Cellular Localization and Biochemical Analysis of Mammalian CDC50A, a Glycosylated β-subunit for P4 ATPases

Journal of Histochemistry and Cytochemistry

Volumn 60, Issue 3, 2012, Pages 205-218

  Folmer, Dineke E ^a   Mok, Kam S ^a   de Wee, Sebastiaan W ^a   Duijst, Suzanne ^a   Hiralall, Johan K ^a   Seppen, Jurgen ^a   Oude Elferink, Ronald P J ^a   Paulusma, Coen C ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

subunit; b; CDC50; cholestasis; membrane; P4 ATPase; phospholipid; vesicular transport

Indexed keywords

GLYCOPROTEIN; POLYCLONAL ANTIBODY; PROTEIN CDC50A; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; CDC50A PROTEIN, HUMAN; CDC50A PROTEIN, MOUSE; CDC50C PROTEIN, MOUSE; ISOENZYME; MEMBRANE PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENDOTHELIUM CELL; KIDNEY PROXIMAL TUBULE; LIVER CELL; MOUSE; NONHUMAN; PANCREAS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; SECRETORY VESICLE; STOMACH; TISSUE DISTRIBUTION; TRANS GOLGI NETWORK; ANIMAL; ANTIBODY SPECIFICITY; BIOSYNTHESIS; CELL LINE; CYTOLOGY; GLYCOSYLATION; HAMSTER; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY; LIVER; METABOLISM; RAT; WESTERN BLOTTING;

MAMMALIA;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL MEMBRANE; CRICETINAE; ENDOTHELIAL CELLS; GLYCOSYLATION; HEPATOCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; ISOENZYMES; KIDNEY; LIVER; MEMBRANE PROTEINS; MICE; ORGAN SPECIFICITY; PANCREAS; RATS; STOMACH;

EID: 84859642842     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155411435705     Document Type: Article

References (32)

