Pharmacological interventions for improved colonic anastomotic healing: A meta-analysis

World Journal of Gastroenterology

Volumn 20, Issue 35, 2014, Pages 12637-12648

  Øines, Mari Nanna ^a   Krarup, Peter Martin ^a   Jorgensen, Lars Nannestad ^a   Ågren, Magnus Sven ^a,b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Anastomotic healing; Breaking strength; Bursting pressure; Collagen; Colorectal surgery; Experimental; Meta analysis

Indexed keywords

APROTININ; ERYTHROPOIETIN; GROWTH HORMONE; ILOPROST; IMMUNOMODULATING AGENT; MATRIX METALLOPROTEINASE INHIBITOR; PROSTACYCLIN DERIVATIVE; PROTEINASE INHIBITOR; SOMATOMEDIN C; TACROLIMUS; GASTROINTESTINAL AGENT;

ANASTOMOSIS LEAKAGE; COLON; COLON ANASTOMOSIS; COLORECTAL SURGERY; HUMAN; HYPERBARIC OXYGEN; INCIDENCE; NONHUMAN; PRESSURE; RECTUM; REVIEW; UPREGULATION; WOUND HEALING; ADVERSE EFFECTS; ANASTOMOSIS; ANASTOMOTIC LEAK; ANIMAL; ANIMAL MODEL; CHI SQUARE DISTRIBUTION; COLON RESECTION; DRUG EFFECTS; META ANALYSIS; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; SURGERY; TIME; TREATMENT OUTCOME;

ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; ANIMALS; CHI-SQUARE DISTRIBUTION; COLECTOMY; COLON; GASTROINTESTINAL AGENTS; HUMANS; MODELS, ANIMAL; RECTUM; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; WOUND HEALING;

EID: 84909619409     PISSN: 10079327     EISSN: 22192840     Source Type: Journal    
DOI: 10.3748/wjg.v20.i35.12637     Document Type: Review

References (103)

1. Peeters KC, Tollenaar RA, Marijnen CA, Klein Kranenbarg E, Steup WH, Wiggers T, Rutten HJ, van de Velde CJ. Risk factors for anastomotic failure after total mesorectal excision of rectal cancer. Br J Surg 2005; 92: 211-216 [PMID: 15584062 DOI: 10.1002/bjs.4806]
2. Krarup PM, Jorgensen LN, Andreasen AH, Harling H. A nationwide study on anastomotic leakage after colonic cancer surgery. Colorectal Dis 2012; 14: e661-e667 [PMID: 22564292 DOI: 10.1111/j.1463-1318.2012.03079.x]
3. Krarup PM, Nordholm-Carstensen A, Jorgensen LN, Harling H. Anastomotic leak increases distant recurrence and long-term mortality after curative resection for colonic cancer: a nationwide cohort study. Ann Surg 2014; 259: 930-938 [PMID: 24045445 DOI: 10.1097/SLA.0b013e3182a6f2fc]
4. Eriksen TF, Lassen CB, Gögenur I. Treatment with corticosteroids and the risk of anastomotic leakage following lower gastrointestinal surgery: a literature survey. Colorectal Dis 2014; 16: O154-O160 [PMID: 24215329 DOI: 10.1111/codi.12490]
5. Klein M, Gögenur I, Rosenberg J. Postoperative use of non-steroidal anti-inflammatory drugs in patients with anastomotic leakage requiring reoperation after colorectal resection: cohort study based on prospective data. BMJ 2012; 345: e6166 [PMID: 23015299 DOI: 10.1136/bmj.e6166]
6. Hendriks T, Mastboom WJ. Healing of experimental intestinal anastomoses. Parameters for repair. Dis Colon Rectum 1990; 33: 891-901 [PMID: 2209281 DOI: 10.1007/BF02051930]
7. Syk I, A˚gren MS, Adawi D, Jeppsson B. Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model. Br J Surg 2001; 88: 228-234 [PMID: 11167872 DOI: 10.1046/j.1365-2168.2001.01649.x]
8. A˚gren MS, Andersen TL, Andersen L, Schiødt CB, Surve V, Andreassen TT, Risteli J, Franzén LE, Delaissé JM, Heegaard AM, Jorgensen LN. Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity. Int J Colorectal Dis 2011; 26: 329-337 [PMID: 21193914 DOI: 10.1007/s00384-010-1106-3]
