Hydrogen sulfide in signaling pathways

Clinica Chimica Acta

Volumn 439, Issue , 2015, Pages 212-218

  Olas, Beata ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Garlic; Gasotransmitter; Hydrogen sulfide; Signaling pathways

Indexed keywords

2 OXOGLUTARIC ACID; 3 MERCAPTOPYRUVIC ACID; ACETYLSALICYLIC ACID; ALLICIN; CYSTATHIONINE; CYSTEINE; GASOTRANSMITTER; GLUTAMIC ACID; HOMOCYSTEINE; HYDROGEN SULFIDE; S ALLYLCYSTEINE; SERINE; THIOSULFATE;

AMINO ACID SYNTHESIS; ANTIOXIDANT ACTIVITY; BIOGENESIS; CARDIOVASCULAR SYSTEM; DIET SUPPLEMENTATION; DRUG MECHANISM; GARLIC; HEART PROTECTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NERVOUS SYSTEM; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; REVIEW; SIGNAL TRANSDUCTION; ANIMALS; BLOOD; CHEMISTRY; HUMANS; METABOLISM;

ALLIUM SATIVUM;

ANIMALS; HUMANS; HYDROGEN SULFIDE; SIGNAL TRANSDUCTION;

EID: 84909957404     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2014.10.037     Document Type: Review

References (131)

