-
1
-
-
36248968708
-
SnapShot: EGFR signaling pathway
-
Yarden Y, Shilo BZ. SnapShot: EGFR signaling pathway. Cell 2007;131:1018.
-
(2007)
Cell
, vol.131
, pp. 1018
-
-
Yarden, Y.1
Shilo, B.Z.2
-
2
-
-
28244478626
-
Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis
-
Bertotti A, Comoglio PM, Trusolino L. Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis. Cancer Res 2005;65:10674-9.
-
(2005)
Cancer Res
, vol.65
, pp. 10674-10679
-
-
Bertotti, A.1
Comoglio, P.M.2
Trusolino, L.3
-
3
-
-
0035977147
-
A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth
-
Trusolino L, Bertotti A, Comoglio PM. A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Cell 2001;107:643-54.
-
(2001)
Cell
, vol.107
, pp. 643-654
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
4
-
-
33845697707
-
Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
-
Bertotti A, Comoglio PM, Trusolino L. Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth. J Cell Biol 2006;175:993-1003.
-
(2006)
J Cell Biol
, vol.175
, pp. 993-1003
-
-
Bertotti, A.1
Comoglio, P.M.2
Trusolino, L.3
-
5
-
-
79954622199
-
Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis
-
Gentile A, Lazzari L, Benvenuti S, Trusolino L, Comoglio PM. Ror1 is a pseudokinase that is crucial for Met-driven tumorigenesis. Cancer Res 2011;71:3132-41.
-
(2011)
Cancer Res
, vol.71
, pp. 3132-3141
-
-
Gentile, A.1
Lazzari, L.2
Benvenuti, S.3
Trusolino, L.4
Comoglio, P.M.5
-
6
-
-
44449151030
-
Drug development of MET inhibitors: Targeting oncogene addiction and expedience
-
Comoglio PM, Giordano S, Trusolino L. Drug development of MET inhibitors: targeting oncogene addiction and expedience. Nat Rev Drug Discov 2008;7:504-16.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 504-516
-
-
Comoglio, P.M.1
Giordano, S.2
Trusolino, L.3
-
7
-
-
84869065974
-
ROR1 and ROR2 in human malignancies: Potentials for targeted therapy
-
Rebagay G, Yan S, Liu C, Cheung NK. ROR1 and ROR2 in human malignancies: potentials for targeted therapy. Front Oncol 2012;2:34.
-
(2012)
Front Oncol
, vol.2
, pp. 34
-
-
Rebagay, G.1
Yan, S.2
Liu, C.3
Cheung, N.K.4
-
8
-
-
0027074850
-
A novel family of cell surface receptors with tyrosine kinase-like domain
-
Masiakowski P, Carroll RD. A novel family of cell surface receptors with tyrosine kinase-like domain. J Biol Chem 1992;267:26181-90.
-
(1992)
J Biol Chem
, vol.267
, pp. 26181-26190
-
-
Masiakowski, P.1
Carroll, R.D.2
-
9
-
-
84863384604
-
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma
-
Yamaguchi T, Yanagisawa K, Sugiyama R, et al. NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma. Cancer Cell 2012;21:348-61.
-
(2012)
Cancer Cell
, vol.21
, pp. 348-361
-
-
Yamaguchi, T.1
Yanagisawa, K.2
Sugiyama, R.3
-
10
-
-
0036159121
-
The Ror receptor tyrosine kinase family
-
Forrester WC. The Ror receptor tyrosine kinase family. Cell Mol Life Sci 2002;59:83-96.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 83-96
-
-
Forrester, W.C.1
-
11
-
-
84869051908
-
Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family
-
Artim SC, Mendrola JM, Lemmon MA. Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. Biochem J 2012;448:213-20.
-
(2012)
Biochem J
, vol.448
, pp. 213-220
-
-
Artim, S.C.1
Mendrola, J.M.2
Lemmon, M.A.3
-
12
-
-
84890921845
-
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties
-
Murphy JM, Zhang Q, Young SN, et al. A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Biochem J 2014;457:323-34.
-
(2014)
Biochem J
, vol.457
, pp. 323-334
-
-
Murphy, J.M.1
Zhang, Q.2
Young, S.N.3
-
13
-
-
84869049935
-
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia
-
Bicocca VT, Chang BH, Masouleh BK, et al. Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia. Cancer Cell 2012;22:656-67.