9. Garcia-Granero A, Frasson M, Flor-Lorente B, Blanco F, Puga R, Carratalá A, Garcia-Granero E. Procalcitonin and C-reactive protein as early predictors of anastomotic leak in colorectal surgery: a prospective observational study. Dis Colon Rectum 2013; 56: 475-483 [PMID: 23478615 DOI: 10.1097/DCR.0b013e31826ce825]
10. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol 2009; 62: 1006-1012 [PMID: 19631508 DOI: 10.1016/j.jclinepi.2009.06.005]
11. Pommergaard HC, Achiam MP, Rosenberg J. External coating of colonic anastomoses: a systematic review. Int J Colorectal Dis 2012; 27: 1247-1258 [PMID: 22907760 DOI: 10.1007/s00384-012-1547-y]
12. Bostanoʇlu S, Dinc¸er S, Keskin A, Bostanoʇlu A, Dursun A, Serim C. Beneficial effect of Iloprost on impaired colonic anastomotic healing induced by intraperitoneal 5-fluorouracil infusion. Dis Colon Rectum 1998; 41: 642-648 [PMID: 9593250 DOI: 10.1007/BF02235275]
13. Galanopoulos G, Pramateftakis MG, Raptis D, Mantzoros I, Kanellos D, Angelopoulos S, Koliakos G, Zaraboukas T, Lazaridis C. The effects of iloprost on colonic anastomotic healing in rats. Tech Coloproctol 2011; 15 Suppl 1: S117-S120 [PMID: 21956403 DOI: 10.1007/s10151-011-0758-5]
14. Vasiliadis K, Pramateftakis MG, Blouhos K, Mantzoros I, Koliakos G, Zaraboukas T, Kanellos I, Demetriades H, Alamdari DH, Betsis D. Effect of iloprost on impaired anastomotic healing caused by 5-fluorouracil plus leucovorin. Dis Colon Rectum 2007; 50: 899-907 [PMID: 17353975 DOI: 10.1007/s10350-006-0878-6]
15. Kiyama T, Tajiri T, Tokunaga A, Yoshiyuki T, Barbul A. Tacrolimus enhances colon anastomotic healing in rats. Wound Repair Regen 2002; 10: 308-313 [PMID: 12406167 DOI: 10.1046/j.1524-475X.2002.t01-1-10506.x]
16. Raptis D, Mantzoros I, Pramateftakis MG, Despoudi K, Zaraboukas T, Koliakos G, Kanellos I, Lazarides Ch. The effects of tacrolimus on colonic anastomotic healing in rats. Int J Colorectal Dis 2012; 27: 299-308 [PMID: 22065109 DOI: 10.1007/s00384-011-1337-y]
17. Schäffer M, Fuchs N, Völker J, Schulz T, Kapischke M, Viebahn R. Differential effect of tacrolimus on dermal and intestinal wound healing. J Invest Surg 2005; 18: 71-79 [PMID: 16036775 DOI: 10.1080/08941930590926294]
18. Dinc S, Gulcelik MA, Kuru B, Ergeneci D, Camlibel M, Caydere M, Alagol H. Effects of locally applied recombinant human granulocyte-macrophage colony-stimulating factor on ischemic bowel anastomoses in rat. Eur Surg Res 2004; 36: 59-63 [PMID: 14730225 DOI: 10.1159/000075076]
19. Fatouros MS, Vekinis G, Bourantas KL, Mylonakis EP, Scopelitou AS, Malamou-Mitsis VD, Kappas AM. Influence of growth factors erythropoietin and granulocyte macrophage colony stimulating factor on mechanical strength and healing of colonic anastomoses in rats. Eur J Surg 1999; 165: 986-992 [PMID: 10574109 DOI: 10.1080/110241599750008143]
20. Demirer S, Sengül N, Inan A, Eroʇlu A, Bumin C, Kuterdem E. Effect of recombinant human granulocyte/macrophage colony-stimulating factor on the healing of colonic anastomosis in rats. J Invest Surg 2001; 14: 221-225 [PMID: 11680532 DOI: 10.1080/089419301750420250]
21. Tadros T, Wobbes T, Hendriks T. Opposite effects of interleukin-2 on normal and transfusion-suppressed healing of experimental intestinal anastomoses. Ann Surg 1993; 218: 800-808 [PMID: 8257231]
