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Volumn 23, Issue 5, 2009, Pages 1572-1583

Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster: Potential physiological implications

Author keywords

Brain muscle arnt like protein 1; G6Pase; GILZ; GREs; Histone acetyltransferase; Hypothalamic pituitary adrenal axis

Indexed keywords

GLUCOCORTICOID RECEPTOR; HETERODIMER; HISTONE ACETYLTRANSFERASE; LYSINE; MESSENGER RNA; PROTEIN BMAL1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CLOCK;

EID: 67349271210     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.08-117697     Document Type: Article
Times cited : (263)

References (56)
  • 1
    • 34249002259 scopus 로고    scopus 로고
    • Glucocorticoid action networks and complex psychiatric and/or somatic disorders
    • Chrousos, G. P., and Kino, T. (2007) Glucocorticoid action networks and complex psychiatric and/or somatic disorders. Stress 10, 213-219
    • (2007) Stress , vol.10 , pp. 213-219
    • Chrousos, G.P.1    Kino, T.2
  • 2
    • 34347214187 scopus 로고    scopus 로고
    • Glucocorticoid effect on gene expression
    • Steckler, T., Kalin, N. H., and Reul, J. M. H. M., eds Elsevier BV, Amsterdam, The Netherlands
    • Kino, T., and Chrousos, G. P. (2004) Glucocorticoid effect on gene expression. In Handbook on Stress and the Brain Part 1 (Steckler, T., Kalin, N. H., and Reul, J. M. H. M., eds) pp. 295-312, Elsevier BV, Amsterdam, The Netherlands
    • (2004) Handbook on Stress and the Brain Part 1 , pp. 295-312
    • Kino, T.1    Chrousos, G.P.2
  • 3
    • 1442272396 scopus 로고    scopus 로고
    • Glucocorticoid therapy
    • Felig, P., and Frohman, L. A., eds McGraw-Hill, New York
    • Chrousos, G. P. (2001) Glucocorticoid therapy. In Endocrinology & Metabolism (Felig, P., and Frohman, L. A., eds) pp. 609-632, McGraw-Hill, New York
    • (2001) Endocrinology & Metabolism , pp. 609-632
    • Chrousos, G.P.1
  • 6
    • 33644875471 scopus 로고    scopus 로고
    • Intracellular glucocorticoid signaling: A formerly simple system turns stochastic
    • 2005
    • Chrousos, G. P., and Kino, T. (2005) Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci. STKE 2005, pe48
    • (2005) Sci. STKE
    • Chrousos, G.P.1    Kino, T.2
  • 7
    • 34547731515 scopus 로고    scopus 로고
    • Nuclear receptor coregulators and human disease
    • DOI 10.1210/er.2007-0012
    • Lonard, D. M., Lanz, R. B., and O'Malley, B. W. (2007) Nuclear receptor coregulators and human disease. Endocr. Rev. 28, 575-587 (Pubitemid 47236337)
    • (2007) Endocrine Reviews , vol.28 , Issue.5 , pp. 575-587
    • Lonard, D.M.1    Lanz, R.B.2    O'Malley, B.W.3
  • 8
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos, G. P. (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 332, 1351-1362
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 9
    • 3142520021 scopus 로고    scopus 로고
    • Glucocorticoid and mineralocorticoid receptors and associated diseases
    • Kino, T., and Chrousos, G. P. (2004) Glucocorticoid and mineralocorticoid receptors and associated diseases. Essays Biochem. 40, 137-155 (Pubitemid 38901170)
    • (2004) Essays in Biochemistry , vol.40 , pp. 137-155
    • Kino, T.1    Chrousos, G.P.2
  • 10
    • 0025021084 scopus 로고
    • Transplanted suprachiasmatic nucleus determines circadian period
    • Ralph, M. R., Foster, R. G., Davis, F. C., and Menaker, M. (1990) Transplanted suprachiasmatic nucleus determines circadian period. Science 247, 975-978 (Pubitemid 20081665)
    • (1990) Science , vol.247 , Issue.4945 , pp. 975-978
    • Ralph, M.R.1    Foster, R.G.2    Davis, F.C.3    Menaker, M.4
  • 11
    • 0018762961 scopus 로고
    • Neural regulation of circadian rhythms
