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Volumn 5, Issue 9, 2014, Pages 855-866

Anti-inflammatory activity of iridoid and catechol derivatives from Eucommia ulmoides Oliver

Author keywords

4 (1,2 dimethoxyethyl)benzene 1,2 diol; Eucommia ulmoides Oliver; Genipin; Neurodegenerative diseases; Neuroinflammation

Indexed keywords

4 (1,2 DIMETHOXYETHYL)BENZENE 1,2 DIOL; ANTIINFLAMMATORY AGENT; CATECHOL DERIVATIVE; DU ZHONG; GENIPIN; HYDROCORTISONE; IRIDOID; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CATECHOL; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; NITRITE; PLANT MEDICINAL PRODUCT;

EID: 84908571400     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5001205     Document Type: Article
Times cited : (41)

References (70)
  • 1
    • 84864765533 scopus 로고    scopus 로고
    • Microglia and mast cells: Two tracks on the road to neuroinflammation
    • Skaper, S. D., Giusti, P., and Facci, L. (2012) Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J. 26, 3103-3117.
    • (2012) FASEB J. , vol.26 , pp. 3103-3117
    • Skaper, S.D.1    Giusti, P.2    Facci, L.3
  • 2
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer, P. L., Itagaki, S., Boyes, B. E., and McGeer, E. G. (1988) Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38, 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 3
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi, F. (2001) Immune function of microglia. Glia 36, 165-179.
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 4
    • 30444459031 scopus 로고    scopus 로고
    • The role of inflammation in CNS injury and disease
    • Lucas, S. M., Rothwell, N. J., and Gibson, R. M. (2006) The role of inflammation in CNS injury and disease. Br. J. Pharmacol. 147 (Suppl 1), S232-240.
    • (2006) Br. J. Pharmacol. , vol.147 , pp. S232-S240
    • Lucas, S.M.1    Rothwell, N.J.2    Gibson, R.M.3
  • 5
    • 0029760138 scopus 로고    scopus 로고
    • Molecular mechanisms of microglial activation
    • Zielasek, J., and Hartung, H. P. (1996) Molecular mechanisms of microglial activation. Adv. Neuroimmunol. 6, 191-122.
    • (1996) Adv. Neuroimmunol. , vol.6 , pp. 191-1122
    • Zielasek, J.1    Hartung, H.P.2
  • 6
    • 62949112658 scopus 로고    scopus 로고
    • Periventricular white matter damage in the hypoxic neonatal brain: Role of microglial cells
    • Kaur, C., and Ling, E. A. (2009) Periventricular white matter damage in the hypoxic neonatal brain: role of microglial cells. Prog. Neurobiol. 87, 264-280.
    • (2009) Prog. Neurobiol. , vol.87 , pp. 264-280
    • Kaur, C.1    Ling, E.A.2
  • 7
    • 0033567065 scopus 로고    scopus 로고
    • Enzymatic function of nitric oxide synthases
    • Andrew, P. J., and Mayer, B. (1999) Enzymatic function of nitric oxide synthases. Cardiovasc. Res. 43, 521-531.
    • (1999) Cardiovasc. Res. , vol.43 , pp. 521-531
    • Andrew, P.J.1    Mayer, B.2
  • 8
    • 33744984393 scopus 로고    scopus 로고
    • Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms
    • Pannu, R., and Singh, I. (2006) Pharmacological strategies for the regulation of inducible nitric oxide synthase: Neurodegenerative versus neuroprotective mechanisms. Neurochem. Int. 49, 170-182.
    • (2006) Neurochem. Int. , vol.49 , pp. 170-182
    • Pannu, R.1    Singh, I.2
  • 9
    • 0029841018 scopus 로고    scopus 로고
    • Measurement of nitric oxide and peroxynitrite generation in the postischemic heart - Evidence for peroxynitrite-mediated reperfusion injury
    • Wang, P. H., and Zweier, J. L. (1996) Measurement of nitric oxide and peroxynitrite generation in the postischemic heart - Evidence for peroxynitrite-mediated reperfusion injury. J. Biol. Chem. 271, 29223-29230.
