Stress, the stress system and the role of glucocorticoids

NeuroImmunoModulation

Volumn 22, Issue , 2014, Pages 6-19

  Nicolaides, Nicolas C ^a,b   Kyratzi, Elli ^b   Lamprokostopoulou, Agaristi ^b   Chrousos, George P ^a,b,c   Charmandari, Evangelia ^a,b  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^b Diabetes First Department of Pediatrics   (Greece)

^c KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

Author keywords

Glucocorticoid receptor; Glucocorticoids; Hypothalamic pituitary adrenal axis; Stress response; Stress system

Indexed keywords

GLUCOCORTICOID;

ACUTE STRESS; ADRENAL MEDULLA; ARTICLE; BRAIN CIRCULATION; CHOLINERGIC SYSTEM; CHRONIC STRESS; COGNITION; EPIGENETICS; GENOMICS; GROWTH CURVE; HOMEOSTASIS; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; METABOLISM; NEGATIVE FEEDBACK; NON COMMUNICABLE DISEASE; STRESS; STRESS MANAGEMENT; ANIMAL; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MENTAL STRESS; PATHOLOGY;

ANIMALS; GLUCOCORTICOIDS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; PITUITARY-ADRENAL SYSTEM; STRESS, PSYCHOLOGICAL;

EID: 84908564409     PISSN: 10217401     EISSN: 14230216     Source Type: Journal    
DOI: 10.1159/000362736     Document Type: Article

References (75)

