VEGFRs and Notch: A dynamic collaboration in vascular patterning

Biochemical Society Transactions

Volumn 37, Issue 6, 2009, Pages 1233-1236

  Jakobsson, Lars ^a   Bentley, Katie ^a   Gerhardt, Holger ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Angiogenesis; Delta like 4 (Dll4); Notch; Patterning; Sprouting; Vascular endothelial growth factor receptor (VEGFR)

Indexed keywords

CELL PROTEIN; DELTA LIKE 4 PROTEIN; NOTCH RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; ARTICLE; BINDING AFFINITY; CELL MIGRATION; CELL PROLIFERATION; CELL SELECTION; CELL SURVIVAL; ENDOTHELIUM CELL; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMALS; BLOOD VESSELS; ENDOTHELIAL CELLS; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 70450196329     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0371233     Document Type: Article

References (38)

1. Gerhardt, H., Golding, M., Fruttiger, M., Ruhrberg, C., Lundkvist, A., Abramsson, A., Jeltsch, M., Mitchell, C., Alitalo, K., Shima, D. and Betsholtz, C. (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J. Cell Biol. 161, 1163-1177
2. Ruhrberg, C., Gerhardt, H., Golding, M., Watson, R., Ioannidou, S., Fujisawa, H., Betsholtz, C. and Shima, D.T. (2002) Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. Genes Dev. 16, 2684-2698
3. Ferrara, N. (2002) Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29, 10-14
4. Olsson, A.K., Dimberg, A., Kreuger, J. and Claesson-Welsh, L. (2006) VEGF receptor signalling: in control of vascular function. Nat. Rev. Mol. Cell Biol. 7, 359-371
5. Dumont, D.J., Jussila, L., Taipale, J., Lymboussaki, A., Mustonen, T., Pajusola, K., Breitman, M. and Alitalo, K. (1998) Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. Science 282, 946-949
6. Fong, G.H., Rossant, J., Gertsenstein, M. and Breitman, M.L. (1995) Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 376, 66-70
7. Shalaby, F., Rossant, J., Yamaguchi, T.P., Gertsenstein, M., Wu, X.F., Breitman, M.L. and Schuh, A.C. (1995) Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature 376, 62-66
8. Benedito, R., Roca, C., Sorensen, I., Adams, S., Gossler, A., Fruttiger, M. and Adams, R.H. (2009) The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis. Cell 137, 1124-1135
9. Hellström, M., Phng, L.K., Hofmann, J.J., Wallgard, E., Coultas, L., Lindblom, P., Alva, J., Nilsson, A.K., Karlsson, L., Gaiano, N. et al. (2007) Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature 445, 776-780
10. Siekmann, A.F. and Lawson, N.D. (2007) Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries. Nature 445, 781-784
11. Suchting, S., Freitas, C., le Noble, F., Benedito, R., Breant, C., Duarte, A. and Eichmann, A. (2007) The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching. Proc. Natl. Acad. Sci. U.S.A. 104, 3225-3230
12. Williams, C.K., Li, J.L., Murga, M., Harris, A.L. and Tosato, G. (2006) Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. Blood 107, 931-939
13. Harrington, L.S., Sainson, R.C., Williams, C.K., Taylor, J.M., Shi, W., Li, J.L. and Harris, A.L. (2008) Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells. Microvasc. Res. 75, 144-154
14. Holderfield, M.T., Henderson Anderson, A.M., Kokubo, H., Chin, M.T., Johnson, R.L. and Hughes, C.C. (2006) HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes. Biochem. Biophys. Res. Commun. 346, 637-648
15. Bentley, K., Gerhardt, H. and Bates, P.A. (2008) Agent-based simulation of Notch-mediated tip cell selection in angiogenic sprout initialisation. J. Theor. Biol. 250, 25-36
16. Hiratsuka, S., Minowa, O., Kuno, J., Noda, T. and Shibuya, M. (1998) Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc. Natl. Acad. Sci. U.S.A. 95, 9349-9354
17. Park, J.E., Chen, H.H., Winer, J., Houck, K.A. and Ferrara, N. (1994) Placenta growth factor: potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR. J. Biol. Chem. 269, 25646-25654