    • Rusak, B., and Zucker, I. (1979) Neural regulation of circadian rhythms. Physiol. Rev. 59, 449-526
    • (1979) Physiol. Rev. , vol.59 , pp. 449-526
    • Rusak, B.1    Zucker, I.2
  • 12
    • 0037987893 scopus 로고    scopus 로고
    • The biological clock tunes the organs of the body: Timing by hormones and the autonomic nervous system
    • Buijs, R. M., van Eden, C. G., Goncharuk, V. D., and Kalsbeek, A. (2003) The biological clock tunes the organs of the body: timing by hormones and the autonomic nervous system. J. Endocrinol. 177, 17-26
    • (2003) J. Endocrinol. , vol.177 , pp. 17-26
    • Buijs, R.M.1    Van Eden, C.G.2    Goncharuk, V.D.3    Kalsbeek, A.4
  • 13
    • 33645077065 scopus 로고    scopus 로고
    • Enlightening the adrenal gland
    • Schibler, U., and Brown, S. A. (2005) Enlightening the adrenal gland. Cell. Metab. 2, 278-281
    • (2005) Cell. Metab. , vol.2 , pp. 278-281
    • Schibler, U.1    Brown, S.A.2
  • 15
    • 0037184977 scopus 로고    scopus 로고
    • A web of circadian pacemakers
    • Schibler, U., and Sassone-Corsi, P. (2002) A web of circadian pacemakers. Cell 111, 919-922
    • (2002) Cell , vol.111 , pp. 919-922
    • Schibler, U.1    Sassone-Corsi, P.2
  • 16
    • 0041346143 scopus 로고    scopus 로고
    • Circadian rhythms. Clocks on the brain
    • Green, C. B., and Menaker, M. (2003) Circadian rhythms. Clocks on the brain. Science 301, 319-320
    • (2003) Science , vol.301 , pp. 319-320
    • Green, C.B.1    Menaker, M.2
  • 17
    • 0038454431 scopus 로고    scopus 로고
    • Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice
    • DOI 10.1126/science.1082795
    • Dudley, C. A., Erbel-Sieler, C., Estill, S. J., Reick, M., Franken, P., Pitts, S., and McKnight, S. L. (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301, 379-383 (Pubitemid 36877075)
    • (2003) Science , vol.301 , Issue.5631 , pp. 379-383
    • Dudley, C.A.1    Erbel-Sieler, C.2    Estill, S.J.3    Reick, M.4    Franken, P.5    Pitts, S.6    McKnight, S.L.7
  • 18
    • 0030887045 scopus 로고    scopus 로고
    • Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway
    • DOI 10.1074/jbc.272.13.8581
    • Hogenesch, J. B., Chan, W. K., Jackiw, V. H., Brown, R. C., Gu, Y. Z., Pray-Grant, M., Perdew, G. H., and Bradfield, C. A. (1997) Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. J. Biol. Chem. 272, 8581-8593 (Pubitemid 27147824)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.13 , pp. 8581-8593
    • Hogenesch, J.B.1    Chan, W.K.2    Jackiw, V.H.3    Brown, R.C.4    Gu, Y.-Z.5    Pray-Grant, M.6    Perdew, G.H.7    Bradfield, C.A.8
  • 21
    • 33646145721 scopus 로고    scopus 로고
    • Circadian regulator CLOCK is a histone acetyltransferase
    • Doi, M., Hirayama, J., and Sassone-Corsi, P. (2006) Circadian regulator CLOCK is a histone acetyltransferase. Cell 125, 497-508
    • (2006) Cell , vol.125 , pp. 497-508
    • Doi, M.1    Hirayama, J.2    Sassone-Corsi, P.3
  • 22
    • 0035967914 scopus 로고    scopus 로고
    • Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: A humoral mechanism to reset a peripheral clock
    • DOI 10.1016/S0092-8674(01)00401-9
    • McNamara, P., Seo, S. P., Rudic, R. D., Sehgal, A., Chakravarti, D., and FitzGerald, G. A. (2001) Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell 105, 877-889 (Pubitemid 32635089)
    • (2001) Cell , vol.105 , Issue.7 , pp. 877-889
    • McNamara, P.1    Seo, S.-B.2    Rudic, R.D.3    Sehgal, A.4    Chakravarti, D.5    Fitzgerald, G.A.6
  • 24
    • 22344454972 scopus 로고    scopus 로고
    • G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus
    • DOI 10.1083/jcb.200409150