1. Bryde S,Hennrich H,Verhulst PM,Devaux PF,Lenoir G,Holthuis JC.CDC50 proteins are critical components of the human class-1 P4-ATPase transport machinery.J Biol Chem. 2010;285:40562-40572.
2. Coleman JA,Molday RS.Critical role of the {beta}-subunit CDC50A in the stable expression, assembly, subcellular localization, and lipid transport activity of the P4-ATPase ATP8A2.J Biol Chem. 2011;286:17205-17216.
3. Eppens EF,van Mil SW,de Vree JM,Mok KS,Juijn JA,Oude Elferink RPJ,Berger R,Houwen RH,Klomp LW.FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte.J Hepatol. 2001;35:436-443.
4. Folmer DE,Oude Elferink RPJ,Paulusma CC.P4 ATPases: lipid flippases and their role in disease.Biochim Biophys Acta. 2009;1791:628-635.
5. Halleck MS,Lawler JF,Blackshaw S,Gao L,Nagarajan P,Hacker C,Pyle S,Newman JT,Nakanishi Y,Ando H, et al.Differential expression of putative transbilayer amphipath transporters.Physiol Genomics. 1999;1:139-150.
6. Harder R,Uhlig H,Kashan A,Schutt B,Duijvestijn A,Butcher EC,Thiele HG,Hamann A.Dissection of murine lymphocyte-endothelial cell interaction mechanisms by SV-40-transformed mouse endothelial cell lines: novel mechanisms mediating basal binding, and alpha 4-integrin-dependent cytokine-induced adhesion.Exp Cell Res. 1991;197:259-267.
7. He Y,Hakvoort TB,Vermeulen JL,Labruyère WT,de Waart DR,van der Hel WS,Ruijter JM,Uylings HB,Lamers WH.Glutamine synthetase deficiency in murine astrocytes results in neonatal death.Glia. 2010;58:741-754.
8. Holthuis JC,Levine TP.Lipid traffic: floppy drives and a superhighway.Nat Rev Mol Cell Biol. 2005;6:209-220.
9. Jungermann K,Kietzmann T.Zonation of parenchymal and nonparenchymal metabolism in liver.Annu Rev Nutr. 1996;16:179-203.
10. Katoh Y,Katoh M.Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico.Oncol Rep. 2004;12:939-943.
11. Koenderink JB,Geibel S,Grabsch E,De Pont JJ,Bamberg E,Friedrich T.Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket.J Biol Chem. 2003;278:51213-51222.
12. Lopez-Marques RL,Poulsen LR,Hanisch S,Meffert K,Buch-Pedersen MJ,Jakobsen MK,Pomorski TG,Palmgren MG.Intracellular targeting signals and lipid specificity determinants of the ALA/ALIS P4-ATPase complex reside in the catalytic ALA {alpha}-subunit.Mol Biol Cell. 2010;21:791-801.
13. Markovich D,Aronson PS.Specificity and regulation of renal sulfate transporters.Annu Rev Physiol. 2007;69:361-375.
14. Moorman AF,de Boer PA,Geerts WJ,van den Zande L,Lamers WH,Charles R.Complementary distribution of carbamoylphosphate synthetase (ammonia) and glutamine synthetase in rat liver acinus is regulated at a pretranslational level.J Histochem Cytochem. 1988;36:751-755.
15. Moorman AFM,de Boer PAJ,Evans D,Charles R,Lamers WH.Expression patterns of mRNAs for alpha-fetoprotein and albumin in the developing rat: the ontogenesis of hepatocyte heterogeneity.Histochem J. 1990;22:653-660.
16. Muthusamy BP,Natarajan P,Zhou X,Graham TR.Linking phospholipid flippases to vesicle-mediated protein transport.Biochim Biophys Acta. 2009;1791:612-619.
17. Oude Elferink RPJ,Ottenhoff R,Liefting W,de Haan J,Jansen PLM.Hepatobiliary transport of glutathione and glutathione conjugate in rats with hereditary hyperbilirubinemia.J Clin Invest. 1989;84:476-483.
18. Paulusma CC,de Waart DR,Kunne C,Mok KS,Oude Elferink RPJ.Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.J Biol Chem. 2009;284:9947-9954.
19. Paulusma CC,Folmer DE,Ho-Mok KS,de Waart DR,Hilarius PM,Verhoeven AJ,Oude Elferink RPJ.ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.Hepatology. 2008;47:268-278.
20. Paulusma CC,Groen A,Kunne C,Ho-Mok KS,Spijkerboer AL,de Waart DR,Hoek FJ,Vreeling H,Hoeben KA,van Marle J, et al.Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.Hepatology. 2006;44:195-204.
21. Paulusma CC,Oude Elferink RPJ.The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.Biochim Biophys Acta. 2005;1741:11-24.
22. Paulusma CC,Oude Elferink RPJ.P4 ATPases: the physiological relevance of lipid flipping transporters.FEBS Lett. 2010;584:2708-2716.
23. Paulusma CC,Oude Elferink RPJ,Jansen PLM.Progressive familial intrahepatic cholestasis type 1.Semin Liver Dis. 2010;30:117-124.
24. Rindler MJ,Xu CF,Gumper I,Smith NN,Neubert TA.Proteomic analysis of pancreatic zymogen granules: identification of new granule proteins.J Proteome Res. 2007;6:2978-2992.
25. Seppen J,Rijnberg M,Cooreman MP,Oude Elferink RPJ.Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes.J Hepatol. 2002;36:459-465.
26. Siggs OM,Arnold CN,Huber C,Pirie E,Xia Y,Lin P,Nemazee D,Beutler B.The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow.Nat Immunol. 2011a;12:434-440.
27. Siggs OM,Schnabl B,Webb B,Beutler B.X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C.Proc Natl Acad Sci U S A. 2011b;108:7890-7895.
28. Ujhazy P,Ortiz D,Misra S,Li S,Moseley J,Jones H,Arias IM.Familial intrahepatic cholestasis 1: studies of localization and function.Hepatology. 2001;34:768-775.
29. van der Velden LM,Wichers CG,van Breevoort AE,Coleman JA,Molday RS,Berger R,Klomp LW,van de Graaf SF.Heteromeric interactions required for abundance and subcellular localization of human CDC50 proteins and class 1 P4 ATPases.J Biol Chem. 2010;285:40088-40096.
30. van der Woerd WL,van Mil SW,Stapelbroek JM,Klomp LW,van de Graaf SF,Houwen RH.Familial cholestasis: progressive familial intrahepatic cholestasis, benign recurrent intrahepatic cholestasis and intrahepatic cholestasis of pregnancy.Best Pract Res Clin Gastroenterol. 2010;24:541-553.
31. Wang L,Beserra C,Garbers DL.A novel aminophospholipid transporter exclusively expressed in spermatozoa is required for membrane lipid asymmetry and normal fertilization.Dev Biol. 2004;267:203-215.
32. Yabas M,The CE,Frankenreiter S,Lal D,Roots CM,Whittle B,Andrews DT,Zhang Y,Teoh NC,Sprent J, et al.ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes.Nat Immunol. 2011;12:441-449.