-
(2012)
Cancer Cell
, vol.22
, pp. 656-667
-
-
Bicocca, V.T.1
Chang, B.H.2
Masouleh, B.K.3
-
14
-
-
0033595154
-
Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPRMET
-
Vigna E, Gramaglia D, Longati P, et al. Loss of the exon encoding the juxtamembrane domain is essential for the oncogenic activation of TPRMET. Oncogene 1999;18:4275-81.
-
(1999)
Oncogene
, vol.18
, pp. 4275-4281
-
-
Vigna, E.1
Gramaglia, D.2
Longati, P.3
-
15
-
-
0033575864
-
Mutant Met-mediated transformation is liganddependent and can be inhibited by HGF antagonists
-
Michieli P, Basilico C, Pennacchietti S, et al. Mutant Met-mediated transformation is liganddependent and can be inhibited by HGF antagonists. Oncogene 1999;18:5221-31.
-
(1999)
Oncogene
, vol.18
, pp. 5221-5231
-
-
Michieli, P.1
Basilico, C.2
Pennacchietti, S.3
-
16
-
-
0028351702
-
A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family
-
Ponzetto C, Bardelli A, Zhen Z, et al. A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family. Cell 1994;77:261-71.
-
(1994)
Cell
, vol.77
, pp. 261-271
-
-
Ponzetto, C.1
Bardelli, A.2
Zhen, Z.3
-
17
-
-
0025959661
-
The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation
-
Naldini L, Vigna E, Ferracini R, et al. The tyrosine kinase encoded by the MET proto-oncogene is activated by autophosphorylation. Mol Cell Biol 1991;11:1793-803.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 1793-1803
-
-
Naldini, L.1
Vigna, E.2
Ferracini, R.3
-
18
-
-
0025932538
-
C-terminal truncated forms of Met, the hepatocyte growth factor receptor
-
Prat M, Crepaldi T, Gandino L, et al. C-terminal truncated forms of Met, the hepatocyte growth factor receptor. Mol Cell Biol 1991;11:5954-62.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5954-5962
-
-
Prat, M.1
Crepaldi, T.2
Gandino, L.3
-
19
-
-
0034278156
-
Lentiviral vectors: Excellent tools for experimental gene transfer and promising candidates for gene therapy
-
Vigna E, Naldini L. Lentiviral vectors: excellent tools for experimental gene transfer and promising candidates for gene therapy. J Gene Med 2000;2:308-16.
-
(2000)
J Gene Med
, vol.2
, pp. 308-316
-
-
Vigna, E.1
Naldini, L.2
-
20
-
-
3042622326
-
Multiparametric analysis of apoptosis by flow and image cytometry
-
Telford WG, Komoriya A, Packard BZ. Multiparametric analysis of apoptosis by flow and image cytometry. Methods Mol Biol 2004;263:141-60.
-
(2004)
Methods Mol Biol
, vol.263
, pp. 141-160
-
-
Telford, W.G.1
Komoriya, A.2
Packard, B.Z.3
-
21
-
-
84882629652
-
EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis
-
Breindel JL, Haskins JW, Cowell EP, et al. EGF receptor activates MET through MAPK to enhance non-small cell lung carcinoma invasion and brain metastasis. Cancer Res 2013;73:5053-65.
-
(2013)
Cancer Res
, vol.73
, pp. 5053-5065
-
-
Breindel, J.L.1
Haskins, J.W.2
Cowell, E.P.3
-
22
-
-
0034702178
-
Cross-talk between the proto-oncogenes Met and Ron
-
Follenzi A, Bakovic S, Gual P, et al. Cross-talk between the proto-oncogenes Met and Ron. Oncogene 2000;19:3041-9.
-
(2000)
Oncogene
, vol.19
, pp. 3041-3049
-
-
Follenzi, A.1
Bakovic, S.2
Gual, P.3
-
23
-
-
84866765957
-
Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c-Met signaling
-
Li PP, Madhavan R, Peng HB. Differential regulation of axonal growth and neuromuscular junction assembly by HGF/c-Met signaling. Dev Dyn 2012;241:1562-74.
-
(2012)
Dev Dyn
, vol.241
, pp. 1562-1574
-
-
Li, P.P.1
Madhavan, R.2
Peng, H.B.3
-
24
-
-
72949083968
-
Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells
-
Navab R, Liu J, Seiden-Long I, et al. Co-overexpression of Met and hepatocyte growth factor promotes systemic metastasis in NCI-H460 non-small cell lung carcinoma cells. Neoplasia 2009;11:1292-300.
