Intestinal bile salt absorption in Atp8b1 deficient mice>

Journal of Hepatology

Volumn 47, Issue 1, 2007, Pages 114-122

  Groen, Annemiek ^a   Kunne, Cindy ^a   Paulusma, Coen C ^a   Kramer, Werner ^b   Agellon, Luis B ^c   Bull, Laura N ^d   Oude Elferink, Ronald P J ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

^c UNIVERSITY OF ALBERTA   (Canada)

^d SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Asbt; Atp8b1; Bile salts; Intestine; Ussing chamber

Indexed keywords

ADENOSINE TRIPHOSPHATASE; APICAL SODIUM DEPENDENT BILE SALT TRANSPORTER; BILE SALT; CARRIER PROTEIN; LIPID BINDING PROTEIN; PROTEIN ATP8B1; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATP8B1 GENE; BILE ACID METABOLISM; CONTROLLED STUDY; ENTEROHEPATIC CIRCULATION; EXPLANT; FEMALE; GENE; GENE MUTATION; INTESTINE ABSORPTION; INTESTINE PERFUSION; INTRAHEPATIC CHOLESTASIS; MALE; MOUSE; NONHUMAN; PORTAL VEIN BLOOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATASES; ANIMALS; BILE ACIDS AND SALTS; CHOLATES; CHOLESTASIS, INTRAHEPATIC; DIET; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION; INTESTINAL ABSORPTION; MICE; MICE, KNOCKOUT; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; PERFUSION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SIGNAL TRANSDUCTION; SYMPORTERS; TAUROCHOLIC ACID; TRANSCRIPTION FACTORS;

EID: 34249312304     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2007.02.011     Document Type: Article

References (38)

