Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes

American Journal of Physiology - Cell Physiology

Volumn 307, Issue 9, 2014, Pages C774-C787

  Al Khalili, Lubna ^a   de Castro Barbosa, Thais ^a   Östling, JöRgen ^b   Massart, Julie ^a   Cuesta, Pablo Garrido ^a,c   Osler, Megan E ^a   Katayama, Mutsumi ^a   Nyström, Ann Christin ^b   Oscarsson, Jan ^b   Zierath, Juleen R ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF OVIEDO   (Spain)

Author keywords

2 D DIGE; Bortezomib; Carbonylation; Glucose incorporation into glycogen; Myotubes; Palmitate oxidation; Proteasome; Protein synthesis; Ubiquitin; Velcade

Indexed keywords

BORTEZOMIB; CELL PROTEIN; INSULIN; BORONIC ACID DERIVATIVE; ENZYME INHIBITOR; GLUCOSE; GLYCOGEN; PROTEASOME; PROTEASOME INHIBITOR; PROTEOME; PYRAZINE DERIVATIVE;

ARTICLE; CELL STRESS; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN TREATMENT; LIPID METABOLISM; MALE; METABOLIC REGULATION; MUSCLE BIOPSY; MUSCLE CELL; MYOTUBE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PROTEIN CARBONYLATION; PROTEIN HOMEOSTASIS; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

BORONIC ACIDS; BORTEZOMIB; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; ENZYME INHIBITORS; GLUCOSE; GLYCOGEN; HUMANS; INSULIN; INSULIN RESISTANCE; LIPID METABOLISM; MALE; MUSCLE, SKELETAL; OXIDATIVE STRESS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN CARBONYLATION; PROTEOME; PYRAZINES; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84908542711     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00110.2014     Document Type: Article

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