Optimizing detection limits in whispering gallery mode biosensing

Optics Express

Volumn 22, Issue 5, 2014, Pages 5491-5511

  Foreman, Matthew R ^a   Jin, Wei Liang ^b   Vollmer, Frank ^a  

^a MAX PLANCK INSTITUTE FOR THE SCIENCE OF LIGHT   (Germany)

^b PEKING UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FISHER INFORMATION MATRIX; JITTER; WHISPERING GALLERY MODES;

COUPLING GEOMETRY; DETECTION LIMITS; DETECTION SENSITIVITY; FREQUENCY FLUCTUATION; RESONANCE SHIFT; SENSING MODALITIES; SWEPT-FREQUENCY; TECHNICAL NOISE;

OPTIMIZATION;

EID: 84896369243     PISSN: None     EISSN: 10944087     Source Type: Journal    
DOI: 10.1364/OE.22.005491     Document Type: Conference Paper

References (53)

1. M. Baaske and F. Vollmer "Optical Resonator Biosensors: Molecular Diagnostic and Nanoparticle Detection on an Integrated Platform", ChemPhysChem 13, 427-436 (2012).
2. K. J. Vahala "Optical microcavities" Nature 424, 839-846 (2003).
3. F. Vollmer, S. Arnold, and D. Keng "Single virus detection from the reactive shift of a whispering-gallery mode", Proc. Natl. Acad. Sci. USA 105, 20701-20704 (2008).
4. M. Noto, F. Vollmer, D. Keng, I. Teraoka, and S. Arnold "Nanolayer characterization through wavelength multiplexing of a microsphere resonator", Opt. Lett 30, 510-512 (2005).
5. F. Vollmer, S. Arnold, D. Braun, I. Teraoka, and A. Libchaber "Multiplexed DNA quantification by spectroscopic shift of two microsphere cavities", Biophys. J. 85, 1974-1979 (2003).
6. F. Vollmer, D. Braun, A. Libchaber, M. Khoshsima, I. Teraoka, and S. Arnold "Protein detection by optical shift of a resonant microcavity", Appl. Phys. Lett. 80, 4057-4059 (2002).
7. S. Arnold, M. Khoshsima, I. Teraoka, S. Holler, and F. Vollmer. "Shift of whispering-gallery modes in microspheres by protein adsorption", Opt. Lett. 28, 272-274, (2003).
8. W. Ahn, S. V. Boriskina, Y. Hong, and B. M. Reinhard "Photonic- plasmonic mode coupling in on-chip integrated optoplasmonic molecules", ACS Nano. 6, 951-960 (2012).
9. F. Vollmer and L. Yang "Label-free detection with high-Q microcavities: a review of biosensing mechanisms for integrated devices", Nanophot. 1, 267-291 (2012).
10. M. L. Gorodetsky, A. A. Savchenkov, and V. S. Ilchenko "Ultimate Q of optical microsphere resonators", Opt. Lett. 21, 453-455 (1996).
11. M. R. Foreman and F. Vollmer "Theory of resonance shifts of whispering gallery mode sensors by arbitrary plasmonic nanoparticles", New. J. Phys. 15, 083006 (2013).
12. M. A. Santiago-Cordoba, S. V. Boriskina, F. Vollmer, and M. C. Demirel "Nanoparticle-based protein detection by optical shift of a resonant microcavity", Appl. Phys. Lett. 99, 073701 (2011).
13. V. R. Dantham, S. Holler, C. Barbre, D. Keng, V. Kolchenko, and S. Arnold "Label-free detection of single protein using a nanoplasmonic-photonic hybrid microcavity", Nano. Lett. 13, 3347-3351 (2013).
14. J. Zhu, S. J Ozdemir, Y.-F. Xiao, L. Li, L. He, D.-R. Chen, and L. Yang "On-chip single nanoparticle detection and sizing by mode splitting in an ultrahigh-Q microresonator", Nat. Phot. 4, 46-49 (2010).
15. J. Knittel, J. D. Swaim, D. L. McAuslan, G. A. Brawley, and W. P. Bowen "Back-scatter based whispering gallery mode sensing", Sci. Rep. 3, 2974 (2013).