    • Kino, T., Tiulpakov, A., Ichijo, T., Chheng, L., Kozasa, T., and Chrousos, G. P. (2005) G protein β interacts with the glucocorticoid receptor and suppresses its transcriptional activity in the nucleus. J. Cell Biol. 169, 885-896 (Pubitemid 41002865)
    • (2005) Journal of Cell Biology , vol.169 , Issue.6 , pp. 885-896
    • Kino, T.1    Tiulpakov, A.2    Ichijo, T.3    Chheng, L.4    Kozasa, T.5    Chrousos, G.P.6
  • 25
    • 1842531011 scopus 로고    scopus 로고
    • The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: Implications for intermediary metabolism
    • DOI 10.1210/me.2003-0341
    • De Martino, M. U., Bhattachryya, N., Alesci, S., Ichijo, T., Chrousos, G. P., and Kino, T. (2004) The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism. Mol. Endocrinol. 18, 820-833 (Pubitemid 38429475)
    • (2004) Molecular Endocrinology , vol.18 , Issue.4 , pp. 820-833
    • De Martino, M.U.1    Bhattachryya, N.2    Alesci, S.3    Ichijo, T.4    Chrousos, G.P.5    Kino, T.6
  • 26
    • 0036885129 scopus 로고    scopus 로고
    • HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: Potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection
    • Mirani, M., Elenkov, I., Volpi, S., Hiroi, N., Chrousos, G. P., and Kino, T. (2002) HIV-1 protein Vpr suppresses IL-12 production from human monocytes by enhancing glucocorticoid action: potential implications of Vpr coactivator activity for the innate and cellular immunity deficits observed in HIV-1 infection. J. Immunol. 169, 6361-6368 (Pubitemid 36903484)
    • (2002) Journal of Immunology , vol.169 , Issue.11 , pp. 6361-6368
    • Mirani, M.1    Elenkov, I.2    Volpi, S.3    Hiroi, N.4    Chrousos, G.P.5    Kino, T.6
  • 27
    • 0036776455 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators
    • DOI 10.1128/JVI.76.19.9724-9734.2002
    • Kino, T., Gragerov, A., Slobodskaya, O., Tsopanomichalou, M., Chrousos, G. P., and Pavlakis, G. N. (2002) Human immunodeficiency virus type-1 accessory protein Vpr induces transcription of the HIV-1 and glucocorticoid-responsive promoters by binding directly to p300/CBP coactivators. J. Virol. 76, 9724-9734 (Pubitemid 35006513)
    • (2002) Journal of Virology , vol.76 , Issue.19 , pp. 9724-9734
    • Kino, T.1    Gragerov, A.2    Slobodskaya, O.3    Tsopanomichalou, M.4    Chrousos, G.P.5    Pavlakis, G.N.6
  • 28
    • 34347255773 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: Clinical implications for the nervous system response to glucocorticoids and stress
    • DOI 10.1210/me.2006-0345
    • Kino, T., Ichijo, T., Amin, N. D., Kesavapany, S., Wang, Y., Kim, N., Rao, S., Player, A., Zheng, Y. L., Garabedian, M. J., Kawasaki, E., Pant, H. C., and Chrousos, G. P. (2007) Cyclin-dependent kinase 5 differentially regulates the transcriptional activity of the glucocorticoid receptor through phosphorylation: clinical implications for the nervous system response to glucocorticoids and stress. Mol. Endocrinol. 21, 1552-1568 (Pubitemid 47001081)
    • (2007) Molecular Endocrinology , vol.21 , Issue.7 , pp. 1552-1568
    • Kino, T.1    Ichijo, T.2    Amin, N.D.3    Kesavapany, S.4    Wang, Y.5    Kim, N.6    Rao, S.7    Player, A.8    Zheng, Y.-L.9    Garabedian, M.J.10    Kawasaki, E.11    Pant, H.C.12    Chrousos, G.P.13
  • 29
    • 39149111943 scopus 로고    scopus 로고
    • Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Iβ and releases it from a glucocorticoid-responsive gene promoter, relieving repression: Implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation
    • Ichijo, T., Chrousos, G. P., and Kino, T. (2008) Activated glucocorticoid receptor interacts with the INHAT component Set/TAF-Iβ and releases it from a glucocorticoid-responsive gene promoter, relieving repression: implications for the pathogenesis of glucocorticoid resistance in acute undifferentiated leukemia with Set-Can translocation. Mol. Cell. Endocrinol. 283, 19-31
