Simvastatin improves wound strength after intestinal anastomosis in the rat

Journal of Gastrointestinal Surgery

Volumn 13, Issue 9, 2009, Pages 1707-1716

  Cakmak, G Karadeniz ^a,c   Irkorucu, O ^a   Ucan, B H ^a   Emre, A U ^a   Bahadir, B ^a   Demirtas, C ^b   Tascilar, O ^a   Karakaya, K ^a   Acikgoz, S ^a   Kertis, G ^a   Ankarali, H ^a   Pasaoglu, H ^b   Comert, M ^a  

^a ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

^c ZONGULDAK KARAELMAS UNIVERSITY   (Turkey)

Author keywords

Anatomosis; Bursting pressure; Dehiscence; Hydroxyproline; Simvastatin; Wound healing

Indexed keywords

COLLAGEN; SIMVASTATIN;

ANALYSIS OF VARIANCE; ANASTOMOSIS; ANIMAL; ARTICLE; COLON RESECTION; COMPARATIVE STUDY; COMPRESSIVE STRENGTH; DISEASE MODEL; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INTESTINE; MALE; METABOLISM; METHODOLOGY; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; RAT; REFERENCE VALUE; WISTAR RAT; WOUND HEALING;

ANALYSIS OF VARIANCE; ANASTOMOSIS, SURGICAL; ANIMALS; COLECTOMY; COLLAGEN; COMPRESSIVE STRENGTH; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; INTESTINES; MALE; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE VALUES; SIMVASTATIN; WOUND HEALING;

EID: 70349434727     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-009-0951-2     Document Type: Article

References (38)

