Single-molecule nucleic acid interactions monitored on a label-free microcavity biosensor platform

Nature Nanotechnology

Volumn 9, Issue 11, 2014, Pages 933-939

  Baaske, Martin D ^a   Foreman, Matthew R ^a   Vollmer, Frank ^a  

^a MAX PLANCK INSTITUTE FOR THE SCIENCE OF LIGHT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; MICROCAVITIES; NANORODS; NUCLEIC ACIDS; OLIGONUCLEOTIDES; PLASMONICS; PLASMONS; WHISPERING GALLERY MODES;

BIO-SENSOR PLATFORMS; BIOSENSING PLATFORMS; INTERACTION KINETICS; NUCLEIC ACID HYBRIDIZATION; OPTICAL MICROCAVITIES; SINGLE MOLECULE LEVEL; SINGLE-MOLECULE SENSITIVITY; SPECIFIC INTERACTION;

MOLECULES;

DIMETICONE; MICROSPHERE; NANOROD; NUCLEIC ACID; OLIGONUCLEOTIDE; GOLD; NANOTUBE;

ARTICLE; BIOENGINEERING; BIOSENSOR; CHEMICAL INTERACTION; DISSOCIATION CONSTANT; DNA STRAND; HYBRIDIZATION; INFORMATION PROCESSING; KINETICS; LIMIT OF DETECTION; MELTING POINT; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NOISE; NUCLEIC ACID ANALYSIS; NUCLEIC ACID HYBRIDIZATION; OPTICAL TWEEZERS; PREDICTION; CHEMISTRY; DEVICES; EQUIPMENT DESIGN; SURFACE PLASMON RESONANCE; ULTRASTRUCTURE;

EQUIPMENT DESIGN; GOLD; NANOTUBES; NUCLEIC ACID HYBRIDIZATION; NUCLEIC ACIDS; SURFACE PLASMON RESONANCE;

EID: 84909947883     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2014.180     Document Type: Article

References (48)