1. Chrousos GP: Stress and disorders of the stress system. Nat Rev Endocrinol 2009; 5: 374-381.
2. Chrousos GP, Gold PW: The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis. JAMA 1992; 267: 1244-1252.
3. Charmandari E, Tsigos C, Chrousos GP: Endocrinology of the stress response. Annu Rev Physiol 2005; 67: 259-284.
4. Chrousos GP, Kino T: Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 2007; 10: 213-219.
5. Chrousos GP, Loriaux DL, Gold PW (eds): Mechanisms of Physical and Emotional Stress: Advances in Experimental Medicine and Biology. New York, Plenum Press, 1988, vol 245.
6. Kontopoulou TD, Marketos SG: Homeostasis: The ancient Greek origin of a modern scientific principle. Hormones 2002; 1: 124-125.
7. Fink G: Stress: definition and history; in Squire LR (ed): Encyclopedia of Neuroscience. Oxford, Academic Press, 2009, pp 549- 555, vol 9.
8. Selye H: A syndrome produced by diverse nocuous agents. Nature 1936; 138: 32.
9. Szabo S, Tache Y, Somogyi A: The legacy of Hans Selye and the origins of stress research: A retrospective 75 years after his landmark brief 'letter' to the editor of Nature . Stress 2012; 15: 472-478.
10. Charmandari E, Kino T, Souvatzoglou E, Chrousos GP: Pediatric stress: hormonal mediators and human development. Horm Res 2003; 59: 161-179.
11. Chrousos GP: Stressors, stress, and neuroendocrine integration of the adaptive response: The 1997 Hans Selye Memorial Lecture. Ann NY Acad Sci 1998; 851: 311-335.
12. Chrousos GP: The hypothalamic-pituitaryadrenal axis and immune-mediated inflammation. N Engl J Med 1995; 332: 1351-1362.
13. Chrousos GP, Calabrese JR, Avgerinos P, Kling MA, Rubinow D, Oldfield EH, et al: Corticotropin releasing factor: basic studies and clinical applications. Prog Neuropsychopharmacol Biol Psychiatry 1985; 9: 349-359.
14. Calogero AE, Bernardini R, Gold PW, Chrousos GP: Regulation of rat hypothalamic corticotropin- releasing hormone secretion in vitro: potential clinical implications. Adv Exp Med Biol 1988; 245: 167-181.
15. Smith MA, Kling MA, Whitfield HJ, Brandt HA, Demitrack MA, Geracioti TD, Chrousos GP, Gold PW: Corticotropin-releasing hormone: from endocrinology to psychobiology. Horm Res 1989; 31: 66-71.
16. Bornstein SR, Chrousos GP: Clinical review 104: Adrenocorticotropin (ACTH)- And non- ACTH-mediated regulation of the adrenal cortex: neural and immune inputs. J Clin Endocrinol Metab 1999; 84: 1729-1736.
17. Hammes SR, Levin ER: Extranuclear steroid receptors: nature and actions. Endocr Rev 2007; 28: 726-741.
18. Chrousos GP, Kino T: Intracellular glucocorticoid signaling: A formerly simple system turns stochastic. Sci STKE 2005; 2005:pe48.
19. Nicolaides NC, Galata Z, Kino T, Chrousos GP, Charmandari E: The human glucocorticoid receptor: molecular basis of biologic function. Steroids 2010; 75: 1-12.
20. Lu NZ, Cidlowski JA: Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 2005; 18: 331-342.
21. Nader N, Chrousos GP, Kino T: Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: potential physiological implications. FASEB J 2009; 23: 1572-1583.
22. Nader N, Chrousos GP, Kino T: Interactions of the circadian CLOCK system and the HPA axis. Trends Endocrinol Metab 2010; 21: 277- 286.
23. Kino T, Chrousos GP: Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: circadian rhythm-associated alterations of glucocorticoid actions in target tissues. Mol Cell Endocrinol 2011; 336: 23-30.
24. Kino T, Chrousos GP: Circadian CLOC Kmediated regulation of target-tissue sensitivity to glucocorticoids: implications for cardiometabolic diseases. Endocr Dev 2011; 20: 116- 126.
25. Charmandari E, Chrousos GP, Lambrou GI, Pavlaki A, Koide H, Ng SSM, Kino T: Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS ONE 2011; 6:e25612.
26. Ayroldi E, Cannarile L, Migliorati G, Nocentini G, Delfino DV, Riccardi C: Mechanisms of the anti-inflammatory effects of glucocorticoids: genomic and nongenomic interference with MAPK signaling pathways. FASEB J 2012; 26: 4805-4820.
27. Song IH, Buttgereit F: Non-genomic glucocorticoid effects to provide the basis for new drug developments. Mol Cell Endocrinol 2006; 246: 142-146.
28. Lee SR, Kim HK, Youm JB, Dizon LA, Song IS, Jeong SH, Seo DY, Ko KS, Rhee BD, Kim N, Han J: Non-genomic effect of glucocorticoids on cardiovascular system. Pflugers Arch 2012; 464: 549-559.
