Cigarette smoking promotes inflammation in patients with copd by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Zhang, Ming Qiang ^a   Wan, Yong ^b   Jin, Yang ^a   Xin, Jian Bao ^a   Zhang, Jian Chu ^a   Xiong, Xian Zhi ^a   Chen, Long ^a   Chen, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b WUHAN NO 1 HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MUSCARINIC M3 RECEPTOR; MUSCARINIC M5 RECEPTOR;

AGED; APOPTOSIS; ARTICLE; CD4+ ALPHA 7+ T CELL; CD4+ T LYMPHOCYTE; CELL ISOLATION; CELL SURVIVAL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MALE; POLARIZATION; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOKING; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH10 CELL; TH17 CELL; TH2 CELL; UPREGULATION; ADVERSE EFFECTS; CLINICAL TRIAL; IMMUNOLOGY; MIDDLE AGED; PATHOLOGY;

AGED; CELL SURVIVAL; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTOR, MUSCARINIC M3; RECEPTOR, MUSCARINIC M5; SMOKING; T-LYMPHOCYTES, REGULATORY; TH1 CELLS; TH17 CELLS;

EID: 84910019943     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112350     Document Type: Article

References (46)

1. Hogg JC, Chu F, Utokaparch S, Woods R, Elliott WM, et al. (2004) The nature of small-airway obstruction in chronic obstructive pulmonary disease. N Engl J Med 350: 2645-2653.
2. Barnes PJ, Shapiro SD, Pauwels RA (2003) Chronic obstructive pulmonary disease: molecular and cellular mechanisms. Eur Respir J 22: 672-688.
3. Saetta M, Di Stefano A, Maestrelli P, Ferraresso A, Drigo R, et al. (1993) Activated T-lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis. Am Rev Respir Dis 147: 301-306.
4. Glader P, von Wachenfeldt K, Lofdahl CG (2006) Systemic CD4 + T-cell activation is correlated with FEV1 in smokers. Respir Med 100: 1088-1093.
5. Zhu X, Gadgil AS, Givelber R, George MP, Stoner MW, et al. (2009) Peripheral T cell functions correlate with the severity of chronic obstructive pulmonary disease. J Immunol 182: 3270-3277.
6. Glader P, Moller S, Lilja J, Wieslander E, Lofdahl CG, et al. (2006) Cigarette smoke extract modulates respiratory defence mechanisms through effects on Tcells and airway epithelial cells. Respir Med 100: 818-827.
7. Vassallo R, Tamada K, Lau JS, Kroening PR, Chen L (2005) Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. J Immunol 175: 2684-2691.
8. Saetta M, Baraldo S, Corbino L, Turato G, Braccioni F, et al. (1999) CD8+ve cells in the lungs of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 160: 711-717.
9. Grando SA, Kawashima K, Kirkpatrick CJ, Meurs H, Wessler I (2012) The non-neuronal cholinergic system: basic science, therapeutic implications and new perspectives. Life Sci 91: 969-972.
10. Fujii T, Takada-Takatori Y, Kawashima K (2008) Basic and clinical aspects of non-neuronal acetylcholine: expression of an independent, non-neuronal cholinergic system in lymphocytes and its clinical significance in immunotherapy. J Pharmacol Sci 106: 186-192.
11. Kawashima K, Fujii T, Moriwaki Y, Misawa H, Horiguchi K (2012) Reconciling neuronally and nonneuronally derived acetylcholine in the regulation of immune function. Ann N Y Acad Sci 1261: 7-17.
12. Gross NJ, Skorodin MS (1984) Role of the parasympathetic system in airway obstruction due to emphysema. N Engl J Med 311: 421-425.
13. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, et al. (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176: 532-555.
14. Profita M, Riccobono L, Montalbano AM, Bonanno A, Ferraro M, et al. (2012) In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD. Immunobiology 217: 345-353.
15. Inatsu A, Kogiso M, Jeschke MG, Asai A, Kobayashi M, et al. (2011) Lack of Th17 cell generation in patients with severe burn injuries. J Immunol 187: 2155-2161.
16. Pace E, Gagliardo R, Melis M, La Grutta S, Ferraro M, et al. (2004) Synergistic effects of fluticasone propionate and salmeterol on in vitro T-cell activation and apoptosis in asthma. J Allergy Clin Immunol 114: 1216-1223.
17. Blue ML, Janoff A (1978) Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cigarette smoke condensate in vitro. Am Rev Respir Dis 117: 317-325.
18. Wouters EF (2005) Local and systemic inflammation in chronic obstructive pulmonary disease. Proc Am Thorac Soc 2: 26-33.
19. Cosio MG, Saetta M, Agusti A (2009) Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 360: 2445-2454.
20. Wang H, Ying H, Wang S, Gu X, Weng Y, et al. (2014) Imbalance of peripheral blood Th17 and Treg responses in patients with chronic obstructive pulmonary disease. Clin Respir J.
