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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 20, 2014, Pages 4812-4817

Novel ROCK inhibitors for the treatment of pulmonary arterial hypertension

(11) Shaw, Duncan a Hollingworth, Greg a Soldermann, Nicolas b Sprague, Elizabeth c Schuler, Walter b Vangrevelinghe, Eric b Duggan, Nicholas a Thomas, Matthew a Kosaka, Takatoshi a Waters, Nigel a Van Eis, Maurice J b

a NOVARTIS HORSHAM RESEARCH CENTRE (United Kingdom)

b NOVARTIS PHARMA AG (Switzerland)

c NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH (United States)

Author keywords

Inhibitors; Intra tracheal dosing; Lymphocyte depletion; Pulmonary arterial hypertension; Rho kinase

Indexed keywords

PROTEIN KINASE INHIBITOR; RHO KINASE;

ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; DOSE RESPONSE; ENZYMOLOGY; HUMAN; HYPERTENSION, PULMONARY; LEWIS RAT; METABOLISM; MOUSE; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERTENSION, PULMONARY; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; RATS; RATS, INBRED LEW; RHO-ASSOCIATED KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908702865 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2014.09.002 Document Type: Article

Times cited : (32)

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