1. Vollmer, F. & Yang, L. Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices. Nanophotonics 1, 267-291 (2012).
2. Washburn, A. L., Gunn, L. C. & Bailey, R. C. Label-free quantitation of a cancer biomarker in complex media using silicon photonic microring resonators. Anal. Chem. 81, 9499-9506 (2009).
3. Robinson, J. T., Chen, L. & Lipson, M. On-chip gas detection in silicon optical microcavities. Opt. Express 16, 4296-4301 (2008).
4. Bahl, G. et al. Brillouin cavity optomechanics with microfluidic devices. Nature Commun. 4, 1994 (2013).
5. Armani, A. M. & Vahala, K. J. Heavy water detection using ultra-high-Q microcavities. Opt. Lett. 31, 1896-1898 (2006).
6. Vollmer, F. & Arnold, S. Whispering-gallery-mode biosensing: label-free detection down to single molecules. Nature Methods 5, 591-596 (2008).
7. Lu, T. et al. High sensitivity nanoparticle detection using optical microcavities. Proc. Natl Acad. Sci. USA 108, 5976-5979 (2011).
8. Vollmer, F., Arnold, S. & Keng, D. Single virus detection from the reactive shift of a whispering-gallery mode. Proc. Natl Acad. Sci. USA 105, 20701-20704 (2008).
9. Shao, L. et al. Detection of single nanoparticles and lentiviruses using microcavity resonance broadening. Adv. Mater. 25, 5616-5620 (2013).
10. Zhu, J. G. et al. On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator. Nature Photon. 4, 46-49 (2010).
11. Lin, S. Y., Schonbrun, E. & Crozier, K. Optical manipulation with planar silicon microring resonators. Nano Lett. 10, 2408-2411 (2010).
12. Mandal, S., Serey, X. & Erickson, D. Nanomanipulation using silicon photonic crystal resonators. Nano Lett. 10, 99-104 (2010).
13. Santiago-Cordoba, M. A., Boriskina, S. V., Vollmer, F. & Demirel, M. C. Nanoparticle-based protein detection by optical shift of a resonant microcavity. Appl. Phys. Lett. 99, 073701 (2011).
14. Swaim, J. D., Knittel, J. & Bowen, W. P. Detection limits in whispering gallery biosensors with plasmonic enhancement. Appl. Phys. Lett. 99, 243109 (2011).
15. Foreman, M. R. & Vollmer, F. Theory of resonance shifts of whispering gallery modes by arbitrary plasmonic nanoparticles. New J. Phys. 15, 083006 (2013).
16. Dantham, V. R. et al. Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity. Nano Lett. 13, 3347-3351 (2013).
17. Santiago-Cordoba, M. A., Cetinkaya, M., Boriskina, S. V., Vollmer, F. & Demirel, M. C. Ultrasensitive detection of a protein by optical trapping in a photonic-plasmonic microcavity. J. Biophoton. 5, 629-638 (2012).
18. Cooper, M. A. Optical biosensors in drug discovery. Nature Rev. Drug Discov. 1, 515-528 (2002).
19. Fan, X. D. et al. Sensitive optical biosensors for unlabeled targets: a review. Anal. Chim. Acta 620, 8-26 (2008).
20. Sassolas, A., Leca-Bouvier, B. D. & Blum, L. J. DNA biosensors and microarrays. Chem. Rev. 108, 109-139 (2008).
21. Ndieyira, J. W. et al. Surface-stress sensors for rapid and ultrasensitive detection of active free drugs in human serum. Nature Nanotech. 9, 225-232 (2014).
22. Zijlstra, P., Paulo, P. M. R. & Orrit, M. Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod. Nature Nanotech. 7, 379-382 (2012).
23. Zheng, G. F., Patolsky, F., Cui Y., Wang, W. U. & Lieber, C. M. Multiplexed electrical detection of cancer markers with nanowire sensor arrays. Nature Biotechnol. 23, 1294-1301 (2005).
24. Xuexin, D. et al. Quantification of the affinities and kinetics of protein interactions using silicon nanowire biosensors. Nature Nanotech. 7, 401-407 (2012).
25. Ament, I., Prasad, J., Henkel, A., Schmachtel, S. & Sonnichsen, C. Single unlabeled protein detection on individual plasmonic nanoparticles. Nano Lett. 12, 1092-1095 (2012).
26. Wu, Y., Zhang, D. Y., Yin, P. & Vollmer, F. Ultraspecific and highly sensitive nucleic acid detection by integrating a DNA catalytic network with a label-free microcavity. Small 10, 2067-2076 (2014).
27. Sorgenfrei, S. et al. Label-free single-molecule detection of DNA-hybridization kinetics with a carbon nanotube field-effect transistor. Nature Nanotech. 6, 125-131 (2011).
28. He, L. N., Ozdemir, K., Zhu, J. G., Kim, W. & Yang, L. Detecting single viruses and nanoparticles using whispering gallery microlasers. Nature Nanotech. 6, 428-432 (2011).
29. Foreman, M. R., Jin, W. & Vollmer, F. Optimizing detection limits in whispering gallery mode biosensing. Opt. Express 22, 5491-5511 (2014).
30. Foreman, M. R. & Vollmer, F. Level repulsion in hybrid photonic-plasmonic microresonators for enhanced biodetection. Phys. Rev. A 88, 023831 (2013).
31. Baaske, M. & Vollmer, F. Optical resonator biosensors: molecular diagnostic and nanoparticle detection on an integrated platform. ChemPhysChem 13, 427-436 (2012).
32. Prodan, E., Radloff, C., Halas, N. J. & Nordlander, P. A hybridization model for the plasmon response of complex nanostructures. Science 302, 419-422 (2003).
33. Huang, X. H., Neretina, S. & El-Sayed, M. A. Gold nanorods: from synthesis and properties to biological and biomedical applications. Adv. Mater. 21, 4880-4910 (2009).
34. Kaplan, A. et al. Finite element simulation of a perturbed axial-symmetric whispering-gallery mode and its use for intensity enhancement with a nanoparticle coupled to a microtoroid. Opt. Express 21, 14169-14180 (2013).
35. Knittel, J., Swaim, J. D., McAuslan, D. L., Brawley, G. A. & Bowen, W. P. Back-scatter based whispering gallery mode sensing. Sci. Rep. 3, 2974 (2013).
36. Swaim, J. D., Knittel, J. & Bowen, W. P. Tapered nanofiber trapping of high-refractive-index nanoparticles. Appl. Phys. Lett. 103, 203111 (2013).
37. Zhu, J. G., Ozdemir, S. K. & Yang, L. Optical detection of single nanoparticles with a subwavelength fiber-taper. IEEE Photon. Technol. Lett. 23, 1346-1348 (2011).
38. Wilson, K. A., Finch, C. A., Anderson, P., Vollmer, F. & Hickman, J. J. Whispering gallery mode biosensor quantification of fibronectin adsorption kinetics onto alkylsilane monolayers and interpretation of resultant cellular response. Biomaterials 33, 225-236 (2012).
39. Arnold, S., Ramjit, R., Keng, D., Kolchenko, V. & Teraoka, I. MicroParticle photophysics illuminates viral bio-sensing. Faraday Discuss. 137, 65-83 (2008).
40. Topolancik, J. & Vollmer, F. Photoinduced transformations in bacteriorhodopsin membrane monitored with optical microcavities. Biophys. J. 92, 2223-2229 (2007).
41. Noto, M., Vollmer, F., Keng, D., Teraoka, I. & Arnold, S. Nanolayer characterization through wavelength multiplexing of a microsphere resonator. Opt. Lett. 30, 510-512 (2005).
42. Lutti, J., Langbein, W. & Borri, P. A monolithic optical sensor based on whispering-gallery modes in polystyrene microspheres. Appl. Phys. Lett. 93, 151103 (2008).
43. Collot, L., Lefevreseguin, V., Brune, M., Raimond, J. M. & Haroche, S. Very high-Q whispering gallery mode resonances observed on fused-silica microspheres. Europhys. Lett. 23, 327-334 (1993).
44. Gorodetsky, M. L., Savchenkov, A. A. & Ilchenko, V. S. Ultimate Q of optical microsphere resonators. Opt. Lett. 21, 453-455 (1996).
45. Gorodetsky, M. L. & Ilchenko, V. S. Optical microsphere resonators: optimal coupling to high-Q whispering-gallery modes. J. Opt. Soc. Am. B 16, 147-154 (1999).
46. Mazzei, A., Gotzinger, S., Menezes, L. D., Sandoghdar, V. & Benson, O. Optimization of prism coupling to high-Q modes in a microsphere resonator using a near-field probe. Opt. Commun. 250, 428-433 (2005).
47. Walker, D. A., Leitsch, E. K., Nap, R. J., Szleifer, I. & Grzybowski, B. A. Geometric curvature controls the chemical patchiness and self-assembly of nanoparticles. Nature Nanotech. 8, 676-681 (2013).
48. Shi, D., Song, C., Jiang, Q., Wang, Z-G. & Ding, B. A facile and efficient method to modify gold nanorods with thiolated DNA at a low pH value. Chem. Commun. 49, 2533-2535 (2013).