Anastomotic leak increases distant recurrence and long-term mortality after curative resection for colonic cancer: A nationwide cohort study

Annals of Surgery

Volumn 259, Issue 5, 2014, Pages 930-938

  Krarup, Peter Martin ^a   Nordholm Carstensen, Andreas ^a   Jorgensen, Lars N ^a   Harling, Henrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

adjuvant chemotherapy; anastomotic leakage; colon cancer; mortality; nationwide; recurrence

Indexed keywords

FLUOROURACIL; FOLINIC ACID; OXALIPLATIN;

ADJUVANT CHEMOTHERAPY; ADULT; AGED; ANASTOMOSIS LEAKAGE; ARTICLE; BLOOD TRANSFUSION; CANCER COMBINATION CHEMOTHERAPY; CANCER MORTALITY; CANCER PATIENT; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHARLSON COMORBIDITY INDEX; COHORT ANALYSIS; COLON CANCER; COLON RESECTION; COMPUTER ASSISTED TOMOGRAPHY; CONTRAST ENHANCEMENT; DISTANT METASTASIS; FEMALE; FOLLOW UP; HEMICOLECTOMY; HUMAN; INCIDENCE; LAPAROSCOPY; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; OVERALL SURVIVAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK FACTOR; SURGICAL APPROACH;

AGED; AGED, 80 AND OVER; ANASTOMOSIS, SURGICAL; ANASTOMOTIC LEAK; CAUSE OF DEATH; COLECTOMY; COLON; COLONIC NEOPLASMS; CONFIDENCE INTERVALS; DENMARK; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REGISTRIES; RISK ASSESSMENT; TIME FACTORS;

EID: 84899481727     PISSN: 00034932     EISSN: 15281140     Source Type: Journal    
DOI: 10.1097/SLA.0b013e3182a6f2fc     Document Type: Article

References (35)

1. Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011; 61: 69-90.
2. Kube R, Mroczkowski P, Granowski D, et al. Anastomotic leakage after colon cancer surgery: a predictor of significant morbidity and hospital mortality, and diminished tumour-free survival. Eur J Surg. Oncol. 2010; 36: 120-124.
3. Khan AA, Wheeler JM, Cunningham C, et al. The management and outcome of anastomotic leaks in colorectal surgery. Colorectal Dis. 2008; 10: 587-592.
4. Bertelsen CA, Andreasen AH, Jorgensen T, et al. Anastomotic leakage after anterior resection for rectal cancer: risk factors. Colorectal Dis. 2010; 12: 37-43.
5. Krarup PM, Jorgensen LN, Andreasen AH, et al. A nationwide study on anastomotic leakage after colonic cancer surgery. Colorectal Dis. 2012; 14: e661-e667.
6. Marra F, Steffen T, Kalak N, et al. Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer. Eur J Surg. Oncol. 2009; 35: 1060-1064.
7. Branagan G, Finnis D. Prognosis after anastomotic leakage in colorectal surgery. Dis Colon Rectum. 2005; 48: 1021-1026.
8. Eberhardt JM, Kiran RP, Lavery IC. The impact of anastomotic leak and intraabdominal abscess on cancer-related outcomes after resection for colorectal cancer: a case control study. Dis Colon Rectum. 2009; 52: 380-386.
9. Mirnezami A, Mirnezami R, Chandrakumaran K, et al. Increased local recurrence and reduced survival from colorectal cancer following anastomotic leak: systematic review and meta-analysis. Ann Surg. 2011; 253: 890-899.
10. den Dulk M, Marijnen CA, Collette L, et al. Multicentre analysis of oncological and survival outcomes following anastomotic leakage after rectal cancer surgery. Br J Surg. 2009; 96: 1066-1075.
11. Bertelsen CA, Andreasen AH, Jorgensen T, et al. Anastomotic leakage after curative anterior resection for rectal cancer: short and long-term outcome. Colorectal Dis. 2010; 12: e76-e81.
12. De Marco MF, Janssen-Heijnen ML, van der Heijden LH, et al. Comorbidity and colorectal cancer according to subsite and stage: a population-based study. Eur J Cancer. 2000; 36: 95-99.
13. Sarfati D, Hill S, Blakely T, et al. The effect of comorbidity on the use of adjuvant chemotherapy and survival from colon cancer: a retrospective cohort study. BMC Cancer. 2009; 9: 116.
14. Charlson ME, Pompei P, AlesKL, et al.Anewmethod of classifying prognostic comorbidity in longitudinal studies: development and validation. JChronicDis. 1987; 40: 373-383.
15. Sundararajan V, Henderson T, Perry C, et al. New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality. J Clin Epidemiol. 2004; 57: 1288-1294.
16. Schmidt M, Jacobsen JB, Lash TL, et al. 25 year trends in first time hospitalisation for acute myocardial infarction, subsequent short and long term mortality, and the prognostic impact of sex and comorbidity: a Danish nationwide cohort study. BMJ. 2012; 344: e356.
17. Schemper M, Smith TL. A note on quantifying follow-up in studies of failure time. Control Clin Trials. 1996; 17: 343-346.
18. Jorgren F, Johansson R, Damber L, et al. Anastomotic leakage after surgery for rectal cancer: a risk factor for local recurrence, distant metastasis and reduced cancer-specific survival? Colorectal Dis. 2011; 13: 272-283.
19. Katoh H, Yamashita K, Wang G, et al. Anastomotic leakage contributes to the risk for systemic recurrence in stage II colorectal cancer. J Gastrointest Surg. 2011; 15: 120-129.
20. Lin JK, Yueh TC, Chang SC, et al. The influence of fecal diversion and anastomotic leakage on survival after resection of rectal cancer. J Gastrointest Surg. 2011; 15: 2251-2261.
21. Akyol AM, McGregor JR, Galloway DJ, et al. Anastomotic leaks in colorectal cancer surgery: a risk factor for recurrence? Int J Colorectal Dis. 1991; 6: 179-183.
22. Docherty JG, McGregor JR, Akyol AM, et al. Comparison of manually constructed and stapled anastomoses in colorectal surgery. West of Scotland and Highland Anastomosis Study Group. Ann Surg. 1995; 221: 176-184.
23. Fujita S, Teramoto T, Watanabe M, et al. Anastomotic leakage after colorectal cancer surgery: a risk factor for recurrence and poor prognosis. Jpn J Clin Oncol. 1993; 23: 299-302.
24. Law WL, Choi HK, Lee YM, et al. Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy. J Gastrointest Surg. 2007; 11: 8-15.
25. Abulafi AM, Williams NS. Local recurrence of colorectal cancer: the problem, mechanisms, management and adjuvant therapy. Br J Surg. 1994; 81: 7-19.
26. Chuang D, Paddison JS, Booth RJ, et al. Differential production of cytokines following colorectal surgery. ANZ J Surg. 2006; 76: 821-824.
27. Lee YS, Choi I, Ning Y, et al. Interleukin-8 and its receptor CXCR2 in the tumour microenvironment promote colon cancer growth, progression and metastasis. Br J Cancer. 2012; 106: 1833-1841.
28. Kapiteijn E, Marijnen CA, Nagtegaal ID, et al. Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer. N Engl JMed. 2001; 345: 638-646.
29. Iversen LH, Norgaard M, Jacobsen J, et al. The impact of comorbidity on survival of Danish colorectal cancer patients from 1995 to 2006-a populationbased cohort study. Dis Colon Rectum. 2009; 52: 71-78.
30. Moertel CG, Fleming TR, Macdonald JS, et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med. 1990; 322: 352-358.
31. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet. 1995; 345: 939-944.
32. Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle. 2009; 8: 3267-3273.
33. Smith JD, Paty PB, Guillem JG, et al. Anastomotic leak is not associated with oncologic outcome in patients undergoing low anterior resection for rectal cancer. Ann Surg. 2012; 256: 1034-1038.
34. El Shayeb M, Scarfe A, Yasui Y, et al. Reasons physicians do not recommend and patients refuse adjuvant chemotherapy for stage III colon cancer: a population based chart review. BMC Res Notes. 2012; 5: 269.
35. Biagi JJ, Raphael MJ, MackillopWJ, et al. Association between time to initiation of adjuvant chemotherapy and survival in colorectal cancer: a systematic review and meta-analysis. JAMA. 2011; 305: 2335-2342.