Selective estrogen-receptor modulators suppress microglial activation and neuronal cell death via an estrogen receptor-dependent pathway

Journal of Steroid Biochemistry and Molecular Biology

Volumn 145, Issue , 2015, Pages 85-93

  Ishihara, Yasuhiro ^a   Itoh, Kouichi ^b   Ishida, Atsuhiko ^a   Yamazaki, Takeshi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b TOKUSHIMA BUNRI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; INTERLEUKIN 1BETA; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; RALOXIFENE; TAMOXIFEN CITRATE; TUMOR NECROSIS FACTOR ALPHA; CULTURE MEDIUM; ESTRADIOL; ESTROGEN RECEPTOR; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ESTROGEN RESPONSIVE ELEMENT; FEMALE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; LUCIFERASE ASSAY; MALE; MICROGLIA; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NONHUMAN; PRIMARY CELL; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; CELL DEATH; CELL SURVIVAL; CHEMISTRY; CULTURE MEDIUM; DNA RESPONSIVE ELEMENT; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; INFLAMMATION; METABOLISM; NERVE CELL; PATHOLOGY; PLASMID; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; FEMALE; INFLAMMATION; MALE; MICROGLIA; NEURONS; PLASMIDS; RALOXIFENE; RATS; RATS, WISTAR; RECEPTORS, ESTROGEN; RESPONSE ELEMENTS; SELECTIVE ESTROGEN RECEPTOR MODULATORS; TAMOXIFEN;

EID: 84908454946     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2014.10.002     Document Type: Article

References (39)