1. Wang R. Gasotransmitters: growing pains and joys. Trends Biochem Sci 2014, 39:227-232.
2. Wang R. Two's company, three's a crowd: can H2S be the third endogenous gaseous transmitter?. FASEB J 2002, 16:1792-1798.
3. Wang R. The evolution of gasotransmitter biology and medicine: from atmospheric toxic gases to endogenous gaseous signaling molecules. Signal transduction and the gasotransmitters: NO, CO and H2S in biology and medicine 2004, 3-32. Humana Press. R. Wang (Ed.).
4. Zhong G., Chen F., Cheng Y., Tang C., Du J. The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase. J Hypertens 2003, 21:1879-1885.
5. Ali M.Y., Ping C.Y., Mok Y.Y., et al. Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?. Br J Pharmacol 2006, 149:625-634.
6. Oh G.S., Pae H.O., Lee B.S., et al. Hydrogen sulfide inhibits nitric oxide production and nuclear factor-kappaB via heme oxygenase-1 expression in RAW264.7 macrophages stimulated with lipopolysaccharide. Free Radic Biol Med 2006, 41:106-119.
7. Farrugia G., Szurszewski J.H. Carbon monoxide, hydrogen sulfide, and nitric oxide as signaling molecules in the gastrointestinal tract. Gastroenterology 2014, 147:303-313.
8. Filipovic M.R., Macinkovic I., Zhang D., Devarie-Baez N.O., Park C.M., Xian M. The mechanism(s) of protein persulfide formation: detection of protein S-sulfhydration by a tag-switch assay. Nitric Oxide 2014, 39:S5-S7. Abstract.
9. 2S and its role in redox signaling. BBA 1844, 2014:1355-1366.
10. Xu S., Liu Z., Liu P. Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis. Int J Cardiol 2014, 172:313-317.
11. Collin M., Thiemermann C. Hydrogen sulfide and sulfite: novel mediators in the pathophysiology of shock and inflammation. Shock 2005, 24:595-596.
12. Wang R. The gasotransmitter role of hydrogen sulfide. Antioxid Redox Signal 2003, 5:493-501.
13. Li L., Moore P.K. An overview of the biological significance of endogenous gases: new role for old molecules. Biochem Soc Trans 2007, 35:1138-1141.
14. Li L., Rose P., Moore P.K. Hydrogen sulphide and cell signaling. Annu Rev Pharmacol Toxicol 2011, 109:169-187.
15. Moore L., Li P.K. Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?. Trends Pharmacol Sci 2008, 29:84-90.
16. Toohey J.I. Sulfur signaling: is the agent sulfide or sulfane?. Anal Biochem 2011, 413:1-7.
17. Kimura H. The physiological role of hydrogen sulfide and beyond. Nitric Oxide 2014, 41:4-10.
18. Olas B. Hydrogen sulfide in hemostasis: friend or foe?. Chem Biol Interact 2014, 217:49-56.
19. 2S: a "double face" molecule in health and disease. Biofactors 2013, 39:186-196.
20. Whiteman M., Moore P.K. Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide. J Cell Mol Med 2009, 13:488-507.
21. Hogg P.J. Contribution of allosteric disulfide bonds to regulation of hemostasis. J Thromb Haemost 2009, 1:13-16.
22. Zhao W., Zhang J., Lu Y., Wang R. The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 2001, 20:6008-6016.
23. Olson K.R. Is hydrogen sulfide a circulating "gasotransmitter" in vertebrate blood?. BBA 2009, 1787:856-863.
24. Olson K.R., DeLeon E.R., Liu F. Controversies and conundrums in hydrogen sulfide biology. Nitric Oxide 2014, 41:11-26.
25. 35S-sulphide in the rat. Biochem Pharmacol 1972, 21:2313-2321.
26. Bartholomew T.C., Powell G.M., Dodgson K.S., Curtis C.G. Oxidation of sodium sulphide by rat liver, lungs and kidney. Biochem Pharmacol 1980, 29:2431-2437.
27. Kabil O., Banerjee R. Redox biochemistry of hydrogen sulfide. J Biol Chem 2010, 285:21903-21907.
28. Furne J., Saeed A., Levitt M.D. Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values. Am J Physiol Regul Integr Comp Physiol 2008, 295:R1479-R1485.
29. Olson K.R. A practical look at the chemistry and biology of hydrogen sulfide. Antioxid Redox Signal 2012, 17:32-44.