21. Hodge G, Nairn J, Holmes M, Reynolds PN, Hodge S (2007) Increased intracellular T helper 1 proinflammatory cytokine production in peripheral blood, bronchoalveolar lavage and intraepithelial T cells of COPD subjects. Clin Exp Immunol 150: 22-29.
22. Isajevs S, Taivans I, Strazda G, Kopeika U, Bukovskis M, et al. (2009) Decreased FOXP3 expression in small airways of smokers with COPD. Eur Respir J 33: 61-67.
23. D'Alessio FR, Tsushima K, Aggarwal NR, West EE, Willett MH, et al. (2009) CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. J Clin Invest 119: 2898-2913.
24. Noack M, Miossec P (2014) Th17 and regulatory T cell balance in autoimmune and inflammatory diseases. Autoimmun Rev 13: 668-677.
25. Lane N, Robins RA, Corne J, Fairclough L (2010) Regulation in chronic obstructive pulmonary disease: the role of regulatory T-cells and Th17 cells. Clin Sci (Lond) 119: 75-86.
26. Tan DB, Fernandez S, Price P, French MA, Thompson PJ, et al. (2014) Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD). Immunobiology.
27. Hou J, Sun Y, Hao Y, Zhuo J, Liu X, et al. (2013) Imbalance between subpopulations of regulatory T cells in COPD. Thorax.
28. De Rosa MJ, Esandi MC, Garelli A, Rayes D, Bouzat C (2005) Relationship between alpha 7 nAChR and apoptosis in human lymphocytes. J Neuroimmunol 160: 154-161.
29. Kolahian S, Gosens R (2012) Cholinergic regulation of airway inflammation and remodelling. J Allergy (Cairo) 2012: 681258.
30. Lee J, Taneja V, Vassallo R (2012) Cigarette smoking and inflammation: cellular and molecular mechanisms. J Dent Res 91: 142-149.
31. Hellstrom-Lindahl E, Nordberg A (1996) Muscarinic receptor subtypes in subpopulations of human blood mononuclear cells as analyzed by RT-PCR technique. J Neuroimmunol 68: 139-144.
32. Sato KZ, Fujii T, Watanabe Y, Yamada S, Ando T, et al. (1999) Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines. Neurosci Lett 266: 17-20.
33. Kawashima K, Fujii T (2000) Extraneuronal cholinergic system in lymphocytes. Pharmacol Ther 86: 29-48.
34. Qian J, Galitovskiy V, Chernyavsky AI, Marchenko S, Grando SA (2011) Plasticity of the murine spleen T-cell cholinergic receptors and their role in in vitro differentiation of naive CD4 T cells toward the Th1, Th2 and Th17 lineages. Genes Immun 12: 222-230.
35. Zhang J, Deng L, Xiong X, Wang P, Xin J, et al. (2011) Effect of tiotropium bromide on expression of CD(8) (+)CD (25) (+)FoxP (3) (+) regulatory T cells in patients with stable chronic obstructive pulmonary disease. J Huazhong Univ Sci Technolog Med Sci 31: 463-468.
36. Profita M, Albano GD, Riccobono L, Di Sano C, Montalbano AM, et al. (2014) Increased levels of Th17 cells are associated with non-neuronal acetylcholine in COPD patients. Immunobiology 219: 392-401.
37. Noakes PS, Holt PG, Prescott SL (2003) Maternal smoking in pregnancy alters neonatal cytokine responses. Allergy 58: 1053-1058.
38. Kawashima K, Fujii T (2003) The lymphocytic cholinergic system and its contribution to the regulation of immune activity. Life Sci 74: 675-696.
39. Kawashima K, Fujii T, Moriwaki Y, Misawa H (2012) Critical roles of acetylcholine and the muscarinic and nicotinic acetylcholine receptors in the regulation of immune function. Life Sci 91: 1027-1032.
40. Wessler I, Kilbinger H, Bittinger F, Kirkpatrick CJ (2001) The biological role of non-neuronal acetylcholine in plants and humans. Jpn J Pharmacol 85: 2-10.
41. Fujihara M, Nagai N, Sussan TE, Biswal S, Handa JT (2008) Chronic cigarette smoke causes oxidative damage and apoptosis to retinal pigmented epithelial cells in mice. PLoS One 3: e3119.
42. Carnevali S, Petruzzelli S, Longoni B, Vanacore R, Barale R, et al. (2003) Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 284: L955-L963.
43. Menon R, Fortunato SJ, Yu J, Milne GL, Sanchez S, et al. (2011) Cigarette smoke induces oxidative stress and apoptosis in normal term fetal membranes. Placenta 32: 317-322.
44. Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, et al. (2006) Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol 291: L19-L29.
45. Tagawa Y, Hiramatsu N, Kasai A, Hayakawa K, Okamura M, et al. (2008) Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP). Free Radic Biol Med 45: 50-59.
46. Zhong CY, Zhou YM, Pinkerton KE (2008) NF-kappaB inhibition is involved in tobacco smoke-induced apoptosis in the lungs of rats. Toxicol Appl Pharmacol 230: 150-158.