Improved CT-based estimate of pulmonary gas trapping accounting for scanner and lung-volume variations in a multicenter asthmatic study

Journal of Applied Physiology

Volumn 117, Issue 6, 2014, Pages 593-603

  Choi, Sanghun ^a,b   Hoffman, Eric A ^a,c   Wenzel, Sally E ^d   Castro, Mario ^e   Lin, Ching Long ^a,b  

^a IA United States   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF IOWA   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Air trapping; Asthma; Lung mechanics; Protocols; Quantitative computed tomography

Indexed keywords

ADULT; AGED; ALGORITHM; ASTHMA; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; LUNG; LUNG VOLUME; MALE; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PROCEDURES; RADIOGRAPHY; REPRODUCIBILITY; TOTAL LUNG CAPACITY; TRACHEA;

ADULT; AGED; ALGORITHMS; ASTHMA; FEMALE; FORCED EXPIRATORY VOLUME; FUNCTIONAL RESIDUAL CAPACITY; HUMANS; LUNG; LUNG VOLUME MEASUREMENTS; MALE; MIDDLE AGED; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, X-RAY COMPUTED; TOTAL LUNG CAPACITY; TRACHEA;

EID: 84908451679     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00280.2014     Document Type: Article

References (56)

1. Arppe A. polytomous: Polytomous logistic regression for fixed and mixed effects. R Package Version 0.1.4. The R Project for Statistical Computing, 2012.
2. Bakker ME, Stolk J, Putter H, Shaker SB, Parr DG, Piitulainen E, Russi EW, Dirksen A, Stockley RA, Reiber JH. Variability in densitometric assessment of pulmonary emphysema with computed tomography. Invest Radiol 40: 777-783, 2005.
3. Behrendt FF, Das M, Mahnken AH, Kraus T, Bakai A, Stanzel S, Gunther RW, Wildberger JE. Computer-aided measurements of pulmonary emphysema in chest multidetector-row spiral computed tomography: Effect of image reconstruction parameters. J Comput Assist Tomogr 32: 899-904, 2008.
4. Birnbaum BA, Hindman N, Lee J, Babb JS. Multi-detector row CT attenuation measurements: Assessment of intra-and interscanner variability with an anthropomorphic body CT phantom. Radiology 242: 109-119, 2007.
5. Bodduluri S, Newell JD Jr, Hoffman EA, Reinhardt JM. Registrationbased lung mechanical analysis of chronic obstructive pulmonary disease (COPD) using a supervised machine learning framework. Acad Radiol 20: 527-536, 2013.
6. Boedeker KL, McNitt-Gray MF, Rogers SR, Truong DA, Brown MS, Gjertson DW, Goldin JG. Emphysema: Effect of reconstruction algorithm on CT imaging measures. Radiology 232: 295-301, 2004.
7. Busacker A, Newell JD Jr, Keefe T, Hoffman EA, Granroth JC, Castro M, Fain S, Wenzel S. A multivariate analysis of risk factors for the air-trapping asthmatic phenotype as measured by quantitative CT analysis. Chest 135: 48-56, 2009.
8. Castillo R, Castillo E, Martinez J, Guerrero T. Ventilation from four-dimensional computed tomography: Density versus Jacobian methods. Phys Med Biol 55: 4661-4685, 2010.
9. Castro M, Fain SB, Hoffman EA, Gierada DS, Erzurum SC, Wenzel S, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lung imaging in asthmatic patients: The picture is clearer. J Allergy Clin Immunol 128: 467-478, 2011.
10. Choi S, Hoffman EA, Wenzel SE, Tawhai MH, Yin Y, Castro M, Lin C. Registration-based assessment of regional lung function via volumetric CT images of normal subjects vs. severe asthmatics. J Appl Physiol 115: 730-742, 2013.
11. Coates A, Peslin R, Rodenstein D, Stocks J. Measurement of lung volumes by plethysmography. Eur Respir J 10: 1415-1427, 1997.
12. Couper D, Lavange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S, SPIROMICS Research Group. Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax 69: 491-494, 2014.
13. Elliott AR, Prisk GK, Guy HJ, West JB. Lung volumes during sustained microgravity on Spacelab SLS-1. J Appl Physiol 4: 2005-2014, 1994.
14. Fain SB, Peterson ET, Sorkness RL, Wenzel S, Castro M, Busse WW. Severe asthma research program-phenotyping and quantification of severe asthma. Imaging Decisions MRI 13: 24-27, 2009.
