Development and evaluation of ST-1829 based on 5-benzylidene-2-phenylthiazolones as promising agent for anti-leukotriene therapy

European Journal of Medicinal Chemistry

Volumn 89, Issue , 2015, Pages 503-523

  Lill, Andreas P ^a   Rödl, Carmen B ^a   Steinhilber, Dieter ^a   Stark, Holger ^a,b   Hofmann, Bettina ^a  

^a GOETHE UNIVERSITY   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

5 Lipoxygenase; Anti leukotriene therapy; Hydroxythiazoles; Inflammation; Solubility; Structureeactivity relationship

Indexed keywords

5 ( 4 CHLOROBENZYL) 2,4 TOLYLTHIAZOL 4 OL; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONATE 5 LIPOXYGENASE INHIBITOR; LEUKOTRIENE RECEPTOR BLOCKING AGENT; OXYGENASE INHIBITOR; PLASMA PROTEIN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; 5-(4-CHLOROBENZYL)-2-P-TOLYLTHIAZOL-4-OL; 5-(4-METHOXYBENZYLIDENE)-2-P-TOLYLTHIAZOL-4(5H)-ONE; LEUKOTRIENE; LIPOXYGENASE INHIBITOR;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ASSAY; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC50; PROCESS OPTIMIZATION; SERUM; STRUCTURE ACTIVITY RELATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; METABOLISM; SYNTHESIS;

ARACHIDONATE 5-LIPOXYGENASE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEUKOTRIENE ANTAGONISTS; LEUKOTRIENES; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84908456983     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.10.054     Document Type: Article

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