    • (2008) Mol. Cell. Endocrinol. , vol.283 , pp. 19-31
    • Ichijo, T.1    Chrousos, G.P.2    Kino, T.3
  • 30
    • 0032511229 scopus 로고    scopus 로고
    • A serum shock induces circadian gene expression in mammalian tissue culture cells
    • DOI 10.1016/S0092-8674(00)81199-X
    • Balsalobre, A., Damiola, F., and Schibler, U. (1998) A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 93, 929-937 (Pubitemid 28280787)
    • (1998) Cell , vol.93 , Issue.6 , pp. 929-937
    • Balsalobre, A.1    Damiola, F.2    Schibler, U.3
  • 31
    • 29644434851 scopus 로고    scopus 로고
    • The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: Potential clinical implications
    • DOI 10.1074/jbc.M509338200
    • Ichijo, T., Voutetakis, A., Cotrim, A. P., Bhattachryya, N., Fujii, M., Chrousos, G. P., and Kino, T. (2005) The Smad6-histone deacetylase 3 complex silences the transcriptional activity of the glucocorticoid receptor: potential clinical implications. J. Biol. Chem. 280, 42067-42077 (Pubitemid 43023176)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.51 , pp. 42067-42077
    • Ichijo, T.1    Voutetakis, A.2    Cotrim, A.P.3    Bhattachryya, N.4    Fujii, M.5    Chrousos, G.P.6    Kino, T.7
  • 32
    • 28144439406 scopus 로고    scopus 로고
    • The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements
    • DOI 10.1210/me.2004-0497
    • Vander Kooi, B. T., Onuma, H., Oeser, J. K., Svitek, C. A., Allen, S. R., Vander Kooi, C. W., Chazin, W. J., and O'Brien, R. M. (2005) The glucose-6-phosphatase catalytic subunit gene promoter contains both positive and negative glucocorticoid response elements. Mol. Endocrinol. 19, 3001-3022 (Pubitemid 41697718)
    • (2005) Molecular Endocrinology , vol.19 , Issue.12 , pp. 3001-3022
    • Vander Kooi, B.T.1    Onuma, H.2    Oeser, J.K.3    Svitek, C.A.4    Allen, S.R.5    Vander Kooi, C.W.6    Chazin, W.J.7    O'Brien, R.M.8
  • 33
    • 3042792367 scopus 로고    scopus 로고
    • GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis
    • DOI 10.1182/blood-2003-12-4295
    • Asselin-Labat, M. L., David, M., Biola-Vidamment, A., Lecoeuche, D., Zennaro, M. C., Bertoglio, J., and Pallardy, M. (2004) GILZ, a new target for the transcription factor FoxO3, protects T lymphocytes from interleukin-2 withdrawal-induced apoptosis. Blood 104, 215-223 (Pubitemid 38879860)
    • (2004) Blood , vol.104 , Issue.1 , pp. 215-223
    • Asselin-Labat, M.-L.1    David, M.2    Biola-Vidamment, A.3    Lecoeuche, D.4    Zennaro, M.-C.5    Bertoglio, J.6    Pallardy, M.7
  • 34
    • 40849102229 scopus 로고    scopus 로고
    • Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes
    • Blind, R. D., and Garabedian, M. J. (2008) Differential recruitment of glucocorticoid receptor phospho-isoforms to glucocorticoid-induced genes. J. Steroid. Biochem. Mol. Biol. 109, 150-157
    • (2008) J. Steroid. Biochem. Mol. Biol. , vol.109 , pp. 150-157
    • Blind, R.D.1    Garabedian, M.J.2
  • 35
    • 18844383647 scopus 로고    scopus 로고
    • Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2
    • DOI 10.1210/jc.2004-2298
    • Smit, P., Russcher, H., de Jong, F. H., Brinkmann, A. O., Lamberts, S. W., and Koper, J. W. (2005) Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2. J. Clin. Endocrinol. Metab. 90, 2994-3000 (Pubitemid 40686355)
    • (2005) Journal of Clinical Endocrinology and Metabolism , vol.90 , Issue.5 , pp. 2994-3000
    • Smit, P.1    Russcher, H.2    De Jong, F.H.3    Brinkmann, A.O.4    Lamberts, S.W.J.5    Koper, J.W.6
  • 36
    • 31344446119 scopus 로고    scopus 로고
    • Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression
    • DOI 10.1084/jem.20050466
    • Ito, K., Yamamura, S., Essilfie-Quaye, S., Cosio, B., Ito, M., Barnes, P. J., and Adcock, I. M. (2006) Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression. J. Exp. Med. 203, 7-13 (Pubitemid 43139638)
    • (2006) Journal of Experimental Medicine , vol.203 , Issue.1 , pp. 7-13
    • Ito, K.1    Yamamura, S.2    Essilfie-Quaye, S.3    Cosio, B.4    Ito, M.5    Barnes, P.J.6    Adcock, I.M.7
  • 37
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • DOI 10.1016/S0092-8674(00)80521-8
    • Gu, W., and Roeder, R. G. (1997) Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90, 595-606 (Pubitemid 27357952)
    • (1997) Cell , vol.90 , Issue.4 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 38
    • 0031239891 scopus 로고    scopus 로고
    • Acetylation of general transcription factors by histone acetyltransferases
    • Imhof, A., Yang, X. J., Ogryzko, V. V., Nakatani, Y., Wolffe, A. P., and Ge, H. (1997) Acetylation of general transcription factors by histone acetyltransferases. Curr. Biol. 7, 689-692 (Pubitemid 27408867)
    • (1997) Current Biology , vol.7 , Issue.9 , pp. 689-692
    • Imhof, A.1    Yang, X.-J.2    Ogryzko, V.V.3    Nakatani, Y.4    Wolffe, A.P.5    Ge, H.6
  • 39
    • 0032506542 scopus 로고    scopus 로고
    • Regulation of activity of the transcription factor GATA-1 by acetylation
    • DOI 10.1038/25166
    • Boyes, J., Byfield, P., Nakatani, Y., and Ogryzko, V. (1998) Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396, 594-598 (Pubitemid 28563723)
    • (1998) Nature , vol.396 , Issue.6711 , pp. 594-598
    • Boyes, J.1    Byfield, P.2    Nakatani, Y.3    Ogryzko, V.4
  • 40
    • 0034730493 scopus 로고    scopus 로고
    • Resetting of circadian time in peripheral tissues by glucocorticoid signaling
    • DOI 10.1126/science.289.5488.2344
    • Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schutz, G., and Schibler, U. (2000) Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science 289, 2344-2347 (Pubitemid 30739737)
    • (2000) Science , vol.289 , Issue.5488 , pp. 2344-2347
    • Balsalobre, A.1    Brown, S.A.2    Marcacci, L.3    Tronche, F.4    Kellendonk, C.5    Reichardt, H.M.6    Schutz, G.7    Schibler, U.8
  • 41
    • 0037126636 scopus 로고    scopus 로고
    • Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators
    • DOI 10.1093/emboj/20.24.7128
    • Le Minh, N., Damiola, F., Tronche, F., Schutz, G., and Schibler, U. (2001) Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J. 20, 7128-7136 (Pubitemid 34062304)
    • (2001) EMBO Journal , vol.20 , Issue.24 , pp. 7128-7136
    • Le Minh, N.1    Damiola, F.2    Tronche, F.3    Schutz, G.4    Schibler, U.5
  • 43
    • 0031872236 scopus 로고    scopus 로고
    • Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture
    • DOI 10.1111/j.1749-6632.1998.tb09006.x
    • Chrousos, G. P. (1998) Stressors, stress, and neuroendocrine integration of the adaptive response. The 1997 Hans Selye Memorial Lecture. Ann. N. Y. Acad. Sci. 851, 311-335 (Pubitemid 28370393)
    • (1998) Annals of the New York Academy of Sciences , vol.851 , pp. 311-335
    • Chrousos, G.P.1
  • 44
    • 0033671092 scopus 로고    scopus 로고
    • The stress response and immune function: Clinical implications. The 1999 Novera H. Spector Lecture
    • Chrousos, G. P. (2000) The stress response and immune function: clinical implications. The 1999 Novera H. Spector Lecture. Ann. N. Y. Acad. Sci. 917, 38-67
    • (2000) Ann. N. Y. Acad. Sci. , vol.917 , pp. 38-67
    • Chrousos, G.P.1
  • 45
    • 0033940092 scopus 로고    scopus 로고
    • The role of stress and the hypothalamic-pituitary-adrenal axis in the pathogenesis of the metabolic syndrome: Neuro-endocrine and target tissue-related causes