15. Fuld MK, Grout RW, Guo J, Morgan JH, Hoffman EA. Systems for lung volume standardization during static and dynamic MDCT-based quantitative assessment of pulmonary structure and function. Acad Radiol 19: 930-940, 2012.
16. Galban CJ, Han MK, Boes JL, Chughtai KA, Meyer CR, Johnson TD, Galban S, Rehemtulla A, Kazerooni EA, Martinez FJ, Ross BD. Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression. Nat Med 18: 1711-1715, 2012.
17. Gevenois PA, de Maertelaer V, De Vuyst P, Zanen J, Yernault JC. Comparison of computed density and macroscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 152: 653-657, 1995.
18. Gierada DS, Bierhals AJ, Choong CK, Bartel ST, Ritter JH, Das NA, Hong C, Pilgram TK, Bae KT, Whiting BR. Effects of CT section thickness and reconstruction kernel on emphysema quantification: Relationship to the magnitude of the CT emphysema index. Acad Radiol 17: 146-156, 2010.
19. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general US population. Am J Respir Crit Care Med 159: 179-187, 1999.
20. Hoffman EA, Simon BA, McLennan G. State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomog-raphy phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc 3: 519-532, 2006.
21. Hothorn T, Bretz F, Westfall P. Simultaneous inference in general parametric models. Biom J 50: 346-363, 2008.
22. Hu S, Hoffman EA, Reinhardt JM. Automatic lung segmentation for accurate quantitation of volumetric X-ray CT images. IEEE Trans Med Imaging 20: 490-498, 2001.
23. in 't Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 161: 1902-1906, 2000.
24. Iyer K, Grant R, Zamba G, Hoffman E. Repeatability and sample size assessment associated with computed tomography-based lung density metrics. J COPD F 1: 97-104, 2014.
25. Jarjour NN, Erzurum SC, Bleecker ER, Calhoun WJ, Castro M, Comhair SA, Chung KF, Curran-Everett D, Dweik RA, Fain SB, Fitzpatrick AM, Gaston BM, Israel E, Hastie A, Hoffman EA, Holguin F, Levy BD, Meyers DA, Moore WC, Peters SP, Sorkness RL, Teague WG, Wenzel SE, Busse WW, NHLBI Severe Asthma Research Program (SARP). Severe asthma: Lessons learned from the National Heart, Lung, and Blood Institute Severe Asthma Research Program. Am J Respir Crit Care Med 185: 356-362, 2012.
26. Kim SS, Seo JB, Kim N, Chae EJ, Lee YK, Oh YM, Lee SD. Improved correlation between CT emphysema quantification and pulmonary function test by density correction of volumetric CT data based on air and aortic density. Eur J Radiol 83: 56-63, 2014.
27. King GG, Eberl S, Salome CM, Young IH, Woolcock AJ. Differences in airway closure between normal and asthmatic subjects measured with single-photon emission computed tomography and technegas. Am J Respir Crit Care Med 158: 1900-1906, 1998.
28. Kumar H, Vasilescu DM, Yin Y, Hoffman EA, Tawhai MH, Lin C. Multiscale imaging and registration-driven model for pulmonary acinar mechanics in the mouse. J Appl Physiol 114: 971-978, 2013.
29. Lopez-Raton M, Rodriguez-Alvarez MX. OptimalCutpoints-package {OptimalCutpoints}. Computing Optimal Cutpoints in diagnostic tests, version 1.1. inside-R, 2013.
30. Lutchen KR, Jensen A, Atileh H, Kaczka DW, Israel E, Suki B, Ingenito EP. Airway constriction pattern is a central component of asthma severity: The role of deep inspirations. Am J Respir Crit Care Med 164: 207-215, 2001.
31. Mansel JK, Stogner SW, Petrini MF, Norman JR. Mechanical ventilation in patients with acute severe asthma. Am J Med 89: 42-48, 1990.
32. Mathew L, Wheatley A, Castillo R, Castillo E, Rodrigues G, Guerrero T, Parraga G. Hyperpolarized 3He magnetic resonance imaging: Comparison with four-dimensional X-ray computed tomography imaging in lung cancer. Acad Radiol 19: 1546-1553, 2012.
33. Mets O, de Jong P, van Ginneken B, Gietema H, Lammers J. Quantitative computed tomography in COPD: Possibilities and limitations. Lung 190: 133-145, 2012.
34. Mobberley SD, Fuld MK, Sieren JP, Primak AN, Hoffman EA. Scatter correction associated with dedicated dual-source CT hardware improves accuracy of lung air measures. Acad Radiol 20: 1334-1343, 2013.