-
(2009)
Neoplasia
, vol.11
, pp. 1292-1300
-
-
Navab, R.1
Liu, J.2
Seiden-Long, I.3
-
25
-
-
0023674310
-
Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases
-
Gonzatti-Haces M, Seth A, Park M, et al. Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci USA 1988;85:21-5.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 21-25
-
-
Gonzatti-Haces, M.1
Seth, A.2
Park, M.3
-
26
-
-
0029999150
-
Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility
-
Ponzetto C, Zhen Z, Audero E, et al. Specific uncoupling of GRB2 from the Met receptor. Differential effects on transformation and motility. J Biol Chem 1996;271:14119-23.
-
(1996)
J Biol Chem
, vol.271
, pp. 14119-14123
-
-
Ponzetto, C.1
Zhen, Z.2
Audero, E.3
-
27
-
-
0033579464
-
Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
-
Blom N, Gammeltoft S, Brunak S. Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J Mol Biol 1999;294:1351-62.
-
(1999)
J Mol Biol
, vol.294
, pp. 1351-1362
-
-
Blom, N.1
Gammeltoft, S.2
Brunak, S.3
-
28
-
-
0033214312
-
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
-
Takahashi T, Fournier A, Nakamura F, et al. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 1999;99:59-69.
-
(1999)
Cell
, vol.99
, pp. 59-69
-
-
Takahashi, T.1
Fournier, A.2
Nakamura, F.3
-
29
-
-
77955101693
-
Inhibition of Src impairs the growth of met-addicted gastric tumors
-
Bertotti A, Bracco C, Girolami F, et al. Inhibition of Src impairs the growth of met-addicted gastric tumors. Clin Cancer Res 2010;16:3933-43.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 3933-3943
-
-
Bertotti, A.1
Bracco, C.2
Girolami, F.3
-
31
-
-
67749117934
-
Signal integration by JNK and p38 MAPK pathways in cancer development
-
Wagner EF, Nebreda AR. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 2009;9:537-49.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 537-549
-
-
Wagner, E.F.1
Nebreda, A.R.2
-
32
-
-
34347207060
-
SFK-STAT pathway: An alternative and important way to malignancies
-
Hayakawa F, Naoe T. SFK-STAT pathway: an alternative and important way to malignancies. Ann N Y Acad Sci 2006;1086:213-22.
-
(2006)
Ann N Y Acad Sci
, vol.1086
, pp. 213-222
-
-
Hayakawa, F.1
Naoe, T.2
-
33
-
-
0032518375
-
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
-
Boccaccio C, Andò M, Tamagnone L, et al. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway. Nature 1998;391:285-8.
-
(1998)
Nature
, vol.391
, pp. 285-288
-
-
Boccaccio, C.1
Andò, M.2
Tamagnone, L.3
-
34
-
-
0041488671
-
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
-
Bivona TG, Pérez De Castro I, Ahearn IM, et al. Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 2003;424:694-8.
-
(2003)
Nature
, vol.424
, pp. 694-698
-
-
Bivona, T.G.1
Pérez De Castro, I.2
Ahearn, I.M.3
-
35
-
-
84859075498
-
The role of pseudokinases in cancer
-
Zhang H, Photiou A, Grothey A, et al. The role of pseudokinases in cancer. Cell Signal 2012;24:1173-84.
-
(2012)
Cell Signal
, vol.24
, pp. 1173-1184
-
-
Zhang, H.1
Photiou, A.2
Grothey, A.3
-
36
-
-
34547881522
-
Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma
-
Huang PH, Mukasa A, Bonavia R, et al. Quantitative analysis of EGFRvIII cellular signaling networks reveals a combinatorial therapeutic strategy for glioblastoma. Proc Natl Acad Sci USA 2007;104:12867-72.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 12867-12872
-
-
Huang, P.H.1
Mukasa, A.2
Bonavia, R.3
-
37
-
-
0642346939
-
Tyrosine kinase signal specificity: Lessons from the HGF receptor
-
Bertotti A, Comoglio PM. Tyrosine kinase signal specificity: lessons from the HGF receptor. Trends Biochem Sci 2003;28:527-33.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 527-533
-
-
Bertotti, A.1
Comoglio, P.M.2
-
38
-
-
46749088657
-
The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src
-
Akbarzadeh S, Wheldon LM, Sweet SM, et al. The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. PLoS One 2008;3:e1873.