16. L. Xu, H. Li, X. Wu, L. Shang, and L. Liu "Ultra-sensitive label-free biosensing by using single-mode coupled microcavity laser", Proc. SPIE, 7682, 76820C (2010).
17. T. McGarvey, A. Conjusteau, and H. Mabuchi "Finesse and sensitivity gain in cavity-enhanced absorption spectroscopy of biomolecules in solution", Opt. Express, 14, 10441-10451 (2006).
18. J. D. Swaim, J. Knittel, and W. P. Bowen "Detection limits in whispering gallery biosensors with plasmonic enhancement", Appl. Phys. Lett. 99, 243109 (2011).
19. L. Shao, X.-F. Jiang, X.-C. Yu, B.-B. Li, W. R. Clements, F. Vollmer, W. Wang, Y.-F. Xiao, and Q. Gong "Detection of single nanoparticles and lentiviruses using microcavity resonance broadening", Adv. Mat. 25, 5616-5620 (2013).
20. S. Arnold, R. Ramjit, D. Keng, V. Kolchenko, and I. Teraoka "Microparticle photophysics illuminates viral biosensing", Faraday Disc. 137, 65-83, (2008).
21. J. L. Nadeau, V. S. Ilchenko, D. Kossakovski, G. H. Bearman, and L. Maleki "High-Q whispering-gallery mode sensor in liquids", Proc. SPIE 4629, 172 (2002).
22. N. M. Hanumegowda, C. J. Stica, B. C. Patel, I. White, and X. Fan "Refractometric sensors based on microsphere resonators", Appl. Phys. Lett. 87, 201107 (2005).
23. X. Lopez-Yglesias, J. M. Gamba, and R. C. Flagan "The physics of extreme sensitivity in whispering gallery mode optical biosensors", J. Appl. Phys. 111, 084701 (2012).
24. A. B. Matsko, A. A. Savchenkov, N. Yu, and L. Maleki "Whispering gallery mode resonators as frequency references. I. Fundamental limitations", J. Opt. Soc. Am. B 24, 1324-1335 (2007).
25. M. L. Gorodetsky and I. S. Grudinin "Fundamental thermal fluctuations in microspheres", J. Opt. Soc. Am. B 21, 697-705 (2004).
26. W.-L. Jin, X. Yi, Y. Hu, B. Li, and Y. Xiao, "Temperature- insensitive detection of low-concentration nanoparticles using a functionalized high-Q microcavity", Appl. Opt. 52, 155-161 (2013).
27. A. A. Savchenkov, A. B. Matsko, V. S. Ilchenko, N. Yu, and L. Maleki "Whispering-gallery-mode resonators as frequency references. II. Stabilization", J. Opt. Soc. Am. B. 24, 2099-2997 (2007).
28. T. Carmon, L. Yang, and K. J. Vahala "Dynamical thermal behavior and thermal self-stability of microcavities", Opt. Express 12, 4742-4750 (2004).
29. I. Teraoka "Analysis of thermal stabilization of whispering gallery mode resonance", Opt. Commun. 310 212-216 (2014).
30. L. L. Scharf, Statistical Signal Processing: Detection, Estimation, and Time Series Analysis, (Addison-Wesley Publishing Co., USA, 1991).
31. C. Vignet and J.-F. Bercher "Analysis of signals in the Fisher-Shannon information plane", Phys. Lett. A 312, 27-33 (2003).
32. H. Cramér, Mathematical Methods of Statistics, (Princeton University Press, USA, 1946).
33. M. R. Foreman and P. Török, "Information and resolution in electromagnetic optical systems", Phys. Rev. A 82, 043835 (2010).
34. M. Abramowitz and I. Stegun, Handbook of Mathematical Functions, (Dover Publications, New York, 1970).
35. T. Lu, H. Lee, T. Chen, S. Herchak, J.-H. Kim, S. E. Fraser, R. C. Flagan, and K. Vahala "High sensitivity nanoparticle detection using optical microcavities", Proc. Natl. Acad. Sci. USA 108, 5976-5979 (2011).