30. 2S during circulatory shock: some unresolved questions. Nitric Oxide 2014, 41:48-61.
31. Reiffenstein R.J., Hulbert W.C., Roth S.H. Toxicology of hydrogen sulphide. Annu Rev Pharmacol Toxicol 1992, 32:109-134.
32. 2S": facts and apparent artifacts. Nitric Oxide 2014, 41:85-96.
33. Lowicka E., Beltowski J. Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists. Pharmacol Rep 2007, 59:4-24.
34. Hancock J.T., Whiteman M. Hydrogen sulfide and cell signaling: team player or referee?. Plant Physiol Biochem 2014, 78:37-42.
35. Huges M.N., Centelles M.N., Moore K.P. Making and working with hydrogen sulfide: the chemistry and generation of hydrogen sulfide in vitro and its measurement in vivo: a review. Free Radic Biol Med 2009, 47:1346-1353.
36. 2S by 3-mercaptopyruvate sulphurtransferase. J Biochem 2011, 149:357-359.
37. Wang R. Physiological implications of hydrogen sulfide - a whiff exploration that blossomed. Physiol Rev 2012, 92:791-896.
38. Shibuya N., Tanaka M., Yoshida M., et al. 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 2009, 11:703-714.
39. Shibuya N., Mikami Y., Kimura Y., Nagahara N., Kimura H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J Biochem 2009, 149:623-626.
40. Lefer D.J. A new gaseous signalling molecule emerges: cardioprotecive role of hydrogen sulfide. Proc Natl Acad Sci U S A 2007, 104:17907-17908.
41. Ishigami M., Hiraki K., Umemura K., Ogasawara Y., Ishii K., Kimura H. A source of hydrogen sulfide and a mechanism of its release in the brain. Antioxid Redox Signal 2009, 11:205-214.
42. Yang G., Zhao K., Ju Y., et al. Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal 2013, 18:1906-1919.
43. Enokido Y., Suzuki, Iwasawa K., Namekata K., Okazawa H., Kimura H. Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocytes lineage of developing mouse CNS. FASEB J 2005, 19:1854-1856.
44. Kimura H. Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 2013, 63:492-497.
45. Shibuya N., Koike S., Tanaka M., et al. A novel pathway for the production of hydrogen sulfide from d-cysteine in mammalian cells. Nat Commun 2013, 4:1366.
46. Ubuka T., Umemura S., Yuasa S., Kinuta M., Watanabe K. Purification and characterization of mitochondrial cysteine aminotransferase from rat liver. Physiol Chem Phys 1978, 10:483-500.
47. Hosoki R., Matsuki N., Kimura H. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide. Biochem Biophys Res Commun 1997, 237:527-531.
48. Yan H., Du J., Tang C. The possible role of hydrogen sulfide on the pathogenesis of spontaneous hypertension in rats. Biochem Biophys Res Commun 2004, 313:22-27.
49. Jeong S.O., Pae H.O., Oh G.S., et al. Hydrogen sulfide potentiates interleukin-1beta-induced nitric oxide production via enhancement of extracellular signal-regulated kinase activation in rat vascular smooth muscle cells. Biochem Biophys Res Commun 2006, 345:938-944.
50. Zhu Y.Z., Wang Z.J., Ho P., et al. Hydrogen sulfide and its possible roles in myocardial ischemia in experimental rats. J Appl Physiol 2007, 102:261-268.
51. Hu Y., Chen X., Pan T.T., et al. Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Arch 2008, 455:607-616.
52. Minamishima S., Bougaki M., Sips P.Y., et al. Hydrogen sulfide improves survival after cardiac arrest and cardiopulmonary resuscitation via a nitric oxide synthase 3-dependent mechanism in mice. Circulation 2009, 120:888-896.
53. Wagner C.A. Hydrogen sulfide: a new gaseous signal molecule and blood pressure regulator. J Nephrol 2009, 22:173-176.
54. Elsey D.J., Fowkes R.C., Baxter G.F. Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S). Cell Biochem Funct 2010, 28:95-106.
55. Predmore B.L., Julian D., Cardounel A.J. Hydrogen sulfide increases nitric oxide production from endothelial cells by an akt-dependent mechanism. Front Physiol 2011, 2:104.
