메뉴 건너뛰기




Volumn 20, Issue 21, 2014, Pages 5349-5358

New strategies in advanced cervical cancer: From angiogenesis blockade to immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; BRIVANIB; CISPLATIN; LIVE VACCINE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MK 1775; NOTCH RECEPTOR; PACLITAXEL; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SUNITINIB; TEMSIROLIMUS; TOPOTECAN; UNCLASSIFIED DRUG; VASCULOTROPIN; WART VIRUS VACCINE; CAPSID PROTEIN; HPV L1 PROTEIN, HUMAN PAPILLOMAVIRUS; ONCOPROTEIN;

EID: 84910028030     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-1099     Document Type: Review
Times cited : (67)

References (71)
  • 5
    • 0001351967 scopus 로고
    • The diagnostic value of vaginal smears in carcinoma of the uterus
    • Papanicolaou GN, Traut HF. The diagnostic value of vaginal smears in carcinoma of the uterus. Am J Obstet Gynecol 1941;42:193.
    • (1941) Am J Obstet Gynecol , vol.42 , pp. 193
    • Papanicolaou, G.N.1    Traut, H.F.2
  • 6
    • 0003155061 scopus 로고
    • A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions
    • Durst M, Gissmann L, Ikenberg H, zur Hausen H. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Natl Acad Sci USA 1983;80:3812-5.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 3812-3815
    • Durst, M.1    Gissmann, L.2    Ikenberg, H.3    Zur Hausen, H.4
  • 7
    • 84899524861 scopus 로고    scopus 로고
    • Development and implementation of papillomavirus prophylactic vaccines
    • Frazer IH. Development and implementation of papillomavirus prophylactic vaccines. J Immunol 2014;192:4007-11.
    • (2014) J Immunol , vol.192 , pp. 4007-4011
    • Frazer, I.H.1
  • 8
    • 84896720902 scopus 로고    scopus 로고
    • HPV vaccines to prevent cervicalcancer andgenitalwarts: An update
    • Dochez C, Bogers JJ, Verhelst R, Rees H. HPV vaccines to prevent cervicalcancer andgenitalwarts: an update. Vaccine 2014;32:1595-601.
    • (2014) Vaccine , vol.32 , pp. 1595-1601
    • Dochez, C.1    Bogers, J.J.2    Verhelst, R.3    Rees, H.4
  • 9
    • 33947595236 scopus 로고    scopus 로고
    • Quadrivalent human papillomavirus vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP)
    • Markowitz LE, Dunne EF, Saraiya M, Lawson HW, Chesson H, Unger ER, et al. Quadrivalent human papillomavirus vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2007;56:1-24.
    • (2007) MMWR Recomm Rep , vol.56 , pp. 1-24
    • Markowitz, L.E.1    Dunne, E.F.2    Saraiya, M.3    Lawson, H.W.4    Chesson, H.5    Unger, E.R.6
  • 10
    • 77953080981 scopus 로고    scopus 로고
    • FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP)
    • Centers for Disease Control and Prevention (CDC). FDA licensure of bivalent human papillomavirus vaccine (HPV2, Cervarix) for use in females and updated HPV vaccination recommendations from the Advisory Committee on Immunization Practices (ACIP). MMWR Morb Mortal Wkly Rep 2010;59:626-9.
    • (2010) MMWR Morb Mortal Wkly Rep , vol.59 , pp. 626-629
    • Centers for Disease Control and Prevention (CDC).1
  • 11
    • 84255198571 scopus 로고    scopus 로고
    • Recommendations on the use of quadrivalent human papillomavirus vaccine in males-Advisory Committee on Immunization Practices (ACIP), 2011
    • Centers for Disease Control and Prevention (CDC). Recommendations on the use of quadrivalent human papillomavirus vaccine in males-Advisory Committee on Immunization Practices (ACIP), 2011. MMWR Morb Mortal Wkly Rep 2011;60:1705-8.
    • (2011) MMWR Morb Mortal Wkly Rep , vol.60 , pp. 1705-1708
    • Centers for Disease Control and Prevention (CDC).1
  • 12
    • 84900489815 scopus 로고    scopus 로고
    • Efficacy and immunogenicity of a novel 9-valent HPV L1 virus-like particle vaccine in 16-to 26-year old women
    • Joura E, on behalf of the V503-001 study team. Efficacy and immunogenicity of a novel 9-valent HPV L1 virus-like particle vaccine in 16-to 26-year old women. EUROGIN 2013;8-4.