18. Fong, G.H., Zhang, L., Bryce, D.M. and Peng, J. (1999) Increased hemangioblast commitment, not vascular disorganization, is the primary defect in Flt-1 knock-out mice. Development 126, 3015-3025
19. Clauss, M., Weich, H., Breier, G., Knies, U., Rockl, W., Waltenberger, J. and Risau, W. (1996) The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis. J. Biol. Chem. 271, 17629-17634
20. Kearney, J.B., Ambler, C.A., Monaco, K.A., Johnson, N., Rapoport, R.G. and Bautch, V.L. (2002) Vascular endothelial growth factor receptor Flt-1 negatively regulates developmental blood vessel formation by modulating endothelial cell division. Blood 99, 2397-2407
21. Kappas, N.C., Zeng, G., Chappell, J.C., Kearney, J.B., Hazarika, S., Kallianos, K.G., Patterson, C., Annex, B.H. and Bautch, V.L. (2008) The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching. J. Cell Biol. 181, 847-858
22. Shalaby, F., Ho, J., Stanford, W.L., Fischer, K.D., Schuh, A.C., Schwartz, L., Bernstein, A. and Rossant, J. (1997) A requirement for Flk1 in primitive and definitive hematopoiesis and vasculogenesis. Cell 89, 981-990
23. Sakurai, Y., Ohgimoto, K., Kataoka, Y., Yoshida, N. and Shibuya, M. (2005) Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc. Natl. Acad. Sci. U.S.A. 102, 1076-1081
24. Adams, R.H. and Alitalo, K. (2007) Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8, 464-478
25. Tammela, T., Zarkada, G., Wallgard, E., Murtomaki, A., Suchting, S., Wirzenius, M., Waltari, M., Hellström, M., Schomber, T., Peltonen, R. et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454, 656-660
26. Matsumura, K., Hirashima, M., Ogawa, M., Kubo, H., Hisatsune, H., Kondo, N., Nishikawa, S., Chiba, T. and Nishikawa, S. (2003) Modulation of VEGFR-2-mediated endothelial-cell activity by VEGF-C/VEGFR-3. Blood 101, 1367-1374
27. Roca, C. and Adams, R.H. (2007) Regulation of vascular morphogenesis by Notch signaling. Genes Dev. 21, 2511-2524
28. Kageyama, R., Masamizu, Y. and Niwa, Y. (2007) Oscillator mechanism of Notch pathway in the segmentation clock. Dev. Dyn. 236, 1403-1409
29. Phng, L.K. and Gerhardt, H. (2009) Angiogenesis: a team effort coordinated by notch. Dev. Cell 16, 196-208
30. Siekmann, A.F., Covassin, L. and Lawson, N.D. (2008) Modulation of VEGF signalling output by the Notch pathway. BioEssays 30, 303-313
31. Fruttiger, M. (2002) Development of the mouse retinal vasculature: angiogenesis versus vasculogenesis. Invest. Ophthalmol. Visual Sci. 43, 522-527
32. Claxton, S. and Fruttiger, M. (2004) Periodic Delta-like 4 expression in developing retinal arteries. Gene Expression Patterns 5, 123-127
33. Leslie, J.D., Ariza-McNaughton, L., Bermange, A.L., McAdow, R., Johnson, S.L. and Lewis, J. (2007) Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis. Development 134, 839-844
34. Lobov, I.B., Renard, R.A., Papadopoulos, N., Gale, N.W., Thurston, G., Yancopoulos, G.D. and Wiegand, S.J. (2007) Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc. Natl. Acad. Sci. U.S.A. 104, 3219-3224
35. Mailhos, C., Modlich, U., Lewis, J., Harris, A., Bicknell, R. and Ish-Horowicz, D. (2001) Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis. Differentiation 69, 135-144
36. Liu, Z.J., Shirakawa, T., Li, Y., Soma, A., Oka, M., Dotto, G.P., Fairman, R.M., Velazquez, O.C. and Herlyn, M. (2003) Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis. Mol. Cell. Biol. 23, 14-25
37. Shawber, C.J., Funahashi, Y., Francisco, E., Vorontchikhina, M., Kitamura, Y., Stowell, S.A., Borisenko, V., Feirt, N., Podgrabinska, S., Shiraishi, K. et al. (2007) Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression. J. Clin. Invest. 117, 3369-3382
38. Lewis, J. (2008) From signals to patterns: space, time, and mathematics in developmental biology. Science 322, 399-403