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Volumn 20, Issue 11, 2012, Pages 3575-3583

Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl- thiazolinones as potent 5-lipoxygenase inhibitors

(6) Barzen, Sebastian a Rödl, Carmen B a Lill, Andreas a Steinhilber, Dieter a Stark, Holger a Hofmann, Bettina a

a GOETHE UNIVERSITY (Germany)

Author keywords

5 Lipoxygenase; Asthma; Inflammation; Leukotrienes; Polymorphonuclear leukocytes; Structure activity relationships

Indexed keywords

2 (4 AMINOPHENYL) 5 [1 (4 METHOXYPHENYL)ETHYLIDENE] 5H THIAZOL 4 ONE; 5 (4 METHOXYBENZYLIDENE) 2 (NAPHTHALEN 2 YL) 5H THIAZOL 4 ONE; 5 [1 (4 METHOXYPHENYL)ETHYLIDENE] 2 (4 TOLYL) 5H THIAZOL 4 ONE; 5 BENZYLIDENE 2 PHENYLTHIAZOLINONE DERIVATIVE; ALPHA PENTYL 3 (2 QUINOLYLMETHOXY)BENZYL ALCOHOL; ANTIINFLAMMATORY AGENT; ARACHIDONATE 5 LIPOXYGENASE; LIPOXYGENASE INHIBITOR; ST 1098; ST 1130; ST 1131; ST 1237; UNCLASSIFIED DRUG;

ARTICLE; CELL ASSAY; CELL VIABILITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

ARACHIDONATE 5-LIPOXYGENASE; CELL SURVIVAL; CELL-FREE SYSTEM; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; HUMANS; INHIBITORY CONCENTRATION 50; LIPOXYGENASE INHIBITORS; MOLECULAR STRUCTURE; NEUTROPHILS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 84861185532 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.04.003 Document Type: Article

Times cited : (19)

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