Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo

Brain Research

Volumn 1316, Issue , 2010, Pages 101-111

  Liu, Jun Li ^a   Tian, Dai Shi ^a   Li, Zai Wang ^a   Qu, Wen Sheng ^a   Zhan, Yan ^a   Xie, Min Jie ^a   Yu, Zhi Yuan ^a   Wang, Wei ^a   Wu, Gang ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Inflammation; Microglia; Neuronal apoptosis; Tamoxifen; Whole brain irradiation

Indexed keywords

INTERLEUKIN 1BETA; TAMOXIFEN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN DAMAGE; BRAIN EDEMA; BRAIN RADIATION; CELL ACTIVATION; CELL COUNT; CELLULAR STRESS RESPONSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; HIPPOCAMPUS; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MACROGLIA; MALE; MEMBRANE PERMEABILITY; MICROGLIA; NERVE CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; RADIATION INJURY; RAT; TREATMENT OUTCOME;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BRAIN; BRAIN INJURIES; CELL LINE; CULTURE MEDIA, CONDITIONED; CYTOKINES; INTERLEUKIN-1BETA; MALE; MICE; MICROGLIA; NEURONS; NEUROPROTECTIVE AGENTS; RADIATION INJURIES, EXPERIMENTAL; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TAMOXIFEN; TUMOR NECROSIS FACTOR-ALPHA;

MURINAE;

EID: 75349093738     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2009.12.055     Document Type: Article

References (50)