    • (2013) EUROGIN , pp. 8-14
    • Joura, E.1
  • 13
    • 84860564294 scopus 로고    scopus 로고
    • American cancer society, American society for colposcopy and cervical pathology, and American society for clinical pathology screening guidelines for the prevention and detection of cervical cancer
    • Saslow D, Solomon D, Lawson HW, Killackey M, Kulasingam SL, Cain J, et al. American cancer society, American society for colposcopy and cervical pathology, and American society for clinical pathology screening guidelines for the prevention and detection of cervical cancer. Am J Clin Pathol 2012;137:516-42.
    • (2012) Am J Clin Pathol , vol.137 , pp. 516-542
    • Saslow, D.1    Solomon, D.2    Lawson, H.W.3    Killackey, M.4    Kulasingam, S.L.5    Cain, J.6
  • 14
    • 84862750557 scopus 로고    scopus 로고
    • Screening for cervical cancer: U.S. Preventive services task force recommendation statement
    • Mover VAU.S. Preventive Services Task Force. Screening for cervical cancer: U.S. preventive services task force recommendation statement. Ann Intern Med 2012;156:880-91.
    • (2012) Ann Intern Med , vol.156 , pp. 880-891
    • Mover, V.A.1    U.S. Preventive Services Task Force2
  • 15
    • 84876149435 scopus 로고    scopus 로고
    • 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors
    • Massad LS, Einstein MH, Huh WK, Katki HA, Kinney WK, Schiffman M, et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors. J Low Genit Tract Dis 2013;17:S1-S27.
    • (2013) J Low Genit Tract Dis , vol.17 , pp. S1-S27
    • Massad, L.S.1    Einstein, M.H.2    Huh, W.K.3    Katki, H.A.4    Kinney, W.K.5    Schiffman, M.6
  • 16
    • 80052388064 scopus 로고    scopus 로고
    • Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: A subanalysis of the ATHENA study
    • Castle PE, Stoler MH, Wright TC Jr, Sharma A, Wright TL, Behrens CM. Performance of carcinogenic human papillomavirus (HPV) testing and HPV16 or HPV18 genotyping for cervical cancer screening of women aged 25 years and older: a subanalysis of the ATHENA study. Lancet Oncol 2011;12:880-90.
    • (2011) Lancet Oncol , vol.12 , pp. 880-890
    • Castle, P.E.1    Stoler, M.H.2    Wright, T.C.3    Sharma, A.4    Wright, T.L.5    Behrens, C.M.6
  • 18
    • 34447508354 scopus 로고    scopus 로고
    • Multimodality therapy for locally advanced cervical carcinoma: State of the art and future directions
    • Monk BJ, Tewari KS, Koh WJ. Multimodality therapy for locally advanced cervical carcinoma: state of the art and future directions. J Clin Oncol 2007;25:2952-65.
    • (2007) J Clin Oncol , vol.25 , pp. 2952-2965
    • Monk, B.J.1    Tewari, K.S.2    Koh, W.J.3
  • 19
    • 84886094737 scopus 로고    scopus 로고
    • Oncogenic mutations in cervical cancer: Genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix
    • Wright AA, Howitt BE, Myers AP, Dahlberg SE, Palescandolo E, van Hummelen P, et al. Oncogenic mutations in cervical cancer: genomic differences between adenocarcinomas and squamous cell carcinomas of the cervix. Cancer 2013;119:3776-83.
    • (2013) Cancer , vol.119 , pp. 3776-3783
    • Wright, A.A.1    Howitt, B.E.2    Myers, A.P.3    Dahlberg, S.E.4    Palescandolo, E.5    Van Hummelen, P.6
  • 21
    • 0037421589 scopus 로고    scopus 로고
    • Epidemiologic classifi cation of human papillomavirus types associated with cervical cancer
    • Munoz N, Bosch X, de Sanjose S, Herrero R, Castellsague X, Shah KV, et al. Epidemiologic classifi cation of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518-27.
    • (2003) N Engl J Med , vol.348 , pp. 518-527
    • Munoz, N.1    Bosch, X.2    De Sanjose, S.3    Herrero, R.4    Castellsague, X.5    Shah, K.V.6
  • 22
    • 84902263092 scopus 로고    scopus 로고
    • Human papillomavirus 16, 18, 31 and 5 viral load, integration and methylation status stratified by cervical disease stage
    • Marongui L, Godi A, Parry JV, Beddows S. Human papillomavirus 16, 18, 31 and 5 viral load, integration and methylation status stratified by cervical disease stage. BMC Cancer 2014;14:384.
