OxLDL induces macrophage γ-GCS-HS protein expression: A role for oxLDL-associated lipid hydroperoxide in GSH synthesis

Journal of Lipid Research

Volumn 42, Issue 5, 2001, Pages 813-823

  Shen, L ^a   Sevanian, A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

glutamylcysteine synthetase; Oxidized low density lipoprotein; Reactive oxygen species

Indexed keywords

ACETYL LOW DENSITY LIPOPROTEIN; ALDEHYDE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; LIPID HYDROPEROXIDE; MALONALDEHYDE; OXIDIZED LOW DENSITY LIPOPROTEIN; PEROXIDE; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DECOMPOSITION; ENZYME ACTIVITY; ENZYME INDUCTION; GLUTATHIONE METABOLISM; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIOXIDANTS; AZOLES; CELL LINE; ENZYME INDUCTION; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; HUMANS; IMMUNOBLOTTING; LIPID PEROXIDES; LIPOPROTEINS, LDL; MACROPHAGES; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; PROTEIN SUBUNITS; REACTIVE OXYGEN SPECIES; SELENIUM; TIME FACTORS;

EID: 0034993697     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (65)

1. The role of oxidized lipoproteins in atherogenesis
2. Cell-mediated oxidation of low-density lipoprotein: The elusive mechanism(s)
3. Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages
4. Activation of NADPH oxidase required for macrophage-mediated oxidation of low-density lipoprotein
5. Pathways for oxidation of low density lipoprotein by myeloperoxidase: Tyrosyl radical, reactive aldehydes, hypochlorous acid and molecular chlorine
6. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species
7. Purification and characterization of a bovine acetyl low density lipoprotein receptor
8. CD36 is a receptor for oxidized low density lipoprotein
9. Scavenger receptors and oxidized low density lipoproteins
10. Detection of thiyl radical adducts formed during hydroxyl radical- and peroxynitrite-mediated oxidation of thiols - A high resolution ESR spin-trapping study at Q-band (35 GHz)
11. Diversity of glutathione peroxidases
12. Structure, catalytic mechanism, and evolution of the glutathione transferases
13. On the enzymology of amino acid transport
14. Direct evidence for inter-organ transport of glutathione and that the non-filtration renal mechanism for glutathione utilization involves gamma-glutamyl transpeptidase
15. Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione
16. Mechanism for the changes in levels of glutathione upon exposure of cultured mammalian cells to tertiary-butylhylhydroperoxide and diamide
17. Effect of in vivo hyperoxiaon the glutathione system in neonatal rat lung
18. Effect of hyperbaric oxygen treatment and perfluorochemical administration on glutathione status of the lung
19. Treatment of macrophages with oxidized low-density lipoprotein increases their intracellular glutathione content
20. Protective role of glutathione synthesis in response to oxidized low density lipoprotein in human vascular endothelial cells
21. Cardiac transport of glutathione disulfide and S-conjugate. Studies with isolated perfused rat heart during hydroperoxide metabolism
22. The role of jun, fos and the AP-1 complex in cell-proliferation and transformation
23. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-)
24. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts
25. 2 gradients across biomembranes
26. A spectrophotometric microtiter-based assay for the detection of hydroperoxy derivatives of linoleic acid
27. Microsomal lipid peroxidation
28. Enzymatic and immunological measurements of soluble and membrane-bound phospholipid-hydroperoxide glutathione peroxidase
29. Oxidation of glutathione during hydroperoxide metabolism. A study using isolated hepatocytes and the glutathione reductase inhibitor 1,3-bis(2-chloroethyl)-1-nitrosourea
30. High-performance liquid chromatography of thiols and disulfides: Dinitrophenol derivatives
31. Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
32. Presence of a modified low density lipoprotein in humans
33. Ebselen, a selenoorganic compound as glutathione peroxidase mimic
34. Amino acid sequence of rat kidney gamma-glutamylcysteine synthetase
35. Transcriptional regulation of gamma-glutamylcysteine synthetase-heavy subunit by oxidants in human alveolar epithelial cells
36. Low density lipoprotein oxidation and its pathobiological significance
37. Oxidative hypothesis of atherogenesis
38. Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins: Effects of antioxidant vitamins C and E on oxidized LDL-induced adaptive increases in cystine transport and glutathione
39. Phospholipid hydroperoxide glutathione peroxidase activity of human glutathione transferases
40. The relationship of biliary glutathione disulfide efflux and intracellular glutathione disulfide content in perfused rat liver
41. Antioxidant and redox regulation of gene transcription
42. Study of gene regulation by NF-kappa B and AP-1 in response to reactive oxygen intermediates
43. Reduction of HDL- and LDL-associated cholesteryl ester and phospholipid hydroperoxides by phospholipid hydroperoxide glutathione peroxidase and Ebselen (PZ 51)
44. Mapping of the glutamate-cysteine ligase catalytic subunit gene (GLCLC) to human chromosome 6p12 and mouse chromosome 9D-E and of the regulatory subunit gene (GLCLR) to human chromosome 1p21-p22 and mouse chromosome 3H1-3
45. Cloning and sequencing of the cDNA for the light subunit of human liver gamma-glutamylcysteine synthetase and relative mRNA levels for heavy, and light subunits in human normal tissues
46. Up-regulation of gamma-glutamylcysteine synthetase activity in melphalan-resistant human multiple myeloma cells expressing increased glutathione levels
47. Regulation of human gamma-glutamylcysteine synthetase: Co-ordinate induction of the catalytic and regulatory subunits in HepG2 cells
48. Overexpression of the regulatory subunit of gamma-glutamylcysteine synthetase in HeLa cells increases gamma-glutamylcysteine synthetase activity and confers drug resistance
49. Reversible dissociation of gamma-glutamylcysteine synthetase into two subunits
50. Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase
51. Glutathione redox potential in response to differentiation and enzyme inducers
52. Oxidative stresses induced the cystine transport activity in human erythrocytes
53. Cystine uptake and glutathione level in endothelial cells exposed to oxidative stress
54. Constitutive and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase heavy, subunit gene is regulated by a distal antioxidant response element/TRE sequence
55. Role of hydroperoxyeicosatetraenoic acids in oxidative stress-induced activating protein 1 (AP-1) activity
56. The level of intracellular glutathione is a key regulator for the induction of stress-activated signal transduction pathways including Jun N-terminal protein kinases and p38 kinase by alkylating agents
57. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
58. Distribution of the monochlorobimane-glutathione conjugate between nucleus and cytosol in isolated hepatocytes
59. Bcl-2 expression causes redistribution of glutathione to the nucleus
60. Tissue-specific functions of individual glutathione peroxidases
61. 2
62. Oxidized low density lipoprotein (ox-LDL) binding to ox-LDL receptor-1 in endothelial cells induces the activation of NF-kappaB through an increased production of intracellular reactive oxygen species
63. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor CD36
64. Increased transcription of the regulatory subunit of gamma-glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion
65. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells