Identification of novel glycans with disialylated structures in α3 integrin from mouse kidney cells with the phenotype of polycystic kidney disease

Journal of Proteome Research

Volumn 13, Issue 11, 2014, Pages 4901-4909

  Zhang, Anna Fan ^a   Wu, Shiaw Lin ^a   Jung, Yunjoon ^b   Qin, Shan ^b   Hancock, William S ^a   Kreidberg, Jordan A ^b,c  

^a NORTHEASTERN UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD STEM CELL INSTITUTE   (United States)

Author keywords

glycans; glycopeptide analysis; N linked glycosylation; Pkd1 + + cells; Pkd1 cells; polycystic kidney disease; site specific identification; 3 integrin

Indexed keywords

ALPHA3 INTEGRIN; GLYCAN; MONOSACCHARIDE; POLYCYSTIC KIDNEY DISEASE 1 PROTEIN; POLYCYSTIN; POLYSACCHARIDE; SIALIC ACID DERIVATIVE;

ANIMAL CELL; ARTICLE; DRUG IDENTIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KIDNEY CELL; KIDNEY POLYCYSTIC DISEASE; LIGHT CHAIN; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; MUTATOR GENE; NONHUMAN; PHENOTYPE; POLYCYSTIN 1 GENE; POLYCYSTIN 2 GENE; PROTEIN GLYCOSYLATION; ANIMAL; GENETICS; IMMUNOPRECIPITATION; ISOLATION AND PURIFICATION; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; IMMUNOPRECIPITATION; INTEGRIN ALPHA3; MASS SPECTROMETRY; MICE; MICE, KNOCKOUT; POLYCYSTIC KIDNEY DISEASES; POLYSACCHARIDES; SIALIC ACIDS; TRPP CATION CHANNELS;

EID: 84908894912     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr5009702     Document Type: Article

References (17)

1. Lu, W. Late onset of renal and hepatic cysts in Pkd1-targeted heterozygotes Nat. Genet. 1999, 21 (2) 160-161
2. Legate, K. R.; Wickstrom, S. A.; Fassler, R. Genetic and cell biological analysis of integrin outside-in signaling Genes Dev. 2009, 23 (4) 397-418
3. Hehlgans, S.; Haase, M.; Cordes, N. Signaling via integrins: implications for cell survival and anticancer strategies Biochim. Biophys. Acta 2007, 1775, 163-180
4. Liu, Y. Coordinate integrin and c-Met signaling regulate Wnt gene expression during epithelial morphogenesis Development 2009, 136 (5) 843-853
5. Nauli, S. M. Loss of polycystin-1 in human cyst-lining epithelia leads to ciliary dysfunction J. Am. Soc. Nephrol. 2006, 17 (4) 1015-1025
6. Qin, S. Failure to ubiquitinate c-Met leads to hyperactivation of mTOR signaling in a mouse model of autosomal dominant polycystic kidney disease J. Clin. Invest. 2010, 120 (10) 3617-3628
7. Gundry, R. L. The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation Mol. Cell. Proteomics 2009, 8 (11) 2555-2569
8. Wollscheid, B. Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins Nat. Biotechnol. 2009, 27 (4) 378-386
9. Howe, A. Integrin signaling and cell growth control Curr. Opin Cell Biol. 1998, 10 (2) 220-231
10. Coppolino, M. G.; Dedhar, S. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events Biochem. J. 1999, 340 (Pt 1) 41-50
11. Nicolaou, N. Gain of glycosylation in integrin alpha3 causes lung disease and nephrotic syndrome J. Clin. Invest. 2012, 122 (12) 4375-4387
12. Moolenaar, C. E. Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212 Cancer Res. 1990, 50 (4) 1102-1106
13. Tanaka, F. Prognostic significance of polysialic acid expression in resected non-small cell lung cancer Cancer Res. 2001, 61 (4) 1666-1670
14. Kitazume-Kawaguchi, S.; Kabata, S.; Arita, M. Differential biosynthesis of polysialic or disialic acid Structure by ST8Sia II and ST8Sia IV J. Biol. Chem. 2001, 276 (19) 15696-15703
15. Wu, S. L. Identification of potential glycan cancer markers with sialic acid attached to sialic acid and up-regulated fucosylated galactose structures in epidermal growth factor receptor secreted from A431 cell line Mol. Cell. Proteomics 2013, 12 (5) 1239-1249
16. Hanash, S. M.; Baik, C. S.; Kallioniemi, O. Emerging molecular biomarkers-blood-based strategies to detect and monitor cancer Nat. Rev. Clin. Oncol. 2011, 8 (3) 142-150
17. Baron, A. T. Soluble epidermal growth factor receptor (sEGFR/sErbB1) as a potential risk, screening, and diagnostic serum biomarker of epithelial ovarian cancer Cancer Epidemiol., Biomarkers Prev. 2003, 12 (2) 103-113