    • (2014) BMC Cancer , vol.14 , pp. 384
    • Marongui, L.1    Godi, A.2    Parry, J.V.3    Beddows, S.4
  • 23
    • 40849139208 scopus 로고    scopus 로고
    • Epigenetics in cancer
    • Esteller M. Epigenetics in cancer. N Engl J Med 2008;358:1148-59.
    • (2008) N Engl J Med , vol.358 , pp. 1148-1159
    • Esteller, M.1
  • 24
    • 84898670865 scopus 로고    scopus 로고
    • A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women
    • Hansel A, Steinbach D, Greinke C, Schmitz M, Eiselt J, Scheungraber C, et al. A promising DNA methylation signature for the triage of high-risk human papillomavirus DNA-positive women. PLoS One 2014;9:e91905.
    • (2014) PLoS One , vol.9 , pp. e91905
    • Hansel, A.1    Steinbach, D.2    Greinke, C.3    Schmitz, M.4    Eiselt, J.5    Scheungraber, C.6
  • 25
    • 84896403826 scopus 로고    scopus 로고
    • Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women
    • Vasiljevic N, Scibior-Bentkowska D, Brentnall AR, Cuzick J, Lorincz AT. Credentialing of DNA methylation assays for human genes as diagnostic biomarkers of cervical intraepithelial neoplasia in high-risk HPV positive women. Gynecol Oncol 2014;132:709-14.
    • (2014) Gynecol Oncol , vol.132 , pp. 709-714
    • Vasiljevic, N.1    Scibior-Bentkowska, D.2    Brentnall, A.R.3    Cuzick, J.4    Lorincz, A.T.5
  • 26
    • 85067765737 scopus 로고    scopus 로고
    • Investigating human papillomavirus 16 methylation as a biomarker for high-grade cervical intraepithelial neoplasia
    • Mir S. Investigating human papillomavirus 16 methylation as a biomarker for high-grade cervical intraepithelial neoplasia. Obstet Gynecol 2014;123(Suppl 1):184S-5S.
    • (2014) Obstet Gynecol , vol.123 , pp. 184S-5S
    • Mir, S.1
  • 27
    • 84896739532 scopus 로고    scopus 로고
    • Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): A ransomised controlled non-inferiority trial
    • Verhoef VM, Bosgraaf RP, van Kemenade FJ, Rozendaal L, Heidman DA, Hesselink AT, et al. Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): A ransomised controlled non-inferiority trial. Lancet Oncol 2014;15:315-22.
    • (2014) Lancet Oncol , vol.15 , pp. 315-322
    • Verhoef, V.M.1    Bosgraaf, R.P.2    Van Kemenade, F.J.3    Rozendaal, L.4    Heidman, D.A.5    Hesselink, A.T.6
  • 28
    • 2442602302 scopus 로고    scopus 로고
    • DNA aneuploidy and integration of human papillomavirus type 16 E6/E7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri
    • Melsheimer P, Vinokurova S, Wentzensen N, Bastert G, von Knebel Doeberitz M. DNA aneuploidy and integration of human papillomavirus type 16 E6/E7 oncogenes in intraepithelial neoplasia and invasive squamous cell carcinoma of the cervix uteri. Clin Cancer Res 2004;10:3059-63.
    • (2004) Clin Cancer Res , vol.10 , pp. 3059-3063
    • Melsheimer, P.1    Vinokurova, S.2    Wentzensen, N.3    Bastert, G.4    Von Knebel Doeberitz, M.5
  • 29
    • 7144250518 scopus 로고    scopus 로고
    • Role of a p53 polymorphism in the development of human papillomavirus-associated cancer
    • Storey A, Thomas M, Kalita A, Harwood C, Gardiol D, Mantovani F, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature 1998;393:229-34.
    • (1998) Nature , vol.393 , pp. 229-234
    • Storey, A.1    Thomas, M.2    Kalita, A.3    Harwood, C.4    Gardiol, D.5    Mantovani, F.6
  • 30
    • 84870364676 scopus 로고    scopus 로고
    • p53Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: A systematic review and meta-analysis
    • Habbous S, Pang V, Eng L, Xu W, Kurtz G, Liu FF, et al. p53Arg72Pro polymorphism, HPV status and initiation, progression, and development of cervical cancer: a systematic review and meta-analysis. Clin Cancer Res 2012;18:6407-15.