    • (1996) J. Biol. Chem. , vol.271 , pp. 29223-29230
    • Wang, P.H.1    Zweier, J.L.2
  • 10
    • 0036244508 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite interactions with mitochondria
    • Radi, R., Cassina, A., and Hodara, R. (2002) Nitric oxide and peroxynitrite interactions with mitochondria. Biol. Chem. 383, 401-409.
    • (2002) Biol. Chem. , vol.383 , pp. 401-409
    • Radi, R.1    Cassina, A.2    Hodara, R.3
  • 11
    • 34548726106 scopus 로고    scopus 로고
    • TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: New drug candidates and targets
    • Tweedie, D., Sambamurti, K., and Greig, N. H. (2007) TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: New drug candidates and targets. Curr. Alzheimer Res. 4, 378-385.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 378-385
    • Tweedie, D.1    Sambamurti, K.2    Greig, N.H.3
  • 12
    • 84860122734 scopus 로고    scopus 로고
    • Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System
    • Montgomery, S. L., and Bowers, W. J. (2012) Tumor Necrosis Factor-alpha and the Roles it Plays in Homeostatic and Degenerative Processes Within the Central Nervous System. J. Neuroimmune Pharmacol. 7, 42-59.
    • (2012) J. Neuroimmune Pharmacol. , vol.7 , pp. 42-59
    • Montgomery, S.L.1    Bowers, W.J.2
  • 13
    • 0036949091 scopus 로고    scopus 로고
    • Local neuroinflammation and the progression of Alzheimer's disease
    • McGeer, P. L., and McGeer, E. G. (2002) Local neuroinflammation and the progression of Alzheimer's disease. J. Neuro Virol. 8, 529-538.
    • (2002) J. Neuro Virol. , vol.8 , pp. 529-538
    • McGeer, P.L.1    McGeer, E.G.2
  • 14
    • 0032557738 scopus 로고    scopus 로고
    • Inhibition of TNFalpha attenuates infarct volume and ICAM-1 expression in ischemic mouse brain
    • Yang, G. Y., Gong, C., Qin, Z., Ye, W., Mao, Y., and Bertz, A. L. (1998) Inhibition of TNFalpha attenuates infarct volume and ICAM-1 expression in ischemic mouse brain. NeuroReport 9, 2131-2134.
    • (1998) NeuroReport , vol.9 , pp. 2131-2134
    • Yang, G.Y.1    Gong, C.2    Qin, Z.3    Ye, W.4    Mao, Y.5    Bertz, A.L.6
  • 15
    • 0033512004 scopus 로고    scopus 로고
    • Inflammatory mediators and stroke: New opportunities for novel therapeutics
    • Barone, F. C., and Feuerstein, G. Z. (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J. Cereb. Blood Flow Metab. 19, 819-834.
    • (1999) J. Cereb. Blood Flow Metab. , vol.19 , pp. 819-834
    • Barone, F.C.1    Feuerstein, G.Z.2
  • 16
    • 0034281374 scopus 로고    scopus 로고
    • Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells
    • Tian, D., Litvak, V., and Lev, S. (2000) Cerebral ischemia and seizures induce tyrosine phosphorylation of PYK2 in neurons and microglial cells. J. Neurosci. 20, 6478-6487.
    • (2000) J. Neurosci. , vol.20 , pp. 6478-6487
    • Tian, D.1    Litvak, V.2    Lev, S.3
  • 18
    • 84882866377 scopus 로고    scopus 로고
    • NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders
    • Lee, M., McGeer, E., Kodela, R., Kashfi, K., and McGeer, P. L. (2013) NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: A new candidate for treatment of neurodegenerative disorders. Glia 61, 1724-1734.
