Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 43, 2014, Pages 15420-15425

  Rogers, Joseph M ^a,b   Oleinikovas, Vladimiras ^a,c   Shammas, Sarah L ^a   Wong, Chi T ^a,d   De Sancho, David ^a   Baker, Christopher M ^a   Clarke, Jane ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF TOKYO   (Japan)

^c UNIVERSITY COLLEGE LONDON   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

BCL 2; Coarse grained simulation; Protein folding; Protein protein interactions; Stopped flow

Indexed keywords

INTRINSICALLY DISORDERED PROTEIN; LIGAND; PROTEIN MCL 1; PUMA PROTEIN; MUTANT PROTEIN; ONCOPROTEIN; PROTEIN BINDING;

ALPHA HELIX; ARTICLE; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; CHEMISTRY; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE;

INTRINSICALLY DISORDERED PROTEINS; KINETICS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; MUTANT PROTEINS; MUTATION; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTO-ONCOGENE PROTEINS;

EID: 84908572919     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1409122111     Document Type: Article

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