1. Herbey II, Ivankova NV, Katkoori VR, Mamaeva OA. Colorectal cancer and hypercholesterolemia: review of current research. Exp Oncol 2005;27(3):166-178.
2. Kwak B, Mulhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 2000;6:1399-1402. doi:10.1038/82219.
3. Pruefer D, Makowski J, Schnell M, Buerke U, Dahm M, Oelert H, Sibelius U, Grandel U, Grimminger F, Seeger W, Meyer J, Darius H, Buerke M. Simvastatin inhibits inflammatory properties of Staphylococcus aureus alpha toxin. Circulation 2003;15:2104-2110.
4. Merx MW, Liehn EA, Graf J, van de Sandt A, Schaltenbrand M, Schrader J, Hanrath P, Weber C. Statin treatment after onset of sepsis in a murine model improves survival. Circulation 2005;112(1):117-124. doi:10.1161/CIRCULATIONAHA.104.502195.
5. Yang YX, Hennessy S, Propert K, Hwang WT, Sarkar M, Lewis JD. Chronic statin therapy and the risk of colorectal cancer. Pharmacoepidemiol Drug Saf 2008;17(9):869-876. doi:10.1002/pds.1599.
6. Rugale C, Delbosc S, Mimran A, Jover B. Simvastatin reverses target organ damage and oxidative stress in angiotensin II hypertension: comparison with apocynin, tempol, and hydralazine. J Cardiovasc Pharmacol 2007;50(3):293-298.
7. Laws PE, Spark JI, Cowled PA, Fitridge RA. The role of statins in vascular disease. Eur J Vasc Endovasc Surg 2004;27(1):6-16. doi:10.1016/j.ejvs.2003.09.014.
8. Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS, Low M, Greenson JK, Rennert G. Statins and the risk of colorectal cancer. N Engl J Med 2005;352:2184-2192. doi:10.1056/NEJMoa043792.
9. Hoffmeister M, Chang-Claude J, Brenner H. Individual and joint use of statins and low-dose aspirin and risk of colorectal cancer: a population-based case-control study. Int J Cancer 2007;121(6):1325-1330. doi:10.1002/ijc.22796.
10. McArdle CS, McMillan DC, Hole DJ. Impact of anastomotic leakage on long-term survival of patients undergoing curative resection for colorectal cancer. Br J Surg 2005;92(9):1150-1154. doi:10.1002/bjs.5054.
11. Hulka JF, Omran K, Berger GS. Classification of adnexal adhesions: a proposal and evaluation of its prognostic value. Fertil Steril 1978;41:661-665.
12. Jamall IS, Finelli VN, Que Hee SS. A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues. Anal Biochem 1981;15:70-75. doi:10.1016/0003-2697(81)90261-X.
13. Hunter MIS, Nlemadi{dotless}m BC, Davidson DIW. Lipid peroxidation products and antioxidant proteins in plasma and cerebrospinal fluid from multiple sclerosis patients. Neurochem Res 1985;10:1645-52. doi:10.1007/BF00988606.
14. Eckerson HW, Wyte CM, La Du BN. The human serum paraoxanase/arylesterase polymorphism. Hum Genet 1983;35:1126-1138.
15. Chiu CJ, McArdle AH, Brown R et al. Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal. Arch Surg 1970;101:478-483.
16. Houdart R, Lavergne A, Galian A et al. Evolution anatomo-pathologique des anastomoses digestives bord a bord en un plan. Etude de 210 anastomoses coliques chez le rat de 2e and 180e jour. Gastroenterol Clin Biol 1983;7:465-473.
17. Hutschenreiter G, Haina D, Paulini K et al. Wundheilung nach laser und rotlichtbestralung. Z Exp Chir 1980;13:75-85.
18. Garcia JC, Arias C, Garci{dotless}'a C et al. Modificacio'n de los mediadores inflamatorios en isquemia-reperfusio'n intestinal en unmodelo de diabetes tipo II. Cir Esp 2002;71:276-286.
19. Walker KG, Bell SW, Rickard MJ et al. Anastomotic leakage is predictive of diminished survival after potentially curative resection for colorectal cancer. Ann Surg 2004;240:255-259. doi:10.1097/01.sla.0000133186.81222.08.
20. Bonovas S, Filioussi K, Flordellis CS, Sitaras NM. Statins and the risk of colorectal cancer: a meta-analysis of 18 studies involving more than 1.5 million patients. J Clin Oncol 2007;25(23):3462-3468. doi:10.1200/JCO.2007.10.8936.
21. Coogan PF, Smith J, Rosenberg L. Statin use and risk of colorectal cancer. J Natl Cancer Inst 2007;99(1):32-40.
22. Adah F, Benghuzzi H, Tucci M, Russell G, England B. Cholesterol production inhibitor (statin) increased bone healing in surgically created femoral defect in an animal model. Biomed Sci Instrum 2007;43:95-103.
23. Serin-Kilicoglu S, Erdemli E. New addition to the statin's effect. J Trauma 2007;63(1):187-191. doi:10.1097/01.TA.0000240974.07999.bc.
24. Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-1010. doi:10.1038/79510.
25. Weis M, Heeschen C, Glassford AJ, Cooke JP. Statins have biphasic effects on angiogenesis. Circulation 2002;105:739-745. doi:10.1161/hc0602.103393.
26. Demierre MF, Higgins PD, Gruber SB, Hawk E, Lippman SM. Statins and cancer prevention. Nat Rev Cancer 2005;5(12):930-942. doi:10.1038/nrc1751.
27. Park KW, Hwang KK, Cho HJ, Hur J, Yang HM, Yoon CH, Kang HJ, Oh BH, Park YB, Kim HS. Simvastatin enhances endothelial differentiation of peripheral blood mononuclear cells in hypercholesterolemic patients and induces pro-angiogenic cytokine IL-8 secretion from monocytes. Clin Chim Acta 2008;388(1-2):156-166. doi:10.1016/j.cca.2007.10.027.
28. Takenaka M, Hirade K, Tanabe K, Akamatsu S, Dohi S, Matsuno H, Kozawa O. Simvastatin stimulates VEGF release via p44/p42 MAP kinase in vascular smooth muscle cells. Biochem Biophys Res Commun 2003;301(1):198-203. doi:10.1016/S0006-291X(02)03014-0.
29. Thornton FJ, Barbul A. Healing in the gastrointestinal tract. Surg Clin North Am 1997;77:549-573. doi:10.1016/S0039-6109(05)70568-5.
30. Cowled PA, Khanna A, Laws PE, Field JB, Varelias A, Fitridge RA. Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury. J Surg Res 2007;141(2):267-276. doi:10.1016/j.jss.2006.11.021.
31. Shao H, Shen Y, Liu H, Dong G, Qiang J, Jing H. Simvastatin suppresses lung inflammatory response in a rat cardiopulmonary bypass model. Ann Thorac Surg 2007;84(6):2011-2018. doi:10.1016/j.athoracsur.2007.07.022.
32. Syk I, Ågren MS, Adawi D et al. Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental model. Br J Surg 2001;88:228-234. doi:10.1046/j.1365-2168.2001.01649.x.
33. de Hingh IH, Siemonsma MA, de Man BM et al. The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the rat. Int J Colorectal Dis 2002;17:348-354. doi:10.1007/s00384-002-0418-3.
34. Ferri N, Colombo G, Ferrandi C, Raines EW, Levkau B, Corsini A. Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol 2007;27(5):1043. doi:10.1161/ATVBAHA.107.139881.
35. Nomura S, Yoshimura K, Akiyama N, Mikamo A, Furutani A, Aoki H, Matsuzaki M, Hamano K. HMG-CoA reductase inhibitors reduce matrix metalloproteinase-9 activity in human varicose veins. Eur Surg Res 2005;37(6):370-378. doi:10.1159/000090339.
36. Turner NA, O'Regan DJ, Ball SG et al. Simvastatin inhibitsMMP-9 secretion from human saphenous vein smooth muscle cells by inhibiting the RhoA/ROCK pathway and reducing MMP-9 mRNA levels. FASEB J 2005;19:804.
37. Sun XF, Wang LL, Wang JK, Yang J, Zhao H, Wu BY, Wang YF, Wang L. Effects of simvastatin on lung injury induced by ischaemia-reperfusion of the hind limbs in rats. J Int Med Res 2007;35(4):523-533.
38. Aarons CB, Cohen PA, Gower A, Reed KL, Leeman SE, Stucchi AF, Becker JM. Statins (HMG-CoA reductase inhibitors) decrease postoperative adhesions by increasing peritoneal fibrinolytic activity. Ann Surg 2007;245(2):176-184. doi:10.1097/01.sla.0000236627.07927.7c.