22. Cakmak GK, Irkorucu O, Ucan BH, Tascilar O, Emre AU, Karakaya K, Bahadir B, Acikgoz S, Pasaoglu H, Ankarali H, Ugurbas E, Demirtas C, Comert M. The effects of resveratrol on the healing of left colonic anastomosis. J Invest Surg 2009; 22: 353-361 [PMID: 19842890 DOI: 10.1080/08941930903214701]
23. Bedirli A, Salman B, Pasaoglu H, Ofluoglu E, Sakrak O. Effects of nuclear factor-κB inhibitors on colon anastomotic healing in rats. J Surg Res 2011; 171: 355-360 [PMID: 20605167 DOI: 10.1016/j.jss.2010.01.028]
24. Cali RL, Smyrk TC, Blatchford GJ, Thorson AG, Christensen MA. Effect of prostaglandin E1 and steroid on healing colonic anastomoses. Dis Colon Rectum 1993; 36: 1148-1151 [PMID: 8253012 DOI: 10.1007/BF02052264]
25. Kaplan M, Mentes BB, Tatlicioʇlu E, Kayhan B, Aybay C. Effect of mucosal immunomodulation with fed cholera toxin on healing of experimental colonic anastomosis. Dis Colon Rectum 2002; 45: 819-825 [PMID: 12072636 DOI: 10.1007/s10350-004-6303-0]
26. Okada M, Bothin C, Kanazawa K, Midtvedt T. Experimental study of the influence of intestinal flora on the healing of intestinal anastomoses. Br J Surg 1999; 86: 961-965 [PMID: 10417574 DOI: 10.1046/j.1365-2168.1999.01161.x]
27. Rosin RD, Exarchakos G, Gilmore OJ, Ellis H. Topical noxythiolin in colonic healing. Br J Surg 1978; 65: 603-606 [PMID: 698527]
28. Törkvist L, Ma˚nsson P, Raud J, Larsson J, Thorlacius H. Role of CD18-dependent neutrophil recruitment in skin and intestinal wound healing. Eur Surg Res 2001; 33: 249-254 [PMID: 11684830 DOI: 10.1159/000049714]
29. Aguilar-Nascimento JE, Prado S, Zaffani G, Salomão AB, Neves Jde S, Dock-Nascimento DB, Mello PR, Okay TS. Perioperative administration of probiotics: effects on immune response, anastomotic resistance and colonic mucosal trophism. Acta Cir Bras 2006; 21 Suppl 4: 80-83 [PMID: 17293972 DOI: 10.1590/S0102-86502006001000017]
30. Aslan A, Temiz M, Hakverdi S, Polat G, Tumer C, Temiz A, Canbolant E. Effect of mesalamine on healing in experimental colon anastomosis: a randomised experimental study. Int J Surg 2008; 6: 40-44 [PMID: 18088577 DOI: 10.1016/j.ijsu.2007.09.003]
31. Teke Z, Sacar M, Yenisey C, Atalay AO, Bicakci T, Erdem E. Activated protein C prevents deleterious effects of remote reperfusion injury caused by intestinal ischemia on wound healing in the left colonic anastomoses: an experimental study in the murine model. Am J Surg 2008; 196: 774-787 [PMID: 18466864 DOI: 10.1016/j.amjsurg.2007.09.039]
32. Teke Z, Aytekin FO, Kabay B, Yenisey C, Aydin C, Tekin K, Sacar M, Ozden A. Pyrrolidine dithiocarbamate prevents deleterious effects of remote ischemia/reperfusion injury on healing of colonic anastomoses in rats. World J Surg 2007; 31: 1835-1842 [PMID: 17566823 DOI: 10.1007/s00268-007-9106-3]
33. Colak T, Nayci A, Polat G, Polat A, Comelekoglu U, Kanik A, Turkmenoglu O, Aydin S. Effects of trapidil on the healing of colonic anastomoses in an experimental rat model. ANZ J Surg 2003; 73: 916-921 [PMID: 14616570 DOI: 10.1046/j.1445-2197.2003.02683.x]
34. Faruquzzaman SK. The healing role of erythropoietin in the obstructive vs nonobstructive left colonic anastomosis. Bratisl Lek Listy 2009; 110: 530-535 [PMID: 19827335]