    • (2013) Glia , vol.61 , pp. 1724-1734
    • Lee, M.1    McGeer, E.2    Kodela, R.3    Kashfi, K.4    McGeer, P.L.5
  • 22
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher, P., Beckman, J. S., and Liaudet, L. (2007) Nitric oxide and peroxynitrite in health and disease. Physiol. Rev. 87, 315-424.
    • (2007) Physiol. Rev. , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 23
    • 33847644971 scopus 로고    scopus 로고
    • The inflammatory response in stroke
    • Wang, Q., Tang, X. N., and Yenari, M. A. (2007) The inflammatory response in stroke. J. Neuroimmunol. 184, 53-68.
    • (2007) J. Neuroimmunol. , vol.184 , pp. 53-68
    • Wang, Q.1    Tang, X.N.2    Yenari, M.A.3
  • 24
    • 84924948342 scopus 로고    scopus 로고
    • Characterisation of protein kinases targeting p65 NF-KB phosphorylation and transactivation
    • Buss, H., Schmitz, L., Dorrie, A., Resch, K., and Kracht, M. (2002) Characterisation of protein kinases targeting p65 NF-KB phosphorylation and transactivation. Naunyn-Schmiedeberg's Arch. Pharmacol. 365, R56-R56.
    • (2002) Naunyn-Schmiedeberg's Arch. Pharmacol. , vol.365 , pp. R56-R56
    • Buss, H.1    Schmitz, L.2    Dorrie, A.3    Resch, K.4    Kracht, M.5
  • 26
    • 18744403704 scopus 로고    scopus 로고
    • Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensive rat
    • Lang, C., Liu, Z., Taylor, H. W., and Baker, D. G. (2005) Effect of Eucommia ulmoides on systolic blood pressure in the spontaneous hypertensive rat. Am. J. Chin. Med. 33, 215-230.
    • (2005) Am. J. Chin. Med. , vol.33 , pp. 215-230
    • Lang, C.1    Liu, Z.2    Taylor, H.W.3    Baker, D.G.4
  • 27
    • 0015366232 scopus 로고
    • Alteration of the course of hypertension in the spontaneously hypertensive rat
    • Freis, E. D., Ragan, D., Pillsbury, H., 3rd, and Mathews, M. (1972) Alteration of the course of hypertension in the spontaneously hypertensive rat. Circ. Res. 31, 1-7.
    • (1972) Circ. Res. , vol.31 , pp. 1-7
    • Freis, E.D.1    Ragan, D.2    Pillsbury, H.3    Mathews, M.4
  • 28
    • 84863244479 scopus 로고    scopus 로고
    • Eucommia ulmoides bark protects against renal injury in cadmium-challenged rats
    • Liu, E., Han, L., Wang, J., He, W., Shang, H., Gao, X., and Wang, T. (2012) Eucommia ulmoides bark protects against renal injury in cadmium-challenged rats. J. Med. Food 15, 307-314.
    • (2012) J. Med. Food , vol.15 , pp. 307-314
    • Liu, E.1    Han, L.2    Wang, J.3    He, W.4    Shang, H.5    Gao, X.6    Wang, T.7
  • 29
    • 33846235930 scopus 로고    scopus 로고
    • Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice
    • Park, S. A., Choi, M. S., Jung, U. J., Kim, M. J., Kim, D. J., Park, H. M., Park, Y. B., and Lee, M. K. (2006) Eucommia ulmoides Oliver leaf extract increases endogenous antioxidant activity in type 2 diabetic mice. J. Med. Food 9, 474-479.
    • (2006) J. Med. Food , vol.9 , pp. 474-479
    • Park, S.A.1    Choi, M.S.2    Jung, U.J.3    Kim, M.J.4    Kim, D.J.5    Park, H.M.6    Park, Y.B.7    Lee, M.K.8
  • 31
    • 31144450053 scopus 로고    scopus 로고
    • Current pharmacotherapy for Alzheimer's disease
    • Lleo, A., Greenberg, S. M., and Growdon, J. H. (2006) Current pharmacotherapy for Alzheimer's disease. Annu. Rev. Med. 57, 513-533.