    • (2012) Clin Cancer Res , vol.18 , pp. 6407-6415
    • Habbous, S.1    Pang, V.2    Eng, L.3    Xu, W.4    Kurtz, G.5    Liu, F.F.6
  • 32
    • 84857734203 scopus 로고    scopus 로고
    • Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer
    • Schwarz JK, Payton JE, Rashmi R, Xiang T, Jia Y, Huettner P, et al. Pathway-specific analysis of gene expression data identifies the PI3K/Akt pathway as a novel therapeutic target in cervical cancer. Clin Cancer Res 2012;18:1464-71.
    • (2012) Clin Cancer Res , vol.18 , pp. 1464-1471
    • Schwarz, J.K.1    Payton, J.E.2    Rashmi, R.3    Xiang, T.4    Jia, Y.5    Huettner, P.6
  • 35
    • 0034005996 scopus 로고    scopus 로고
    • Development and assessment of a general theory of cervical carcinogenesis utilizing a severe combined immunodeficiency murine-human xenograft model
    • Tewari KS, Taylor JA, Liao SY, DiSaia PJ, Burger RA, Monk BJ, et al. Development and assessment of a general theory of cervical carcinogenesis utilizing a severe combined immunodeficiency murine-human xenograft model. Gynecol Oncol 2000;77:137-48.
    • (2000) Gynecol Oncol , vol.77 , pp. 137-148
    • Tewari, K.S.1    Taylor, J.A.2    Liao, S.Y.3    DiSaia, P.J.4    Burger, R.A.5    Monk, B.J.6
  • 36
    • 84902603350 scopus 로고    scopus 로고
    • Clinical impact of de-regulated Notch-1 and Notch-3 in the development and progression of HPV-associated different histological subtypes of precancerous and cancerous lesions of human uterine cervix
    • Tripathi R, Rath G, Jawanjal P, Sharma S, Singhal P, Bhambhani S, et al. Clinical impact of de-regulated Notch-1 and Notch-3 in the development and progression of HPV-associated different histological subtypes of precancerous and cancerous lesions of human uterine cervix. PLoS One 2014;9:e98642.
    • (2014) PLoS One , vol.9 , pp. e98642
    • Tripathi, R.1    Rath, G.2    Jawanjal, P.3    Sharma, S.4    Singhal, P.5    Bhambhani, S.6
  • 38
    • 0031260289 scopus 로고    scopus 로고
    • Angiogenesis in cervical neoplasia: Microvessel quantification in precancerous lesions and invasive carcinomas with clinicopathologic correlations
    • Dellas A, Moch H, Schultheiss E, Feichter G, Almendral AC, Gudat F, et al. Angiogenesis in cervical neoplasia: microvessel quantification in precancerous lesions and invasive carcinomas with clinicopathologic correlations. Gynecol Oncol 1997;67:27-33.
    • (1997) Gynecol Oncol , vol.67 , pp. 27-33
    • Dellas, A.1    Moch, H.2    Schultheiss, E.3    Feichter, G.4    Almendral, A.C.5    Gudat, F.6
  • 39
    • 0032852528 scopus 로고    scopus 로고
    • Molecular and biological properties of vascular endothelial growth factor
    • Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med (Berl) 1999;77:527-43.
    • (1999) J Mol Med (Berl) , vol.77 , pp. 527-543
    • Ferrara, N.1
  • 40
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim KJ, Li B, Winer J, et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 1993;362:841-4.
    • (1993) Nature , vol.362 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 41
    • 0029816983 scopus 로고    scopus 로고
    • Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: Novel concepts of angiostatic therapy from intravital videomicroscopy
    • Borgstrom P, Hillan KJ, Sriramarao P, Ferrara N. Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy. Cancer Res 1996;56:4032-9.
    • (1996) Cancer Res , vol.56 , pp. 4032-4039
    • Borgstrom, P.1    Hillan, K.J.2    Sriramarao, P.3    Ferrara, N.4
  • 42
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 44
    • 61549141361 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: A gynecologic oncology group study
    • Monk BJ, Sill MW, Burger RA, Gray HJ, Buekers TE, Roman LD. Phase II trial of bevacizumab in the treatment of persistent or recurrent squamous cell carcinoma of the cervix: a gynecologic oncology group study. J Clin Oncol 2009;27:1069-74.