36. A. Zeira and A. Nehorai, "Frequency domain Cramer-Rao bound for Gaussian Processes", IEEE Trans. Acoust. Speech. Sig. Proc. 38 1063-1066 (1990).
37. Y.-F. Xiao "Optical cavity QED in Solid-State Systems - Theory to Realization", PhD thesis (University of Science and Technology of China, 2007).
38. M. L. Gorodetsky and V. S. Ilchenko "Optical microsphere resonators: optimal coupling to high-Q whisperinggallery modes", J. Opt. Soc. Am. B 16, 147-154 (1999).
39. M. Bass, C. M. DeCusatis, and J. M. Enoch Handbook of Optics, 3rd ed., Vol. 4. (McGraw-Hill, USA 2009).
40. G. M. Hale and M. R. Querry "Optical Constants of Water in the 200-nm to 200-μm Wavelength Region", Appl. Opt. 12, 555-563 (1973).
41. M. Cai, O. Painter, and K. J. Vahala "Observation of Critical Coupling in a Fiber Taper to a Silica-Microsphere Whispering-Gallery Mode System", Phys. Rev. Lett. 85, 74-77 (2000).
42. J. Topolancik and F. Vollmer "Photoinduced transformations in bacteriorhodopsin membrane monitored with optical microcavities", Biophys. J. 92, 2223-2229 (2007).
43. D. Q. Chowdhury, S. C. Hill, and P. W. Barber, "Morphology-dependent resonances in radially inhomogeneous spheres", J. Opt. Soc. Am. A 8, 1702-1705 (1991).
44. I. Teraoka and S. Arnold "Theory of resonance shifts in TE and TM whispering gallery modes by nonradial perturbations for sensing applications", J. Opt. Soc. Am. B 23, 1381-1389 (2006).
45. S. Arnold, S. I. Shopova, and S. Holler "Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism", Opt. Express 18, 281-287 (2010).
46. A. Mazzei A, S. Götzinger, L. de S. Menezes, G. Zumofen, O. Benson, and V. Sandoghdar "Controlled Coupling of Counterpropagating Whispering-Gallery Modes by a Single Rayleigh Scatterer: A Classical Problem in a Quantum Optical Light", Phys. Rev. Lett. 99, 173603 (2007).
47. X. Yi, Y.-F. Xiao, Y. Feng, D.-Y. Qiu, J.-Y. Fan, Y. Li, and Q. Gong "Mode-splitting-based optical label-free biosensing with a biorecognition-covered microcavity", J. Appl. Phys. 111, 114702 (2012).
48. U. Resch-Genger, M. Grabolle, S. Cavaliere-Jaricot, R. Nitschke, and T. Nann "Quantum dots versus organic dyes as fluorescent labels", Nat. Methods 5, 763-775 (2008).
49. M. R. Foreman and F. Vollmer "Level repulsion in hybrid photonic-plasmonic microresonators for enhanced biodetection", Phys. Rev. A 88, 023831 (2013).
50. D. S. Weiss, V. Sandoghdar, J. Hare, V. Lefèvre-Seguin, J. M. Raimond, and S. Haroche "Splitting of high-Q Mie modes induced by light backscattering in silica microspheres", Opt. Lett. 20, 1835-1837 (1995).
51. Y.-F. Xiao, Y.-C. Liu, B.-B. Li, Y.-L. Chen, Y. Li, and Q. Gong "Strongly enhanced light-matter interaction in a hybrid photonic-plasmonic resonator", Phys. Rev. A 85, 031805 (2012).
52. A. N. Bashkatov and E. A. Genina "Water refractive index in dependence on temperature and wavelength: a simple approximation", Proc. SPIE 5068, 393-395 (2003).
53. C. Lam, P. T. Leung, and K. Young "Explicit asymptotic formulas for the positions, widths, and strengths of resonances in mie scattering", J. Opt. Soc. Am. B, 9, 1585-1592 (1992).