology. 2013, 38:23-38.
29. Nemoto S., et al. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem. 2005, 280:16456-16460.
30. Oaks A.W., et al. Age-dependent effects of A53T alpha-synuclein on behavior and dopaminergic function. PLoS ONE. 2013, 8(4):e60378.
31. Ohlsson R., et al. CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet. 2001, 17:520-527.
32. Onishchenko N., et al. Long-lasting depression-like behavior and epigenetic changes of BDNF gene expression induced by perinatal exposure to methylmercury. J Neurochem. 2008, 106:1378-1387.
33. Pinto J.G., et al. Comparing development of synaptic proteins in rat visual, somatosensory, and frontal cortex. Front Neural Circuits. 2013, 7:97.
34. Rodgers J.T., et al. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS Lett. 2008, 582:46-53.
35. Roth T.L., et al. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry. 2009, 65:760-769.
36. Roth T.L., et al. Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder. J Psychiatr Res. 2011, 45:919-926.
37. Sales A.J., et al. Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors. Br J Pharmacol. 2011, 164:1711-1721.
38. Sánchez-Villegas A., et al. Dietary fat intake and the risk of depression: the SUN Project. PLoS One. 2011, 6:e16268.
39. Sengupta P. The laboratory rat: relating its age with human's. Int J Prev Med. 2013, 4:624-630.
40. Simopoulos A.P. Evolutionary aspects of diet, the omega-6/omega-3 ratio and genetic variation: nutritional implications for chronic diseases. Biomed Pharmacother. 2006, 60:502-507.
41. Skene P.J., et al. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state. Mol Cell. 2010, 37:457-468.
42. Tyagi E., et al. Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders. PLoS One. 2013, 8:e57945.
43. Walf A.A., Frye C.A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc. 2007, 2:322-328.
44. Webster M.J., et al. BDNF mRNA expression during postnatal development, maturation and aging of the human prefrontal cortex. Brain Res Dev Brain Res. 2002, 139:139-150.
45. Young G., Conquer J. Omega-3 fatty acids and neuropsychiatric disorders. Reprod Nutr Dev. 2005, 45:1-28.
46. Zhou Z., et al. Brain-specific phosphorylation of MeCP2 regulates activity-dependent Bdnf transcription, dendritic growth, and spine maturation. Neuron. 2006, 52:255-269.
47. Zuccato C., Cattaneo E. Brain-derived neurotrophic factor in neurodegenerative diseases. Nat Rev Neurol. 2009, 5:311-322.