    • (2006) Annu. Rev. Med. , vol.57 , pp. 513-533
    • Lleo, A.1    Greenberg, S.M.2    Growdon, J.H.3
  • 33
    • 70350712465 scopus 로고    scopus 로고
    • Isolation of antifungal compounds from Gardenia jasminoides
    • Lelono, R. A., Tachibana, S., and Itoh, K. (2009) Isolation of antifungal compounds from Gardenia jasminoides. Pak. J. Biol. Sci. 12, 949-956.
    • (2009) Pak. J. Biol. Sci. , vol.12 , pp. 949-956
    • Lelono, R.A.1    Tachibana, S.2    Itoh, K.3
  • 34
    • 16344371938 scopus 로고    scopus 로고
    • Synthesis and characterization of a novel chitosan-gelatin bioconjugate with fluorescence emission
    • Mi, F. L. (2005) Synthesis and characterization of a novel chitosan-gelatin bioconjugate with fluorescence emission. Biomacromolecules 6, 975-987.
    • (2005) Biomacromolecules , vol.6 , pp. 975-987
    • Mi, F.L.1
  • 35
    • 78149459962 scopus 로고    scopus 로고
    • Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents
    • Mailloux, R. J., Adjeitey, C. N., and Harper, M. E. (2010) Genipin-induced inhibition of uncoupling protein-2 sensitizes drug-resistant cancer cells to cytotoxic agents. PLoS One 5, e13289.
    • (2010) PLoS One , vol.5 , pp. e13289
    • Mailloux, R.J.1    Adjeitey, C.N.2    Harper, M.E.3
  • 36
    • 0035676786 scopus 로고    scopus 로고
    • Antithrombotic effect of geniposide and genipin in the mouse thrombosis model
    • Suzuki, Y., Kondo, K., Ikeda, Y., and Umemura, K. (2001) Antithrombotic effect of geniposide and genipin in the mouse thrombosis model. Planta Med. 67, 807-810.
    • (2001) Planta Med. , vol.67 , pp. 807-810
    • Suzuki, Y.1    Kondo, K.2    Ikeda, Y.3    Umemura, K.4
  • 37
    • 67650751098 scopus 로고    scopus 로고
    • Neuroprotective action of genipin on tunicamycin-induced cytotoxicity in neuro2a cells
    • Tanaka, M., Yamazaki, M., and Chiba, K. (2009) Neuroprotective action of genipin on tunicamycin-induced cytotoxicity in neuro2a cells. Biol. Pharm. Bull. 32, 1220-1223.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 1220-1223
    • Tanaka, M.1    Yamazaki, M.2    Chiba, K.3
  • 38
    • 77954376984 scopus 로고    scopus 로고
    • Effect of genipin on cholestasis induced by estradiol-17beta-glucuronide and lithocholate-3-O-glucuornide in rats
    • Goto, H., and Takikawa, H. (2010) Effect of genipin on cholestasis induced by estradiol-17beta-glucuronide and lithocholate-3-O-glucuornide in rats. Hepatol. Res. 40, 524-529.
    • (2010) Hepatol. Res. , vol.40 , pp. 524-529
    • Goto, H.1    Takikawa, H.2
  • 39
    • 78650945927 scopus 로고    scopus 로고
    • Potent inhibitor design against H1N1 swine influenza: Structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese medicine database
    • Lin, C. H., Chang, T. T., Sun, M. F., Chen, H. Y., Tsai, F. J., Chang, K. L., Fisher, M., and Chen, C. Y. (2011) Potent inhibitor design against H1N1 swine influenza: Structure-based and molecular dynamics analysis for M2 inhibitors from traditional Chinese medicine database. J. Biomol. Struct. Dyn. 28, 471-482.
