Hypoxia inducible factor-1α suppresses Peroxiredoxin 3 expression to promote proliferation of CCRCC cells

FEBS Letters

Volumn 588, Issue 18, 2014, Pages 3390-3394

  Xi, Hao ^a   Gao, Yao Hui ^b   Han, Dong Yan ^a   Li, Qian Yu ^a   Feng, Li Jin ^a   Zhang, Wei ^a   Ji, Guo ^a   Xiao, Jia Cheng ^a   Zhang, Hui Zhen ^c   Wei, Qing ^a  

^a TONGJI UNIVERSITY   (China)

^b Department of Science and Education MingHang Central Hospital   (China)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

HIF 1 ; Proliferation; Prx3; VHL

Indexed keywords

HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PEROXIREDOXIN 3; PRDX3 PROTEIN, HUMAN; VHL PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELL HYPOXIA; CELL PROLIFERATION; DNA RESPONSIVE ELEMENT; ENZYME REPRESSION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEK293 CELL LINE; HIF-1Α; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; PHYSIOLOGY; PROLIFERATION; PRX3; TUMOR CELL LINE; VHL;

HIF-1Α; PROLIFERATION; PRX3; VHL;

CARCINOMA, RENAL CELL; CELL HYPOXIA; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME REPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY NEOPLASMS; PEROXIREDOXIN III; RESPONSE ELEMENTS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 84908689217     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2014.07.030     Document Type: Article

References (24)

1. A.L. Harris Hypoxia-a key regulatory factor in tumour growth Nat. Rev. Cancer 2 2002 38 47
2. P. Vaupel Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis Oncologist 13 Suppl 3 2008 21 26
3. G.L. Wang, B.H. Jiang, E.A. Rue, and G.L. Semenza Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension Proc. Natl. Acad. Sci. USA 92 1995 5510 5514
4. W.G. Kaelin Jr., and P.J. Ratcliffe Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol. Cell 30 2008 393 402
5. R. Fukuda, B. Kelly, and G.L. Semenza Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1 Cancer Res. 63 2003 2330 2334
6. I. Papandreou, R.A. Cairns, L. Fontana, A.L. Lim, and N.C. Denko HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption Cell Metab. 3 2006 187 197
7. J.W. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab. 3 2006 177 185
8. Semenza, G. L. (2007) Hypoxia-inducible factor 1 (HIF-1) pathway, Science's STKE: signal transduction knowledge environment. 2007, cm8.
9. C.M. Tang, and J. Yu Hypoxia-inducible factor-1 as a therapeutic target in cancer J. Gastroenterol. Hepatol. 28 2013 401 405
10. S.H. Liao, X.Y. Zhao, Y.H. Han, J. Zhang, L.S. Wang, L. Xia, K.W. Zhao, Y. Zheng, M. Guo, and G.Q. Chen Proteomics-based identification of two novel direct targets of hypoxia-inducible factor-1 and their potential roles in migration/invasion of cancer cells Proteomics 9 2009 3901 3912
11. L. Flohe, H. Budde, and B. Hofmann Peroxiredoxins in antioxidant defense and redox regulation BioFactors 19 2003 3 10
12. J. Duan, Y. Lang, C. Song, J. Xiong, Y. Wang, and Y. Yan SiRNA targeting of PRDX3 enhances cisplatin induced apoptosis in ovarian cancer cells through the suppression of the NFkappaB signaling pathway Mol. Med. Rep. 7 2013 1688 1694
13. S. Watabe, T. Hiroi, Y. Yamamoto, Y. Fujioka, H. Hasegawa, N. Yago, and S.Y. Takahashi SP-22 is a thioredoxin-dependent peroxide reductase in mitochondria Eur. J. Biochem./FEBS 249 1997 52 60
14. D.R. Wonsey, K.I. Zeller, and C.V. Dang The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation Proc. Natl. Acad. Sci. USA 99 2002 6649 6654
15. X. Pan, T. Zhou, Y.H. Tai, C. Wang, J. Zhao, Y. Cao, Y. Chen, P.J. Zhang, M. Yu, C. Zhen, R. Mu, Z.F. Bai, H.Y. Li, A.L. Li, B. Liang, Z. Jian, W.N. Zhang, J.H. Man, Y.F. Gao, W.L. Gong, L.X. Wei, and X.M. Zhang Elevated expression of CUEDC2 protein confers endocrine resistance in breast cancer Nat. Med. 17 2011 708 714
16. Y.H. Gao, C.X. Li, S.M. Shen, H. Li, G.Q. Chen, Q. Wei, and L.S. Wang Hypoxia-inducible factor 1alpha mediates the down-regulation of superoxide dismutase 2 in von Hippel-Lindau deficient renal clear cell carcinoma Biochem. Biophys. Res. Commun. 435 2013 46 51
17. L.E. Moore, M.L. Nickerson, P. Brennan, J.R. Toro, E. Jaeger, J. Rinsky, S.S. Han, D. Zaridze, V. Matveev, V. Janout, H. Kollarova, V. Bencko, M. Navratilova, N. Szeszenia-Dabrowska, D. Mates, L.S. Schmidt, P. Lenz, S. Karami, W.M. Linehan, M. Merino, S. Chanock, P. Boffetta, W.H. Chow, F.M. Waldman, and N. Rothman Von Hippel-Lindau (VHL) inactivation in sporadic clear cell renal cancer: associations with germline VHL polymorphisms and etiologic risk factors PLoS Genet. 7 2011 e1002312
18. A.P. Young, S. Schlisio, Y.A. Minamishima, Q. Zhang, L. Li, C. Grisanzio, S. Signoretti, and W.G. Kaelin Jr. VHL loss actuates a HIF-independent senescence programme mediated by Rb and p400 Nat. Cell Biol. 10 2008 361 369
19. S. Narravula, and S.P. Colgan Hypoxia-inducible factor 1-mediated inhibition of peroxisome proliferator-activated receptor alpha expression during hypoxia J. Immunol. 166 2001 7543 7548
20. J.T. Erler, C.J. Cawthorne, K.J. Williams, M. Koritzinsky, B.G. Wouters, C. Wilson, C. Miller, C. Demonacos, I.J. Stratford, and C. Dive Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance Mol. Cell. Biol. 24 2004 2875 2889
21. M. Rigoulet, E.D. Yoboue, and A. Devin Mitochondrial ROS generation and its regulation: mechanisms involved in H(2)O(2) signaling Antioxid. Redox Signal. 14 2011 459 468
22. J. Wang, and J. Yi Cancer cell killing via ROS: to increase or decrease, that is the question Cancer Biol. Ther. 7 2008 1875 1884
23. H. Pelicano, D. Carney, and P. Huang ROS stress in cancer cells and therapeutic implications Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy 7 2004 97 110
24. L. Nonn, M. Berggren, and G. Powis Increased expression of mitochondrial Peroxiredoxin-3 (thioredoxin peroxidase-2) protects cancer cells against hypoxia and drug-induced hydrogen peroxide-dependent apoptosis Molecular cancer research: MCR 1 2003 682 689