56. Huang Y.E., Tang Z.H., Xie W., et al. Endogenous hydrogen sulfide mediates the cardioprotection induced by ischemic postconditioning in the early reperfusion phase. Exp Ther Med 2012, 4:1117-1123.
57. Sun W.H., Liu F., Chen Y., Zhu Y.C. Hydrogen sulfide decreases the levels of ROS by inhibiting mitochondrial complex IV and increasing SOD activities in cardiomyocytes under ischemia/reperfusion. Biochem Biohys Res Commun 2012, 421:164-169.
58. Issa K., Kimmoun A., Collin S., et al. Compared effects of inhibition and exogenous administration of hydrogen sulphide in ischaemia-reperfusion injury. Crit Care 2013, 17:1-12.
59. Du J., Hui Y., Cheung Y., et al. The possible role of hydrogen sulfide as a smooth muscle cell proliferation inhibitor in rat cultured cells. Heart Vessels 2004, 19:75-80.
60. Sivarajah A., Collino M., Yasin M., et al. Anti-apoptotic and anti-inflammatory effects of hydrogen sulfide in a rat model of regional myocardial I/R. Shock 2009, 31:267-274.
61. Polhemus D.J., Lefer D.J. Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease. Circ Res 2014, 114:730-737.
62. Hong M., Tang X.Q., He K. Effect of hydrogen sulfide on human colon cancer SW480 cell proliferation and migration in vitro. Nan Fang Yi Ke Da Xue Xue Bao 2014, 20:699-703.
63. Hellmich M., Coletta C., Chao C., Szabo C. The therapeutic potential of cystathionine-beta-synthetase/hydrogen sulfide inhibition in cancer. Antioxid Redox Signal 2014, [in press].
64. Chi X.P., Quyang X.Y., Wang Y.X. Hydrogen sulfide synergistically upregulates Porphyromonas gingivalis lipoplysaccharide-induced expression of Il-6 and Il-8 via NF-κB signalling in periodontal fibroblasts. Arch Oral Biol 2014, 59:954-961.
65. Mustafa A.K., Sikka G., Gazi S.K., et al. Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 2011, 109:1259-1268.
66. Zhang Z., Huang H., Liu P., Tang C., Wang J. Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K ATP channels. Can J Physiol Pharmacol 2007, 85:1248-1253.
67. Gade A.R., Kang M., Akbarali H.J. Hydrogen sulfide as an allosteric modulator of ATP-sensitive potassium channels in colonic inflammation. Mol Pharmacol 2013, 83:294-306.
68. Cooper C.E., Brown G.C. The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: chemical mechanism and physiological significance. J Bioenerg Biomembr 2008, 40:533-539.
69. Cheng Y., Nidisang J., Tang G., Cao K., Wang R. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol 2004, 287:H2316-H2323.
70. ATP channel by exogenous and endogenous hydrogen sulfide in vascular smooth muscle cells. Am Soc Pharmacol Exp Ther 2005, 69:1757-1764.
71. Bełtowski J. Siarkowodór jako biologicznie aktywny mediator w układzie krazenia. Postepy Hig Med Dosw 2004, 58:285-291.
72. Ufnal M., Zera T. Rola tlenku azotu, siarkowodoru oraz tlenku wegla w regulacji układu krazenia i ich potencjał farmakoterapeutyczny. Kardiol Pol 2010, (supl. V):436-440.
73. Bhatia M. Hydrogen sulfide as a vasodilator. Life 2005, 57:603-606.
74. Yang G., Sun X., Wang R. Hydrogen sulfide-induced apoptosis of human aorta smooth muscle cells via the activation of mitogen-activated protein kinases and caspase-3. FASEB J 2004, 18:1782-1784.
75. 2S on human aorta smooth muscle cells. FASEB J 2006, 20:553-555.
76. 2+ release through InsP3 receptors and relaxes airway smooth muscle. J Physiol 2013, 591:5999-6015.
77. 2S-dependent cardiac effects in frog and rat. Am J Physiol Regul Integr Comp Physiol 2013, 305:R443-R451.
78. Zagli G., Patacchini R., Trevisani M., et al. Hydrogen sulfide inhibits human platelet aggregation. Eur J Pharmacol 2007, 559:65-68.
79. Kram L., Grambow E., Mueller-Graf F., Sorg H., Vollmar B. The anti-thrombotic effect of hydrogen sulfide is partly mediated by an upregulation of nitric oxide synthases. Thromb Res 2013, 132:e112-e117.