29. Bellavance MA, Rivest S: The neuroendocrine control of the innate immune system in health and brain diseases. Immunol Rev 2012; 248: 36-55.
30. Hinz B, Hirschelmann R: Rapid non-genomic feedback effects of glucocorticoids on CRFinduced ACTH secretion in rats. Pharm Res 2000; 17: 1273-1277.
31. Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M: Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci USA 2005; 102: 19204-19207.
32. Hafezi-Moghadam A, Simoncini T, Yang Z, Limbourg FP, Plumier JC, Rebsamen MC, Hsieh CM, Chui DS, Thomas KL, Prorock AJ, Laubach VE, Moskowitz MA, French BA, Ley K, Liao JK: Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase. Nat Med 2002; 8: 473- 479.
33. Lowenberg M, Verhaar AP, Bilderbeek J, Marle J, Buttgereit F, Peppelenbosch MP, van Deventer SJ, Hommes DW: Glucocorticoids cause rapid dissociation of a T-cell-receptorassociated protein complex containing LCK and FYN. EMBO Rep 2006; 7: 1023-1029.
34. Sapolsky RM, Romero LM, Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000; 21: 55-89.
35. Groeneweg FL, Karst H, de Kloet ER, Joels M: Rapid non-genomic effects of corticosteroids and their role in the central stress response. J Endocrinol 2011; 209: 153-167.
36. Prager EM, Johnson LR: Stress at the synapse: signal transduction mechanisms of adrenal steroids at neuronal membranes. Sci Signal 2009; 2:re5.
37. Tasker JG, Di S, Malcher-Lopes R: Minireview: rapid glucocorticoid signaling via membrane- Associated receptors. Endocrinology 2006; 147: 5549-5556.
38. Chrousos GP: The stress response and immune function: clinical implications - The 1999 Novera H. Spector lecture. Ann NY Acad Sci 2000; 917: 38-67.
39. Karalis K, Sano H, Redwine J, Listwak S, Wilder RL, Chrousos GP: Autocrine or paracrine inflammatory actions of corticotropinreleasing hormone in vivo. Science 1991; 254: 421-423.
40. Elenkov IJ, Chrousos GP: Stress hormones, Th1/Th2-patterns, pro/anti- inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 1999; 10: 359-368.
41. Elenkov IJ, Kvetnansky R, Hashiramoto A, Bakalov VK, Link AA, Zachman K, Crane M, Jezova D, Rovensky J, Dimitrov MA, Gold PW, Bonini S, Fleisher T, Chrousos GP, Wilder RL: Low- versus high-baseline epinephrine output shapes opposite innate cytokine profiles: presence of Lewis- And Fischer-like neurohormonal immune phenotypes in humans? J Immunol 2008; 181: 1737-1745.
42. Theoharides TC, Singh LK, Boucher W, Pang X, Letourneau R, Webster E, Chrousos GP: Corticotropin-releasing hormone induces skin mast cell degranulation and increased vascular permeability, a possible explanation for its proinflammatory effects. Endocrinology 1998; 139: 403-413.
43. Theoharides TC, Spanos C, Pang X, Alferes L, Ligris K, Letourneau R, Rozniecki JJ, Webster E, Chrousos GP: Stress-induced intracranial mast cell degranulation: A corticotropin-releasing hormone-mediated effect. Endocrinology 1995; 136: 5745-5750.
44. Burguera B, Muruais C, Penalva A, Dieguez C, Casanueva FF: Dual and selective actions of glucocorticoids upon basal and stimulated growth hormone release in man. Neuroendocrinology 1990; 51: 51-58.
45. Magiakou MA, Mastorakos G, Gomez MT, Rose SR, Chrousos GP: Suppressed spontaneous and stimulated growth hormone secretion in patients with Cushing's disease before and after surgical cure. J Clin Endocrinol Metab 1994; 78: 131-137.
46. Bamberger CM, Schulte HM, Chrousos GP: Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 1996; 17: 245-261.
47. Magiakou MA, Mastorakos G, Chrousos GP: Final stature in patients with endogenous Cushing's syndrome. J Clin Endocrinol Metab 1994; 79: 1082-1085.
48. Skuse D, Albanese A, Stanhope R, Gilmour J, Voss L: A new stress-related syndrome of growth failure and hyperphagia in children, associated with reversibility of growth hormone insufficiency. Lancet 1996; 348: 353- 358.
49. Albanese A, Hamill G, Jones J, Skuse D, Matthews DR, Stanhope R: Reversibility of physiological growth hormone secretion in children with psychosocial dwarfism. Clin Endocrinol (Oxf) 1994; 40: 687-692.
50. Benker G, Raida M, Olbricht T, Wagner R, Reinhardt W, Reinwein D: TSH secretion in Cushing's syndrome: relation to glucocorticoid excess, diabetes, goitre and the 'sick euthyroid syndrome'. Clin Endocrinol (Oxf) 1990; 33: 777-786.