1. Acker J.C., et al. Serial in vivo observations of cerebral vasculature after treatment with a large single fraction of radiation. Radiat. Res. 149 (1998) 350-359
2. Argaw A.T., et al. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J. Immunol 177 (2006) 5574-5584
3. Bernstein M., and Gutin P.H. Interstitial irradiation of brain tumors: a review. Neurosurgery 9 (1981) 741-750
4. Biegon A., et al. A permanently charged tamoxifen derivative displays anticancer activity and improved tissue selectivity in rodents. Cancer Res 56 (1996) 4328-4331
5. Chiang C.S., et al. Delayed molecular responses to brain irradiation. Int. J. Radiat. Biol. 72 (1997) 45-53
6. Chiang C.S., and McBride W.H. Radiation enhances tumor necrosis factor alpha production by murine brain cells. Brain Res. 566 (1991) 265-269
7. Cushman M., et al. Tamoxifen and cardiac risk factors in healthy women: suggestion of an anti-inflammatory effect. Arterioscler. Thromb. Vasc. Biol. 21 (2001) 255-261
8. Dhandapani K., and Brann D. Neuroprotective effects of estrogen and tamoxifen in vitro: a facilitative role for glia?. Endocrine 21 (2003) 59-66
9. Donson A.M., et al. Tamoxifen radiosensitization in human glioblastoma cell lines. J Neurosurg 90 (1999) 533-536
10. Esposito E., et al. Raloxifene, a selective estrogen receptor modulator, reduces carrageenan-induced acute inflammation in normal and ovariectomized rats. Endocrinology 146 (2005) 3301-3308
11. Fisher B.J., et al. Phase I study of topotecan plus cranial radiation for glioblastoma multiforme: results of Radiation Therapy Oncology Group Trial 9507. J Clin Oncol 19 (2001) 1111-1117
12. Hosli P., et al. Malignant glioma: should chemotherapy be overthrown by experimental treatments?. Ann. Oncol. 9 (1998) 589-600
13. Hwang S.Y., et al. Ionizing radiation induces astrocyte gliosis through microglia activation. Neurobiol. Dis. 21 (2006) 457-467
14. Kimelberg H.K., et al. Acute treatment with tamoxifen reduces ischemic damage following middle cerebral artery occlusion. Neuroreport 11 (2000) 2675-2679
15. Kimelberg H.K., et al. Neuroprotective activity of tamoxifen in permanent focal ischemia. J. Neurosurg. 99 (2003) 138-142
16. Kyrkanides S., et al. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res. Mol. Brain Res. 104 (2002) 159-169
17. Kyrkanides S., et al. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J. Neuroimmunol. 95 (1999) 95-106
18. Legutko B., et al. Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator. Neuropharmacology 40 (2001) 1019-1027
19. Li Y.Q., et al. Early radiation-induced endothelial cell loss and blood-spinal cord barrier breakdown in the rat spinal cord. Radiat. Res. 161 (2004) 143-152
20. Lin T.N., et al. Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24 (1993) 117-121
21. Mastronardi L., et al. Tamoxifen as a potential treatment of glioma. Anticancer Drugs 9 (1998) 581-586
22. McCaffrey G., et al. Occludin oligomeric assembly at tight junctions of the blood-brain barrier is disrupted by peripheral inflammatory hyperalgesia. J. Neurochem. 106 (2008) 2395-2409
23. Mehta S.H., et al. Tamoxifen, a selective estrogen receptor modulator, reduces ischemic damage caused by middle cerebral artery occlusion in the ovariectomized female rat. Neuroendocrinology 77 (2003) 44-50
24. Misiewicz B., et al. The estrogen antagonist tamoxifen inhibits carrageenan induced inflammation in LEW/N female rats. Life Sci. 58 (1996) PL281-6
25. Monje M.L., et al. Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8 (2002) 955-962
26. Monje M.L., et al. Inflammatory blockade restores adult hippocampal neurogenesis. Science 302 (2003) 1760-1765
27. Osuka K., et al. Tamoxifen inhibits nitrotyrosine formation after reversible middle cerebral artery occlusion in the rat. J. Neurochem. 76 (2001) 1842-1850
28. Perez E.A., et al. Phase I trial of high-dose tamoxifen in combination with cisplatin in patients with lung cancer and other advanced malignancies. Cancer Invest. 21 (2003) 1-6
29. Ramanan S., et al. PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. Free Radic. Biol. Med. 45 (2008) 1695-1704
30. Rola R., et al. Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice. Exp. Neurol. 188 (2004) 316-330
31. Rutledge E.M., et al. Pharmacological characterization of swelling-induced d-[3H]aspartate release from primary astrocyte cultures. Am. J. Physiol. 274 (1998) C1511-1520
32. Schindler M.K., et al. Aging-dependent changes in the radiation response of the adult rat brain. Int. J. Radiat. Oncol. Biol. Phys. 70 (2008) 826-834
33. Sharma H.S. Hyperthermia induced brain oedema: current status and future perspectives. Indian. J. Med. Res. 123 (2006) 629-652
34. Sharma H.S., et al. Prostaglandins modulate alterations of microvascular permeability, blood flow, edema and serotonin levels following spinal cord injury: an experimental study in the rat. Neuroscience 57 (1993) 443-449
35. Stupp R., et al. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J. Clin. Oncol. 20 (2002) 1375-1382
36. Suuronen T., et al. Anti-inflammatory effect of selective estrogen receptor modulators (SERMs) in microglial cells. Inflamm. Res. 54 (2005) 194-203
37. Tapia-Gonzalez S., et al. Selective oestrogen receptor (ER) modulators reduce microglia reactivity in vivo after peripheral inflammation: potential role of microglial ERs. J. Endocrinol. 198 (2008) 219-230
38. Tian D.S., et al. Attenuation of astrogliosis by suppressing of microglial proliferation with the cell cycle inhibitor olomoucine in rat spinal cord injury model. Brain Res. 1154 (2007) 206-214
39. Tian D.S., et al. Tamoxifen attenuates inflammatory-mediated damage and improves functional outcome after spinal cord injury in rats. J. Neurochem. 109 (2009) 1658-1667
40. Tian D.S., et al. Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res. 1135 (2007) 177-185
41. Tian D.S., et al. Suppression of astroglial scar formation and enhanced axonal regeneration associated with functional recovery in a spinal cord injury rat model by the cell cycle inhibitor olomoucine. J. Neurosci. Res. 84 (2006) 1053-1063
42. Tofilon P.J., and Fike J.R. The radioresponse of the central nervous system: a dynamic process. Radiat. Res. 153 (2000) 357-370
43. Uyama O., et al. Quantitative evaluation of vascular permeability in the gerbil brain after transient ischemia using Evans blue fluorescence. J. Cereb. Blood Flow Metab. 8 (1988) 282-284
44. Wiseman H., et al. Tamoxifen inhibits lipid peroxidation in cardiac microsomes. Comparison with liver microsomes and potential relevance to the cardiovascular benefits associated with cancer prevention and treatment by tamoxifen. Biochem. Pharmacol. 45 (1993) 1851-1855
45. Wu W.M., et al. Tamoxifen decreases renal inflammation and alleviates disease severity in autoimmune NZB/W F1 mice. Scand. J. Immunol. 52 (2000) 393-400
46. Yuan H., et al. Effects of fractionated radiation on the brain vasculature in a murine model: blood-brain barrier permeability, astrocyte proliferation, and ultrastructural changes. Int. J. Radiat. Oncol. Biol. Phys. 66 (2006) 860-866
47. Yuan H., et al. Radiation-induced permeability and leukocyte adhesion in the rat blood-brain barrier: modulation with anti-ICAM-1 antibodies. Brain Res. 969 (2003) 59-69
48. Zhang Q., et al. Cell cycle inhibition attenuates microglial proliferation and production of IL-1beta, MIP-1alpha, and NO after focal cerebral ischemia in the rat. Glia 57 (2009) 908-920
49. Zhang W., et al. Enhancement of radiosensitivity by tamoxifen in C6 glioma cells. Neurosurgery 31 (1992) 725-729 discussion 729-30
50. Zhu Z., et al. Inhibiting cell cycle progression reduces reactive astrogliosis initiated by scratch injury in vitro and by cerebral ischemia in vivo. Glia 55 (2007) 546-558