    • (2009) J Clin Oncol , vol.27 , pp. 1069-1074
    • Monk, B.J.1    Sill, M.W.2    Burger, R.A.3    Gray, H.J.4    Buekers, T.E.5    Roman, L.D.6
  • 46
    • 70350247885 scopus 로고    scopus 로고
    • Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patientswith cervical carcinoma
    • Karim R, Jordanova ES, Piersma SJ, Kenter GG, Chen L, Boer JM, et al. Tumor-expressed B7-H1 and B7-DC in relation to PD-1+ T-cell infiltration and survival of patientswith cervical carcinoma. Clin Cancer Res 2009;15:6341-7.
    • (2009) Clin Cancer Res , vol.15 , pp. 6341-6347
    • Karim, R.1    Jordanova, E.S.2    Piersma, S.J.3    Kenter, G.G.4    Chen, L.5    Boer, J.M.6
  • 47
    • 77955874058 scopus 로고    scopus 로고
    • Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer
    • Monk BJ, Mas Lopez L, Zarba JJ, Oaknin A, Tarpin C, Termrungruanglert W, et al. Phase II, open-label study of pazopanib or lapatinib monotherapy compared with pazopanib plus lapatinib combination therapy in patients with advanced and recurrent cervical cancer. J Clin Oncol 2010;28:3562-9.
    • (2010) J Clin Oncol , vol.28 , pp. 3562-3569
    • Monk, B.J.1    Mas, L.L.2    Zarba, J.J.3    Oaknin, A.4    Tarpin, C.5    Termrungruanglert, W.6
  • 49
    • 84904052981 scopus 로고    scopus 로고
    • Chemotherapy in the treatment of metastatic, persistent, and recurrent cervical cancer
    • Eskander RN, Tewari KS. Chemotherapy in the treatment of metastatic, persistent, and recurrent cervical cancer. Curr Opin Obstet Gynecol 2014;26:1-10.
    • (2014) Curr Opin Obstet Gynecol , vol.26 , pp. 1-10
    • Eskander, R.N.1    Tewari, K.S.2
  • 51
    • 85067756020 scopus 로고    scopus 로고
    • NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)
    • NCCN.org
    • NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). Cervical Cancer Version 1.2014 NCCN.org.
    • (2014) Cervical Cancer Version 1
  • 53
    • 84906815244 scopus 로고    scopus 로고
    • Evidence-based therapy for recurrent cervical cancer
    • Monk BJ, Tewari KS. Evidence-based therapy for recurrent cervical cancer. J Clin Oncol 2014;32:2687-90.
    • (2014) J Clin Oncol , vol.32 , pp. 2687-2690
    • Monk, B.J.1    Tewari, K.S.2
  • 54
    • 84910029185 scopus 로고    scopus 로고
    • Targeting angiogenesis in advanced cervical cancer
    • In press
    • Eskander RN, Tewari KS. Targeting angiogenesis in advanced cervical cancer. Ther Adv Med Oncol 2014. In press.
    • (2014) Ther Adv Med Oncol
    • Eskander, R.N.1    Tewari, K.S.2
  • 55
    • 70450196329 scopus 로고    scopus 로고
    • VEGFRs and Notch: A dynamic collaboration in vascular patterning
    • Jakobsson L, Bentley K, Gerhardt H. VEGFRs and Notch: a dynamic collaboration in vascular patterning. Biochem Soc Trans 2009;37:1233-6.
    • (2009) Biochem Soc Trans , vol.37 , pp. 1233-1236
    • Jakobsson, L.1    Bentley, K.2    Gerhardt, H.3
  • 56
    • 84859453770 scopus 로고    scopus 로고
    • Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signaling
    • Benedito R, Rocha SF, Woeste M, Zamykal M, Radtke F, Casanovas O, et al. Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signaling. Nature 2012;484:110-4.
    • (2012) Nature , vol.484 , pp. 110-114
    • Benedito, R.1    Rocha, S.F.2    Woeste, M.3    Zamykal, M.4    Radtke, F.5    Casanovas, O.6
  • 58
    • 84863338519 scopus 로고    scopus 로고
    • PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations
    • Janku F, Wheler JJ, Westin SN, Moulder SL, Naing A, Tsimberidou AM, et al. PI3K/AKT/mTOR inhibitors in patients with breast and gynecologic malignancies harboring PIK3CA mutations. J Clin Oncol 2012;30:777-82.
    • (2012) J Clin Oncol , vol.30 , pp. 777-782
    • Janku, F.1    Wheler, J.J.2    Westin, S.N.3    Moulder, S.L.4    Naing, A.5    Tsimberidou, A.M.6
  • 59
    • 77951938324 scopus 로고    scopus 로고
    • A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies
    • Temkin SM, Yamada SD, Fleming GF. A phase I study of weekly temsirolimus and topotecan in the treatment of advanced and/or recurrent gynecologic malignancies. Gynecol Oncol 2010;117:473-6.