    • (2011) J. Biomol. Struct. Dyn. , vol.28 , pp. 471-482
    • Lin, C.H.1    Chang, T.T.2    Sun, M.F.3    Chen, H.Y.4    Tsai, F.J.5    Chang, K.L.6    Fisher, M.7    Chen, C.Y.8
  • 41
    • 79960647993 scopus 로고    scopus 로고
    • Genipin Selectively Inhibits TNF-alpha-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-gamma in Human Endothelial Cells
    • Hwa, J. S., Mun, L., Kim, H. J., Seo, H. G., Lee, J. H., Kwak, J. H., Lee, D. U., and Chang, K. C. (2011) Genipin Selectively Inhibits TNF-alpha-activated VCAM-1 But Not ICAM-1 Expression by Upregulation of PPAR-gamma in Human Endothelial Cells. Korean J. Physiol. Pharmacol. 15, 157-162.
    • (2011) Korean J. Physiol. Pharmacol. , vol.15 , pp. 157-162
    • Hwa, J.S.1    Mun, L.2    Kim, H.J.3    Seo, H.G.4    Lee, J.H.5    Kwak, J.H.6    Lee, D.U.7    Chang, K.C.8
  • 43
    • 44249090414 scopus 로고    scopus 로고
    • Anti-inflammatory effects of catechols in lipopolysaccharides-timulated microglia cells: Inhibition of microglial neurotoxicity
    • Zheng, L. T., Ryu, G. M., Kwon, B. M., Lee, W. H., and Suk, K. (2008) Anti-inflammatory effects of catechols in lipopolysaccharides-timulated microglia cells: inhibition of microglial neurotoxicity. Eur. J. Pharmacol. 588, 106-113.
    • (2008) Eur. J. Pharmacol. , vol.588 , pp. 106-113
    • Zheng, L.T.1    Ryu, G.M.2    Kwon, B.M.3    Lee, W.H.4    Suk, K.5
  • 46
    • 22244485338 scopus 로고    scopus 로고
    • Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: Possible role of increased norepinephrine turnover
    • Kaneko, Y. S., Mori, K., Nakashima, A., Sawada, M., Nagatsu, I., and Ota, A. (2005) Peripheral injection of lipopolysaccharide enhances expression of inflammatory cytokines in murine locus coeruleus: Possible role of increased norepinephrine turnover. J. Neurochem. 94, 393-404.
    • (2005) J. Neurochem. , vol.94 , pp. 393-404
    • Kaneko, Y.S.1    Mori, K.2    Nakashima, A.3    Sawada, M.4    Nagatsu, I.5    Ota, A.6
  • 47
    • 0035873933 scopus 로고    scopus 로고
    • The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium
    • Tintinger, G. R., Theron, A. J., Anderson, R., and Ker, J. A. (2001) The anti-inflammatory interactions of epinephrine with human neutrophils in vitro are achieved by cyclic AMP-mediated accelerated resequestration of cytosolic calcium. Biochem. Pharmacol. 61, 1319-1328.
    • (2001) Biochem. Pharmacol. , vol.61 , pp. 1319-1328
    • Tintinger, G.R.1    Theron, A.J.2    Anderson, R.3    Ker, J.A.4
  • 48
    • 67649565938 scopus 로고    scopus 로고
    • Influence of acute epinephrine infusion on endotoxin-induced parameters of heart rate variability: A randomized controlled trial
    • Jan, B. U., Coyle, S. M., Oikawa, L. O., Lu, S. E., Calvano, S. E., Lehrer, P. M., and Lowry, S. F. (2009) Influence of acute epinephrine infusion on endotoxin-induced parameters of heart rate variability: A randomized controlled trial. Ann. Surg. 249, 750-756.