35. Kaemmer DA, Otto J, Binneboesel M, Klink C, Krones C, Jansen M, Cloer C, Oettinger A, Schumpelick V, Klinge U. Erythropoietin (EPO) influences colonic anastomotic healing in a rat model by modulating collagen metabolism. J Surg Res 2010; 163: e67-e72 [PMID: 20739030 DOI: 10.1016/j.jss.2010.04.053]
36. Moran M, Ozmen MM, Duzgun AP, Gok R, Renda N, Seckin S, Coskun F. The effect of erythropoietin on healing of obstructive vs nonobstructive left colonic anastomosis: an experimental study. World J Emerg Surg 2007; 2: 13 [PMID: 17502005 DOI: 10.1186/1749-7922-2-13]
37. Ozel Turkcu U, Cakmak GK, Demir EO, Bakkal H, Oner MO, Okyay RD, Bassorgun IC, Ciftcioglu MA. The effect of erythropoietin on anastomotic healing of irradiated rats. J Invest Surg 2012; 25: 127-135 [PMID: 22149012 DOI: 10.3109/08941939.2011.611583]
38. Adas M, Kemik O, Adas G, Arikan S, Kuntsal L, Kapran Y, Toklu AS. Is combined therapy more effective than growth hormone or hyperbaric oxygen alone in the healing of left ischemic and non-ischemic colonic anastomoses? Clinics (Sao Paulo) 2013; 68: 1440-1445 [PMID: 24270957 DOI: 10.6061/clinics/2013(11)10]
39. Christensen H, Oxlund H, Laurberg S. Growth hormone increases the bursting strength of colonic anastomoses. An experimental study in the rat. Int J Colorectal Dis 1990; 5: 130-134 [PMID: 2212841 DOI: 10.1007/BF00300401]
40. Christensen H, Oxlund H, Laurberg S. Postoperative biosynthetic human growth hormone increases the strength and collagen deposition of experimental colonic anastomoses. Int J Colorectal Dis 1991; 6: 133-138 [PMID: 1744483 DOI: 10.1007/BF00341232]
41. Christensen H, Flyvbjerg A. Dose-dependent stimulatory effect of human growth hormone on the strength and collagen deposition of colonic anastomoses in the rat. Acta Endocrinol (Copenh) 1992; 126: 438-443 [PMID: 1621489 DOI: 10.1530/acta.0.1260438]
42. Christensen H, Oxlund H. Growth hormone increases the collagen deposition rate and breaking strength of left colonic anastomoses in rats. Surgery 1994; 116: 550-556 [PMID: 8079185]
43. Karahasanoglu T, Altinli E, Hamzaoglu I, Paksoy M, Yeşildere T, Alemdaroglu K. Effect of growth hormone treatment on the healing of left colonic anastomoses in protein-malnourished rats. Br J Surg 1998; 85: 931-933 [PMID: 9692566 DOI: 10.1046/j.1365-2168.1998.00696.x]
44. Egger B, Inglin R, Zeeh J, Dirsch O, Huang Y, Büchler MW. Insulin-like growth factor I and truncated keratinocyte growth factor accelerate healing of left-sided colonic anastomoses. Br J Surg 2001; 88: 90-98 [PMID: 11136318 DOI: 10.1046/j.1365-2168.2001.01617.x]
45. Mantzoros I, Kanellos I, Angelopoulos S, Koliakos G, Pramateftakis MG, Kanellos D, Zacharakis E, Zaraboukas T, Betsis D. The effect of insulin-like growth factor I on healing of colonic anastomoses in cortisone-treated rats. Dis Colon Rectum 2006; 49: 1431-1438 [PMID: 16826333 DOI: 10.1007/s10350-006-0603-5]
46. Petersen TI, Kissmeyer-Nielsen P, Flyvbjerg A, Laurberg S, Christensen H. Effect of insulin-like growth factor I (IGF-I) administration on the healing of colonic anastomoses in rats. Int J Colorectal Dis 1996; 11: 19-24 [PMID: 8919336 DOI: 10.1007/BF00418850]
47. Zacharakis E, Demetriades H, Kanellos D, Sapidis N, Zacharakis E, Mantzoros I, Kanellos I, Koliakos G, Zaraboukas T, Topouridou K, Betsis D. Contribution of insulin-like growth factor I to the healing of colonic anastomoses in rats. J Invest Surg 2007; 20: 9-14 [PMID: 17365402 DOI: 10.1080/08941930601126074]
