Competition between human cells by entosis

Cell Research

Volumn 24, Issue 11, 2014, Pages 1299-1310

  Sun, Qiang ^a,b   Luo, Tianzhi ^c   Ren, Yixin ^c   Florey, Oliver ^d   Shirasawa, Senji ^e   Sasazuki, Takehiko ^f   Robinson, Douglas N ^c   Overholtzer, Michael ^b,g  

^a BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e FUKUOKA UNIVERSITY   (Japan)

^f NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^g WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

cell cannibalism; cell competition; cell in cell structure; entosis; Kras; Rho GTPase; tumor evolution

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; AMIDE; ENZYME INHIBITOR; KRAS PROTEIN, HUMAN; MYOSIN; MYOSIN ADENOSINE TRIPHOSPHATASE; ONCOPROTEIN; PYRIDINE DERIVATIVE; RAC1 PROTEIN; RAC1 PROTEIN, HUMAN; RAS PROTEIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK1 PROTEIN, HUMAN; ROCK2 PROTEIN, HUMAN;

ANIMAL; ANTAGONISTS AND INHIBITORS; APOPTOSIS; DOWN REGULATION; DRUG EFFECTS; ENTOSIS; FEMALE; GENETICS; HCT116 CELL LINE; HUMAN; MCF 7 CELL LINE; METABOLISM; MOUSE; NEOPLASMS; PATHOLOGY; RNA INTERFERENCE; SCID MOUSE; TUMOR CELL LINE;

ACTOMYOSIN; AMIDES; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DOWN-REGULATION; ENTOSIS; ENZYME INHIBITORS; FEMALE; HCT116 CELLS; HUMANS; MCF-7 CELLS; MICE; MICE, SCID; MYOSINS; NEOPLASMS; PROTO-ONCOGENE PROTEINS; PYRIDINES; RAC1 GTP-BINDING PROTEIN; RAS PROTEINS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; RNA INTERFERENCE;

EID: 84908556984     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2014.138     Document Type: Article

References (49)