    • (2009) Ann. Surg. , vol.249 , pp. 750-756
    • Jan, B.U.1    Coyle, S.M.2    Oikawa, L.O.3    Lu, S.E.4    Calvano, S.E.5    Lehrer, P.M.6    Lowry, S.F.7
  • 49
    • 80052264023 scopus 로고    scopus 로고
    • Experimental approaches to study functional recovery following cerebral ischemia
    • Lipsanen, A., and Jolkkonen, J. (2011) Experimental approaches to study functional recovery following cerebral ischemia. Cell. Mol. Life Sci. 68, 3007-3017.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 3007-3017
    • Lipsanen, A.1    Jolkkonen, J.2
  • 50
    • 34547678127 scopus 로고    scopus 로고
    • Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation
    • Park, E. K., Rhee, H. I., Jung, H. S., Ju, S. M., Lee, Y. A., Lee, S. H., Hong, S. J., Yang, H. I., Yoo, M. C., and Kim, K. S. (2007) Antiinflammatory effects of a combined herbal preparation (RAH13) of Phellodendron amurense and Coptis chinensis in animal models of inflammation. Phytother. Res. 21, 746-750.
    • (2007) Phytother. Res. , vol.21 , pp. 746-750
    • Park, E.K.1    Rhee, H.I.2    Jung, H.S.3    Ju, S.M.4    Lee, Y.A.5    Lee, S.H.6    Hong, S.J.7    Yang, H.I.8    Yoo, M.C.9    Kim, K.S.10
  • 51
    • 39149085654 scopus 로고    scopus 로고
    • Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells
    • Nakaso, K., Ito, S., and Nakashima, K. (2008) Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells. Neurosci. Lett. 432, 146-150.
    • (2008) Neurosci. Lett. , vol.432 , pp. 146-150
    • Nakaso, K.1    Ito, S.2    Nakashima, K.3
  • 52
    • 84899938968 scopus 로고    scopus 로고
    • EPO-Dependent Activation of PI3K/Akt/FoxO3a Signalling Mediates Neuroprotection in In Vitro and In Vivo Models of Parkinson's Disease
    • Jia, Y., Mo, S. J., Feng, Q. Q., Zhan, M. L., Ouyang, L. S., Chen, J. C., Ma, Y. X., Wu, J. J., and Lei, W. L. (2014) EPO-Dependent Activation of PI3K/Akt/FoxO3a Signalling Mediates Neuroprotection in In Vitro and In Vivo Models of Parkinson's Disease. J. Mol. Neurosci. 53, 117-124.
    • (2014) J. Mol. Neurosci. , vol.53 , pp. 117-124
    • Jia, Y.1    Mo, S.J.2    Feng, Q.Q.3    Zhan, M.L.4    Ouyang, L.S.5    Chen, J.C.6    Ma, Y.X.7    Wu, J.J.8    Lei, W.L.9
  • 54
    • 2442716392 scopus 로고    scopus 로고
    • TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity
    • Kim, W. K., Hwang, S. Y., Oh, E. S., Piao, H. Z., Kim, K. W., and Han, I. O. (2004) TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity. J. Immunol. 172, 7015-7023.
    • (2004) J. Immunol. , vol.172 , pp. 7015-7023
    • Kim, W.K.1    Hwang, S.Y.2    Oh, E.S.3    Piao, H.Z.4    Kim, K.W.5    Han, I.O.6
  • 55
    • 2142640818 scopus 로고    scopus 로고
    • 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages
    • Jhun, B. S., Jin, Q., Oh, Y. T., Kim, S. S., Kong, Y., Cho, Y. H., Ha, J., Baik, H. H., and Kang, I. (2004) 5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochem. Biophys. Res. Commun. 318, 372-380.