48. Egger B, Tolmos J, Procaccino F, Sarosi I, Friess H, Büchler MW, Stamos M, Eysselein VE. Keratinocyte growth factor promotes healing of left-sided colon anastomoses. Am J Surg 1998; 176: 18-24 [PMID: 9683126 DOI: 10.1016/S0002-9610(98)00104-4]
49. Karaman K, Bostanci EB, Dincer N, Ulas M, Ozer I, Dalgic T, Ercin U, Bilgihan A, Ginis Z, Akoglu M. Effects of thyroid hormone supplementation on anastomotic healing after segmental colonic resection. J Surg Res 2012; 176: 460-467 [PMID: 22316672 DOI: 10.1016/j.jss.2011.11.1015]
50. Sakalloglu AE, Yagmurlu A, Dindar H, Hasirci N, Renda N, Gokcora IH. Effects of low-dose epidermal growth factor loaded gelatin microspheres in colonic anastomosis. Technol Health Care 2002; 10: 328-331
51. Ishii M, Tanaka E, Imaizumi T, Sugio Y, Sekka T, Tanaka M, Yasuda M, Fukuyama N, Shinozaki Y, Hyodo K, Tanioka K, Mochizuki R, Kawai T, Mori H, Makuuchi H. Local VEGF administration enhances healing of colonic anastomoses in a rabbit model. Eur Surg Res 2009; 42: 249-257 [PMID: 19346745 DOI: 10.1159/000210671]
52. Tasdelen A, Algin C, Ates E, Kiper H, Inal M, Sahin F. Effect of leptin on healing of colonic anastomoses in rats. Hepatogastroenterology 2004; 51: 994-997 [PMID: 15239232]
53. Yol S, Tekin A, Yilmaz H, Küc¸ükkartallar T, Esen H, Caglayan O, Tatkan Y. Effects of platelet rich plasma on colonic anastomosis. J Surg Res 2008; 146: 190-194 [PMID: 18028949 DOI: 10.1016/j.jss.2007.05.015]
54. Saribeyoʇlu K, Baca B, Hamzaoʇlu I, Pekmezci S, Karahasanoʇlu T, Hamzaoʇlu H. Does becaplermin (platelet-derived growth factor-BB) reverse detrimental effects of ischemia on colonic anastomosis? Dis Colon Rectum 2003; 46: 516-520 [PMID: 12682547 DOI: 10.1097/01.DCR.0000054663.95931.A0]
55. Redstone HA, Buie WD, Hart DA, Wallace L, Hornby PJ, Sague S, Holst JJ, Sigalet DL. The effect of glucagon-like Peptide-2 receptor agonists on colonic anastomotic wound healing. Gastroenterol Res Pract 2010; 2010: [PMID: 20953406 DOI: 10.1155/2010/672453]
56. Ozdogan M, Oruk I, Renda N, Kaynaroglu V, Baykal A. The effect of exogenous melatonin on experimental colonic anastomosis. Acta Chir Belg 2005; 105: 302-305 [PMID: 16018525]
57. Colak T, Dag A, Turkmenoglu O, Polat A, Comelekoglu U, Bagdatoglu O, Polat G, Akca T, Sucullu I, Aydin S. The effect of octreotide on healing of injured colonic anastomosis with immediate postoperative intraperitoneal administration of 5-Fluorouracil. Dis Colon Rectum 2007; 50: 660-669 [PMID: 17216142 DOI: 10.1007/s10350-006-0810-0]
58. Apostolidis SA, Michalopoulos AA, Papadopoulos VN, Paramythiotis D, Zatagias A, Gigis P, Harlaftis N. Effect of ranitidine on healing of normal and transfusion-suppressed experimental anastomoses. Tech Coloproctol 2004; 8 Suppl 1: s104-s107 [PMID: 15655589 DOI: 10.1007/s10151-004-0126-9]
59. Erenoʇlu C, Uluutku H, Emeksiz S, Akin ML, Foley E, Celenk T. Effect of hyperbaric oxygen on anastomoses created under the influence of 5-FU. Undersea Hyperb Med 2003; 30: 321-326 [PMID: 14756235]
60. Hamzaoʇlu I, Karahasanoʇlu T, Aydin S, Sahin DA, Carkman S, Sariyar M, Alemdaroʇlu K. The effects of hyperbaric oxygen on normal and ischemic colon anastomoses. Am J Surg 1998; 176: 458-461 [PMID: 9874433 DOI: 10.1016/S0002-9610(98)00234-7]
61. Kirk D, Irvin TT. The role of oxygen therapy in the healing of experimental skin wounds and colonic anastomosis. Br J Surg 1977; 64: 100-103 [PMID: 890244]