1. Gerloff T., Stieger B., Hagenbuch B., Madon J., Landmann L., Roth J., et al. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273 (1998) 10046-10050
2. Green R.M., Hoda F., and Ward K.L. Molecular cloning and characterization of the murine bile salt export pump. Gene 241 (2000) 117-123
3. Shneider B.L., Dawson P.A., Christie D.M., Hardikar W., Wong M.H., and Suchy F.J. Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter. J Clin Invest 95 (1995) 745-754
4. Wong M.H., Oelkers P., Craddock A.L., and Dawson P.A. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter. J Biol Chem 269 (1994) 1340-1347
5. Craddock A.L., Love M.W., Daniel R.W., Kirby L.C., Walters H.C., Wong M.H., et al. Expression and transport properties of the human ileal and renal sodium- dependent bile acid transporter. Am J Physiol 274 (1998) 157-169
6. Kanda T., Niot I., Foucaud L., Fujii H., Bernard A., Ono T., et al. Effect of bile on the intestinal bile-acid binding protein (I-BABP) expression. In vitro and in vivo studies. FEBS Lett 384 (1996) 131-134
7. Grober J., Zaghini I., Fujii H., Jones S.A., Kliewer S.A., Willson T.M., et al. Identification of a bile acid-responsive element in the human ileal bile acid-binding protein gene. Involvement of the farnesoid X receptor/9-cis-retinoic acid receptor heterodimer. J Biol Chem 274 (1999) 29749-29754
8. Dawson P.A., Hubbert M., Haywood J., Craddock A.L., Zerangue N., Christian W.V., et al. The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter. J Biol Chem 280 (2005) 6960-6968
9. Hagenbuch B., Stieger B., Foguet M., Lubbert H., and Meier P.J. Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A 88 (1991) 10629-10633
10. Hagenbuch B., and Meier P.J. Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+/bile acid cotransporter. J Clin Invest 93 (1994) 1326-1331
11. Bull L.N., van Eijk M.J., Pawlikowska L., DeYoung J.A., Juijn J.A., Liao M., et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet 18 (1998) 219-224
12. Klomp L.W., Vargas J.C., van Mil S.W., Pawlikowska L., Strautnieks S.S., van Eijk M.J., et al. Characterization of mutations in ATP8B1 associated with hereditary cholestasis. Hepatology 40 (2004) 27-38
13. Summerskill W.H. The syndrome of benign recurrent cholestasis. Am J Med 38 (1965) 298-305
14. Bull L.N., Carlton V.E., Stricker N.L., Baharloo S., DeYoung J.A., Freimer N.B., et al. Kocoshis SA, Reyes J, Knisely AS. Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): evidence for heterogeneity. Hepatology 26 (1997) 155-164
15. Knisely A.S. Progressive familial intrahepatic cholestasis: a personal perspective. Pediatr Dev Pathol 3 (2000) 113-125
16. Lykavieris P., van Mil S., Cresteil D., Fabre M., Hadchouel M., Klomp L., et al. Progressive familial intrahepatic cholestasis type 1 and extrahepatic features: no catch-up of stature growth, exacerbation of diarrhea, and appearance of liver steatosis after liver transplantation. J Hepatol 39 (2003) 447-452
17. Egawa H., Yorifuji T., Sumazaki R., Kimura A., Hasegawa M., and Tanaka K. Intractable diarrhea after liver transplantation for Byler's disease: successful treatment with bile adsorptive resin. Liver Transpl 8 (2002) 714-716
18. Halleck M.S., and Lawler Jr. J.F. Blackshaw S, Gao L, Nagarajan P, Hacker C, Pyle S, Newman JT, Nakanishi Y, Ando H, Weinstock D, Williamson P, Schlegel RA. Differential expression of putative transbilayer amphipath transporters. Physiol Genomics 1 (1999) 139-150
19. Tang X., Halleck M.S., Schlegel R.A., and Williamson P. A subfamily of P-type ATPases with aminophospholipid transporting activity. Science 272 (1996) 1495-1497
20. Dolis D., Moreau C., Zachowski A., and Devaux P.F. Aminophospholipid translocase and proteins involved in transmembrane phospholipid traffic. Biophys Chem 68 (1997) 221-231
21. van Mil S.W., van Oort M.M., van dB I., Berger R., Houwen R.H., and Klomp L.W. Fic1 is expressed at apical membranes of different epithelial cells in the digestive tract and is induced in the small intestine during postnatal development of mice. Pediatr Res 56 (2004) 981-987
22. Ujhazy P., Ortiz D., Misra S., Li S., Moseley J., Jones H., et al. Familial intrahepatic cholestasis 1: studies of localization and function. Hepatology 34 (2001) 768-775
23. Paulusma C.C., Groen A., Kunne C., Ho-Mok K.S., Spijkerboer A.L., de Waart D.R., et al. ATP8B1 deficiency reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology 44 (2006) 195-204
24. Chen F., Ananthanarayanan M., Emre S., Neimark E., Bull L.N., Knisely A.S., et al. Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity. Gastroenterology 126 (2004) 756-764
25. Russell D.W. The enzymes, regulation, and genetics of bile acid synthesis. Annu Rev Biochem (2003)
26. Eppens E.F., van Mil S.W., de Vree J.M., Mok K.S., Juijn J.A., Oude Elferink R.P., et al. FIC1, the protein affected in two forms of hereditary cholestasis, is localized in the cholangiocyte and the canalicular membrane of the hepatocyte. J Hepatol 35 (2001) 436-443
27. Pawlikowska L., Groen A., Eppens E.F., Kunne C., Ottenhoff R., Looije N., et al. A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Hum Mol Genet 13 (2004) 881-892
28. Kramer W., and Glombik H. Bile acid reabsorption inhibitors (BARI): novel hypolipidemic drugs. Curr Med Chem 13 (2006) 997-1016
29. Athman R., Tsocas A., Presset O., Robine S., Roze C., and Ferrary E. In vivo absorption of water and electrolytes in mouse intestine. Application to villin -/- mice. Am J Physiol Gastrointest Liver Physiol 282 (2002) G634-G639
30. Oude Elferink R.P., Ottenhoff R., van Wijland M., Smit J.J., Schinkel A.H., and Groen A.K. Regulation of biliary lipid secretion by mdr2 P-glycoprotein in the mouse. J Clin Invest 95 (1995) 31-38
31. Bijlsma P.B., Kiliaan A.J., Scholten G., Heyman M., Groot J.A., and Taminiau J.A. Carbachol, but not forskolin, increases mucosal-to-serosal transport of intact protein in rat ileum in vitro. Am J Physiol 271 (1996) G147-G155
32. Turley S.D., and Dietschy J.M. Re-evaluation of the 3 alpha-hydroxysteroid dehydrogenase assay for total bile acids in bile. J Lipid Res 19 (1978) 924-928
33. Bootsma A.H., Overmars H., van Rooij A., van Lint A.E., Wanders R.J., van Gennip A.H., et al. Rapid analysis of conjugated bile acids in plasma using electrospray tandem mass spectrometry: application for selective screening of peroxisomal disorders. J Inherit Metab Dis 22 (1999) 307-310
34. Labonte E.D., Li Q., Kay C.M., and Agellon L.B. The relative ligand binding preference of the murine ileal lipid binding protein. Protein Expr Purif 28 (2003) 25-33
35. Koenderink J.B., Geibel S., Grabsch E., De Pont J.J., Bamberg E., and Friedrich T. Electrophysiological analysis of the mutated Na,K-ATPase cation binding pocket. J Biol Chem 278 (2003) 51213-51222
36. Alvarez L., Jara P., Sanchez-Sabate E., Hierro L., Larrauri J., Diaz M.C., et al. Reduced hepatic expression of farnesoid X receptor in hereditary cholestasis associated to mutation in ATP8B1. Hum Mol Genet 13 (2004) 2451-2460
37. Kok T., Hulzebos C.V., Wolters H., Havinga R., Agellon L.B., Stellaard F., et al. Enterohepatic circulation of bile salts in farnesoid X receptor-deficient mice: efficient intestinal bile salt absorption in the absence of ileal bile acid-binding protein. J Biol Chem 278 (2003) 41930-41937
38. Demeilliers C., Jacquemin E., Barbu V., Mergey M., Paye F., Fouassier L., et al. Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation. Hepatology 43 (2006) 1125-1134