1. Simpson P, Morata G. Differential mitotic rates and patterns of growth in compartments in the Drosophila wing. Dev Biol 1981; 85:299-308.
2. Morata G, Ripoll P. Minutes: mutants of Drosophila autonomously affecting cell division rate. Dev Biol 1975; 42:211-221.
3. Moreno E, Basler K. dMyc transforms cells into super-competitors. Cell 2004; 117:117-129.
4. de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA. Drosophila myc regulates organ size by inducing cell competition. Cell 2004; 117:107-116.
5. Li W, Baker NE. Engulfment is required for cell competition. Cell 2007; 129:1215-1225.
6. Ohsawa S, Sugimura K, Takino K, et al. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell 2011; 20:315-328.
7. Moreno E. Is cell competition relevant to cancer? Nat Rev Cancer 2008; 8:141-147.
8. Baker NE, Li W. Cell competition and its possible relation to cancer. Cancer Res 2008; 68:5505-5507.
9. Kajita M, Hogan C, Harris AR, et al. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 2010; 123:171-180.
10. Hogan C, Dupre-Crochet S, Norman M, et al. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 2009; 11:460-467.
11. Norman M, Wisniewska KA, Lawrenson K, et al. Loss of Scribble causes cell competition in mammalian cells. J Cell Sci 2012; 125(Pt 1):59-66.
12. Tamori Y, Bialucha CU, Tian AG, et al. Involvement of Lgl and Mahjong/VprBP in cell competition. PLoS Biol 2010; 8:e1000422.
13. Overholtzer M, Mailleux AA, Mouneimne G, et al. A nonapoptotic cell death process, entosis, that occurs by cellin- cell invasion. Cell 2007; 131:966-979.
14. Sharma N, Dey P. Cell cannibalism and cancer. Diagn Cytopathol 2011; 39:229-233.
15. Overholtzer M, Brugge JS. The cell biology of cell-in-cell structures. Nat Rev Mol Cell Biol 2008; 9:796-809.
16. Krajcovic M, Johnson NB, Sun Q, et al. A non-genetic route to aneuploidy in human cancers. Nat Cell Biol 2011; 13:324-330.
17. Florey O, Kim SE, Sandoval CP, Haynes CM, Overholtzer M. Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes. Nat Cell Biol 2011; 13:1335-1343.
18. Sun Q, Cibas ES, Huang H, Hodgson L, Overholtzer M. Induction of entosis by epithelial cadherin expression. Cell Res 2014; 24:1288-1298.
19. Xia P, Zhou J, Song X, et al. Aurora A orchestrates entosis by regulating a dynamic MCAK-TIP150 interaction. J Mol Cell Biol 2014; 6:240-254.
20. Pollock CB, Shirasawa S, Sasazuki T, Kolch W, Dhillon AS. Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. Cancer Res 2005; 65:1244-1250.
21. Ward KA, Li WI, Zimmer S, Davis T. Viscoelastic properties of transformed cells: role in tumor cell progression and metastasis formation. Biorheology 1991; 28:301-313.
22. Cross SE, Jin YS, Rao J, Gimzewski JK. Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol 2007; 2:780-783.
23. Guck J, Schinkinger S, Lincoln B, et al. Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence. Biophys J 2005; 88:3689-3698.
24. Xu W, Mezencev R, Kim B, et al. Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells. PLoS One 2012; 7:e46609.
25. Anderson KW, Li WI, Cezeaux J, Zimmer S. In vitro studies of deformation and adhesion properties of transformed cells. Cell Biophys 1991; 18:81-97.
26. Plodinec M, Loparic M, Monnier CA, et al. The nanomechanical signature of breast cancer. Nat Nanotechnol 2012; 7:757-765.
27. Yamada S, Nelson WJ. Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol 2007; 178:517-527.
28. Ren Y, Effler JC, Norstrom M, et al. Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I. Curr Biol 2009; 19:1421-1428.
29. Luo T, Mohan K, Srivastava V, et al. Understanding the cooperative interaction between myosin II and actin cross-linkers mediated by actin filaments during mechanosensation. Biophys J 2012; 102:238-247.
30. Liu Z, Tan JL, Cohen DM, et al. Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci USA 2010; 107:9944-9949.
31. Krajcovic M, Krishna S, Akkari L, Joyce JA, Overholtzer M. mTOR regulates phagosome and entotic vacuole fission. Mol Biol Cell 2013; 24:3736-3745.
32. Navin N, Kendall J, Troge J, et al. Tumour evolution inferred by single-cell sequencing. Nature 2011; 472:90-94.
33. Krajcovic M, Overholtzer M. Mechanisms of ploidy increase in human cancers: a new role for cell cannibalism. Cancer Res 2012; 72:1596-1601.
34. Moreno E, Basler K, Morata G. Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development. Nature 2002; 416:755-759.
35. Lolo FN, Casas-Tinto S, Moreno E. Cell competition time line: winners kill losers, which are extruded and engulfed by hemocytes. Cell Rep 2012; 2:526-539.
36. Oliver ER, Saunders TL, Tarle SA, Glaser T. Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute. Development 2004; 131:3907-3920.
37. Sancho M, Di-Gregorio A, George N, et al. Competitive interactions eliminate unfit embryonic stem cells at the onset of differentiation. Dev Cell 2013; 26:19-30.
38. Claveria C, Giovinazzo G, Sierra R, Torres M. Myc-driven endogenous cell competition in the early mammalian embryo. Nature 2013; 500:39-44.
39. Marusyk A, Porter CC, Zaberezhnyy V, DeGregori J. Irradiation Selects for p53-Deficient Hematopoietic Progenitors. PLoS Biol 2010; 8:e1000324.
40. Bondar T, Medzhitov R. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 2010; 6:309-322.
41. Shirasawa S, Furuse M, Yokoyama N, Sasazuki T. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 1993; 260:85-88.
42. Xu X, Omelchenko T, Hall A. LKB1 tumor suppressor protein regulates actin filament assembly through Rho and its exchange factor Dbl independently of kinase activity. BMC Cell Biol 2010; 11:77.
43. Noren NK, Arthur WT, Burridge K. Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem 2003; 278:13615-13618.
44. Sun Q, Overholtzer M. Methods for the study of entosis. Methods Mol Biol 2013; 1004:59-66.
45. Sun Q, Zhang Y, Yang G, et al. Transforming growth factor- beta-regulated miR-24 promotes skeletal muscle differentiation. Nucleic Acids Res 2008; 36:2690-2699.
46. Zhang Y, Fan KJ, Sun Q, et al. Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-beta signalling pathway. Nucleic Acids Res 2012; 40:9286-9297.
47. Sun Q, Wang Y, Zhang Y, et al. Expression profiling reveals dysregulation of cellular cytoskeletal genes in HBx-induced hepatocarcinogenesis. Cancer Biol Ther 2007; 6:668-674.
48. Zhou Q, Kee YS, Poirier CC, et al. 14-3-3 coordinates microtubules, Rac, and myosin II to control cell mechanics and cytokinesis. Curr Biol 2010; 20:1881-1889.
49. Hochmuth RM. Micropipette aspiration of living cells. J Biomech 2000; 33:15-22.