62. Yagci G, Ozturk E, Ozgurtas T, Gorgulu S, Kutlu OC, Topal T, Cetiner S, Tufan T. Preoperative and postoperative administration of hyperbaric oxygen improves biochemical and mechanical parameters on ischemic and normal colonic anastomoses. J Invest Surg 2006; 19: 237-244 [PMID: 16835138 DOI: 10.1080/08941930600778230]
63. Schietroma M, Carlei F, Cecilia EM, Piccione F, Bianchi Z, Amicucci G. Colorectal Infraperitoneal anastomosis: the effects of perioperative supplemental oxygen administration on the anastomotic dehiscence. J Gastrointest Surg 2012; 16: 427-434 [PMID: 21975687 DOI: 10.1007/s11605-011-1717-1]
64. Binnebösel M, Junge K, Kaemmer DA, Krones CJ, Titkova S, Anurov M, Schumpelick V, Klinge U. Intraperitoneally applied gentamicin increases collagen content and mechanical stability of colon anastomosis in rats. Int J Colorectal Dis 2009; 24: 433-440 [PMID: 19050902 DOI: 10.1007/s00384-008-0614-x]
65. Subhas G, Bhullar JS, Cook J, Shah A, Silberberg B, Andrus L, Decker M, Mittal VK. Topical gentamicin does not provide any additional anastomotic strength when combined with fibrin glue. Am J Surg 2011; 201: 339-343 [PMID: 21367375 DOI: 10.1016/j.amjsurg.2010.09.022]
66. LeVeen HH, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M. Effects of prophylactic antibiotics on colonic healing. Am J Surg 1976; 131: 47-53 [PMID: 1247153 DOI: 10.1016/0002-9610(76)90419-0]
67. Ugurlu L, Turan M, Canbay E, Elagöz S, Sen M. Effect of nifedipine on the healing of left colonic anastomoses in rats. Surg Today 2003; 33: 902-908 [PMID: 14669080 DOI: 10.1007/s00595-003-2633-0]
68. Turan M, Saraydin SU, Canbay E, Karadayi K, Bulut E, Cetinkaya O, Elagöz S, Sen M. Positive effects of phenytoin on experimental colonic anastomoses. Int J Colorectal Dis 2004; 19: 250-257 [PMID: 14508600 DOI: 10.1007/s00384-003-0533-9]
69. Bark S, Rettura G, Goldman D, Seifter E, Levenson SM, Demetriou AA. Effect of supplemental vitamin A on the healing of colon anastomosis. J Surg Res 1984; 36: 470-474 [PMID: 6727324 DOI: 10.1016/0022-4804(84)90128-8]
70. Karadeniz Cakmak G, Irkorucu O, Ucan BH, Emre AU, Bahadir B, Demirtas C, Tascilar O, Karakaya K, Acikgoz S, Kertis G, Ankarali H, Pasaoglu H, Comert M. Simvastatin improves wound strength after intestinal anastomosis in the rat. J Gastrointest Surg 2009; 13: 1707-1716 [PMID: 19578821 DOI: 10.1007/s11605-009-0951-2]
71. Tümer AR, Kama NA, Tümer L, Reis E, Müftüoʇlu S. Effects of 5-fluorouracil and zinc on healing of colonic anastomoses in rabbits. Eur J Surg 1999; 165: 369-377 [PMID: 10365840 DOI: 10.1080/110241599750006929]
72. A˚gren MS, Andersen L, Heegaard AM, Jorgensen LN. Effect of parenteral zinc sulfate on colon anastomosis repair in the rat. Int J Colorectal Dis 2008; 23: 857-861 [PMID: 18563421 DOI: 10.1007/s00384-008-0501-5]
73. Mätzsch T, Bergqvist D, Blomquist P, Jiborn H. Influence of standard heparin or low molecular weight heparin on healing of abdominal wounds and colonic anastomoses in rats. Acta Chir Scand 1987; 153: 593-598 [PMID: 2829481]
74. Benoit J, Meddahi A, Ayoub N, Barritault D, Sezeur A. New healing agent for colonic anastomosis. Int J Colorectal Dis 1998; 13: 78-81 [PMID: 9638492 DOI: 10.1007/s003840050139]