1. L. Marinova-Mutafchieva, M. Sadeghian, L. Broom, J.B. Davis, A.D. Medhurst, and D.T. Dexter Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson's disease J. Neurochem. 110 2009 966 975
2. S.E. Hickman, E.K. Allison, and J. El Khoury Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice J. Neurosci. 8 2008 8354 8360
3. Y.C. Wang, S. Lin, and Q.W. Yang Toll-like receptors in cerebral ischemic inflammatory injury J. Neuroinflammation 8 2011 134
4. S. Najjar, D.M. Pearlman, K. Alper, A. Najjar, and O. Devinsky Neuroinflammation and psychiatric illness J. Neuroinflammation 10 2013 43
5. D.N. Xanthos, and J. Sandkuhler Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity, nature reviews Neuroscience 15 2014 43 53
6. E. Vegeto, C. Bonincontro, G. Pollio, A. Sala, S. Viappiani, F. Nardi, A. Brusadelli, B. Viviani, P. Ciana, and A. Maggi Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia J. Neurosci. 21 2001 1809 1818
7. A.J. Bruce-Keller, J.L. Keeling, J.N. Keller, F.F. Huang, S. Camondola, and M.P. Mattson Antiinflammatory effects of estrogen on microglial activation Endocrinology 141 2000 3646 3656
8. S. Ghisletti, C. Meda, A. Maggi, and E. Vegeto 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization Mol. Cell. Biol. 25 2005 2957 2968
9. E. Vegeto, S. Belcredito, S. Etteri, S. Ghisletti, A. Brusadelli, C. Meda, A. Krust, S. Dupont, P. Ciana, P. Chambon, and A. Maggi Estrogen receptor-alpha mediates the brain antiinflammatory activity of estradiol Proc. Natl. Acad. Sci. U. S. A. 100 2003 9614 9619
10. C.M. Brown, T.A. Mulcahey, N.C. Filipek, and P.M. Wise Production of proinflammatory cytokines and chemokines during neuroinflammation: novel roles for estrogen receptors alpha and beta Endocrinology 151 2010 4916 4925
11. C.L. Smith, and B.W. O'Malley Coregulator function: a key to understanding tissue specificity of selective receptor modulators Endocr. Rev. 25 2004 45 71
12. R.R. Love, R.B. Mazess, H.S. Barden, S. Epstein, P.A. Newcomb, V.C. Jordan, P.P. Carbone, and D.L. DeMets Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer N. Engl. J. Med. 326 1992 852 856
13. B.S. Komm, and S. Mirkin An overview of current and emerging SERMs J. Steroid Biochem. Mol. Biol. 143C 2014 207 222
14. O. Ismailoglu, B. Oral, A. Gorgulu, R. Sutcu, and N. Demir Neuroprotective effects of tamoxifen on experimental spinal cord injury in rats J. Clin. Neurosci. 17 2010 1306 1310
15. N.E. Franco Rodriguez, J.M. Duenas Jimenez, B. De la Torre Valdovinos, J.R. Lopez Ruiz, L. Hernandez Hernandez, and S.H. Duenas Jimenez Tamoxifen favoured the rat sensorial cortex regeneration after a penetrating brain injury Brain Res. Bull. 98 2013 64 75
16. D.L. Lei, J.M. Long, J. Hengemihle, J. O'Neill, K.F. Manaye, D.K. Ingram, and P.R. Mouton Effects of estrogen and raloxifene on neuroglia number and morphology in the hippocampus of aged female mice Neuroscience 121 2003 659 666
17. S. Tapia-Gonzalez, P. Carrero, O. Pernia, L.M. Garcia-Segura, and Y. Diz-Chaves Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs J. endocrinol. 198 2008 219 230
18. G.E. Barreto, M. Santos-Galindo, and L.M. Garcia-Segura Selective estrogen receptor modulators regulate reactive microglia after penetrating brain injury Front. Aging Neurosci. 6 2014 132
19. J.L. Liu, D.S. Tian, Z.W. Li, W.S. Qu, Y. Zhan, M.J. Xie, Z.Y. Yu, W. Wang, and G. Wu Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo Brain Res. 1316 2010 101 111
20. M. Cerciat, M. Unkila, L.M. Garcia-Segura, and M.A. Arevalo Selective estrogen receptor modulators decrease the production of interleukin-6 and interferon-gamma-inducible protein-10 by astrocytes exposed to inflammatory challenge in vitro Glia 58 2010 93 102
21. A. Suzumura, S.G. Mezitis, N.K. Gonatas, and D.H. Silberberg MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by gamma-interferon J. Neuroimmunol. 15 1987 263 278
22. Y. Ishihara, T. Kawami, A. Ishida, and T. Yamazaki Tributyltin induces oxidative stress and neuronal injury by inhibiting glutathione S-transferase in rat organotypic hippocampal slice cultures Neurochem. Int. 60 2012 782 790
23. P. Ciana, M. Raviscioni, P. Mussi, E. Vegeto, I. Que, M.G. Parker, C. Lowik, and A. Maggi In vivo imaging of transcriptionally active estrogen receptors Nat. Med. 9 2003 82 86
24. S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.A. Gustafsson Mechanisms of estrogen action Physiol. Rev. 81 2001 1535 1565
25. T. Suuronen, T. Nuutinen, J. Huuskonen, J. Ojala, A. Thornell, and A. Salminen Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells Inflamm. Res. 54 2005 194 203
26. H. Kettenmann, U.K. Hanisch, M. Noda, and A. Verkhratsky Physiology of microglia Physiol. Rev. 91 2011 461 553
27. N. Takahashi, A.B. Tonchev, K. Koike, K. Murakami, K. Yamada, T. Yamashima, and M. Inoue Expression of estrogen receptor-beta in the postischemic monkey hippocampus Neurosci. Lett. 369 2004 9 13
28. A. Sierra, A. Gottfried-Blackmore, T.A. Milner, B.S. McEwen, and K. Bulloch Steroid hormone receptor expression and function in microglia Glia 56 2008 659 674
29. A.E. Baker, V.M. Brautigam, and J.J. Watters Estrogen modulates microglial inflammatory mediator production via interactions with estrogen receptor beta Endocrinology 145 2004 5021 5032
30. D.J. Hines, R.M. Hines, S.J. Mulligan, and B.A. Macvicar Microglia processes block the spread of damage in the brain and require functional chloride channels Glia 57 2009 1610 1618
31. N. Vasudevan, and D.W. Pfaff Non-genomic actions of estrogens and their interaction with genomic actions in the brain Front. Neuroendocrin. 29 2008 238 257
32. S. Ghosh, and M. Karin Missing pieces in the NF-kappaB puzzle Cell 109 Suppl 2002 S81 S96
33. M. Cutolo, A. Sulli, B. Seriolo, S. Accardo, and A.T. Masi Estrogens, the immune response and autoimmunity Clin. Exp. Rheumatol. 13 1995 217 226
34. S. Lehnardt Innate immunity and neuroinflammation in the CNS: the role of microglia in Toll-like receptor-mediated neuronal injury Glia 58 2010 253 263
35. J.E. Rossouw, G.L. Anderson, R.L. Prentice, A.Z. LaCroix, C. Kooperberg, M.L. Stefanick, R.D. Jackson, S.A. Beresford, B.V. Howard, K.C. Johnson, J.M. Kotchen, and J. Ockene I. writing group for the women's health initiative, risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the women's health Initiative randomized controlled trial JAMA: J. Am. Med. Assoc. 288 2002 321 333
36. V. Beral, and C. Million Women Study Breast cancer and hormone-replacement therapy in the million women study Lancet 362 2003 419 427
37. E. Weiderpass, J.A. Baron, H.O. Adami, C. Magnusson, A. Lindgren, R. Bergstrom, N. Correia, and I. Persson Low-potency oestrogen and risk of endometrial cancer: a case-control study Lancet 353 1999 1824 1828
38. K. Dhandapani, and D. Brann Neuroprotective effects of estrogen and tamoxifen in vitro: a facilitative role for glia? Endocrine 21 2003 59 66
39. S.H. Mehta, K.M. Dhandapani, L.M. De Sevilla, R.C. Webb, V.B. Mahesh, and D.W. Brann Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat Neuroendocrinology 77 2003 44 50