Identification of a point mutation impairing the binding between aquaporin-4 and neuromyelitis optica Autoantibodies

Journal of Biological Chemistry

Volumn 289, Issue 44, 2014, Pages 30578-30589

  Pisani, Francesco ^a   Mola, Maria Grazia ^a   Simone, Laura ^a   Rosito, Stefania ^a   Alberga, Domenico ^a   Mangiatordi, Giuseppe Felice ^a   Lattanzi, Gianluca ^a   Nicolotti, Orazio ^a   Frigeri, Antonio ^a   Svelto, Maria ^a   Nicchia, Grazia Paola ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ASSAYS; BINS; EPITOPES; FLUORESCENCE MICROSCOPY; MOLECULAR DYNAMICS; REFRACTIVE INDEX;

CONFORMATIONAL EPITOPES; CYTOTOXICITY ASSAYS; EXTRACELLULAR LOOPS; MOLECULAR ASSEMBLY; MOLECULAR CONFORMATION; TOTAL INTERNAL REFLECTION FLUORESCENCE MICROSCOPY; TRANSMEMBRANE REGIONS; WEALTH OF INFORMATION;

ENZYME ACTIVITY;

AQUAPORIN 4; ASPARTIC ACID; AUTOANTIBODY; EPITOPE; HISTIDINE; NEUROMYELITIS OPTICA AUTOANTIBODY; UNCLASSIFIED DRUG; AQP4 PROTEIN, HUMAN; IMMUNOGLOBULIN G; PROTEIN BINDING; WATER;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; MOLECULAR DYNAMICS; MULTIPLE SCLEROSIS; MUTANT; MYELOOPTIC NEUROPATHY; NONHUMAN; PATHOGENESIS; POINT MUTATION; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BLOOD; CHEMISTRY; GENETICS; HELA CELL LINE; IMMUNOLOGY; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; PH; PROTEIN TERTIARY STRUCTURE; TRANSPORT AT THE CELLULAR LEVEL; XENOPUS LAEVIS;

AMINO ACID SEQUENCE; ANIMALS; AQUAPORIN 4; AUTOANTIBODIES; BIOLOGICAL TRANSPORT; EPITOPES; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEUROMYELITIS OPTICA; POINT MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; WATER; XENOPUS LAEVIS;

EID: 84908626208     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.582221     Document Type: Article

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