75. Meddahi A, Benoit J, Ayoub N, Sézeur A, Barritault D. Heparin-like polymers derived from dextran enhance colonic anastomosis resistance to leakage. J Biomed Mater Res 1996; 31: 293-297 [PMID: 8806053]
76. Hotz B, Hotz HG, Arndt M, Holmer C, Buhr HJ, Ritz JP. Fluid resuscitation with human albumin or hydroxyethyl starch - are there differences in the healing of experimental intestinal anastomoses? Scand J Gastroenterol 2010; 45: 106-114 [PMID: 19961343 DOI: 10.3109/00365520903369946]
77. Marjanovic G, Villain C, Juettner E, zur Hausen A, Hoeppner J, Hopt UT, Drognitz O, Obermaier R. Impact of different crystalloid volume regimes on intestinal anastomotic stability. Ann Surg 2009; 249: 181-185 [PMID: 19212167 DOI: 10.1097/SLA.0b013e31818b73dc]
78. Wang P, Gong G, Li Y, Li J. Hydroxyethyl starch 130/0.4 augments healing of colonic anastomosis in a rat model of peritonitis. Am J Surg 2010; 199: 232-239 [PMID: 19897171 DOI: 10.1016/j.amjsurg.2009.01.023]
79. de Hingh IH, Siemonsma MA, de Man BM, Lomme RM, Hendriks T. The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat. Int J Colorectal Dis 2002; 17: 348-354 [PMID: 12172929 DOI: 10.1007/s00384-002-0418-3]
80. Kiyama T, Onda M, Tokunaga A, Efron DT, Barbul A. Effect of matrix metalloproteinase inhibition on colonic anastomotic healing in rats. J Gastrointest Surg 2001; 5: 303-311 [PMID: 11360054 DOI: 10.1016/S1091-255X(01)80052-4]
81. Pasternak B, Rehn M, Andersen L, Agren MS, Heegaard AM, Tengvall P, Aspenberg P. Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses. Int J Colorectal Dis 2008; 23: 271-276 [PMID: 18043927 DOI: 10.1007/s00384-007-0401-0]
82. Siemonsma MA, de Hingh IH, de Man BM, Lomme RM, Verhofstad AA, Hendriks T. Doxycycline improves wound strength after intestinal anastomosis in the rat. Surgery 2003; 133: 268-276 [PMID: 12660638 DOI: 10.1067/msy.2003.27]
83. Delaney P, Lalor D. Enzyme inhibition in colorectal surgery. Br J Surg 1976; 63: 23-24 [PMID: 178396]
84. Young HL, Wheeler MH. Effect of intravenous aprotinin (Trasylol) on the healing of experimental colonic anastomoses in the rabbit. Eur Surg Res 1983; 15: 18-23 [PMID: 6188616]
85. Uzunköy A, Akinci OF, Coskun A, Aslan O, Kocyigit A. Effects of antiadhesive agents on the healing of intestinal anastomosis. Dis Colon Rectum 2000; 43: 370-375 [PMID: 10733119 DOI: 10.1007/BF02258304]
86. Sheridan WG, Shandall AA, Alexander-Williams J, Keighley MR, Boulos PB, Young HL. A multicenter trial of the use of the proteolytic enzyme inhibitor aprotinin in colorectal surgery. Dis Colon Rectum 1989; 32: 505-508 [PMID: 2477204 DOI: 10.1007/BF02554507]
87. Thompson SK, Chang EY, Jobe BA. Clinical review: Healing in gastrointestinal anastomoses, part I. Microsurgery 2006; 26: 131-136 [PMID: 16518804 DOI: 10.1002/micr.20197]
88. Rijcken E, Sachs L, Fuchs T, Spiegel HU, Neumann PA. Growth factors and gastrointestinal anastomotic healing. J Surg Res 2014; 187: 202-210 [PMID: 24290527 DOI: 10.1016/j.jss.2013.10.013]
89. A˚gren MS, Andersen TL, Mirastschijski U, Syk I, Schiødt CB, Surve V, Lindebjerg J, Delaissé JM. Action of matrix metalloproteinases at restricted sites in colon anastomosis repair: an immunohistochemical and biochemical study. Surgery 2006; 140: 72-82 [PMID: 16857445 DOI: 10.1016/j.surg.2005.12.013]
90. Oxlund H, Christensen H, Seyer-Hansen M, Andreassen TT. Collagen deposition and mechanical strength of colon anastomoses and skin incisional wounds of rats. J Surg Res 1996; 66: 25-30 [PMID: 8954827 DOI: 10.1006/jsre.1996.0367]
91. Sorg H, Harder Y, Krueger C, Reimers K, Vogt PM. The nonhematopoietic effects of erythropoietin in skin regeneration and repair: from basic research to clinical use. Med Res Rev 2013; 33: 637-664 [PMID: 22430919 DOI: 10.1002/med.21259]
92. Thorey IS, Hinz B, Hoeflich A, Kaesler S, Bugnon P, Elmlinger M, Wanke R, Wolf E, Werner S. Transgenic mice reveal novel activities of growth hormone in wound repair, angiogenesis, and myofibroblast differentiation. J Biol Chem 2004; 279: 26674-26684 [PMID: 15070902 DOI: 10.1074/jbc.M311467200]
93. Ashcroft GS, Mills SJ. Androgen receptor-mediated inhibition of cutaneous wound healing. J Clin Invest 2002; 110: 615-624 [PMID: 12208862 DOI: 10.1172/JCI15704]
94. Rijcken E, Fuchs T, Sachs L, Kersting CM, Bruewer M, Krieglstein CF. Insulin-like growth factor 1-coated sutures improve anastomotic healing in an experimental model of colitis. Br J Surg 2010; 97: 258-265 [PMID: 20084676 DOI: 10.1002/bjs.6781]
95. Shandall A, Lowndes R, Young HL. Colonic anastomotic healing and oxygen tension. Br J Surg 1985; 72: 606-609 [PMID: 3896373 DOI: 10.1002/bjs.1800720808]
96. Azevedo LA, Parra RS, Da Rocha JJ, Ramalho LN, Ramalho FS, Féres O. Hyperbaric oxygen on the healing of ischemic colonic anastomosis - an experimental study in rats. Undersea Hyperb Med 2010; 37: 405-411 [PMID: 21226391]
97. Meyhoff CS, Wetterslev J, Jorgensen LN, Henneberg SW, Høgdall C, Lundvall L, Svendsen PE, Mollerup H, Lunn TH, Simonsen I, Martinsen KR, Pulawska T, Bundgaard L, Bugge L, Hansen EG, Riber C, Gocht-Jensen P, Walker LR, Bendtsen A, Johansson G, Skovgaard N, Heltø K, Poukinski A, Korshin A, Walli A, Bulut M, Carlsson PS, Rodt SA, Lundbech LB, Rask H, Buch N, Perdawid SK, Reza J, Jensen KV, Carlsen CG, Jensen FS, Rasmussen LS. Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial. JAMA 2009; 302: 1543-1550 [PMID: 19826023 DOI: 10.1001/jama.2009.1452]
98. Toriseva M, Kähäri VM. Proteinases in cutaneous wound healing. Cell Mol Life Sci 2009; 66: 203-224 [PMID: 18810321 DOI: 10.1007/s00018-008-8388-4]
99. Mirastschijski U, Johannesson K, Jeppsson B, A˚gren MS. Effect of a matrix metalloproteinase activity and TNF-alpha converting enzyme inhibitor on intra-abdominal adhesions. Eur Surg Res 2005; 37: 68-75 [PMID: 15818044 DOI: 10.1159/000083150]
100. Terrin N, Schmid CH, Lau J. In an empirical evaluation of the funnel plot, researchers could not visually identify publication bias. J Clin Epidemiol 2005; 58: 894-901 [PMID: 16085192 DOI: 10.1016/j.jclinepi.2005.01.006]
101. Goodyear SJ, Leung E, Menon A, Pedamallu S, Williams N, Wong LS. The effects of population-based faecal occult blood test screening upon emergency colorectal cancer admissions in Coventry and north Warwickshire. Gut 2008; 57: 218-222 [PMID: 18048571 DOI: 10.1136/gut.2007.120253]
102. Cuffy M, Abir F, Audisio RA, Longo WE. Colorectal cancer presenting as surgical emergencies. Surg Oncol 2004; 13: 149-157 [PMID: 15572097 DOI: 10.1016/j.suronc.2004.08.002]
103. Iversen LH, Bülow S, Christensen IJ, Laurberg S, Harling H. Postoperative medical complications are the main cause of early death after emergency surgery for colonic cancer. Br J Surg 2008; 95: 1012-1019 [PMID: 18563787 DOI: 10.1002/bjs.6114]