80. Morel A., Malinowska J., Olas B. Antioxidative properties of hydrogen sulfide may involve in its antiadhesive action on blood platelets. Clin Biochem 2012, 18:1678-1682.
81. Olas B., Kontek B. The possible role of hydrogen sulfide as a modulator of hemostatic parameters of plasma. Chem Biol Interact 2014, 220:20-24.
82. Morel A., Malinowska J., Olas B. Hydrogen sulfide changes adhesive properties of fibrinogen and collagen in vitro. Platelets 2014, 25:147-149.
83. Nishikawa H., Hayashi H., Kubo S., Tsubota-Matsunami M., Sekiguchi F., Kawabata A. Inhibition by hydrogen sulfide of rabbit platelet aggregation and calcium mobilization. Biol Pharm Bull 2013, 36:1278-1282.
84. Grambow E., Mueller-Graf F., Delyagina E., Frank M., Kuhla A., Vollmar B. Effect of the hydrogen sulfide donor GYY4137 on platelet activation and microvascular thrombus formation in mice. Platelets 2013, 25:166-174.
85. Wachowicz B., Olas B., Zbikowska H.M., Buczynski A. Generation of reactive oxygen species in blood platelets. Platelets 2002, 13:175-182.
86. 2-dependent manner. Am J Physiol Heart Circ Physiol 2007, 292:H1953-H1960.
87. Wang X.B., Jin H.F., Du J.B. Role of gas signaling hydrogen sulfide in cardiovascular disease. Zhongguo Dang Dai Er Ke Za Zhi 2009, 11:790-793.
88. Qiao W., Chaoshu T., Hongfang J., Junbao D. Endogenous hydrogen sulfide is involved in the pathogenesis of atherosclerosis. Biochem Biophys Res Commun 2010, 396:182-186.
89. Mani S., Li H., Untereiner A., et al. Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis. Circulation 2013, 127:2523-2534.
90. Palinkas Z., Furtmuller P.G., Nagy A., et al. Interactions of hydrogen sulfide with myeloperoxidase. Br J Pharmacol 2014, [in press].
91. Yan S.K., Chang T., Wang H., Wu L., Wang R., Meng Q.H. Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cell. Biochem Biophys Res Commun 2006, 351:485-491.
92. Chang L., Geng B., Yu F., et al. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats. Amino Acids 2008, 34:573-585.
93. Zhu M., Du J., Liu A., Holmberg L., Tang C., Jin H. Effect of endogenous sulfur dioxide in regulating cardiovascular oxidative stress. Histol Histopathol 2014, 29:1107-1111.
94. Qu K., Chen C.P., Halliwell B., Moore P.K., Wong P.T. Hydrogen sulfide is a mediator of cerebral ischemic damage. Stroke 2006, 37:889-893.
95. Qu K., Lee S.W., Bian J.S., Low C.M., Wong P.T. Hydrogen sulfide: neurochemistry and neurobiology 2008, 52:155-165.
96. Deng J., Lei C., Chen Y., et al. Neuroprotective gases - fantasy or reality for clinical use?. Prog Neurobiol 2014, 115:210-245.
97. Abe K., Kimura H. The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 1996, 16:1066-1071.
98. Nagai Y., Tsugane M., Oka J., Kimura H. Hydrogen sulfide induces calcium waves in astrocytes. FASEB J 2004, 3:557-559.
99. Lee S., Hu Y.S., Hu L.F., et al. Hydrogen sulphide regulates calcium homeostasis in microgial cells. Glia 2006, 54:116-124.
100. Kida K., Yamada M., Tokuda K., et al. Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson's disease. Antioxid Redox Signal 2011, 15:343-352.
101. White B. The vascular effects of hydrogen sulphide 2012, University of Nottingham, [Doctor's work].
102. Lu M., Choo C.H., Hu L.-F., Tan B.H., Hu G., Bian J.B. Hydrogen sulfide regulates intracellular pH in rat primary cultured glia cells. Neurosci Res 2010, 66:92-98.
103. Geng B., Chang L., Pan C., et al. Endogenous hydrogen sulfide regulation of myocardial injury induced by isoproterenol. Biochem Biophys Res Commun 2004, 318:756-763.
104. Russo C., Tringali G., Ragazzoni E., et al. Evidence that hydrogen sulphide can modulate hypothalamo-pituitary-adrenal axis function: in vitro and in vivo studies in the rats. J Neuroendocrinol 2000, 12:225-233.