-
(2008)
PLoS One
, vol.3
, pp. e1873
-
-
Akbarzadeh, S.1
Wheldon, L.M.2
Sweet, S.M.3
-
39
-
-
44849139232
-
Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells
-
Mueller KL, Hunter LA, Ethier SP, et al. Met and c-Src cooperate to compensate for loss of epidermal growth factor receptor kinase activity in breast cancer cells. Cancer Res 2008;68:3314-22.
-
(2008)
Cancer Res
, vol.68
, pp. 3314-3322
-
-
Mueller, K.L.1
Hunter, L.A.2
Ethier, S.P.3
-
40
-
-
33746764457
-
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis
-
Guo W, Pylayeva Y, Pepe A, et al. Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006;126:489-502.
-
(2006)
Cell
, vol.126
, pp. 489-502
-
-
Guo, W.1
Pylayeva, Y.2
Pepe, A.3
-
41
-
-
78649420006
-
MET signalling: Principles and functions in development, organ regeneration and cancer
-
Trusolino L, Bertotti A, Comoglio PM. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010;11:834-48.
-
(2010)
Nat Rev Mol Cell Biol
, vol.11
, pp. 834-848
-
-
Trusolino, L.1
Bertotti, A.2
Comoglio, P.M.3
-
42
-
-
47249140824
-
Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy
-
Daneshmanesh AH, Mikaelsson E, Jeddi-Tehrani M, et al. Ror1, a cell surface receptor tyrosine kinase is expressed in chronic lymphocytic leukemia and may serve as a putative target for therapy. Int J Cancer 2008;123:1190-5.
-
(2008)
Int J Cancer
, vol.123
, pp. 1190-1195
-
-
Daneshmanesh, A.H.1
Mikaelsson, E.2
Jeddi-Tehrani, M.3
-
43
-
-
42949121156
-
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a
-
Fukuda T, Chen L, Endo T, et al. Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci USA 2008;105:3047-52.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3047-3052
-
-
Fukuda, T.1
Chen, L.2
Endo, T.3
-
44
-
-
38949156617
-
Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia
-
Baskar S, Kwong KY, Hofer T, et al. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia. Clin Cancer Res 2008;14:396-404.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 396-404
-
-
Baskar, S.1
Kwong, K.Y.2
Hofer, T.3
-
45
-
-
42449110211
-
Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia
-
Shabani M, Asgarian-Omran H, Omran HA, et al. Overexpression of orphan receptor tyrosine kinase Ror1 as a putative tumor-associated antigen in Iranian patients with acute lymphoblastic leukemia. Tumour Biol 2007;28:318-26.
-
(2007)
Tumour Biol
, vol.28
, pp. 318-326
-
-
Shabani, M.1
Asgarian-Omran, H.2
Omran, H.A.3
-
46
-
-
77958519836
-
Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells
-
Choudhury A, Derkow K, Daneshmanesh AH, et al. Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells. Br J Haematol 2010;151:327-35.
-
(2010)
Br J Haematol
, vol.151
, pp. 327-335
-
-
Choudhury, A.1
Derkow, K.2
Daneshmanesh, A.H.3
-
47
-
-
66649137944
-
RNAi screen for rapid therapeutic target identification in leukemia patients
-
Tyner JW, Deininger MW, Loriaux MM, et al. RNAi screen for rapid therapeutic target identification in leukemia patients. Proc Natl Acad Sci USA 2009;106:8695-700.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 8695-8700
-
-
Tyner, J.W.1
Deininger, M.W.2
Loriaux, M.M.3
-
48
-
-
84879098667
-
Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis
-
Cui B, Zhang S, Chen L, et al. Targeting ROR1 inhibits epithelial-mesenchymal transition and metastasis. Cancer Res 2013;73:3649-60.
-
(2013)
Cancer Res
, vol.73
, pp. 3649-3660
-
-
Cui, B.1
Zhang, S.2
Chen, L.3
-
49
-
-
2342472716
-
Focal adhesion and actin dynamics: A place where kinases and proteases meet to promote invasion
-
Carragher NO, Frame MC. Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol 2004;14:241-9.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 241-249
-
-
Carragher, N.O.1
Frame, M.C.2
-
50
-
-
77953663228
-
Only a subset of Met-activated pathways are required to sustain oncogene addiction
-
Bertotti A, Burbridge MF, Gastaldi S, et al. Only a subset of Met-activated pathways are required to sustain oncogene addiction. Sci Signal 2009;2:er11.
-
(2009)
Sci Signal
, vol.2
, pp. er11
-
-
Bertotti, A.1
Burbridge, M.F.2
Gastaldi, S.3
|