35. Moore WC, Bleecker ER, Curran-Everett D, Erzurum SC, Ameredes BT, Bacharier L, Calhoun WJ, Castro M, Chung KF, Clark MP, Dweik RA, Fitzpatrick AM, Gaston B, Hew M, Hussain I, Jarjour NN, Israel E, Levy BD, Murphy JR, Peter SP, Teague WG, Meyers DA, Busse WW, Wenzel SE, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol 119: 405-413, 2007.
36. Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med 181: 315-323, 2010.
37. Moreno F, Lyons HA. Effect of body posture on lung volumes. J Appl Physiol 16: 27-29, 1961.
38. Muller N, Staples C, Miller R, Abboud R. "Density mask". An objective method to quantitate emphysema using computed tomography. Chest 94: 782-787, 1988.
39. Nadel JA, Tierney DF. Effect of a previous deep inspiration on airway resistance in man. J Appl Physiol 16: 717-719, 1961.
40. Newman KB, Lynch DA, Newman LS, Ellegood D, Newell JD Jr. Quantitative computed tomography detects air trapping due to asthma. Chest 106: 105-109, 1994.
41. Reinhardt JM, Ding K, Cao K, Christensen GE, Hoffman EA, Bodas SV. Registration-based estimates of local lung tissue expansion compared to xenon CT measures of specific ventilation. Med Image Anal 12: 752-763, 2008.
42. Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez J, Müller M. pROC: An open-source package for R and S to analyze and compare ROC curves. BMC Bioinformatics 12: 77, 2011.
43. Schroeder JD, McKenzie AS, Zach JA, Wilson CG, Curran-Everett D, Stinson DS, Newell JD Jr, Lynch DA. Relationships between airflow obstruction and quantitative CT measurements of emphysema, air trapping, and airways in subjects with and without chronic obstructive pulmonary disease. AJR Am J Roentgenol 201: W460-W470, 2013.
44. Sieren J, Newell J Jr, Judy P, Lynch D, Chan K, Guo J, Hoffman E. Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study. Med Phys 39: 5757-5767, 2012.
45. Sorkness RL, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Erzurum SC, Gaston BM, Israel E, Jarjour NN, Moore WC, Peters SP, Teague WG, Wenzel SE, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Lung function in adults with stable but severe asthma: Air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol 104: 394-403, 2008.
46. Stocks J, Quanjer PH. Reference values for residual volume, functional residual capacity and total lung capacity. Eur Respir J 8: 492-506, 1995.
47. The R Core Team. R: A Language and Environment for Statistical Computing, Version 3.1.1. R Foundation for Statistical Computing. 2013.
48. Tschirren J, Hoffman EA, McLennan G, Sonka M. Intrathoracic airway trees: Segmentation and airway morphology analysis from lowdose CT scans. IEEE Trans Med Imaging 24: 1529-1539, 2005.
49. Wanger J, Clausen J, Coates A, Pedersen O, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, Van Der Grinten C. Standardisation of the measurement of lung volumes. Eur Respir J 26: 511-522, 2005.
50. Watson RA, Pride NB. Postural changes in lung volumes and respiratory resistance in subjects with obesity. J Appl Physiol 98: 512-517, 2005.
51. Wenzel SE, Busse WW, National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Severe asthma: Lessons from the Severe Asthma Research Program. J Allergy Clin Immunol 119: 14-21, 2007.
52. Wheatley JR, Pare PD, Engel LA. Reversibility of induced bronchoconstriction by deep inspiration in asthmatic and normal subjects. Eur Respir J 2: 331-339, 1989.
53. Yin Y, Hoffman EA, Lin CL. Local tissue-weight-based nonrigid registration of lung images with application to regional ventilation. Medical Imaging 2009: Biomedical Applications in Molecular, Structural, and Functional Imaging, Proc SPIE, edited by Hu XP and Clough AV. 2009, vol. 7262, article id. 72620C.
54. Yin Y, Hoffman EA, Lin CL. Mass preserving nonrigid registration of CT lung images using cubic B-spline. Med Phys 36: 4213-4222, 2009.
55. Yuan R, Mayo JR, Hogg JC, Paré PD, McWilliams AM, Lam S, Coxson HO. The effects of radiation dose and CT manufacturer on measurements of lung densitometry. Chest 132: 617-623, 2007.
56. Zocchi L, Garzaniti N, Newman S, Macklem PT. Effect of hyperinflation and equalization of abdominal pressure on diaphragmatic action. J Appl Physiol 62: 1655-1664, 1987.