The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1842, Issue 12, 2014, Pages 2378-2386

  van der Mark, Vincent A ^a   de Waart, D Rudi ^a   Ho Mok, Kam S ^a   Tabbers, Merit M ^b   Voogt, Heleen W ^b   Oude Elferink, Ronald P J ^a   Knisely, A S ^c   Paulusma, Coen C ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b EMMA CHILDREN S HOSPITAL   (Netherlands)

^c KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

ATP8B1; Diarrhea; Enterohepatic circulation; PFIC1; SLC10A2

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ATPASE AMINOPHOSPHOLIPID TRANSPORTER CLASS I TYPE 8B MEMBER 1; BILE ACID; BILE SALT; CHLORIDE; HETERODIMER; MEMBRANE PROTEIN; PHOSPHOLIPID; POTASSIUM; SODIUM; TRANSMEMBRANE PROTEIN 30A; UNCLASSIFIED DRUG; ATP8B1 PROTEIN, HUMAN; COTRANSPORTER; ORGANIC ANION TRANSPORTER; SODIUM-BILE ACID COTRANSPORTER; TAUROCHOLIC ACID; TMEM30A PROTEIN, HUMAN;

APICAL MEMBRANE; ARTICLE; ATP8B1 DEFICIENCY; BIOTINYLATION; CACO 2 CELL LINE; CONTROLLED STUDY; ELECTROLYTE TRANSPORT; FECES ANALYSIS; HUMAN; HUMAN CELL; LIVER TRANSPLANTATION; MALABSORPTION; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; CELL MEMBRANE; CHEMISTRY; FECES; GENETICS; INTESTINE; INTRAHEPATIC CHOLESTASIS; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TRANSPORT AT THE CELLULAR LEVEL; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATASES; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CACO-2 CELLS; CELL MEMBRANE; CHOLESTASIS, INTRAHEPATIC; FECES; HUMANS; INTESTINES; MEMBRANE PROTEINS; MUTATION; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PROTEIN MULTIMERIZATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SYMPORTERS; TAUROCHOLIC ACID;

EID: 84910028648     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2014.09.003     Document Type: Article

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