    • (2010) Gynecol Oncol , vol.117 , pp. 473-476
    • Temkin, S.M.1    Yamada, S.D.2    Fleming, G.F.3
  • 60
    • 84880289115 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199)
    • Tinker AV, Ellard S, Welch S, Moens F, Allo G, Tsao MS, et al. Phase II study of temsirolimus (CCI-779) in women with recurrent, unresectable, locally advanced or metastatic carcinoma of the cervix. A trial of the NCIC Clinical Trials Group (NCIC CTG IND 199). Gynecol Oncol 2013;180:269-74.
    • (2013) Gynecol Oncol , vol.180 , pp. 269-274
    • Tinker, A.V.1    Ellard, S.2    Welch, S.3    Moens, F.4    Allo, G.5    Tsao, M.S.6
  • 61
    • 84904670005 scopus 로고    scopus 로고
    • Beyond angiogenesis blockade: Targeted therapy for advanced cervical cancer
    • Eskander RN, Tewari KS. Beyond angiogenesis blockade: targeted therapy for advanced cervical cancer. J Gynecol Oncol 2014;25:1-11.
    • (2014) J Gynecol Oncol , vol.25 , pp. 1-11
    • Eskander, R.N.1    Tewari, K.S.2
  • 62
    • 84875689800 scopus 로고    scopus 로고
    • HPV 16 synthetic long peptide (JPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial
    • van Poelgeest MI, Welters MJ, van Esch EM, Stynenbosch LF, Kerpershoek G, van Persijn van Meerten EL, et al. HPV 16 synthetic long peptide (JPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial. J Transl Med 2013;11:88.
    • (2013) J Transl Med , vol.11 , pp. 88
    • Van Poelgeest, M.I.1    Welters, M.J.2    Van Esch, E.M.3    Stynenbosch, L.F.4    Kerpershoek, G.5    Van Persijn Van Meerten, E.L.6
  • 63
    • 77749270735 scopus 로고    scopus 로고
    • Immunotherapy for cervical cancer: Research status and clinical potential
    • Su J-H, Wu A, Scotney E, Ma B, Monie A, Hung CF, et al. Immunotherapy for cervical cancer: research status and clinical potential. BioDrugs 2010;24:109-29.
    • (2010) BioDrugs , vol.24 , pp. 109-129
    • Su, J.-H.1    Wu, A.2    Scotney, E.3    Ma, B.4    Monie, A.5    Hung, C.F.6
  • 64
    • 84911932332 scopus 로고    scopus 로고
    • ADXS11-001 immunotherapy targeting HPV-E7: Final results from a phase 2 study in Indian women with recurrent cervical cancer
    • Basu P, Mehta AO, Jain MM, Gupta S, Nagarkar RV, Kumar V, et al. ADXS11-001 immunotherapy targeting HPV-E7: final results from a phase 2 study in Indian women with recurrent cervical cancer. J Clin Oncol 2014;32:5s(suppl;abstr 5610).
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Basu, P.1    Mehta, A.O.2    Jain, M.M.3    Gupta, S.4    Nagarkar, R.V.5    Kumar, V.6
  • 66
    • 3442888540 scopus 로고    scopus 로고
    • Human papilloimavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6
    • de Jong A, van Poelgeest MI, van der Hulst JM, Drijfhout JW, Fleuren GJ, Melief CJ, et al. Human papilloimavirus type 16-positive cervical cancer is associated with impaired CD4+ T-cell immunity against early antigens E2 and E6. Cancer Res 2004;64:5449-55.
    • (2004) Cancer Res , vol.64 , pp. 5449-5455
    • De Jong, A.1    Van Poelgeest, M.I.2    Van Der Hulst, J.M.3    Drijfhout, J.W.4    Fleuren, G.J.5    Melief, C.J.6
  • 67
  • 71
    • 84879804595 scopus 로고    scopus 로고
    • Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia
    • Yang W, Song Y, Lu YL, Sun JZ, Wang HW. Increased expression of programmed death (PD)-1 and its ligand PD-L1 correlates with impaired cell-mediated immunity in high-risk human papillomavirus-related cervical intraepithelial neoplasia. Immunology 2013;139:513-22.
    • (2013) Immunology , vol.139 , pp. 513-522
    • Yang, W.1    Song, Y.2    Lu, Y.L.3    Sun, J.Z.4    Wang, H.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.