Discovery and evaluation of novel anti-inflammatory derivatives of natural bioactive curcumin

Drug Design, Development and Therapy

Volumn 8, Issue , 2014, Pages 2161-2171

  Zhang, Yali ^a   Jiang, Xin ^b   Peng, Kesong ^a   Chen, Chengwei ^a   Fu, Lili ^a   Wang, Zhe ^a   Feng, Jianpeng ^a   Liu, Zhiguo ^a,c   Zhang, Huajie ^a   Liang, Guang ^a   Pan, Zheer ^c  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Wenzhou Undersun Biotechnology Co Ltd   (China)

Author keywords

Anti inflammation; Curcumin; Cytokine; Macrophage; Sepsis

Indexed keywords

ANTIINFLAMMATORY AGENT; CURCUMIN DERIVATIVE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; BIOLOGICAL PRODUCT; CURCUMIN; CYTOKINE; NONSTEROID ANTIINFLAMMATORY AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DRUG DETERMINATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE STRUCTURE PROPERTY RELATION; SEPTIC SHOCK; STRUCTURE ANALYSIS; SURVIVAL RATE; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; DRUG EFFECTS; MACROPHAGE; SHOCK, SEPTIC; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL PRODUCTS; CELL LINE; CURCUMIN; CYTOKINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MOLECULAR STRUCTURE; SHOCK, SEPTIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84908514410     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S69914     Document Type: Article

References (31)

1. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2010; 7(1): 33-42.
2. McLaren JE, Michael DR, Ashlin TG, Ramji DP. Cytokines, macrophage lipid metabolism and foam cells: implications for cardiovascular disease therapy. Prog Lipid Res. 2011; 50(4): 331-347.
3. Abraham E, Singer M. Mechanisms of sepsis-induced organ dysfunction. Critical Care Medicine. 2007; 35(10): 2408-2416.
4. Rittirsch D, Flierl MA, Ward PA. Harmful molecular mechanisms in sepsis. Nat Rev Immunol. 2008; 8(10): 776-787.
5. Cohen J. The immunopathogenesis of sepsis. Nature. 2002; 420(6917): 885-891.
6. Reyes CS, García-Muñoz F, Reyes D, González G, Dominguez C, Domenech E. Role of cytokines (interleukin-1β, 6, 8, tumour necrosis factor-α, and soluble receptor of interleukin-2) and C-reactive protein in the diagnosis of neonatal sepsis. Acta Paediatr. 2003; 92(2)221-227.
7. Abdelhamid AE, Chuang SL, Hayes P, Fell JM. In vitro cow's milk protein-specific inflammatory and regulatory cytokine responses in preterm infants with necrotizing enterocolitis and sepsis. Pediatr Res. 2011; 69(2): 165-169.
8. Mokart D, Merlin M, Sannini A, et al. Procalcitonin, interleukin 6 and systemic inflammatory response syndrome (SIRS): early markers of postoperative sepsis after major surgery. Br J Anaesth. 2005; 94(6): 767-773.
9. Weinberg GA, D'Angio CT. The search for new diagnostic tests for neonatal sepsis. J Pediat. 2009; 155(5): 763-764.
10. Hu Y, Tong G, Xu W, et al. Anti-inflammatory effects of simvastatin on adipokines in type 2 diabetic patients with carotid atherosclerosis. Diab Vasc Dis Res. 2009; 6(4): 262-268.
11. Qiu Y, Yanase T, Hu H, et al. Dihydrotestosterone suppresses foam cell formation and attenuates atherosclerosis development. Endocrinology. 2010; 151(7): 3307-3316.
12. Mazor R, Itzhaki O, Sela S, et al. Tumor necrosis factor-α: a possible priming agent for the polymorphonuclear leukocyte-reduced nicotinamide-adenine dinucleotide phosphate oxidase in hypertension. Hypertension. 2010; 55(2): 353-362.
13. Chattopadhyay I, Biswas K, Bandyopadhyay U, Banerjee R. Turmeric and curcumin: biological actions and medicinal applications. Current Science. 2004; 87(1): 44-53.
14. Suzuki M, Nakamura T, Iyoki S, et al. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol Pharm Bull. 2005; 28(8): 1438-1443.
15. Kurup VP, Barrios CS, Raju R, Johnson BD, Levy MB, Fink JN. Immune response modulation by curcumin in a latex allergy model. Clin Mol Allergy. 2007; 5: 1.
16. Nazam Ansari M, Bhandari U, Pillai, KK. Protective role of curcumin in myocardial oxidative damage induced by isoproterenol in rats. Hum Exp Toxicol. 2007; 26(12): 933-938.
17. Kurup VP, Barrios CS. Immunomodulatory effects of curcumin in allergy. Mol Nutr Food Res. 2008; 52(9): 1031-1039.
18. Sugimoto K, Hanai H, Tozawa K, et al. Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology. 2002; 123(6): 1912-1922.
19. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013; 15(1): 195-218.
20. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm. 2007; 4(6): 807-818.
21. 2, cyclooxygenases, lipoxygenase and proinflammatory cytokines. Bioorganic and Medicinal Chemistry. 2014; 22(15): 4151-4161.
22. Bukhari SN, Jantan I, Unsal Tan O, Sher M, Naeem-UI-Hassan M, Qin HL. Biological activity and molecular docking studies of curcumin-related α, β-unsaturated carbonyl-based synthetic compounds as anticancer agents and mushroom tyrosinase inhibitors. J Agric Food Chem. Epub 2014, Jun 10.
23. Wu J, Zhang Y, Cai Y, et al. Discovery and evaluation of piperid-4-one-containing mono-carbonyl analogs of curcumin as anti-inflammatory agents. Bioorg Med Chem. 2013; 21(11): 3058-3065.
24. Liang G, Li X, Chen L, et al. Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. Bioorg Med Chem Lett. 2008; 18(4): 1525-1529.
25. Liang G, Shao L, Wang Y, et al. Exploration and synthesis of curcumin analogues with improved structural stability both in vitro and in vivo as cytotoxic agents. Bioorg Med Chem. 2009; 17(6): 2623-2631.
26. Haase M, Bellomo R, Haase-Fielitz A. Novel biomarkers, oxidative stress, and the role of labile iron toxicity in cardiopulmonary bypass-associated acute kidney injury. J Am Coll Cardiol. 2010; 55(19): 2024-2033.
27. Navarro-Gonzalez J, Mora-Fernandez C, Gomez-Chinchon M, Muros M, Herrera H, Garcia J. Serum and gene expression profile of tumor necrosis factor-alpha and interleukin-6 in hypertensive diabetic patients: effect of amlodipine administration. Int J Immunopathol Pharmacol. 2009; 23(1): 51-59.
28. Joh EH, Gu W, Kim DH. Echinocystic acid ameliorates lung inflammation in mice and alveolar macrophages by inhibiting the binding of LPS to TLR4 in NF-κB and MAPK pathways. Biochem Pharmacol. 2012; 84(3): 331-340.
29. Zhang L, Wu C, Zhao S, et al. Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide. Int immunopharmacol. 2010; 10(3): 331-338.
30. Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol. 1996; 14: 649-683.
31. Xiao X, Yang M, Sun D, Sun S. Curcumin protects against sepsis-induced acute lung injury in rats. J Surg Res. 2012; 176(1): e31-e39.