51. Whirledge S, Cidlowski JA: A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary. Endocrinology 2013; 154: 4450-4468.
52. Rivier C, Rivier J, Vale W: Stress-induced inhibition of reproductive functions: role of endogenous corticotropin-releasing factor. Science 1986; 231: 607-609.
53. Vamvakopoulos NC, Chrousos GP: Hormonal regulation of human corticotropin-releasing hormone gene expression: implications for the stress response and immune/inflammatory reaction. Endocr Rev 1994; 15: 409- 420.
54. Chrousos GP, Torpy DJ, Gold PW: Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann Intern Med 1998; 129: 229-240.
55. MacAdams MR, White RH, Chipps BE: Reduction of serum testosterone levels during chronic glucocorticoid therapy. Ann Intern Med 1986; 104: 648-651.
56. Luger A, Deuster PA, Kyle SB, Gallucci WT, Montgomery LC, Gold PW, Loriaux DL, Chrousos GP: Acute hypothalamic-pituitaryadrenal responses to the stress of treadmill exercise: physiologic adaptations to physical training. N Engl J Med 1987; 316: 1309-1315.
57. MacConnie SE, Barkan A, Lampman RM, Schork MA, Beitins IZ: Decreased hypothalamic gonadotropin-releasing hormone secretion in male marathon runners. N Engl J Med 1986; 315: 411-417.
58. Chrousos GP: The role of stress and the hypothalamic- pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: neuroendocrine and target tissue-related causes. Int J Obes (London) 2000; 24:s50f-s55f.
59. Chrousos GP, Tsigos C: Stress, obesity, and metabolic syndrome. Ann NY Acad Sci 2006; 1083:xi-xiii.
60. Gold PW, Goodwin F, Chrousos GP: Clinical and biochemical manifestations of depression: relationship to the neurobiology of stress (part I). N Engl J Med 1988; 319: 348- 353.
61. Gold PW, Goodwin F, Chrousos GP: Clinical and biochemical manifestations of depression: relationship to the neurobiology of stress (part II). N Engl J Med 1988; 319: 413- 420.
62. Gold PW, Chrousos GP: Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs. low CRH/NE states. Mol Psychiatry 2002; 7: 254- 275.
63. Chrousos G: The glucocorticoid receptor gene, longevity, and the highly prevalent complex disorders of Western societies. Am J Med 2004; 117: 204-207.
64. Murgatroyd C, Wu Y, Bockmuhl Y, Spengler D: Genes learn from stress: how infantile trauma programs us for depression. Epigenetics 2010; 5: 194-199.
65. Meaney MJ, Aitken DH, Bodnoff SR, Iny LJ, Tatarewicz JE, Sapolsky RM: Early postnatal handling alters glucocorticoid receptor concentrations in selected brain regions. Behav Neurosci 1985; 99: 765-770.
66. Meaney MJ, Aitken DH, Sapolsky RM: Thyroid hormones influence the development of hippocampal glucocorticoid receptors in the rat: A mechanism for the effects of postnatal handling on the development of the adrenocortical stress response. Neuroendocrinology 1987; 45: 278-283.
67. Mitchell JB, Iny LJ, Meaney MJ: The role of serotonin in the development and environmental regulation of type II corticosteroid receptor binding in rat hippocampus. Brain Res Dev Brain Res 1990; 55: 231-235.
68. Champagne FA: Early environments, glucocorticoid receptors, and behavioral epigenetics. Behav Neurosci 2013; 127: 628-636.
69. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky PM, Meaney MJ: Maternal care, hippocampal glucocorticoid receptors, and hypothalamic- pituitary-adrenal responses to stress. Science 1997; 277: 1659-1662.
70. Hellstrom IC, Dhir SK, Diorio JC, Meaney MJ: Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade. Philos Trans R Soc Lond B Biol Sci 2012; 367: 2495-2510.
71. Weaver IC, Cervoni N, Champagne FA, D'Alessio AC, Sharma S, Seckl JR, Dymov S, Szyf M, Meaney MJ: Epigenetic programming by maternal behavior. Nature Neuroscience 2004; 7: 847-854.
72. McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, Turecki G, Meaney MJ: Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci 2009; 12: 342- 348.
73. Stankiewicz AM, Swiergiel AH, Lisowski P: Epigenetics of stress adaptations in the brain. Brain Res Bull 2013; 98: 76-92.
74. Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, Szyf M: Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: Altering epigenetic marking later in life. J Neurosci 2005; 25: 11045-11054.
75. Meaney MJ: Nature, nurture, and the disunity of knowledge. Ann NY Acad Sci 2001; 935: 50-61.