    • (2004) Biochem. Biophys. Res. Commun. , vol.318 , pp. 372-380
    • Jhun, B.S.1    Jin, Q.2    Oh, Y.T.3    Kim, S.S.4    Kong, Y.5    Cho, Y.H.6    Ha, J.7    Baik, H.H.8    Kang, I.9
  • 56
    • 32544439901 scopus 로고    scopus 로고
    • Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NFkappaB activation in murine BV2 microglial cells
    • Lee, J. Y., Jhun, B. S., Oh, Y. T., Lee, J. H., Choe, W., Baik, H. H., Ha, J., Yoon, K. S., Kim, S. S., and Kang, I. (2006) Activation of adenosine A3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI 3-kinase/Akt and NFkappaB activation in murine BV2 microglial cells. Neurosci. Lett. 396, 1-6.
    • (2006) Neurosci. Lett. , vol.396 , pp. 1-6
    • Lee, J.Y.1    Jhun, B.S.2    Oh, Y.T.3    Lee, J.H.4    Choe, W.5    Baik, H.H.6    Ha, J.7    Yoon, K.S.8    Kim, S.S.9    Kang, I.10
  • 57
    • 41149177024 scopus 로고    scopus 로고
    • Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt
    • Xing, B., Xin, T., Hunter, R. L., and Bing, G. (2008) Pioglitazone inhibition of lipopolysaccharide-induced nitric oxide synthase is associated with altered activity of p38 MAP kinase and PI3K/Akt. J. Neuroinflammation 5, 4.
    • (2008) J. Neuroinflammation , vol.5 , pp. 4
    • Xing, B.1    Xin, T.2    Hunter, R.L.3    Bing, G.4
  • 59
    • 33750023475 scopus 로고    scopus 로고
    • Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice
    • Pan, M. H., Lai, C. S., Wang, Y. J., and Ho, C. T. (2006) Acacetin suppressed LPS-induced up-expression of iNOS and COX-2 in murine macrophages and TPA-induced tumor promotion in mice. Biochem. Pharmacol. 72, 1293-1303.
    • (2006) Biochem. Pharmacol. , vol.72 , pp. 1293-1303
    • Pan, M.H.1    Lai, C.S.2    Wang, Y.J.3    Ho, C.T.4
  • 60
    • 77649160181 scopus 로고    scopus 로고
    • PI3K inhibition in inflammation: Toward tailored therapies for specific diseases
    • Ghigo, A., Damilano, F., Braccini, L., and Hirsch, E. (2010) PI3K inhibition in inflammation: Toward tailored therapies for specific diseases. BioEssays 32, 185-196.
    • (2010) BioEssays , vol.32 , pp. 185-196
    • Ghigo, A.1    Damilano, F.2    Braccini, L.3    Hirsch, E.4
  • 61
    • 71049149246 scopus 로고    scopus 로고
    • Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages
    • Yang, C. L., Chik, S. C., Li, J. C., Cheung, B. K., and Lau, A. S. (2009) Identification of the bioactive constituent and its mechanisms of action in mediating the anti-inflammatory effects of black cohosh and related Cimicifuga species on human primary blood macrophages. J. Med. Chem. 52, 6707-6715.
    • (2009) J. Med. Chem. , vol.52 , pp. 6707-6715
    • Yang, C.L.1    Chik, S.C.2    Li, J.C.3    Cheung, B.K.4    Lau, A.S.5
  • 62
    • 79952447872 scopus 로고    scopus 로고
    • Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia
    • Or, T. C., Yang, C. L., Law, A. H., Li, J. C., and Lau, A. S. (2011) Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. Neuropharmacology 60, 823-831.
    • (2011) Neuropharmacology , vol.60 , pp. 823-831
    • Or, T.C.1    Yang, C.L.2    Law, A.H.3    Li, J.C.4    Lau, A.S.5
  • 63
    • 79953116123 scopus 로고    scopus 로고
    • Differential effects of Radix Paeoniae Rubra (Chishao) on cytokine and chemokine expression inducible by mycobacteria
    • Wang, L., Yang, C. L., Or, T. C., Chen, G., Zhou, J., Li, J. C., and Lau, A. S. (2011) Differential effects of Radix Paeoniae Rubra (Chishao) on cytokine and chemokine expression inducible by mycobacteria. Chin. Med. 6, 14.