    • Chrousos, G. P. (2000) The role of stress and the hypothalamic-pituitary- adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes. Int. J. Obes. Relat. Metab. Disord. 24, S50-55
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24
    • Chrousos, G.P.1
  • 46
    • 27844606845 scopus 로고    scopus 로고
    • Genetic polymorphisms and multifactorial diseases: Facts and fallacies revealed by the glucocorticoid receptor gene
    • DOI 10.1016/j.tem.2005.10.009, PII S1043276005002390
    • van Rossum, E. F., Russcher, H., and Lamberts, S. W. (2005) Genetic polymorphisms and multifactorial diseases: facts and fallacies revealed by the glucocorticoid receptor gene. Trends Endocrinol. Metab. 16, 445-450 (Pubitemid 41660860)
    • (2005) Trends in Endocrinology and Metabolism , vol.16 , Issue.10 , pp. 445-450
    • Van Rossum, E.F.C.1    Russcher, H.2    Lamberts, S.W.J.3
  • 48
    • 0033520325 scopus 로고    scopus 로고
    • Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase
    • DOI 10.1016/S0092-8674(00)80054-9
    • Chen, H., Lin, R. J., Xie, W., Wilpitz, D., and Evans, R. M. (1999) Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 98, 675-686 (Pubitemid 29418958)
    • (1999) Cell , vol.98 , Issue.5 , pp. 675-686
    • Chen, H.1    Lin, R.J.2    Xie, W.3    Wilpitz, D.4    Evans, R.M.5
  • 51
    • 37249053976 scopus 로고    scopus 로고
    • CLOCK-mediated acetylation of BMAL1 controls circadian function
    • DOI 10.1038/nature06394, PII NATURE06394
    • Hirayama, J., Sahar, S., Grimaldi, B., Tamaru, T., Takamatsu, K., Nakahata, Y., and Sassone-Corsi, P. (2007) CLOCK-mediated acetylation of BMAL1 controls circadian function. Nature 450, 1086-1090 (Pubitemid 350273614)
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1086-1090
    • Hirayama, J.1    Sahar, S.2    Grimaldi, B.3    Tamaru, T.4    Takamatsu, K.5    Nakahata, Y.6    Sassone-Corsi, P.7
  • 53
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-κB - A pivotal transcription factor in chronic inflammatory diseases
    • DOI 10.1056/NEJM199704103361506
    • Barnes, P. J., and Karin, M. (1997) Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336, 1066-1071 (Pubitemid 27163860)
    • (1997) New England Journal of Medicine , vol.336 , Issue.15 , pp. 1066-1071
    • Barnes, P.J.1    Karin, M.2
  • 54
    • 0030936387 scopus 로고    scopus 로고
    • Circadian relationships between interleukin (IL)-6 and hypothalamic- Pituitary-adrenal axis hormones: Failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis
    • DOI 10.1210/jc.82.4.1279
    • Crofford, L. J., Kalogeras, K. T., Mastorakos, G., Magiakou, M. A., Wells, J., Kanik, K. S., Gold, P. W., Chrousos, G. P., and Wilder, R. L. (1997) Circadian relationships between interleukin (IL)-6 and hypothalamic-pituitary- adrenal axis hormones: failure of IL-6 to cause sustained hypercortisolism in patients with early untreated rheumatoid arthritis. J. Clin. Endocrinol. Metab. 82, 1279-1283 (Pubitemid 27166676)
    • (1997) Journal of Clinical Endocrinology and Metabolism , vol.82 , Issue.4 , pp. 1279-1283
    • Crofford, L.J.1    Kalogeras, K.T.2    Mastorakos, G.3    Magiakou, M.-A.4    Wells, J.5    Kanik, K.S.6    Gold, P.W.7    Chrousos, G.P.8    Wilder, R.L.9
  • 56
    • 18844450441 scopus 로고    scopus 로고
    • The search for safer glucocorticoid receptor ligands
    • DOI 10.1210/er.2005-0002
    • Rosen, J., and Miner, J. N. (2005) The search for safer glucocorticoid receptor ligands. Endocr. Rev. 26, 452-464 (Pubitemid 40691300)
    • (2005) Endocrine Reviews , vol.26 , Issue.3 , pp. 452-464
    • Rosen, J.1    Miner, J.N.2


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