105. Kimura H. Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor. Biochem Biophys Res Commun 2000, 267:129-133.
106. Tadeusiewicz J., Olas B. Hydrogen sulfide - gas, which doesn't have only toxic properties. Kosmos 2014, 302:125-135.
107. Kimura H. Signaling molecules: hydrogen sulfide and polysulfide. Antioxid Redox Signal 2014, [in press].
108. Wang Z., Liu D.X., Wang F.W., et al. l-Cysteine promotes the proliferation and differentiation of neural stem cells via the CBS/H(2)S pathway. Neuroscience 2013, 237:106-117.
109. Olas B., Wachowicz Role of reactive nitrogen species in blood platelet functions. Platelets 2007, 18:555-565.
110. Stepnik M. Molekularne aspekty toksycznego działania tlenku azotu. Med Pr 2001, 52:375-381.
111. Whiteman M., Armstrong J.S., Chu S.H., et al. The novel neuromodulator hydrogen sulfide: an endogenous peroxynitrite 'scavenger'?. J Neurochem 2004, 90:765-768.
112. Whiteman M., Cheung N.S., Zhu Y.Z., et al. Hydrogen sulphide: a novel inhibitor of hypochlorous acid-mediated oxidative damage in the brain?. Biochem Biophys Res Commun 2005, 326:794-798.
113. 2+ influx. J Biol Chem 2011, 45:39379-39386.
114. Kimura Y., Kimura H. Hydrogen sulfide protects neurons from oxidative stress. FASEB J 2004, 18:1165-1167.
115. Majewski M. Allium sativum: facts and myths regarding human health. Rocz Panstw Zakl Hig 2014, 65:1-8.
116. Shouk R., Abdou A., Shetty K., Sarkar D., Eid A.H. Mechanisms underlying the antihypertensive effects of garlic bioactives. Nutr Res 2014, 34:106-115.
117. Tadeusiewicz J., Krysztofiak A., Olas B. Garlic - a cure-all for cardiovascular diseases?. Kosmos 2014, 302:37-44.
118. Bayan L., Koulivand P.H., Gorji A. Garlic: a review of potential therapeutic effects. AJP 2014, 4:1-14.
119. Wang X.H., Di Y.H. Mechanism of cooked blanched garlic leaves against platelet aggregation. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2014, 22:753-757.
120. McEwen B.J. The influence of diet and nutrients on platelet function. Semin Thromb Hemost 2014, 40:214-226.
121. Swiderski F., Dabrowska N., Rusaczonek A., Waszkiewicz-Robak B. Bioactive substances of garlic and their role in dietoprophylaxis and dietotherapy. Rocz Panstw Zakl Hig 2007, 58:41-46.
122. Chuah S.C., Moore P.K., Zhu Y.Z. S-allylcysteine mediates cardioprotection on an acute myocardial infarction rat model via a hydrogen sulphide-mediated pathway. Am J Physiol Heart Circ Physiol 2007, 293:H2693-H2701.
123. Scharbert G., Kalb M.L., Duris M., Marschalak C., Kozek-Langenecker S.A. Garlic at dietary doses not impair platelet function. Anesth Analg 2007, 105:1214-1218.
124. Szabo C. Hydrogen sulfide and its therapeutic potential. Nat Rev Drug Discov 2007, 6:917-935.
125. Benavides G.A., Squadrito G.L., Mills R.W., et al. Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A 2007, 104:17977-17982.
126. Guo W., Cheng Z.Y., Zhu Y.Z. Hydrogen sulfide and translational medicine. Acta Pharmacol Sin 2013, 34:1284-1291.
127. Predmore B.L., Lefer D.J. Development of hydrogen sulphide-based therapeutics for cardiovascular diseases. J Cardiovasc Transl Res 2010, 3:487-498.
128. Lei Y.P., Chen H.W., Sheen L.Y., Lii C.K. Diallyl disulfide and diallyl trisulfide suppress oxidized LDL-induced vascular cell adhesion molecule and E-selectin expression through protein kinase A- and B-dependent signaling pathways. J Nutr 2008, 138:996-1003.
129. Lei Y.P., Liu C.T., Sheen L.Y., Chen H.W., Lii C.K. Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Mol Nutr Food Res 2010, 54:S42-S52.
130. 2S-releasing aspirin. Free Radic Biol Med 2010, 48:1263-1272.
131. Wagner F., Scheurerle A., Weber S., et al. Cardiopulmonary, histologic, and inflammatory effects of intravenous Na2S after blunt chest trauma-induced lung contusion in mice. J Trauma 2011, 71:1659-1667.