    • (2011) Chin. Med. , vol.6 , pp. 14
    • Wang, L.1    Yang, C.L.2    Or, T.C.3    Chen, G.4    Zhou, J.5    Li, J.C.6    Lau, A.S.7
  • 64
    • 0027080364 scopus 로고
    • The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells
    • Marks, D. C., Belov, L., Davey, M. W., Davey, R. A., and Kidman, A. D. (1992) The MTT cell viability assay for cytotoxicity testing in multidrug-resistant human leukemic cells. Leuk. Res. 16, 1165-1173.
    • (1992) Leuk. Res. , vol.16 , pp. 1165-1173
    • Marks, D.C.1    Belov, L.2    Davey, M.W.3    Davey, R.A.4    Kidman, A.D.5
  • 65
    • 0031033145 scopus 로고    scopus 로고
    • Nitric oxide scavenging by curcuminoids
    • Sreejayan, and Rao, M. N. (1997) Nitric oxide scavenging by curcuminoids. J. Pharm. Pharmacol. 49, 105-107.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 105-107
    • Sreejayan1    Rao, M.N.2
  • 66
    • 79952447872 scopus 로고    scopus 로고
    • Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia
    • Or, T. C. T., Yang, C. L. H., Law, A. H. Y., Li, J. C. B., and Lau, A. S. Y. (2011) Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. Neuropharmacology 60, 823-831.
    • (2011) Neuropharmacology , vol.60 , pp. 823-831
    • Or, T.C.T.1    Yang, C.L.H.2    Law, A.H.Y.3    Li, J.C.B.4    Lau, A.S.Y.5
  • 67
    • 74549115190 scopus 로고    scopus 로고
    • A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1
    • Cheung, B. K. W., Yim, H. C. H., Lee, N. C. M., and Lau, A. S. Y. (2009) A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1. BMC Immunol. 10, 64.
    • (2009) BMC Immunol. , vol.10 , pp. 64
    • Cheung, B.K.W.1    Yim, H.C.H.2    Lee, N.C.M.3    Lau, A.S.Y.4
  • 68
    • 33748136861 scopus 로고    scopus 로고
    • Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains
    • Kunert-Keil, C., Bisping, F., Kruger, J., and Brinkmeier, H. (2006) Tissue-specific expression of TRP channel genes in the mouse and its variation in three different mouse strains. BMC Genomics 7, 159.
    • (2006) BMC Genomics , vol.7 , pp. 159
    • Kunert-Keil, C.1    Bisping, F.2    Kruger, J.3    Brinkmeier, H.4
  • 69
    • 62449233690 scopus 로고    scopus 로고
    • Cardiac-targeted expression of soluble fas attenuates doxorubicin-induced cardiotoxicity in mice
    • Niu, J., Azfer, A., Wang, K., Wang, X., and Kolattukudy, P. E. (2009) Cardiac-targeted expression of soluble fas attenuates doxorubicin-induced cardiotoxicity in mice. J. Pharmacol. Exp. Ther. 328, 740-748.
    • (2009) J. Pharmacol. Exp. Ther. , vol.328 , pp. 740-748
    • Niu, J.1    Azfer, A.2    Wang, K.3    Wang, X.4    Kolattukudy, P.E.5
  • 70
    • 23244461479 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1
    • Lee, D. C. W., Cheung, C. Y., Law, A. H. Y., Mok, C. K. P., Peiris, M., and Lau, A. S. Y. (2005) p38 mitogen-activated protein kinase-dependent hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. J. Virol. 79, 10147-10154.
    • (2005) J. Virol. , vol.79 , pp. 10147-10154
    • Lee, D.C.W.1    Cheung, C.Y.2    Law, A.H.Y.3    Mok, C.K.P.4    Peiris, M.5    Lau, A.S.Y.6


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