Usefulness of monitoring γ-H2AX and cell cycle arrest in HepG2 cells for estimating genotoxicity using a high-content analysis system

Journal of Biomolecular Screening

Volumn 19, Issue 9, 2014, Pages 1246-1254

  Ando, Masamitsu ^a,b   Yoshikawa, Keisuke ^a   Iwase, Yumiko ^a   Ishiura, Shoichi ^b  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

cell cycle arrest; genotoxicity; high content screening; H2A.X

Indexed keywords

ANISOMYCIN; ANTIBODY; APHIDICOLIN; CAMPTOTHECIN; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CYCLOHEXIMIDE; CYTARABINE; DACTINOMYCIN; DEMECOLCINE; DNA TOPOISOMERASE INHIBITOR; EDETIC ACID; ERYTHROMYCIN; ETOPOSIDE; FAMOTIDINE; GAMMA HISTONE H2AX; HISTONE H2AX; HYDRALAZINE; HYDROXYUREA; LIDOCAINE; MENADIONE; METHYLDOPA; METHYLNITRONITROSOGUANIDINE; MEVINOLIN; NALOXONE; OFLOXACIN; PACLITAXEL; PHOSPHO HISTONE H3 ANTIBODY; TUBULIN; TUBULIN ANTIBODY; UNCLASSIFIED DRUG; UNINDEXED DRUG; BIOLOGICAL MARKER; H2AFX PROTEIN, HUMAN; HISTONE; MUTAGENIC AGENT;

ACCURACY; AMES TEST; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; G2 PHASE CELL CYCLE CHECKPOINT; GENOTOXICITY; HEPG2 CELL LINE; HIGH CONTENT SCREENING; HUMAN; HUMAN CELL; MITOSIS; SCREENING TEST; SENSITIVITY AND SPECIFICITY; CELL CYCLE CHECKPOINT; DOSE RESPONSE; DRUG EFFECTS; HIGH THROUGHPUT SCREENING; METABOLISM; MUTAGEN TESTING; PROCEDURES; TIME;

BIOLOGICAL MARKERS; CELL CYCLE CHECKPOINTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HISTONES; HUMANS; MUTAGENICITY TESTS; MUTAGENS; TIME FACTORS;

EID: 84908879380     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057114541147     Document Type: Article

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